Motif ID: Aire

Z-value: 0.906


Transcription factors associated with Aire:

Gene SymbolEntrez IDGene Name
Aire ENSMUSG00000000731.9 Aire



Activity profile for motif Aire.

activity profile for motif Aire


Sorted Z-values histogram for motif Aire

Sorted Z-values for motif Aire



Network of associatons between targets according to the STRING database.



First level regulatory network of Aire

PNG image of the network

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Top targets:


Showing 1 to 20 of 89 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_61185558 17.326 ENSMUST00000166381.1
 Cdr1
cerebellar degeneration related antigen 1
chr12_-_78983476 3.273 ENSMUST00000070174.7
 Tmem229b
transmembrane protein 229B
chr13_-_110280103 3.070 ENSMUST00000167824.1
 Rab3c
RAB3C, member RAS oncogene family
chr8_+_69808672 2.854 ENSMUST00000036074.8
ENSMUST00000123453.1
 Gmip

Gem-interacting protein

chr10_+_123264076 2.797 ENSMUST00000050756.7
 Fam19a2
family with sequence similarity 19, member A2
chr3_-_116968969 2.593 ENSMUST00000143611.1
ENSMUST00000040097.7
 Palmd

palmdelphin

chr7_-_127895578 2.213 ENSMUST00000033074.6
 Vkorc1
vitamin K epoxide reductase complex, subunit 1
chr9_+_64235201 2.137 ENSMUST00000039011.3
 Uchl4
ubiquitin carboxyl-terminal esterase L4
chr18_+_37400845 2.067 ENSMUST00000057228.1
 Pcdhb9
protocadherin beta 9
chr18_+_37725706 2.058 ENSMUST00000066149.6
 Pcdhga9
protocadherin gamma subfamily A, 9
chr2_+_55435918 1.995 ENSMUST00000067101.3
 Kcnj3
potassium inwardly-rectifying channel, subfamily J, member 3
chr14_+_76476913 1.992 ENSMUST00000140251.2
 Tsc22d1
TSC22 domain family, member 1
chr19_-_28963863 1.870 ENSMUST00000161813.1
 4430402I18Rik
RIKEN cDNA 4430402I18 gene
chr5_-_84417359 1.866 ENSMUST00000113401.1
 Epha5
Eph receptor A5
chr9_-_53610329 1.799 ENSMUST00000034547.5
 Acat1
acetyl-Coenzyme A acetyltransferase 1
chr19_+_34217588 1.729 ENSMUST00000119603.1
 Stambpl1
STAM binding protein like 1
chr10_+_52358767 1.470 ENSMUST00000180473.1
 Gm26741
predicted gene, 26741
chr10_+_86021961 1.456 ENSMUST00000130320.1
 Fbxo7
F-box protein 7
chr2_-_134644079 1.424 ENSMUST00000110119.1
 Tmx4
thioredoxin-related transmembrane protein 4
chr7_+_60155538 1.344 ENSMUST00000057611.4
 Gm7367
predicted pseudogene 7367

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.1 GO:0019882 antigen processing and presentation(GO:0019882)
0.0 2.6 GO:0008360 regulation of cell shape(GO:0008360)
0.7 2.2 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.0 2.1 GO:0016579 protein deubiquitination(GO:0016579)
0.1 2.0 GO:0010107 potassium ion import(GO:0010107)
0.2 1.9 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.0 1.5 GO:0045620 negative regulation of lymphocyte differentiation(GO:0045620)
0.3 1.3 GO:0032788 saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789)
0.0 1.0 GO:0045454 cell redox homeostasis(GO:0045454)
0.1 0.9 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.9 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway(GO:2001238)
0.0 0.8 GO:0015992 proton transport(GO:0015992)
0.2 0.7 GO:0001803 antibody-dependent cellular cytotoxicity(GO:0001788) type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805)
0.1 0.7 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.7 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0 0.7 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.6 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.2 0.5 GO:1900369 negative regulation of RNA interference(GO:1900369)
0.2 0.5 GO:0042726 flavin-containing compound metabolic process(GO:0042726)
0.0 0.5 GO:0042572 retinol metabolic process(GO:0042572)

Gene overrepresentation in cellular_component category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.1 GO:0008021 synaptic vesicle(GO:0008021)
0.0 2.6 GO:0043197 dendritic spine(GO:0043197)
0.0 2.0 GO:0030315 T-tubule(GO:0030315)
0.0 1.9 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 0.8 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.8 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 0.7 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.7 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.7 GO:0005801 cis-Golgi network(GO:0005801)
0.1 0.5 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 0.5 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.3 GO:0045275 respiratory chain complex III(GO:0045275)
0.0 0.2 GO:0001527 microfibril(GO:0001527)
0.0 0.2 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.1 GO:0071942 XPC complex(GO:0071942)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.1 GO:0031489 myosin V binding(GO:0031489)
0.2 2.2 GO:0048038 quinone binding(GO:0048038)
0.0 2.1 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.4 2.0 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.2 1.9 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.3 1.8 GO:0016453 acetyl-CoA C-acetyltransferase activity(GO:0003985) C-acetyltransferase activity(GO:0016453)
0.2 1.7 GO:0016920 pyroglutamyl-peptidase activity(GO:0016920)
0.1 1.3 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 1.0 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 0.9 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 0.8 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.2 0.7 GO:0019770 IgG receptor activity(GO:0019770)
0.1 0.7 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.6 GO:0050699 WW domain binding(GO:0050699)
0.2 0.5 GO:0003692 left-handed Z-DNA binding(GO:0003692)
0.0 0.5 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.0 0.5 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.0 0.5 GO:0035380 C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity(GO:0000252) mevaldate reductase activity(GO:0004495) gluconate dehydrogenase activity(GO:0008875) epoxide dehydrogenase activity(GO:0018451) 5-exo-hydroxycamphor dehydrogenase activity(GO:0018452) 2-hydroxytetrahydrofuran dehydrogenase activity(GO:0018453) acetoin dehydrogenase activity(GO:0019152) phenylcoumaran benzylic ether reductase activity(GO:0032442) D-xylose:NADP reductase activity(GO:0032866) L-arabinose:NADP reductase activity(GO:0032867) D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity(GO:0033709) (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity(GO:0034831) 3-hydroxymenthone dehydrogenase activity(GO:0034840) very long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0035380) dihydrotestosterone 17-beta-dehydrogenase activity(GO:0035410) (R)-2-hydroxyisocaproate dehydrogenase activity(GO:0043713) L-arabinose 1-dehydrogenase (NADP+) activity(GO:0044103) L-xylulose reductase (NAD+) activity(GO:0044105) 3-ketoglucose-reductase activity(GO:0048258) D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity(GO:0052677)
0.1 0.4 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.0 0.4 GO:0070566 adenylyltransferase activity(GO:0070566)