Motif ID: Aire

Z-value: 0.906


Transcription factors associated with Aire:

Gene SymbolEntrez IDGene Name
Aire ENSMUSG00000000731.9 Aire



Activity profile for motif Aire.

activity profile for motif Aire


Sorted Z-values histogram for motif Aire

Sorted Z-values for motif Aire



Network of associatons between targets according to the STRING database.



First level regulatory network of Aire

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_61185558 17.326 ENSMUST00000166381.1
 Cdr1
cerebellar degeneration related antigen 1
chr12_-_78983476 3.273 ENSMUST00000070174.7
 Tmem229b
transmembrane protein 229B
chr13_-_110280103 3.070 ENSMUST00000167824.1
 Rab3c
RAB3C, member RAS oncogene family
chr8_+_69808672 2.854 ENSMUST00000036074.8
ENSMUST00000123453.1
 Gmip

Gem-interacting protein

chr10_+_123264076 2.797 ENSMUST00000050756.7
 Fam19a2
family with sequence similarity 19, member A2
chr3_-_116968969 2.593 ENSMUST00000143611.1
ENSMUST00000040097.7
 Palmd

palmdelphin

chr7_-_127895578 2.213 ENSMUST00000033074.6
 Vkorc1
vitamin K epoxide reductase complex, subunit 1
chr9_+_64235201 2.137 ENSMUST00000039011.3
 Uchl4
ubiquitin carboxyl-terminal esterase L4
chr18_+_37400845 2.067 ENSMUST00000057228.1
 Pcdhb9
protocadherin beta 9
chr18_+_37725706 2.058 ENSMUST00000066149.6
 Pcdhga9
protocadherin gamma subfamily A, 9
chr2_+_55435918 1.995 ENSMUST00000067101.3
 Kcnj3
potassium inwardly-rectifying channel, subfamily J, member 3
chr14_+_76476913 1.992 ENSMUST00000140251.2
 Tsc22d1
TSC22 domain family, member 1
chr19_-_28963863 1.870 ENSMUST00000161813.1
 4430402I18Rik
RIKEN cDNA 4430402I18 gene
chr5_-_84417359 1.866 ENSMUST00000113401.1
 Epha5
Eph receptor A5
chr9_-_53610329 1.799 ENSMUST00000034547.5
 Acat1
acetyl-Coenzyme A acetyltransferase 1
chr19_+_34217588 1.729 ENSMUST00000119603.1
 Stambpl1
STAM binding protein like 1
chr10_+_52358767 1.470 ENSMUST00000180473.1
 Gm26741
predicted gene, 26741
chr10_+_86021961 1.456 ENSMUST00000130320.1
 Fbxo7
F-box protein 7
chr2_-_134644079 1.424 ENSMUST00000110119.1
 Tmx4
thioredoxin-related transmembrane protein 4
chr7_+_60155538 1.344 ENSMUST00000057611.4
 Gm7367
predicted pseudogene 7367
chr12_+_84052114 1.316 ENSMUST00000120927.1
 Acot3
acyl-CoA thioesterase 3
chr8_+_64947177 1.295 ENSMUST00000079896.7
ENSMUST00000026595.5
 Tmem192

transmembrane protein 192

chr13_+_53525703 1.232 ENSMUST00000081132.4
 Gm5449
predicted pseudogene 5449
chr4_-_46566432 0.944 ENSMUST00000030021.7
ENSMUST00000107757.1
 Coro2a

coronin, actin binding protein 2A

chr11_-_115627948 0.922 ENSMUST00000154623.1
ENSMUST00000106503.3
ENSMUST00000141614.1
 Slc25a19


solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19


chr10_-_81014902 0.906 ENSMUST00000126317.1
ENSMUST00000092285.3
ENSMUST00000117805.1
 Gng7


guanine nucleotide binding protein (G protein), gamma 7


chr2_+_25218741 0.861 ENSMUST00000028346.3
 Fam166a
family with sequence similarity 166, member A
chr7_+_45896941 0.855 ENSMUST00000069772.7
ENSMUST00000107716.1
 Tmem143

transmembrane protein 143

chr17_+_35236556 0.774 ENSMUST00000068261.8
 Atp6v1g2
ATPase, H+ transporting, lysosomal V1 subunit G2
chr11_-_69695802 0.760 ENSMUST00000108649.1
ENSMUST00000174159.1
ENSMUST00000181810.1
 BC096441

