Motif ID: Bcl6
Z-value: 1.026
Transcription factors associated with Bcl6:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Bcl6 | ENSMUSG00000022508.5 | Bcl6 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Bcl6 | mm10_v2_chr16_-_23988852_23988852 | 0.62 | 7.1e-04 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.2 | 4.8 | GO:0014012 | peripheral nervous system axon regeneration(GO:0014012) |
0.8 | 2.3 | GO:0010751 | regulation of arginine metabolic process(GO:0000821) negative regulation of nitric oxide mediated signal transduction(GO:0010751) negative regulation of cellular amino acid metabolic process(GO:0045763) |
0.6 | 6.9 | GO:0042572 | retinol metabolic process(GO:0042572) |
0.5 | 1.6 | GO:1904457 | positive regulation of neuronal action potential(GO:1904457) |
0.5 | 1.6 | GO:1901731 | calcium-mediated signaling using extracellular calcium source(GO:0035585) positive regulation of platelet aggregation(GO:1901731) |
0.5 | 3.5 | GO:0034638 | phosphatidylcholine catabolic process(GO:0034638) |
0.5 | 5.0 | GO:0010650 | positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
0.4 | 3.1 | GO:0009449 | gamma-aminobutyric acid biosynthetic process(GO:0009449) |
0.4 | 1.7 | GO:2000427 | positive regulation of apoptotic cell clearance(GO:2000427) |
0.4 | 2.1 | GO:0090164 | asymmetric Golgi ribbon formation(GO:0090164) |
0.4 | 9.7 | GO:0007205 | protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205) |
0.4 | 2.2 | GO:0007021 | tubulin complex assembly(GO:0007021) |
0.3 | 1.4 | GO:0071726 | response to diacyl bacterial lipopeptide(GO:0071724) cellular response to diacyl bacterial lipopeptide(GO:0071726) |
0.3 | 3.4 | GO:0097421 | liver regeneration(GO:0097421) |
0.3 | 0.7 | GO:1904154 | positive regulation of retrograde protein transport, ER to cytosol(GO:1904154) |
0.3 | 1.2 | GO:0010756 | positive regulation of plasminogen activation(GO:0010756) |
0.3 | 2.9 | GO:2001214 | positive regulation of vasculogenesis(GO:2001214) |
0.3 | 0.6 | GO:2000587 | regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000586) negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587) |
0.3 | 2.2 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) |
0.3 | 0.8 | GO:0070973 | COPI-coated vesicle budding(GO:0035964) protein localization to endoplasmic reticulum exit site(GO:0070973) |
0.3 | 1.0 | GO:0042938 | dipeptide transport(GO:0042938) |
0.3 | 1.5 | GO:0045218 | zonula adherens maintenance(GO:0045218) |
0.2 | 0.7 | GO:1900365 | positive regulation of mRNA polyadenylation(GO:1900365) |
0.2 | 3.4 | GO:0009312 | oligosaccharide biosynthetic process(GO:0009312) |
0.2 | 1.1 | GO:0031915 | positive regulation of synaptic plasticity(GO:0031915) positive regulation of receptor binding(GO:1900122) |
0.2 | 0.6 | GO:0021529 | spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) |
0.2 | 0.8 | GO:2000048 | negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048) |
0.2 | 1.3 | GO:0035356 | cellular triglyceride homeostasis(GO:0035356) |
0.2 | 1.7 | GO:0005513 | detection of calcium ion(GO:0005513) |
0.2 | 0.6 | GO:0071492 | cellular response to UV-A(GO:0071492) |
0.2 | 0.8 | GO:0072137 | condensed mesenchymal cell proliferation(GO:0072137) |
0.2 | 0.6 | GO:0060455 | negative regulation of gastric acid secretion(GO:0060455) |
0.2 | 0.7 | GO:0097428 | protein maturation by iron-sulfur cluster transfer(GO:0097428) |
0.2 | 8.4 | GO:0045744 | negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744) |
0.2 | 1.0 | GO:1900451 | rhythmic synaptic transmission(GO:0060024) terminal button organization(GO:0072553) positive regulation of glutamate receptor signaling pathway(GO:1900451) positive regulation of protein localization to synapse(GO:1902474) positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000969) |
0.2 | 0.5 | GO:0046341 | CDP-diacylglycerol metabolic process(GO:0046341) |
0.2 | 0.5 | GO:0060217 | hemangioblast cell differentiation(GO:0060217) |
0.1 | 2.1 | GO:0002115 | store-operated calcium entry(GO:0002115) |
0.1 | 0.5 | GO:0033024 | mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025) |
0.1 | 1.0 | GO:0032261 | purine nucleotide salvage(GO:0032261) IMP salvage(GO:0032264) |
0.1 | 1.9 | GO:0090129 | positive regulation of synapse maturation(GO:0090129) |
0.1 | 2.4 | GO:0071378 | growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378) |
0.1 | 0.5 | GO:0060709 | glycogen cell differentiation involved in embryonic placenta development(GO:0060709) |
0.1 | 0.6 | GO:2000253 | positive regulation of feeding behavior(GO:2000253) |
0.1 | 0.5 | GO:0046684 | response to pyrethroid(GO:0046684) |
0.1 | 0.3 | GO:0097212 | lysosomal membrane organization(GO:0097212) |
0.1 | 0.7 | GO:0060134 | prepulse inhibition(GO:0060134) |
0.1 | 3.5 | GO:1904030 | negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030) |
0.1 | 1.8 | GO:0099517 | anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
0.1 | 0.5 | GO:0032026 | response to magnesium ion(GO:0032026) |
0.1 | 0.4 | GO:0036438 | maintenance of lens transparency(GO:0036438) membrane fission(GO:0090148) ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611) |
0.1 | 0.4 | GO:0030576 | Cajal body organization(GO:0030576) |
0.1 | 1.8 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
0.1 | 0.2 | GO:1903984 | positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984) |
0.1 | 0.6 | GO:0015808 | L-alanine transport(GO:0015808) |
0.1 | 1.2 | GO:0030574 | collagen catabolic process(GO:0030574) |
0.1 | 0.5 | GO:0060923 | cardiac muscle cell fate commitment(GO:0060923) |
0.1 | 1.0 | GO:0010758 | regulation of macrophage chemotaxis(GO:0010758) |
0.1 | 3.4 | GO:0060612 | adipose tissue development(GO:0060612) |
0.1 | 1.2 | GO:0035025 | positive regulation of Rho protein signal transduction(GO:0035025) |
0.1 | 0.2 | GO:2000418 | positive regulation of eosinophil migration(GO:2000418) |
0.1 | 0.3 | GO:0030643 | cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502) |
0.1 | 0.8 | GO:0046688 | response to copper ion(GO:0046688) |
0.0 | 0.4 | GO:0061368 | behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368) |
0.0 | 0.4 | GO:0015868 | purine ribonucleotide transport(GO:0015868) |
0.0 | 0.2 | GO:0010735 | positive regulation of transcription via serum response element binding(GO:0010735) |
0.0 | 0.5 | GO:0045607 | regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980) |
0.0 | 0.5 | GO:0048266 | behavioral response to pain(GO:0048266) |
0.0 | 0.8 | GO:0007614 | short-term memory(GO:0007614) |
0.0 | 1.3 | GO:0006376 | mRNA splice site selection(GO:0006376) |
0.0 | 1.2 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
0.0 | 3.7 | GO:0099643 | neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643) |
0.0 | 0.8 | GO:0035066 | positive regulation of histone acetylation(GO:0035066) |
0.0 | 1.3 | GO:0001541 | ovarian follicle development(GO:0001541) |
0.0 | 0.4 | GO:1902287 | semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287) |
0.0 | 0.2 | GO:1903300 | negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300) |
0.0 | 0.8 | GO:0034605 | cellular response to heat(GO:0034605) |
0.0 | 0.6 | GO:0034723 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-independent nucleosome assembly(GO:0006336) DNA replication-dependent nucleosome organization(GO:0034723) DNA replication-independent nucleosome organization(GO:0034724) |
0.0 | 0.1 | GO:0015862 | uridine transport(GO:0015862) |
0.0 | 0.7 | GO:0008214 | protein demethylation(GO:0006482) protein dealkylation(GO:0008214) |
0.0 | 0.7 | GO:0046627 | negative regulation of insulin receptor signaling pathway(GO:0046627) |
0.0 | 0.6 | GO:0000132 | establishment of mitotic spindle orientation(GO:0000132) |
0.0 | 1.2 | GO:0007613 | memory(GO:0007613) |
0.0 | 0.1 | GO:0006478 | peptidyl-tyrosine sulfation(GO:0006478) |
0.0 | 0.1 | GO:2000807 | regulation of synaptic vesicle clustering(GO:2000807) |
0.0 | 0.2 | GO:0007097 | nuclear migration(GO:0007097) |
0.0 | 0.1 | GO:1901978 | positive regulation of cell cycle checkpoint(GO:1901978) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.7 | 2.2 | GO:0097512 | cardiac myofibril(GO:0097512) |
0.7 | 3.4 | GO:0048237 | rough endoplasmic reticulum lumen(GO:0048237) |
0.6 | 1.7 | GO:0044299 | C-fiber(GO:0044299) |
0.4 | 1.6 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
0.3 | 5.3 | GO:0005614 | interstitial matrix(GO:0005614) |
0.3 | 1.6 | GO:0044316 | cone cell pedicle(GO:0044316) |
0.3 | 5.0 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
0.2 | 1.2 | GO:0001652 | granular component(GO:0001652) |
0.2 | 1.4 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
0.2 | 0.6 | GO:0005940 | septin ring(GO:0005940) |
0.2 | 0.8 | GO:0016035 | zeta DNA polymerase complex(GO:0016035) |
0.2 | 1.8 | GO:1904115 | axon cytoplasm(GO:1904115) |
0.2 | 0.5 | GO:0033193 | Lsd1/2 complex(GO:0033193) |
0.1 | 1.5 | GO:0005915 | zonula adherens(GO:0005915) |
0.1 | 2.3 | GO:0097228 | sperm principal piece(GO:0097228) |
0.1 | 0.6 | GO:0005796 | Golgi lumen(GO:0005796) |
0.1 | 4.8 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
0.1 | 1.0 | GO:0044292 | dendrite terminus(GO:0044292) |
0.1 | 1.1 | GO:0043205 | fibril(GO:0043205) |
0.1 | 2.2 | GO:0031672 | A band(GO:0031672) |
0.1 | 2.0 | GO:0048786 | presynaptic active zone(GO:0048786) |
0.1 | 0.8 | GO:0031011 | Ino80 complex(GO:0031011) |
0.0 | 0.4 | GO:0000815 | ESCRT III complex(GO:0000815) |
0.0 | 0.7 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
0.0 | 0.2 | GO:0030688 | preribosome, small subunit precursor(GO:0030688) |
0.0 | 0.5 | GO:0034706 | voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706) |
0.0 | 0.2 | GO:0070847 | core mediator complex(GO:0070847) |
0.0 | 0.4 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
0.0 | 2.1 | GO:0016459 | myosin complex(GO:0016459) |
0.0 | 1.9 | GO:0042734 | presynaptic membrane(GO:0042734) |
0.0 | 2.1 | GO:0005776 | autophagosome(GO:0005776) |
0.0 | 0.4 | GO:0005869 | dynactin complex(GO:0005869) |
0.0 | 1.7 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
0.0 | 1.3 | GO:0005811 | lipid particle(GO:0005811) |
0.0 | 0.8 | GO:0005801 | cis-Golgi network(GO:0005801) |
0.0 | 0.2 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
0.0 | 0.1 | GO:0020005 | symbiont-containing vacuole membrane(GO:0020005) |
0.0 | 0.1 | GO:0097433 | dense body(GO:0097433) |
0.0 | 0.8 | GO:0043195 | terminal bouton(GO:0043195) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.0 | 6.9 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
0.9 | 3.5 | GO:0004528 | phosphodiesterase I activity(GO:0004528) |
0.8 | 4.8 | GO:0045545 | syndecan binding(GO:0045545) |
0.5 | 3.5 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
0.5 | 3.4 | GO:0001665 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665) |
0.5 | 2.4 | GO:0008269 | JAK pathway signal transduction adaptor activity(GO:0008269) |
0.5 | 1.4 | GO:0003846 | 2-acylglycerol O-acyltransferase activity(GO:0003846) |
0.4 | 1.7 | GO:0031727 | CCR2 chemokine receptor binding(GO:0031727) |
0.4 | 1.5 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
0.3 | 1.4 | GO:0070891 | lipoteichoic acid binding(GO:0070891) |
0.3 | 1.8 | GO:0015277 | kainate selective glutamate receptor activity(GO:0015277) |
0.3 | 2.0 | GO:0004351 | glutamate decarboxylase activity(GO:0004351) |
0.3 | 4.0 | GO:0001871 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
0.3 | 1.3 | GO:0004105 | choline-phosphate cytidylyltransferase activity(GO:0004105) |
0.2 | 2.2 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
0.2 | 2.4 | GO:0016920 | pyroglutamyl-peptidase activity(GO:0016920) |
0.2 | 1.1 | GO:0005314 | high-affinity glutamate transmembrane transporter activity(GO:0005314) |
0.2 | 1.0 | GO:0042895 | antibiotic transporter activity(GO:0042895) |
0.2 | 8.6 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
