Motif ID: Zkscan3

Z-value: 0.463


Transcription factors associated with Zkscan3:

Gene SymbolEntrez IDGene Name
Zkscan3 ENSMUSG00000021327.12 Zkscan3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zkscan3mm10_v2_chr13_-_21402688_21402755-0.067.3e-01Click!


Activity profile for motif Zkscan3.

activity profile for motif Zkscan3


Sorted Z-values histogram for motif Zkscan3

Sorted Z-values for motif Zkscan3



Network of associatons between targets according to the STRING database.



First level regulatory network of Zkscan3

PNG image of the network

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Top targets:


Showing 1 to 20 of 73 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_75422586 1.470 ENSMUST00000138661.1
ENSMUST00000000769.7
 Serpinf1

serine (or cysteine) peptidase inhibitor, clade F, member 1

chr4_+_156026120 1.317 ENSMUST00000103173.3
 Tnfrsf18
tumor necrosis factor receptor superfamily, member 18
chr12_+_112588753 1.268 ENSMUST00000101029.2
 Inf2
inverted formin, FH2 and WH2 domain containing
chr6_-_97459279 1.211 ENSMUST00000113359.1
 Frmd4b
FERM domain containing 4B
chr1_-_173333503 1.064 ENSMUST00000038227.4
 Darc
Duffy blood group, chemokine receptor
chr1_+_132298606 1.061 ENSMUST00000046071.4
 Klhdc8a
kelch domain containing 8A
chr2_-_66634952 0.938 ENSMUST00000100064.2
ENSMUST00000100063.2
 Scn9a

sodium channel, voltage-gated, type IX, alpha

chr2_+_104095796 0.908 ENSMUST00000040423.5
ENSMUST00000168176.1
 Cd59a

CD59a antigen

chr11_-_75422524 0.870 ENSMUST00000125982.1
ENSMUST00000137103.1
 Serpinf1

serine (or cysteine) peptidase inhibitor, clade F, member 1

chr4_+_156026304 0.868 ENSMUST00000040274.7
ENSMUST00000122001.1
 Tnfrsf18

tumor necrosis factor receptor superfamily, member 18

chr8_-_70760889 0.758 ENSMUST00000038626.8
 Mpv17l2
MPV17 mitochondrial membrane protein-like 2
chr5_+_24985840 0.756 ENSMUST00000075081.6
 1500035N22Rik
RIKEN cDNA 1500035N22 gene
chr5_-_73338580 0.714 ENSMUST00000087195.5
 Ociad2
OCIA domain containing 2
chr6_+_125552948 0.654 ENSMUST00000112254.1
ENSMUST00000112253.1
ENSMUST00000001995.7
 Vwf


Von Willebrand factor homolog


chr1_-_40790642 0.653 ENSMUST00000039672.5
 Mfsd9
major facilitator superfamily domain containing 9
chr13_+_42709482 0.632 ENSMUST00000066928.5
ENSMUST00000148891.1
 Phactr1

phosphatase and actin regulator 1

chr13_+_104109737 0.567 ENSMUST00000044385.7
 Sgtb
small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
chr2_-_30194112 0.509 ENSMUST00000113659.1
ENSMUST00000113660.1
 Ccbl1

cysteine conjugate-beta lyase 1

chr6_-_113719880 0.508 ENSMUST00000064993.5
 Ghrl
ghrelin
chr13_-_19395728 0.475 ENSMUST00000039694.7
 Stard3nl
STARD3 N-terminal like

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.3 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.1 2.2 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.0 1.3 GO:0090140 regulation of mitochondrial fission(GO:0090140)
0.0 1.2 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.2 0.9 GO:0090272 negative regulation of fibroblast growth factor production(GO:0090272)
0.0 0.9 GO:0048266 behavioral response to pain(GO:0048266)
0.0 0.9 GO:0006998 nuclear envelope organization(GO:0006998)
0.1 0.8 GO:0061668 mitochondrial ribosome assembly(GO:0061668)
0.2 0.5 GO:0035482 intestine smooth muscle contraction(GO:0014827) gastric motility(GO:0035482) gastric emptying(GO:0035483) regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) negative regulation of tumor necrosis factor biosynthetic process(GO:0042536) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938) positive regulation of cortisol secretion(GO:0051464) regulation of gastro-intestinal system smooth muscle contraction(GO:1904304) regulation of small intestine smooth muscle contraction(GO:1904347) small intestine smooth muscle contraction(GO:1990770)
0.2 0.5 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.1 0.4 GO:1904578 response to thapsigargin(GO:1904578) cellular response to thapsigargin(GO:1904579)
0.1 0.4 GO:0051418 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.0 0.4 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.0 0.4 GO:0006767 water-soluble vitamin metabolic process(GO:0006767)
0.0 0.4 GO:0006829 zinc II ion transport(GO:0006829)
0.1 0.3 GO:1905072 detection of oxygen(GO:0003032) positive regulation of vascular smooth muscle cell differentiation(GO:1905065) cardiac jelly development(GO:1905072)
0.1 0.3 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
0.1 0.3 GO:0038145 macrophage colony-stimulating factor signaling pathway(GO:0038145)
0.1 0.3 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.0 0.3 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)

Gene overrepresentation in cellular_component category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.3 GO:0043203 axon hillock(GO:0043203)
0.0 1.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 0.9 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.8 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 0.7 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.6 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.5 GO:0044232 organelle membrane contact site(GO:0044232)
0.1 0.4 GO:0000923 equatorial microtubule organizing center(GO:0000923)
0.0 0.4 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.4 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.1 0.3 GO:0020018 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.1 0.3 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.0 0.3 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.3 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.3 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 0.2 GO:0005673 transcription factor TFIIE complex(GO:0005673)
0.0 0.2 GO:0060091 kinocilium(GO:0060091)
0.0 0.2 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 2.2 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.9 GO:0031402 sodium ion binding(GO:0031402)
0.0 0.9 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 0.7 GO:0019865 immunoglobulin binding(GO:0019865)
0.0 0.6 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.2 0.5 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.0 0.5 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.1 0.4 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.1 0.4 GO:0016778 diphosphotransferase activity(GO:0016778)
0.1 0.4 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.0 0.4 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 0.4 GO:0051400 BH domain binding(GO:0051400)
0.0 0.4 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 0.3 GO:0005534 galactose binding(GO:0005534)
0.0 0.3 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 0.2 GO:0004875 complement receptor activity(GO:0004875)
0.0 0.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.2 GO:0016004 phospholipase activator activity(GO:0016004) lipase activator activity(GO:0060229)
0.0 0.1 GO:0008527 taste receptor activity(GO:0008527)

Gene overrepresentation in C2:CP category:

Showing 1 to 2 of 2 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.2 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 2.2 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 0.7 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.1 0.5 REACTOME_TRYPTOPHAN_CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.5 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.4 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.3 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.3 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.2 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling