Motif ID: Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec

Z-value: 0.774

Transcription factors associated with Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec:

Gene SymbolEntrez IDGene Name
Arntl ENSMUSG00000055116.7 Arntl
Mitf ENSMUSG00000035158.9 Mitf
Mlx ENSMUSG00000017801.9 Mlx
Mlxipl ENSMUSG00000005373.7 Mlxipl
Tfe3 ENSMUSG00000000134.11 Tfe3
Tfec ENSMUSG00000029553.7 Tfec

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Arntlmm10_v2_chr7_+_113207465_113207595-0.535.0e-03Click!
Mlxiplmm10_v2_chr5_+_135106881_135106918-0.385.3e-02Click!
Mitfmm10_v2_chr6_+_97807014_97807067-0.358.0e-02Click!
Tfe3mm10_v2_chrX_+_7763943_7764087-0.232.5e-01Click!
Mlxmm10_v2_chr11_+_101087277_1010873230.174.1e-01Click!


Activity profile for motif Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec.

activity profile for motif Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec


Sorted Z-values histogram for motif Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec

Sorted Z-values for motif Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec



Network of associatons between targets according to the STRING database.



First level regulatory network of Arntl_Tfe3_Mlx_Mitf_Mlxipl_Tfec

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_35802593 4.354 ENSMUST00000052454.2
 E130304I02Rik
RIKEN cDNA E130304I02 gene
chrY_-_1245685 3.150 ENSMUST00000143286.1
ENSMUST00000137048.1
ENSMUST00000069309.7
ENSMUST00000139365.1
 Uty



ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome



chr10_+_127063599 2.495 ENSMUST00000120226.1
ENSMUST00000133115.1
 Cdk4

cyclin-dependent kinase 4

chr11_+_70000578 2.343 ENSMUST00000019362.8
 Dvl2
dishevelled 2, dsh homolog (Drosophila)
chr19_-_4201591 2.267 ENSMUST00000025740.6
 Rad9a
RAD9 homolog A
chr10_+_127063527 2.231 ENSMUST00000006911.5
 Cdk4
cyclin-dependent kinase 4
chrY_-_1245753 1.997 ENSMUST00000154004.1
 Uty
ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome
chr11_+_98348404 1.631 ENSMUST00000078694.6
 Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr3_+_137864573 1.628 ENSMUST00000174561.1
ENSMUST00000173790.1
 H2afz

H2A histone family, member Z

chr1_-_75219245 1.581 ENSMUST00000079464.6
 Tuba4a
tubulin, alpha 4A
chr6_+_108660616 1.518 ENSMUST00000032194.4
 Bhlhe40
basic helix-loop-helix family, member e40
chr17_-_12769605 1.479 ENSMUST00000024599.7
 Igf2r
insulin-like growth factor 2 receptor
chr14_-_118052235 1.457 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr5_-_137314175 1.419 ENSMUST00000024119.9
 Trip6
thyroid hormone receptor interactor 6
chr11_-_97782377 1.379 ENSMUST00000128801.1
 Rpl23
ribosomal protein L23
chr15_+_59374198 1.336 ENSMUST00000079703.3
ENSMUST00000168722.1
 Nsmce2

non-SMC element 2 homolog (MMS21, S. cerevisiae)

chr11_-_102230127 1.310 ENSMUST00000107150.1
ENSMUST00000156337.1
ENSMUST00000107151.2
ENSMUST00000107152.2
 Hdac5



histone deacetylase 5



chr3_-_108226598 1.303 ENSMUST00000029486.7
ENSMUST00000156371.1
ENSMUST00000141387.1
 Sypl2


synaptophysin-like 2


chr4_-_41275091 1.284 ENSMUST00000030143.6
ENSMUST00000108068.1
 Ubap2

ubiquitin-associated protein 2

chr5_+_99979061 1.278 ENSMUST00000046721.1
 4930524J08Rik
RIKEN cDNA 4930524J08 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 432 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 4.9 GO:0071557 histone H3-K27 demethylation(GO:0071557)
1.2 4.7 GO:0010288 response to lead ion(GO:0010288)
0.1 2.9 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.3 2.7 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.1 2.7 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.3 2.5 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.0 2.5 GO:0006405 RNA export from nucleus(GO:0006405)
0.1 2.4 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.5 2.3 GO:0014022 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.1 2.0 GO:0048255 mRNA stabilization(GO:0048255)
0.3 1.8 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.0 1.8 GO:0072661 protein targeting to plasma membrane(GO:0072661)
0.0 1.8 GO:0043966 histone H3 acetylation(GO:0043966)
0.6 1.7 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.1 1.7 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.0 1.7 GO:0032526 response to retinoic acid(GO:0032526)
0.2 1.5 GO:0046502 uroporphyrinogen III metabolic process(GO:0046502)
0.5 1.4 GO:0010845 positive regulation of reciprocal meiotic recombination(GO:0010845)
0.2 1.4 GO:1904715 negative regulation of chaperone-mediated autophagy(GO:1904715)
0.4 1.3 GO:0032053 ciliary basal body organization(GO:0032053)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 171 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.9 GO:0030529 intracellular ribonucleoprotein complex(GO:0030529) ribonucleoprotein complex(GO:1990904)
0.1 4.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 3.6 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.5 3.3 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 3.1 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.4 2.7 GO:0001740 Barr body(GO:0001740)
0.0 2.6 GO:0031519 PcG protein complex(GO:0031519)
0.0 2.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.4 2.3 GO:0030896 checkpoint clamp complex(GO:0030896)
0.1 2.2 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0 2.2 GO:0022626 cytosolic ribosome(GO:0022626)
0.0 2.1 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 1.8 GO:0030914 STAGA complex(GO:0030914)
0.3 1.7 GO:0044611 nuclear pore inner ring(GO:0044611)
0.5 1.5 GO:0033186 CAF-1 complex(GO:0033186)
0.1 1.5 GO:0035253 ciliary rootlet(GO:0035253)
0.0 1.5 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.2 1.4 GO:0033503 HULC complex(GO:0033503)
0.2 1.4 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.3 1.3 GO:0097413 Lewy body(GO:0097413)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 272 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 4.9 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.1 4.9 GO:0030332 cyclin binding(GO:0030332)
0.1 3.8 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.5 3.3 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.0 3.3 GO:0008186 ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.1 2.8 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 2.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.4 2.5 GO:0043426 MRF binding(GO:0043426)
0.5 2.4 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.1 2.4 GO:0005109 frizzled binding(GO:0005109)
0.6 2.3 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.2 2.2 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.1 2.2 GO:0005123 death receptor binding(GO:0005123)
0.0 2.1 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 2.1 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)
0.2 2.0 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.1 1.8 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 1.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.6 1.7 GO:0031750 D3 dopamine receptor binding(GO:0031750)
0.2 1.6 GO:0031995 insulin-like growth factor II binding(GO:0031995)