0.2 | 0.8 | GO:0015183 | sulfur amino acid transmembrane transporter activity(GO:0000099) L-aspartate transmembrane transporter activity(GO:0015183) |
0.2 | 0.6 | GO:0015038 | glutathione disulfide oxidoreductase activity(GO:0015038) protein-disulfide reductase (glutathione) activity(GO:0019153) |
0.2 | 0.6 | GO:0015173 | hydrogen:amino acid symporter activity(GO:0005280) aromatic amino acid transmembrane transporter activity(GO:0015173) |
0.2 | 2.3 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
0.2 | 2.1 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
0.2 | 5.0 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
0.2 | 0.8 | GO:0016724 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
0.1 | 1.0 | GO:0003876 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
0.1 | 2.3 | GO:0008599 | protein phosphatase type 1 regulator activity(GO:0008599) |
0.1 | 1.7 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
0.1 | 1.8 | GO:0015026 | coreceptor activity(GO:0015026) |
0.1 | 1.0 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
0.1 | 2.2 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
0.1 | 2.3 | GO:0001968 | fibronectin binding(GO:0001968) |
0.1 | 0.5 | GO:0005173 | stem cell factor receptor binding(GO:0005173) |
0.1 | 7.7 | GO:0019210 | protein kinase inhibitor activity(GO:0004860) kinase inhibitor activity(GO:0019210) |
0.1 | 0.5 | GO:0086006 | voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006) |
0.1 | 0.7 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
0.1 | 0.8 | GO:0005044 | scavenger receptor activity(GO:0005044) |
0.1 | 0.6 | GO:0004622 | lysophospholipase activity(GO:0004622) |
0.1 | 1.2 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
0.1 | 0.7 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
0.1 | 1.6 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
0.1 | 1.0 | GO:0042043 | neurexin family protein binding(GO:0042043) |
0.1 | 1.7 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
0.1 | 3.7 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
0.0 | 1.6 | GO:0030507 | spectrin binding(GO:0030507) |
0.0 | 2.1 | GO:0043531 | ADP binding(GO:0043531) |
0.0 | 1.6 | GO:0030552 | cAMP binding(GO:0030552) |
0.0 | 1.9 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
0.0 | 0.3 | GO:0016004 | phospholipase activator activity(GO:0016004) lipase activator activity(GO:0060229) |
0.0 | 0.7 | GO:0051723 | protein methylesterase activity(GO:0051723) |
0.0 | 0.8 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
0.0 | 2.7 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
0.0 | 0.8 | GO:0008432 | JUN kinase binding(GO:0008432) |
0.0 | 2.2 | GO:0019208 | phosphatase regulator activity(GO:0019208) |
0.0 | 0.7 | GO:0008198 | ferrous iron binding(GO:0008198) |
0.0 | 0.4 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
0.0 | 0.6 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
0.0 | 0.6 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
0.0 | 3.0 | GO:0017137 | Rab GTPase binding(GO:0017137) |
0.0 | 0.4 | GO:0070628 | proteasome binding(GO:0070628) |
0.0 | 0.7 | GO:0045296 | cadherin binding(GO:0045296) |
0.0 | 0.1 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
0.0 | 0.2 | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
0.0 | 0.2 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
0.0 | 0.8 | GO:0005507 | copper ion binding(GO:0005507) |
0.0 | 0.5 | GO:0017110 | nucleoside-diphosphatase activity(GO:0017110) |
0.0 | 0.2 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
0.0 | 1.3 | GO:0043178 | alcohol binding(GO:0043178) |
0.0 | 0.6 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
0.0 | 2.0 | GO:0005057 | receptor signaling protein activity(GO:0005057) |
0.0 | 0.1 | GO:0008476 | protein-tyrosine sulfotransferase activity(GO:0008476) |
0.0 | 0.5 | GO:0070888 | E-box binding(GO:0070888) |
0.0 | 0.4 | GO:0045502 | dynein binding(GO:0045502) |