Motif ID: Zfp524

Z-value: 0.593


Transcription factors associated with Zfp524:

Gene SymbolEntrez IDGene Name
Zfp524 ENSMUSG00000051184.6 Zfp524

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zfp524mm10_v2_chr7_+_5015466_5015509-0.047.9e-01Click!


Activity profile for motif Zfp524.

activity profile for motif Zfp524


Sorted Z-values histogram for motif Zfp524

Sorted Z-values for motif Zfp524



Network of associatons between targets according to the STRING database.



First level regulatory network of Zfp524

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_54045182 3.580 ENSMUST00000036700.5
 Adra2a
adrenergic receptor, alpha 2a
chr12_+_4917376 2.721 ENSMUST00000045664.5
 Atad2b
ATPase family, AAA domain containing 2B
chr9_-_122862128 2.408 ENSMUST00000056467.7
 Zfp445
zinc finger protein 445
chr15_+_76660564 2.383 ENSMUST00000004294.10
 Kifc2
kinesin family member C2
chr5_+_76657673 2.276 ENSMUST00000128112.1
 C530008M17Rik
RIKEN cDNA C530008M17 gene
chr17_-_45686899 2.237 ENSMUST00000156254.1
 Tmem63b
transmembrane protein 63b
chr12_+_40446050 2.176 ENSMUST00000037488.6
 Dock4
dedicator of cytokinesis 4
chr18_-_61911783 2.136 ENSMUST00000049378.8
ENSMUST00000166783.1
 Ablim3

actin binding LIM protein family, member 3

chr2_-_24763047 1.889 ENSMUST00000100348.3
ENSMUST00000041342.5
ENSMUST00000114447.1
ENSMUST00000102939.2
ENSMUST00000070864.7
 Cacna1b




calcium channel, voltage-dependent, N type, alpha 1B subunit




chr19_+_26623419 1.810 ENSMUST00000176584.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr1_-_64122256 1.803 ENSMUST00000135075.1
 Klf7
Kruppel-like factor 7 (ubiquitous)
chr4_-_120747248 1.743 ENSMUST00000030376.7
 Kcnq4
potassium voltage-gated channel, subfamily Q, member 4
chr11_+_75531690 1.717 ENSMUST00000149727.1
ENSMUST00000042561.7
ENSMUST00000108433.1
ENSMUST00000143035.1
 Slc43a2



solute carrier family 43, member 2



chr11_-_6065737 1.706 ENSMUST00000002817.5
ENSMUST00000109813.2
ENSMUST00000090443.3
 Camk2b


calcium/calmodulin-dependent protein kinase II, beta


chr11_+_75532127 1.692 ENSMUST00000127226.1
 Slc43a2
solute carrier family 43, member 2
chr9_-_75611308 1.630 ENSMUST00000064433.3
 Tmod2
tropomodulin 2
chr5_-_112228900 1.605 ENSMUST00000182509.1
 Miat
myocardial infarction associated transcript (non-protein coding)
chr5_+_30711564 1.599 ENSMUST00000114729.1
 Dpysl5
dihydropyrimidinase-like 5
chrX_+_106027300 1.590 ENSMUST00000055941.6
 Atp7a
ATPase, Cu++ transporting, alpha polypeptide
chr5_+_30711849 1.565 ENSMUST00000088081.4
ENSMUST00000101442.3
 Dpysl5

