Motif ID: Zic3

Z-value: 0.888


Transcription factors associated with Zic3:

Gene SymbolEntrez IDGene Name
Zic3 ENSMUSG00000067860.5 Zic3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zic3mm10_v2_chrX_+_58030999_580310180.542.5e-04Click!


Activity profile for motif Zic3.

activity profile for motif Zic3


Sorted Z-values histogram for motif Zic3

Sorted Z-values for motif Zic3



Network of associatons between targets according to the STRING database.



First level regulatory network of Zic3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_53159885 2.987 ENSMUST00000030010.3
 Abca1
ATP-binding cassette, sub-family A (ABC1), member 1
chr2_+_120629113 2.097 ENSMUST00000150912.1
ENSMUST00000180041.1
 Stard9

START domain containing 9

chr2_-_39190687 2.080 ENSMUST00000142872.1
ENSMUST00000038874.5
 Scai

suppressor of cancer cell invasion

chr13_+_44729535 1.898 ENSMUST00000174068.1
 Jarid2
jumonji, AT rich interactive domain 2
chr2_-_160872985 1.831 ENSMUST00000109460.1
ENSMUST00000127201.1
 Zhx3

zinc fingers and homeoboxes 3

chr2_-_146511899 1.731 ENSMUST00000131824.1
 Ralgapa2
Ral GTPase activating protein, alpha subunit 2 (catalytic)
chr5_-_114273702 1.712 ENSMUST00000144050.1
ENSMUST00000044790.5
 Foxn4

forkhead box N4

chr2_-_180776900 1.630 ENSMUST00000108878.1
 Bhlhe23
basic helix-loop-helix family, member e23
chr10_+_18845071 1.563 ENSMUST00000019998.7
 Perp
PERP, TP53 apoptosis effector
chr7_+_127800604 1.493 ENSMUST00000046863.5
ENSMUST00000106272.1
ENSMUST00000139068.1
 Hsd3b7


hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7


chr13_+_44730726 1.451 ENSMUST00000173704.1
ENSMUST00000044608.7
ENSMUST00000173367.1
 Jarid2


jumonji, AT rich interactive domain 2


chr12_-_76709997 1.431 ENSMUST00000166101.1
 Sptb
spectrin beta, erythrocytic
chrX_+_56454871 1.402 ENSMUST00000039374.2
ENSMUST00000101553.2
 Ddx26b

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B

chr10_+_106470281 1.368 ENSMUST00000029404.9
ENSMUST00000169303.1
 Ppfia2

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

chr1_-_64121389 1.364 ENSMUST00000055001.3
 Klf7
Kruppel-like factor 7 (ubiquitous)
chr2_-_160872829 1.348 ENSMUST00000176141.1
 Zhx3
zinc fingers and homeoboxes 3
chr5_+_137288273 1.324 ENSMUST00000024099.4
ENSMUST00000085934.3
 Ache

acetylcholinesterase

chr4_+_108165449 1.289 ENSMUST00000116309.3
ENSMUST00000116307.1
 Echdc2

enoyl Coenzyme A hydratase domain containing 2

chr4_+_108165432 1.225 ENSMUST00000052999.6
 Echdc2
enoyl Coenzyme A hydratase domain containing 2
chr9_+_59750876 1.151 ENSMUST00000136740.1
ENSMUST00000135298.1
ENSMUST00000128341.1
 Myo9a


myosin IXa



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 159 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.9 GO:0048813 dendrite morphogenesis(GO:0048813)
0.9 3.5 GO:0055099 response to high density lipoprotein particle(GO:0055099)
0.2 3.3 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.0 3.0 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.1 2.7 GO:0060579 ventral spinal cord interneuron fate commitment(GO:0060579) cell fate commitment involved in pattern specification(GO:0060581)
0.5 2.5 GO:0060178 regulation of exocyst localization(GO:0060178)
0.2 2.4 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.0 2.3 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.2 2.2 GO:0015838 proline transport(GO:0015824) amino-acid betaine transport(GO:0015838)
0.1 2.1 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.3 1.9 GO:0002934 desmosome organization(GO:0002934)
0.3 1.8 GO:0035754 B cell chemotaxis(GO:0035754)
0.0 1.8 GO:0051225 spindle assembly(GO:0051225)
0.0 1.7 GO:0030835 negative regulation of actin filament depolymerization(GO:0030835)
0.2 1.6 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
0.1 1.6 GO:0008209 androgen metabolic process(GO:0008209)
0.1 1.5 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.4 1.4 GO:0033326 cerebrospinal fluid secretion(GO:0033326)
0.0 1.4 GO:0097352 autophagosome maturation(GO:0097352)
0.0 1.4 GO:0098656 anion transmembrane transport(GO:0098656)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.0 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.1 2.9 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.3 2.4 GO:0097165 nuclear stress granule(GO:0097165)
0.0 2.4 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 2.3 GO:0005871 kinesin complex(GO:0005871)
0.0 2.1 GO:0032587 ruffle membrane(GO:0032587)
0.2 1.4 GO:0008091 spectrin(GO:0008091)
0.0 1.4 GO:0016459 myosin complex(GO:0016459)
0.1 1.3 GO:0043083 synaptic cleft(GO:0043083)
0.1 1.2 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 1.1 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 1.1 GO:0005811 lipid particle(GO:0005811)
0.1 1.0 GO:0033269 internode region of axon(GO:0033269)
0.1 1.0 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 1.0 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 1.0 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 0.9 GO:0061700 GATOR2 complex(GO:0061700)
0.0 0.9 GO:0097228 sperm principal piece(GO:0097228)
0.1 0.8 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.7 GO:1903440 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 100 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.6 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 4.5 GO:0005096 GTPase activator activity(GO:0005096)
1.0 3.0 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.1 2.8 GO:0032452 histone demethylase activity(GO:0032452)
0.2 2.5 GO:0004300 enoyl-CoA hydratase activity(GO:0004300)
0.0 2.3 GO:0003777 microtubule motor activity(GO:0003777)
0.3 2.2 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.1 2.1 GO:0030506 ankyrin binding(GO:0030506)
0.1 2.0 GO:0017091 AU-rich element binding(GO:0017091)
0.3 1.8 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.1 1.7 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 1.7 GO:0031490 chromatin DNA binding(GO:0031490)
0.1 1.5 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.1 1.5 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.2 1.4 GO:0045545 syndecan binding(GO:0045545)
0.0 1.4 GO:0003774 motor activity(GO:0003774)
0.0 1.4 GO:0008565 protein transporter activity(GO:0008565)
0.3 1.3 GO:0004104 cholinesterase activity(GO:0004104) choline binding(GO:0033265)
0.2 1.2 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.1 1.2 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.1 2.3 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 2.0 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 1.6 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.5 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.1 1.4 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 1.3 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 1.0 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.0 0.9 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.9 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.8 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.1 0.7 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.7 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 0.6 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.6 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 0.6 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 0.5 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.0 0.5 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.5 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.5 PID_ERBB4_PATHWAY ErbB4 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.0 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.2 1.8 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 1.8 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 1.6 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 1.5 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.4 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 1.3 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 1.3 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.1 1.2 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 1.1 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 0.9 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR Genes involved in Regulated proteolysis of p75NTR
0.1 0.7 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 0.7 REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.1 0.7 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.7 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling
0.1 0.6 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.6 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.6 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 0.6 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.6 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions