Motif ID: Atf4

Z-value: 1.120


Transcription factors associated with Atf4:

Gene SymbolEntrez IDGene Name
Atf4 ENSMUSG00000042406.7 Atf4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Atf4mm10_v2_chr15_+_80255184_802552630.517.4e-03Click!


Activity profile for motif Atf4.

activity profile for motif Atf4


Sorted Z-values histogram for motif Atf4

Sorted Z-values for motif Atf4



Network of associatons between targets according to the STRING database.



First level regulatory network of Atf4

PNG image of the network

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Top targets:


Showing 1 to 20 of 106 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 8.774 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr7_+_144896523 6.430 ENSMUST00000033389.5
 Fgf15
fibroblast growth factor 15
chrX_+_103422010 6.099 ENSMUST00000182089.1
 Gm26992
predicted gene, 26992
chr1_-_71653162 3.011 ENSMUST00000055226.6
 Fn1
fibronectin 1
chr4_+_46450892 2.899 ENSMUST00000102926.4
 Anp32b
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr13_-_53473074 2.562 ENSMUST00000021922.8
 Msx2
msh homeobox 2
chr4_+_43957678 2.466 ENSMUST00000107855.1
 Glipr2
GLI pathogenesis-related 2
chr8_+_75093591 2.195 ENSMUST00000005548.6
 Hmox1
heme oxygenase (decycling) 1
chr1_-_191183244 2.137 ENSMUST00000027941.8
 Atf3
activating transcription factor 3
chr19_-_12501996 1.799 ENSMUST00000045521.7
 Dtx4
deltex 4 homolog (Drosophila)
chr5_+_42067960 1.747 ENSMUST00000087332.4
 Gm16223
predicted gene 16223
chr19_+_53140430 1.732 ENSMUST00000111741.2
 Add3
adducin 3 (gamma)
chrX_+_106187100 1.712 ENSMUST00000081593.6
 Pgk1
phosphoglycerate kinase 1
chr4_-_129189646 1.681 ENSMUST00000106059.1
 S100pbp
S100P binding protein
chr2_+_119351222 1.614 ENSMUST00000028780.3
 Chac1
ChaC, cation transport regulator 1
chr4_-_129189600 1.574 ENSMUST00000117497.1
ENSMUST00000117350.1
 S100pbp

S100P binding protein

chr4_-_129189512 1.548 ENSMUST00000117965.1
ENSMUST00000106061.2
ENSMUST00000072431.6
 S100pbp


S100P binding protein


chr12_-_104865076 1.500 ENSMUST00000109937.1
ENSMUST00000109936.1
 Clmn

calmin

chr13_+_49682100 1.492 ENSMUST00000165316.1
ENSMUST00000047363.7
 Iars

isoleucine-tRNA synthetase

chr8_-_92356103 1.410 ENSMUST00000034183.3
 4933436C20Rik
RIKEN cDNA 4933436C20 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 8.8 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.6 6.4 GO:0070858 negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
0.1 3.2 GO:0010960 magnesium ion homeostasis(GO:0010960)
1.0 3.0 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931) calcium-independent cell-matrix adhesion(GO:0007161)
0.1 2.9 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.9 2.6 GO:0048818 embryonic nail plate morphogenesis(GO:0035880) positive regulation of hair follicle maturation(GO:0048818) positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364)
0.8 2.5 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.0 2.5 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.7 2.2 GO:1904706 response to cisplatin(GO:0072718) negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.5 2.1 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.1 1.9 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.1 1.8 GO:0031065 positive regulation of histone deacetylation(GO:0031065)
0.0 1.7 GO:0006096 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.1 1.6 GO:0010955 negative regulation of protein processing(GO:0010955) negative regulation of protein maturation(GO:1903318)
0.0 1.4 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.4 1.3 GO:0006592 ornithine biosynthetic process(GO:0006592)
0.4 1.3 GO:0006106 fumarate metabolic process(GO:0006106) aspartate catabolic process(GO:0006533) alditol biosynthetic process(GO:0019401)
0.4 1.3 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.2 1.2 GO:1903352 ornithine transport(GO:0015822) L-ornithine transmembrane transport(GO:1903352)
0.1 1.2 GO:0009396 folic acid-containing compound biosynthetic process(GO:0009396)

Gene overrepresentation in cellular_component category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 3.0 GO:0005577 fibrinogen complex(GO:0005577)
0.0 2.2 GO:0005901 caveola(GO:0005901)
0.0 1.7 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.2 1.4 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 1.1 GO:0016459 myosin complex(GO:0016459)
0.1 0.9 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.9 GO:0005643 nuclear pore(GO:0005643)
0.2 0.6 GO:1990037 Lewy body core(GO:1990037)
0.0 0.6 GO:0000793 condensed chromosome(GO:0000793)
0.1 0.5 GO:1990111 spermatoproteasome complex(GO:1990111)
0.1 0.4 GO:0042825 TAP complex(GO:0042825)
0.1 0.4 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.3 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.3 GO:0043203 axon hillock(GO:0043203)
0.1 0.2 GO:0005745 m-AAA complex(GO:0005745)
0.0 0.2 GO:0005869 dynactin complex(GO:0005869)
0.0 0.1 GO:0070552 BRISC complex(GO:0070552)
0.0 0.1 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.0 0.0 GO:0036488 CHOP-C/EBP complex(GO:0036488)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 16.1 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.3 6.4 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 5.2 GO:0000049 tRNA binding(GO:0000049)
0.1 4.8 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.8 3.1 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.5 3.0 GO:0045340 mercury ion binding(GO:0045340)
0.8 2.5 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.5 2.2 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.1 1.6 GO:0005112 Notch binding(GO:0005112)
0.4 1.3 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.2 1.3 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.4 1.2 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.2 1.2 GO:0015189 L-ornithine transmembrane transporter activity(GO:0000064) arginine transmembrane transporter activity(GO:0015181) L-lysine transmembrane transporter activity(GO:0015189)
0.0 1.0 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812)
0.0 0.9 GO:0034185 apolipoprotein binding(GO:0034185)
0.2 0.8 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.2 0.8 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.8 GO:0004896 cytokine receptor activity(GO:0004896)
0.2 0.6 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.1 0.6 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)