dihydropyrimidinase-like 5


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 214 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.1 GO:0015807 L-amino acid transport(GO:0015807)
0.9 3.6 GO:0035624 receptor transactivation(GO:0035624) epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway(GO:0035625) thermoception(GO:0050955)
0.0 3.2 GO:0030032 lamellipodium assembly(GO:0030032)
1.0 3.1 GO:0060003 elastin biosynthetic process(GO:0051542) copper ion export(GO:0060003)
0.3 2.8 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.1 2.6 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.3 2.4 GO:0033602 negative regulation of dopamine secretion(GO:0033602)
0.8 2.3 GO:0032430 positive regulation of phospholipase A2 activity(GO:0032430)
0.2 2.3 GO:0035881 amacrine cell differentiation(GO:0035881) retinal rod cell development(GO:0046548)
0.1 2.3 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.0 2.3 GO:0048813 dendrite morphogenesis(GO:0048813)
0.5 2.2 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0 2.1 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 2.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 2.0 GO:0033344 cholesterol efflux(GO:0033344)
0.1 1.9 GO:0001956 positive regulation of neurotransmitter secretion(GO:0001956)
0.2 1.8 GO:0031547 brain-derived neurotrophic factor receptor signaling pathway(GO:0031547)
0.2 1.8 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.2 1.8 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.1 1.8 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 100 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 14.0 GO:0014069 postsynaptic density(GO:0014069)
0.0 3.3 GO:0043235 receptor complex(GO:0043235)
0.1 3.1 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 3.0 GO:0030139 endocytic vesicle(GO:0030139)
0.1 2.6 GO:0071565 nBAF complex(GO:0071565)
0.1 2.6 GO:0031902 late endosome membrane(GO:0031902)
0.3 2.3 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 2.2 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 2.1 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.2 1.9 GO:0097165 nuclear stress granule(GO:0097165)
0.3 1.8 GO:0044308 axonal spine(GO:0044308)
0.0 1.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.3 1.6 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1 1.6 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 1.6 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.2 1.5 GO:0097427 microtubule bundle(GO:0097427)
0.0 1.5 GO:0032420 stereocilium(GO:0032420)
0.1 1.4 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 1.3 GO:0042734 presynaptic membrane(GO:0042734)
0.0 1.3 GO:0030667 secretory granule membrane(GO:0030667)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 146 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.3 GO:0008017 microtubule binding(GO:0008017)
0.1 5.4 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.1 3.9 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
1.2 3.6 GO:0004936 alpha-adrenergic receptor activity(GO:0004936) epinephrine binding(GO:0051379)
1.0 3.1 GO:0043682 copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682)
0.1 2.8 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 2.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 2.5 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 2.4 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 2.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 2.1 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.5 2.0 GO:0034041 sterol-transporting ATPase activity(GO:0034041)
0.1 1.9 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 1.9 GO:0071617 lysophospholipid acyltransferase activity(GO:0071617)
0.1 1.9 GO:0017091 AU-rich element binding(GO:0017091)
0.2 1.8 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.1 1.7 GO:0042043 neurexin family protein binding(GO:0042043)
0.3 1.6 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.2 1.6 GO:0005523 tropomyosin binding(GO:0005523)
0.0 1.6 GO:0042169 SH2 domain binding(GO:0042169)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.7 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.4 PID_IL2_1PATHWAY IL2-mediated signaling events
0.1 2.3 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 2.1 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 2.0 PID_ATM_PATHWAY ATM pathway
0.0 1.8 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 1.6 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 1.6 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 1.3 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 1.1 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 1.0 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 1.0 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 0.9 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.0 0.8 PID_REELIN_PATHWAY Reelin signaling pathway
0.1 0.7 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.0 0.7 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 0.6 PID_VEGFR1_PATHWAY VEGFR1 specific signals
0.0 0.6 PID_IL12_2PATHWAY IL12-mediated signaling events
0.1 0.5 PID_VEGFR1_2_PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.5 PID_GMCSF_PATHWAY GMCSF-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.4 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 4.5 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.3 3.6 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.2 3.2 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 3.0 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 2.9 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 2.4 REACTOME_TRANSFERRIN_ENDOCYTOSIS_AND_RECYCLING Genes involved in Transferrin endocytosis and recycling
0.1 2.3 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.1 2.3 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 2.2 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 2.0 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 1.8 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 1.6 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 1.5 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.0 1.5 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.3 REACTOME_REGULATORY_RNA_PATHWAYS Genes involved in Regulatory RNA pathways
0.1 1.2 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.1 0.9 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 0.9 REACTOME_SIGNALING_BY_ACTIVATED_POINT_MUTANTS_OF_FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.1 0.9 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation