Motif ID: Alx4

Z-value: 0.782


Transcription factors associated with Alx4:

Gene SymbolEntrez IDGene Name
Alx4 ENSMUSG00000040310.6 Alx4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Alx4mm10_v2_chr2_+_93642307_93642388-0.174.1e-01Click!


Activity profile for motif Alx4.

activity profile for motif Alx4


Sorted Z-values histogram for motif Alx4

Sorted Z-values for motif Alx4



Network of associatons between targets according to the STRING database.



First level regulatory network of Alx4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_-_26989974 2.707 ENSMUST00000089832.4
 Gmnc
geminin coiled-coil domain containing
chr3_+_146121655 2.416 ENSMUST00000039450.4
 Mcoln3
mucolipin 3
chr9_+_119063429 2.385 ENSMUST00000141185.1
ENSMUST00000126251.1
ENSMUST00000136561.1
 Vill


villin-like


chr8_-_4779513 2.148 ENSMUST00000022945.7
 Shcbp1
Shc SH2-domain binding protein 1
chr10_-_77166545 2.101 ENSMUST00000081654.6
 Col18a1
collagen, type XVIII, alpha 1
chr2_+_109917639 2.089 ENSMUST00000046548.7
ENSMUST00000111037.2
 Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr13_-_81710937 1.896 ENSMUST00000161920.1
ENSMUST00000048993.5
 Polr3g

polymerase (RNA) III (DNA directed) polypeptide G

chr13_-_100786402 1.796 ENSMUST00000174038.1
ENSMUST00000091295.7
ENSMUST00000072119.8
 Ccnb1


cyclin B1


chrX_-_23266751 1.734 ENSMUST00000115316.2
 Klhl13
kelch-like 13
chr5_-_138170992 1.721 ENSMUST00000139983.1
 Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr13_+_44121167 1.627 ENSMUST00000163056.1
ENSMUST00000159595.1
 Gm5083

predicted gene 5083

chr19_+_23723279 1.605 ENSMUST00000067077.1
 Gm9938
predicted gene 9938
chr17_-_59013264 1.601 ENSMUST00000174122.1
ENSMUST00000025065.5
 Nudt12

nudix (nucleoside diphosphate linked moiety X)-type motif 12

chr11_+_59306920 1.576 ENSMUST00000000128.3
ENSMUST00000108783.3
 Wnt9a

wingless-type MMTV integration site 9A

chr13_-_102905740 1.569 ENSMUST00000167462.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr19_+_55895508 1.514 ENSMUST00000111646.1
 Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr2_+_126556128 1.468 ENSMUST00000141482.2
 Slc27a2
solute carrier family 27 (fatty acid transporter), member 2
chr11_-_11970540 1.455 ENSMUST00000109653.1
 Grb10
growth factor receptor bound protein 10
chr14_+_26259109 1.441 ENSMUST00000174494.1
 Duxbl3
double homeobox B-like 3
chr2_+_71389239 1.434 ENSMUST00000028408.2
 Hat1
histone aminotransferase 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 108 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.9 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.1 2.7 GO:0006270 DNA replication initiation(GO:0006270)
0.1 2.4 GO:0051693 actin filament capping(GO:0051693)
0.7 2.1 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.1 2.1 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.0 2.1 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.3 1.9 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.4 1.8 GO:0043987 histone H3-S10 phosphorylation(GO:0043987)
0.4 1.6 GO:0006742 NADP catabolic process(GO:0006742) pyridine nucleotide catabolic process(GO:0019364)
0.1 1.6 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.5 1.5 GO:0097089 methyl-branched fatty acid metabolic process(GO:0097089)
0.2 1.5 GO:0048625 myoblast fate commitment(GO:0048625)
0.2 1.5 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.3 1.4 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.1 1.4 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.1 1.4 GO:0006907 pinocytosis(GO:0006907)
0.4 1.3 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.4 1.3 GO:1904956 regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.1 1.3 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.1 1.2 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.2 2.9 GO:0042555 MCM complex(GO:0042555)
0.0 2.5 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 2.3 GO:0005581 collagen trimer(GO:0005581)
0.0 2.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 1.9 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 1.9 GO:0000775 chromosome, centromeric region(GO:0000775)
0.4 1.8 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0 1.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 1.5 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 1.5 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.2 1.4 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.0 1.3 GO:0043034 costamere(GO:0043034)
0.3 1.2 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.0 1.2 GO:0035145 exon-exon junction complex(GO:0035145)
0.2 1.0 GO:0044301 climbing fiber(GO:0044301)
0.0 1.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 0.8 GO:0005687 U4 snRNP(GO:0005687)
0.1 0.8 GO:0045180 basal cortex(GO:0045180)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 77 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.2 GO:0005109 frizzled binding(GO:0005109)
0.1 2.9 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 2.3 GO:0051015 actin filament binding(GO:0051015)
0.2 2.1 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 2.1 GO:0042169 SH2 domain binding(GO:0042169)
0.1 1.9 GO:0001056 RNA polymerase III activity(GO:0001056)
0.4 1.8 GO:0005113 patched binding(GO:0005113)
0.1 1.6 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.1 1.5 GO:0015245 fatty acid transporter activity(GO:0015245)
0.1 1.5 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 1.5 GO:0045295 gamma-catenin binding(GO:0045295)
0.2 1.4 GO:0034452 dynactin binding(GO:0034452)
0.1 1.4 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.0 1.3 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.1 1.2 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 1.2 GO:0000400 four-way junction DNA binding(GO:0000400)
0.0 1.1 GO:0000049 tRNA binding(GO:0000049)
0.2 1.0 GO:1990932 5.8S rRNA binding(GO:1990932)
0.0 1.0 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.0 1.0 GO:0031369 translation initiation factor binding(GO:0031369)