Motif ID: Zfp423

Z-value: 0.437


Transcription factors associated with Zfp423:

Gene SymbolEntrez IDGene Name
Zfp423 ENSMUSG00000045333.9 Zfp423

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zfp423mm10_v2_chr8_-_87804411_878044630.221.7e-01Click!


Activity profile for motif Zfp423.

activity profile for motif Zfp423


Sorted Z-values histogram for motif Zfp423

Sorted Z-values for motif Zfp423



Network of associatons between targets according to the STRING database.



First level regulatory network of Zfp423

PNG image of the network

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Top targets:


Showing 1 to 20 of 79 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_6863769 1.460 ENSMUST00000031768.6
 Dlx6
distal-less homeobox 6
chr11_+_54902743 1.093 ENSMUST00000082430.3
 Gpx3
glutathione peroxidase 3
chr12_+_109459843 1.050 ENSMUST00000173812.1
 Dlk1
delta-like 1 homolog (Drosophila)
chr1_+_167598450 0.903 ENSMUST00000111386.1
ENSMUST00000111384.1
 Rxrg

retinoid X receptor gamma

chr8_+_27260327 0.872 ENSMUST00000033880.5
 Eif4ebp1
eukaryotic translation initiation factor 4E binding protein 1
chr9_-_37552904 0.866 ENSMUST00000065668.5
 Nrgn
neurogranin
chr8_+_58912257 0.856 ENSMUST00000160055.1
 BC030500
cDNA sequence BC030500
chr2_+_180499893 0.780 ENSMUST00000029084.2
 Ntsr1
neurotensin receptor 1
chr11_+_54902917 0.772 ENSMUST00000149324.1
 Gpx3
glutathione peroxidase 3
chr17_-_32166879 0.731 ENSMUST00000087723.3
 Notch3
notch 3
chr6_+_110645572 0.708 ENSMUST00000071076.6
ENSMUST00000172951.1
 Grm7

glutamate receptor, metabotropic 7

chr19_+_6401675 0.672 ENSMUST00000113471.1
ENSMUST00000113469.2
 Rasgrp2

RAS, guanyl releasing protein 2

chr7_+_29307924 0.640 ENSMUST00000108230.1
ENSMUST00000065181.5
 Dpf1

D4, zinc and double PHD fingers family 1

chr16_+_17489639 0.635 ENSMUST00000023448.6
 Aifm3
apoptosis-inducing factor, mitochondrion-associated 3
chrX_+_7822289 0.634 ENSMUST00000009875.4
 Kcnd1
potassium voltage-gated channel, Shal-related family, member 1
chr4_-_106464167 0.620 ENSMUST00000049507.5
 Pcsk9
proprotein convertase subtilisin/kexin type 9
chr4_+_42917234 0.610 ENSMUST00000107976.2
ENSMUST00000069184.2
 N28178

expressed sequence N28178

chr1_+_167598384 0.550 ENSMUST00000015987.3
 Rxrg
retinoid X receptor gamma
chr2_-_147085445 0.524 ENSMUST00000067020.2
 Nkx2-4
NK2 homeobox 4
chr10_+_82954344 0.516 ENSMUST00000095396.3
 Gm4799
predicted gene 4799

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.9 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.0 1.5 GO:0060021 palate development(GO:0060021)
0.0 1.0 GO:0045780 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.0 1.0 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.1 0.9 GO:1990928 response to amino acid starvation(GO:1990928)
0.0 0.9 GO:1900273 positive regulation of long-term synaptic potentiation(GO:1900273)
0.2 0.8 GO:0090238 positive regulation of arachidonic acid secretion(GO:0090238)
0.1 0.8 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.1 0.7 GO:0001661 conditioned taste aversion(GO:0001661)
0.1 0.7 GO:0072103 glomerulus vasculature morphogenesis(GO:0072103) glomerular capillary formation(GO:0072104)
0.2 0.6 GO:0001920 negative regulation of receptor recycling(GO:0001920) negative regulation of low-density lipoprotein particle clearance(GO:0010989) positive regulation of low-density lipoprotein particle receptor catabolic process(GO:0032805)
0.1 0.4 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.0 0.4 GO:0002087 regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
0.0 0.4 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.0 0.4 GO:0090022 regulation of neutrophil chemotaxis(GO:0090022)
0.1 0.3 GO:0097477 lateral motor column neuron migration(GO:0097477)
0.1 0.3 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.1 0.3 GO:1900147 Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
0.1 0.3 GO:0070365 hepatocyte differentiation(GO:0070365)
0.0 0.2 GO:2001032 regulation of double-strand break repair via nonhomologous end joining(GO:2001032)

Gene overrepresentation in cellular_component category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.9 GO:0044327 dendritic spine head(GO:0044327)
0.2 0.8 GO:0032280 symmetric synapse(GO:0032280)
0.1 0.7 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.2 0.6 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.0 0.6 GO:0071565 nBAF complex(GO:0071565)
0.0 0.5 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.5 GO:0097225 sperm midpiece(GO:0097225)
0.1 0.3 GO:0045098 type III intermediate filament(GO:0045098)
0.1 0.3 GO:0000125 PCAF complex(GO:0000125)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.9 GO:0008430 selenium binding(GO:0008430)
0.1 1.5 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 0.9 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.9 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 0.8 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.2 0.7 GO:0070905 serine binding(GO:0070905)
0.2 0.6 GO:0034190 very-low-density lipoprotein particle binding(GO:0034189) apolipoprotein receptor binding(GO:0034190)
0.1 0.6 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.6 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.5 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 0.4 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.0 0.4 GO:0031386 protein tag(GO:0031386)
0.0 0.4 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1 0.3 GO:1990254 keratin filament binding(GO:1990254)
0.1 0.3 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.0 0.3 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.1 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.0 0.1 GO:1904288 BAT3 complex binding(GO:1904288)
0.0 0.1 GO:0005093 Rab GDP-dissociation inhibitor activity(GO:0005093)
0.0 0.1 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.5 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.0 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.7 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 0.6 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.3 PID_MYC_PATHWAY C-MYC pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.0 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 0.9 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.1 0.7 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 0.7 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.7 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.0 0.6 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.3 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins