Motif ID: Zic4
Z-value: 0.987
Transcription factors associated with Zic4:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Zic4 | ENSMUSG00000036972.8 | Zic4 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Zic4 | mm10_v2_chr9_+_91378636_91378646 | 0.04 | 7.9e-01 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 87 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.8 | GO:0048713 | regulation of oligodendrocyte differentiation(GO:0048713) |
| 1.0 | 6.7 | GO:0035093 | spermatogenesis, exchange of chromosomal proteins(GO:0035093) |
| 0.8 | 6.2 | GO:0035726 | common myeloid progenitor cell proliferation(GO:0035726) |
| 1.0 | 4.9 | GO:2001025 | positive regulation of response to drug(GO:2001025) |
| 0.4 | 4.0 | GO:0048170 | positive regulation of long-term neuronal synaptic plasticity(GO:0048170) |
| 0.3 | 3.8 | GO:0007213 | G-protein coupled acetylcholine receptor signaling pathway(GO:0007213) |
| 0.3 | 3.5 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.1 | 3.0 | GO:1900452 | regulation of long term synaptic depression(GO:1900452) |
| 0.9 | 2.8 | GO:0017055 | negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055) |
| 0.5 | 2.6 | GO:1990034 | calcium ion export from cell(GO:1990034) |
| 0.1 | 2.2 | GO:0032897 | negative regulation of viral transcription(GO:0032897) |
| 0.5 | 2.1 | GO:0099527 | postsynapse to nucleus signaling pathway(GO:0099527) |
| 0.1 | 2.1 | GO:2000811 | negative regulation of anoikis(GO:2000811) |
| 0.4 | 1.8 | GO:0009957 | epidermal cell fate specification(GO:0009957) |
| 0.3 | 1.8 | GO:0032811 | negative regulation of gamma-aminobutyric acid secretion(GO:0014053) negative regulation of epinephrine secretion(GO:0032811) |
| 0.1 | 1.8 | GO:0048484 | enteric nervous system development(GO:0048484) |
| 0.2 | 1.7 | GO:0045900 | negative regulation of translational elongation(GO:0045900) |
| 0.1 | 1.7 | GO:1903861 | positive regulation of dendrite extension(GO:1903861) |
| 0.0 | 1.7 | GO:0036075 | endochondral ossification(GO:0001958) replacement ossification(GO:0036075) |
| 0.0 | 1.7 | GO:0030514 | negative regulation of BMP signaling pathway(GO:0030514) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 38 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 6.5 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.3 | 4.9 | GO:1990635 | proximal dendrite(GO:1990635) |
| 0.1 | 4.0 | GO:0097440 | apical dendrite(GO:0097440) |
| 0.1 | 3.9 | GO:0032809 | neuronal cell body membrane(GO:0032809) |
| 0.0 | 3.8 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 2.5 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 2.2 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 2.2 | GO:0030659 | cytoplasmic vesicle membrane(GO:0030659) |
| 0.0 | 2.1 | GO:0005811 | lipid particle(GO:0005811) |
| 0.1 | 2.0 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.4 | 1.8 | GO:0038039 | G-protein coupled receptor heterodimeric complex(GO:0038039) |
| 0.1 | 1.6 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 1.6 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 1.5 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.4 | 1.4 | GO:0032280 | symmetric synapse(GO:0032280) |
| 0.2 | 1.3 | GO:0033391 | chromatoid body(GO:0033391) |
| 0.2 | 1.3 | GO:0031315 | extrinsic component of mitochondrial outer membrane(GO:0031315) |
| 0.0 | 1.3 | GO:0030673 | axolemma(GO:0030673) |
| 0.0 | 1.2 | GO:0032590 | dendrite membrane(GO:0032590) |
| 0.0 | 1.2 | GO:0000118 | histone deacetylase complex(GO:0000118) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 54 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.1 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 1.7 | 6.7 | GO:0061628 | H3K27me3 modified histone binding(GO:0061628) |
| 0.1 | 5.6 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.0 | 5.5 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 4.0 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.3 | 3.5 | GO:0015347 | sodium-independent organic anion transmembrane transporter activity(GO:0015347) |
| 0.2 | 2.9 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.9 | 2.8 | GO:0002153 | steroid receptor RNA activator RNA binding(GO:0002153) |
| 0.1 | 2.8 | GO:0045182 | translation regulator activity(GO:0045182) |
| 0.2 | 2.4 | GO:0008526 | phosphatidylinositol transporter activity(GO:0008526) |
| 0.0 | 2.3 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.1 | 2.1 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.1 | 2.1 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.0 | 2.1 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.0 | 2.1 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.6 | 1.8 | GO:0005119 | smoothened binding(GO:0005119) hedgehog receptor activity(GO:0008158) |
| 0.3 | 1.8 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
| 0.2 | 1.7 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.1 | 1.7 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.0 | 1.7 | GO:0046332 | SMAD binding(GO:0046332) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 26 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.1 | PID_PI3KCI_AKT_PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.1 | 2.8 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 2.4 | PID_ARF6_PATHWAY | Arf6 signaling events |
| 0.0 | 2.1 | PID_ERA_GENOMIC_PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 2.0 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 1.8 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.1 | 1.7 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 1.6 | PID_PS1_PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.0 | 1.5 | PID_HNF3A_PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.3 | PID_LIS1_PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 1.2 | PID_IL6_7_PATHWAY | IL6-mediated signaling events |
| 0.0 | 1.2 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.0 | 1.1 | PID_ARF6_TRAFFICKING_PATHWAY | Arf6 trafficking events |
| 0.0 | 0.9 | PID_GLYPICAN_1PATHWAY | Glypican 1 network |
| 0.0 | 0.9 | PID_P38_ALPHA_BETA_PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.0 | 0.9 | PID_TELOMERASE_PATHWAY | Regulation of Telomerase |
| 0.1 | 0.8 | PID_SYNDECAN_3_PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 0.8 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 0.8 | PID_RAC1_REG_PATHWAY | Regulation of RAC1 activity |
| 0.0 | 0.6 | PID_BMP_PATHWAY | BMP receptor signaling |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 26 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.1 | REACTOME_G_ALPHA_I_SIGNALLING_EVENTS | Genes involved in G alpha (i) signalling events |
| 0.0 | 3.0 | REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 0.0 | 2.9 | REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.0 | 2.8 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.2 | 2.6 | REACTOME_PLATELET_CALCIUM_HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.1 | 2.1 | REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.0 | 1.9 | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.1 | 1.8 | REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.1 | 1.8 | REACTOME_KINESINS | Genes involved in Kinesins |
| 0.1 | 1.6 | REACTOME_PLATELET_SENSITIZATION_BY_LDL | Genes involved in Platelet sensitization by LDL |
| 0.0 | 1.4 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 1.3 | REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.0 | 1.2 | REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 1.1 | REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.0 | 1.1 | REACTOME_SIGNALING_BY_RHO_GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 1.0 | REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION | Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
| 0.0 | 0.8 | REACTOME_HS_GAG_DEGRADATION | Genes involved in HS-GAG degradation |
| 0.0 | 0.8 | REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.0 | 0.7 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 0.6 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