Tnfsf12
cDNA sequence BC096441

tumor necrosis factor (ligand) superfamily, member 12
chr5_+_130369420 0.752 ENSMUST00000086029.3
 Caln1
calneuron 1
chr14_-_18894255 0.747 ENSMUST00000124353.1
 Ube2e2
ubiquitin-conjugating enzyme E2E 2
chrM_+_7759 0.729 ENSMUST00000082407.1
ENSMUST00000082408.1
 mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr16_-_91618986 0.699 ENSMUST00000143058.1
ENSMUST00000049244.8
ENSMUST00000169982.1
ENSMUST00000133731.1
 Dnajc28



DnaJ (Hsp40) homolog, subfamily C, member 28



chr12_-_36156781 0.680 ENSMUST00000020856.4
 Bzw2
basic leucine zipper and W2 domains 2
chr5_+_140735526 0.677 ENSMUST00000120630.2
 Amz1
archaelysin family metallopeptidase 1
chr1_-_171059390 0.667 ENSMUST00000164044.1
ENSMUST00000169017.1
 Fcgr3

Fc receptor, IgG, low affinity III

chr16_+_36875119 0.659 ENSMUST00000135406.1
ENSMUST00000114812.1
ENSMUST00000134616.1
ENSMUST00000023534.6
 Golgb1


Golgb1
golgi autoantigen, golgin subfamily b, macrogolgin 1


golgi autoantigen, golgin subfamily b, macrogolgin 1
chr8_-_31739763 0.651 ENSMUST00000178878.1
 Gm5117
predicted gene 5117
chr12_+_36157124 0.611 ENSMUST00000041640.3
 Ankmy2
ankyrin repeat and MYND domain containing 2
chr7_+_45897429 0.578 ENSMUST00000140243.1
 Tmem143
transmembrane protein 143
chr9_+_109054839 0.559 ENSMUST00000154184.1
 Shisa5
shisa homolog 5 (Xenopus laevis)
chr19_-_6118491 0.558 ENSMUST00000113533.1
 Sac3d1
SAC3 domain containing 1
chr3_+_89715016 0.537 ENSMUST00000098924.2
 Adar
adenosine deaminase, RNA-specific
chr7_-_141434532 0.522 ENSMUST00000133021.1
ENSMUST00000106007.3
ENSMUST00000150026.1
ENSMUST00000133206.2
 Slc25a22



solute carrier family 25 (mitochondrial carrier, glutamate), member 22



chr12_+_10390756 0.505 ENSMUST00000020947.5
 Rdh14
retinol dehydrogenase 14 (all-trans and 9-cis)
chr3_-_89411781 0.493 ENSMUST00000107429.3
ENSMUST00000129308.2
ENSMUST00000107426.1
ENSMUST00000050398.4
ENSMUST00000162701.1
 Flad1




RFad1, flavin adenine dinucleotide synthetase, homolog (yeast)




chr7_-_19665005 0.489 ENSMUST00000055242.9
 Clptm1
cleft lip and palate associated transmembrane protein 1
chr9_-_97111117 0.453 ENSMUST00000085206.4
 Slc25a36
solute carrier family 25, member 36
chr6_+_126939957 0.435 ENSMUST00000032497.3
 D6Wsu163e
DNA segment, Chr 6, Wayne State University 163, expressed
chr13_-_62371936 0.416 ENSMUST00000107989.3
 Gm3604
predicted gene 3604
chrM_+_8600 0.401 ENSMUST00000082409.1
 mt-Co3
mitochondrially encoded cytochrome c oxidase III
chr12_+_69296676 0.394 ENSMUST00000021362.4
 Klhdc2
kelch domain containing 2
chr2_+_164948219 0.375 ENSMUST00000017881.2
 Mmp9
matrix metallopeptidase 9
chr5_+_121660528 0.370 ENSMUST00000031414.8
 Brap
BRCA1 associated protein
chr1_-_65186456 0.362 ENSMUST00000169032.1
 Idh1
isocitrate dehydrogenase 1 (NADP+), soluble
chr15_+_101266839 0.344 ENSMUST00000023779.6
 Nr4a1
nuclear receptor subfamily 4, group A, member 1
chr9_-_113708209 0.322 ENSMUST00000111861.3
ENSMUST00000035086.6
 Pdcd6ip

programmed cell death 6 interacting protein

chr2_-_134644125 0.305 ENSMUST00000038228.4
 Tmx4
thioredoxin-related transmembrane protein 4
chr1_-_90843916 0.285 ENSMUST00000130846.2
ENSMUST00000097653.4
ENSMUST00000056925.9
 Col6a3


collagen, type VI, alpha 3


chrM_+_14138 0.283 ENSMUST00000082421.1
 mt-Cytb
mitochondrially encoded cytochrome b
chr5_+_24100578 0.279 ENSMUST00000030841.5
ENSMUST00000163409.1
 Klhl7

kelch-like 7

chr15_+_10981747 0.267 ENSMUST00000070877.5
 Amacr
alpha-methylacyl-CoA racemase
chr2_-_121473993 0.241 ENSMUST00000056732.3
 Mfap1b
microfibrillar-associated protein 1B
chr10_+_53337686 0.234 ENSMUST00000046221.6
ENSMUST00000163319.1
 Pln

phospholamban

chr14_-_57571551 0.231 ENSMUST00000022518.5
 N6amt2
N-6 adenine-specific DNA methyltransferase 2 (putative)
chr5_-_100373484 0.222 ENSMUST00000182433.1
 Sec31a
Sec31 homolog A (S. cerevisiae)
chr17_+_22689771 0.202 ENSMUST00000055305.8
 Gm9805
predicted gene 9805
chr5_-_113310697 0.200 ENSMUST00000154248.1
 Sgsm1
small G protein signaling modulator 1
chr5_-_105343929 0.196 ENSMUST00000183149.1
 Gbp11
guanylate binding protein 11
chr2_-_6951680 0.196 ENSMUST00000076071.2
 Gm10115
predicted gene 10115
chr18_+_36793918 0.184 ENSMUST00000001419.8
 Zmat2
zinc finger, matrin type 2
chr19_+_3323301 0.149 ENSMUST00000025835.4
 Cpt1a
carnitine palmitoyltransferase 1a, liver
chr11_-_69696058 0.114 ENSMUST00000094070.4
ENSMUST00000180587.1
 BC096441
Tnfsf12
cDNA sequence BC096441
tumor necrosis factor (ligand) superfamily, member 12
chr1_+_44119952 0.109 ENSMUST00000114709.2
 Bivm
basic, immunoglobulin-like variable motif containing
chr2_-_165400398 0.107 ENSMUST00000029213.4
 Ocstamp
osteoclast stimulatory transmembrane protein
chr1_-_5070281 0.102 ENSMUST00000147158.1
ENSMUST00000118000.1
 Rgs20

regulator of G-protein signaling 20

chr11_-_67052563 0.100 ENSMUST00000116363.1
 Adprm
ADP-ribose/CDP-alcohol diphosphatase, manganese dependent
chr8_-_4216912 0.098 ENSMUST00000177491.1
 BC068157
cDNA sequence BC068157
chr7_-_126922887 0.091 ENSMUST00000134134.1
ENSMUST00000119781.1
ENSMUST00000121612.2
 Tmem219


transmembrane protein 219


chr3_-_62506970 0.076 ENSMUST00000029336.4
 Dhx36
DEAH (Asp-Glu-Ala-His) box polypeptide 36
chr6_-_91515878 0.065 ENSMUST00000032182.3
 Xpc
xeroderma pigmentosum, complementation group C
chr8_+_111643425 0.051 ENSMUST00000077791.6
 Zfp1
zinc finger protein 1
chr8_-_4217133 0.036 ENSMUST00000175906.1
 BC068157
cDNA sequence BC068157
chr7_-_14562171 0.033 ENSMUST00000181796.1
 Vmn1r90
vomeronasal 1 receptor 90
chr7_-_121981669 0.030 ENSMUST00000057576.7
 Cog7
component of oligomeric golgi complex 7
chr1_+_86021935 0.026 ENSMUST00000052854.6
ENSMUST00000125083.1
ENSMUST00000152501.1
ENSMUST00000113344.1
ENSMUST00000130504.1
ENSMUST00000153247.2
 Spata3





spermatogenesis associated 3





chr2_+_175283298 0.015 ENSMUST00000098998.3
 Gm14440
predicted gene 14440
chr2_-_94010807 0.007 ENSMUST00000111240.1
 Alkbh3
alkB, alkylation repair homolog 3 (E. coli)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.3 1.3 GO:0032788 saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789)
0.2 0.7 GO:0001803 antibody-dependent cellular cytotoxicity(GO:0001788) type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805)
0.2 1.9 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.2 0.5 GO:1900369 negative regulation of RNA interference(GO:1900369)
0.2 0.5 GO:0042726 flavin-containing compound metabolic process(GO:0042726)
0.1 0.4 GO:0006097 glyoxylate cycle(GO:0006097)
0.1 0.7 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.1 0.9 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 0.4 GO:0031915 positive regulation of synaptic plasticity(GO:0031915) positive regulation of receptor binding(GO:1900122)
0.1 2.0 GO:0010107 potassium ion import(GO:0010107)
0.1 0.3 GO:0090611 ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611) positive regulation of extracellular exosome assembly(GO:1903553)
0.1 0.3 GO:0033762 response to glucagon(GO:0033762)
0.0 0.3 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.0 0.5 GO:0042572 retinol metabolic process(GO:0042572)
0.0 1.5 GO:0045620 negative regulation of lymphocyte differentiation(GO:0045620)
0.0 0.3 GO:0008300 isoprenoid catabolic process(GO:0008300)
0.0 0.1 GO:0034241 positive regulation of macrophage fusion(GO:0034241) regulation of osteoclast proliferation(GO:0090289)
0.0 0.7 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 3.1 GO:0019882 antigen processing and presentation(GO:0019882)
0.0 0.5 GO:2000398 regulation of T cell differentiation in thymus(GO:0033081) regulation of thymocyte aggregation(GO:2000398)
0.0 0.7 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.2 GO:0086023 adrenergic receptor signaling pathway involved in heart process(GO:0086023)
0.0 0.1 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.0 0.5 GO:0015813 L-glutamate transport(GO:0015813)
0.0 0.5 GO:0006862 nucleotide transport(GO:0006862)
0.0 0.4 GO:0033006 regulation of mast cell activation involved in immune response(GO:0033006) regulation of mast cell degranulation(GO:0043304)
0.0 2.1 GO:0016579 protein deubiquitination(GO:0016579)
0.0 1.0 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 0.1 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.0 0.9 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway(GO:2001238)
0.0 0.8 GO:0015992 proton transport(GO:0015992)
0.0 2.6 GO:0008360 regulation of cell shape(GO:0008360)
0.0 0.6 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0044530 supraspliceosomal complex(GO:0044530)
0.1 0.8 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 0.7 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.7 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.3 GO:0045275 respiratory chain complex III(GO:0045275)
0.0 0.5 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.8 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 1.9 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 2.0 GO:0030315 T-tubule(GO:0030315)
0.0 0.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.2 GO:0001527 microfibril(GO:0001527)
0.0 3.1 GO:0008021 synaptic vesicle(GO:0008021)
0.0 0.1 GO:0071942 XPC complex(GO:0071942)
0.0 2.6 GO:0043197 dendritic spine(GO:0043197)
0.0 0.2 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.7 GO:0005801 cis-Golgi network(GO:0005801)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.0 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.3 1.8 GO:0016453 acetyl-CoA C-acetyltransferase activity(GO:0003985) C-acetyltransferase activity(GO:0016453)
0.2 1.9 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.2 0.7 GO:0019770 IgG receptor activity(GO:0019770)
0.2 0.5 GO:0003692 left-handed Z-DNA binding(GO:0003692)
0.2 1.7 GO:0016920 pyroglutamyl-peptidase activity(GO:0016920)
0.2 2.2 GO:0048038 quinone binding(GO:0048038)
0.1 3.1 GO:0031489 myosin V binding(GO:0031489)
0.1 0.7 GO:0042296 ISG15 transferase activity(GO:0042296)
0.1 0.4 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.1 0.3 GO:0031871 proteinase activated receptor binding(GO:0031871)
0.1 1.3 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.1 0.2 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.1 0.8 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 1.0 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 0.3 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.9 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.1 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095)
0.0 0.5 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.0 0.5 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.0 2.1 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.5 GO:0035380 C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity(GO:0000252) mevaldate reductase activity(GO:0004495) gluconate dehydrogenase activity(GO:0008875) epoxide dehydrogenase activity(GO:0018451) 5-exo-hydroxycamphor dehydrogenase activity(GO:0018452) 2-hydroxytetrahydrofuran dehydrogenase activity(GO:0018453) acetoin dehydrogenase activity(GO:0019152) phenylcoumaran benzylic ether reductase activity(GO:0032442) D-xylose:NADP reductase activity(GO:0032866) L-arabinose:NADP reductase activity(GO:0032867) D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity(GO:0033709) (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity(GO:0034831) 3-hydroxymenthone dehydrogenase activity(GO:0034840) very long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0035380) dihydrotestosterone 17-beta-dehydrogenase activity(GO:0035410) (R)-2-hydroxyisocaproate dehydrogenase activity(GO:0043713) L-arabinose 1-dehydrogenase (NADP+) activity(GO:0044103) L-xylulose reductase (NAD+) activity(GO:0044105) 3-ketoglucose-reductase activity(GO:0048258) D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity(GO:0052677)
0.0 0.6 GO:0050699 WW domain binding(GO:0050699)
0.0 0.1 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.0 0.4 GO:0070566 adenylyltransferase activity(GO:0070566)
0.0 0.4 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.4 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.1 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.0 0.3 GO:0016854 racemase and epimerase activity(GO:0016854)
0.0 0.3 GO:0035259 glucocorticoid receptor binding(GO:0035259)