Motif ID: Zkscan1

Z-value: 0.523


Transcription factors associated with Zkscan1:

Gene SymbolEntrez IDGene Name
Zkscan1 ENSMUSG00000029729.6 Zkscan1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zkscan1mm10_v2_chr5_+_138085083_138085147-0.057.5e-01Click!


Activity profile for motif Zkscan1.

activity profile for motif Zkscan1


Sorted Z-values histogram for motif Zkscan1

Sorted Z-values for motif Zkscan1



Network of associatons between targets according to the STRING database.



First level regulatory network of Zkscan1

PNG image of the network

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Top targets:


Showing 1 to 20 of 111 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_79164477 2.943 ENSMUST00000040019.4
 Sox10
SRY-box containing gene 10
chr9_+_98422961 2.042 ENSMUST00000052068.9
 Rbp1
retinol binding protein 1, cellular
chrX_+_20870166 1.907 ENSMUST00000115342.3
ENSMUST00000009530.4
 Timp1

tissue inhibitor of metalloproteinase 1

chr2_-_156839790 1.753 ENSMUST00000134838.1
ENSMUST00000137463.1
ENSMUST00000149275.2
 Gm14230


predicted gene 14230


chr4_+_129960760 1.543 ENSMUST00000139884.1
 1700003M07Rik
RIKEN cDNA 1700003M07 gene
chr15_+_83779999 1.499 ENSMUST00000046168.5
 Mpped1
metallophosphoesterase domain containing 1
chr8_+_72646679 1.425 ENSMUST00000161386.1
ENSMUST00000093427.4
 Nwd1

NACHT and WD repeat domain containing 1

chr1_-_56969864 1.413 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr19_-_45742873 1.338 ENSMUST00000026241.5
ENSMUST00000026240.7
ENSMUST00000111928.1
 Fgf8


fibroblast growth factor 8


chr8_+_72646728 1.322 ENSMUST00000161254.1
 Nwd1
NACHT and WD repeat domain containing 1
chr4_+_101419277 1.304 ENSMUST00000102780.1
ENSMUST00000106946.1
ENSMUST00000106945.1
 Ak4


adenylate kinase 4


chr7_+_144896523 1.296 ENSMUST00000033389.5
 Fgf15
fibroblast growth factor 15
chr19_-_61228396 1.243 ENSMUST00000076046.6
 Csf2ra
colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
chr2_-_105399286 1.118 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1
chr5_-_28210022 1.101 ENSMUST00000118882.1
 Cnpy1
canopy 1 homolog (zebrafish)
chr1_-_56969827 1.028 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr3_+_62338344 0.948 ENSMUST00000079300.6
 Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr17_+_75005523 0.930 ENSMUST00000001927.5
 Ltbp1
latent transforming growth factor beta binding protein 1
chr6_+_83711232 0.926 ENSMUST00000037807.1
 Vax2
ventral anterior homeobox containing gene 2
chr17_+_33524170 0.788 ENSMUST00000087623.6
 Adamts10
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 2.9 GO:0010626 negative regulation of Schwann cell proliferation(GO:0010626)
0.2 2.4 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.5 2.0 GO:0006776 vitamin A metabolic process(GO:0006776)
0.3 1.9 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.4 1.3 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.3 1.3 GO:0070858 negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
0.1 1.3 GO:0046033 AMP metabolic process(GO:0046033)
0.1 1.2 GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011)
0.1 1.2 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.0 1.0 GO:0032418 lysosome localization(GO:0032418)
0.0 0.9 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.0 0.9 GO:0009950 dorsal/ventral axis specification(GO:0009950)
0.0 0.9 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.0 0.8 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 0.8 GO:0038092 nodal signaling pathway(GO:0038092)
0.1 0.7 GO:0070307 lens fiber cell development(GO:0070307)
0.1 0.6 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.1 0.6 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
0.1 0.6 GO:0046541 stabilization of membrane potential(GO:0030322) saliva secretion(GO:0046541) positive regulation of T cell receptor signaling pathway(GO:0050862)
0.0 0.6 GO:0007398 ectoderm development(GO:0007398)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 2.9 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.1 2.7 GO:0005682 U5 snRNP(GO:0005682)
0.0 2.4 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.1 GO:0005604 basement membrane(GO:0005604)
0.1 1.0 GO:0031083 BLOC-1 complex(GO:0031083)
0.3 0.9 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.1 0.8 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.1 0.8 GO:0000796 condensin complex(GO:0000796)
0.0 0.7 GO:0005882 intermediate filament(GO:0005882)
0.0 0.5 GO:0031143 pseudopodium(GO:0031143)
0.0 0.4 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.4 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.1 0.3 GO:0090661 box H/ACA telomerase RNP complex(GO:0090661)
0.1 0.2 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.0 0.2 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.2 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.2 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.2 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 0.1 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.1 GO:0034464 BBSome(GO:0034464)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.3 2.0 GO:0019841 retinol binding(GO:0019841)
0.1 1.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.4 1.3 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.4 1.3 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.1 1.3 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 1.2 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 1.2 GO:0046875 ephrin receptor binding(GO:0046875)
0.2 0.9 GO:0050436 microfibril binding(GO:0050436)
0.1 0.9 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.0 0.8 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.1 0.7 GO:0005212 structural constituent of eye lens(GO:0005212)
0.2 0.6 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.6 GO:0071949 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) FAD binding(GO:0071949)
0.0 0.6 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.2 0.5 GO:0046997 sarcosine dehydrogenase activity(GO:0008480) oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997)
0.2 0.5 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.0 0.5 GO:0042169 SH2 domain binding(GO:0042169)
0.0 0.5 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.1 0.4 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.1 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 1.9 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 1.3 PID_FGF_PATHWAY FGF signaling pathway
0.0 1.1 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.7 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.6 PID_MYC_PATHWAY C-MYC pathway
0.0 0.6 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events
0.0 0.5 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 0.3 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 0.2 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.9 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.2 1.3 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 1.2 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.8 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.7 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.6 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.5 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 0.5 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.4 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.4 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.1 0.3 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.1 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors