Motif ID: Bhlhe40

Z-value: 0.416


Transcription factors associated with Bhlhe40:

Gene SymbolEntrez IDGene Name
Bhlhe40 ENSMUSG00000030103.5 Bhlhe40

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Bhlhe40mm10_v2_chr6_+_108660772_108660874-0.509.0e-03Click!


Activity profile for motif Bhlhe40.

activity profile for motif Bhlhe40


Sorted Z-values histogram for motif Bhlhe40

Sorted Z-values for motif Bhlhe40



Network of associatons between targets according to the STRING database.



First level regulatory network of Bhlhe40

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_148039097 0.940 ENSMUST00000141283.1
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr1_-_75219245 0.617 ENSMUST00000079464.6
 Tuba4a
tubulin, alpha 4A
chr4_+_148039035 0.519 ENSMUST00000097788.4
 Mthfr
5,10-methylenetetrahydrofolate reductase
chrX_+_136270253 0.444 ENSMUST00000178632.1
ENSMUST00000053540.4
 Ngfrap1

nerve growth factor receptor (TNFRSF16) associated protein 1

chr4_-_137048695 0.425 ENSMUST00000049583.7
 Zbtb40
zinc finger and BTB domain containing 40
chr19_-_4201591 0.369 ENSMUST00000025740.6
 Rad9a
RAD9 homolog A
chr10_-_18023229 0.368 ENSMUST00000020002.7
 Abracl
ABRA C-terminal like
chr3_-_95106907 0.367 ENSMUST00000107233.2
 Pip5k1a
phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha
chr11_-_70239794 0.365 ENSMUST00000040428.3
 Rnasek
ribonuclease, RNase K
chr5_+_123252087 0.365 ENSMUST00000121964.1
 Wdr66
WD repeat domain 66
chrX_-_136203637 0.336 ENSMUST00000151592.1
ENSMUST00000131510.1
ENSMUST00000066819.4
 Tceal5


transcription elongation factor A (SII)-like 5


chr3_-_95106779 0.323 ENSMUST00000005768.7
ENSMUST00000107232.2
ENSMUST00000107236.2
 Pip5k1a


phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha


chr1_+_5083105 0.309 ENSMUST00000044369.7
 Atp6v1h
ATPase, H+ transporting, lysosomal V1 subunit H
chrX_+_136270302 0.308 ENSMUST00000113112.1
 Ngfrap1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr3_-_95882031 0.307 ENSMUST00000161994.1
 Gm129
predicted gene 129
chr11_+_97450136 0.305 ENSMUST00000107601.1
 Arhgap23
Rho GTPase activating protein 23
chr7_-_126583523 0.303 ENSMUST00000125508.1
ENSMUST00000147086.1
ENSMUST00000150587.1
 Cln3


ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)


chr16_-_92466081 0.294 ENSMUST00000060005.8
 Rcan1
regulator of calcineurin 1
chr10_-_80139347 0.282 ENSMUST00000105369.1
 Dos
downstream of Stk11
chr8_+_111033890 0.280 ENSMUST00000034441.7
 Aars
alanyl-tRNA synthetase
chr14_+_50924968 0.277 ENSMUST00000049411.5
ENSMUST00000136753.1
ENSMUST00000154288.1
 Apex1


apurinic/apyrimidinic endonuclease 1


chr7_+_35802593 0.255 ENSMUST00000052454.2
 E130304I02Rik
RIKEN cDNA E130304I02 gene
chr17_-_33824346 0.247 ENSMUST00000173879.1
ENSMUST00000166693.2
ENSMUST00000173019.1
ENSMUST00000087342.6
ENSMUST00000173844.1
 Rps28




ribosomal protein S28




chr4_+_134468320 0.242 ENSMUST00000030636.4
ENSMUST00000127279.1
ENSMUST00000105867.1
 Stmn1


stathmin 1


chr7_-_27166413 0.240 ENSMUST00000108382.1
 Egln2
EGL nine homolog 2 (C. elegans)
chrX_+_153832225 0.237 ENSMUST00000148708.1
ENSMUST00000123264.1
ENSMUST00000049999.8
 Spin2c


spindlin family, member 2C


chr5_-_137533212 0.236 ENSMUST00000111038.1
ENSMUST00000143495.1
 Epo
Gnb2
erythropoietin
guanine nucleotide binding protein (G protein), beta 2
chr8_+_85037151 0.224 ENSMUST00000166592.1
 Tnpo2
transportin 2 (importin 3, karyopherin beta 2b)
chr3_-_96727436 0.222 ENSMUST00000154679.1
 Polr3c
polymerase (RNA) III (DNA directed) polypeptide C
chr14_-_50930803 0.219 ENSMUST00000160538.1
ENSMUST00000162957.1
ENSMUST00000161166.1
ENSMUST00000160835.1
ENSMUST00000049312.7
 Tmem55b




transmembrane protein 55b




chrX_-_136068236 0.217 ENSMUST00000049130.7
 Bex2
brain expressed X-linked 2
chr8_+_85036906 0.215 ENSMUST00000093360.4
 Tnpo2
transportin 2 (importin 3, karyopherin beta 2b)
chr3_-_95882193 0.214 ENSMUST00000159863.1
ENSMUST00000159739.1
ENSMUST00000036418.3
 Gm129


predicted gene 129


chr9_+_108002501 0.211 ENSMUST00000035214.4
ENSMUST00000175874.1
 Ip6k1

inositol hexaphosphate kinase 1

chr3_-_96727566 0.207 ENSMUST00000029741.2
 Polr3c
polymerase (RNA) III (DNA directed) polypeptide C
chrX_+_136138996 0.204 ENSMUST00000116527.1
 Bex4
brain expressed gene 4
chr15_+_80255184 0.199 ENSMUST00000109605.3
 Atf4
activating transcription factor 4
chr5_-_137533170 0.190 ENSMUST00000168746.1
ENSMUST00000170293.1
 Gnb2

guanine nucleotide binding protein (G protein), beta 2

chr4_-_119422355 0.184 ENSMUST00000106316.1
ENSMUST00000030385.6
 Ppcs

phosphopantothenoylcysteine synthetase

chr11_-_52000748 0.182 ENSMUST00000109086.1
 Ube2b
ubiquitin-conjugating enzyme E2B
chr3_-_96727453 0.173 ENSMUST00000141377.1
ENSMUST00000125183.1
 Polr3c

polymerase (RNA) III (DNA directed) polypeptide C

chr8_+_3500451 0.171 ENSMUST00000004683.6
ENSMUST00000160338.1
 Mcoln1

mucolipin 1

chr6_+_72097561 0.169 ENSMUST00000069994.4
ENSMUST00000114112.1
 St3gal5

ST3 beta-galactoside alpha-2,3-sialyltransferase 5

chr12_+_86947343 0.166 ENSMUST00000038369.4
 2310044G17Rik
RIKEN cDNA 2310044G17 gene
chr11_+_55204319 0.161 ENSMUST00000108872.2
ENSMUST00000147506.1
ENSMUST00000020499.7
 Slc36a1


solute carrier family 36 (proton/amino acid symporter), member 1


chr12_-_3426700 0.153 ENSMUST00000180149.1
 1110002L01Rik
RIKEN cDNA 1110002L01 gene
chr17_-_56609689 0.147 ENSMUST00000052832.5
 2410015M20Rik
RIKEN cDNA 2410015M20 gene
chr17_+_33824591 0.143 ENSMUST00000048249.6
 Ndufa7
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7 (B14.5a)
chr3_-_10440054 0.143 ENSMUST00000099223.4
ENSMUST00000029047.6
 Snx16

sorting nexin 16

chr8_-_84846860 0.142 ENSMUST00000003912.6
 Calr
calreticulin
chr3_+_89202916 0.141 ENSMUST00000077367.4
ENSMUST00000167998.1
 Gba

glucosidase, beta, acid

chr11_-_52000432 0.133 ENSMUST00000020657.6
 Ube2b
ubiquitin-conjugating enzyme E2B
chr17_-_12769605 0.132 ENSMUST00000024599.7
 Igf2r
insulin-like growth factor 2 receptor
chr8_+_84689308 0.124 ENSMUST00000125370.3
ENSMUST00000175784.1
 Trmt1

tRNA methyltransferase 1

chr5_-_123572976 0.123 ENSMUST00000031388.8
 Vps33a
vacuolar protein sorting 33A (yeast)
chr8_+_84689247 0.117 ENSMUST00000109767.2
ENSMUST00000177084.1
ENSMUST00000109768.2
ENSMUST00000152301.2
ENSMUST00000177423.1
 Trmt1




tRNA methyltransferase 1




chr1_+_155158703 0.116 ENSMUST00000027743.7
 Stx6
syntaxin 6
chr11_+_95666957 0.113 ENSMUST00000125172.1
ENSMUST00000036374.5
 Phb

prohibitin

chr4_-_118490030 0.111 ENSMUST00000047421.5
 Tie1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr16_-_5049882 0.110 ENSMUST00000023189.7
ENSMUST00000115844.1
 Glyr1

glyoxylate reductase 1 homolog (Arabidopsis)

chr1_+_152766540 0.106 ENSMUST00000077755.5
ENSMUST00000097536.4
 Arpc5

actin related protein 2/3 complex, subunit 5

chr16_+_5233615 0.104 ENSMUST00000100196.2
ENSMUST00000049207.8
 Alg1

asparagine-linked glycosylation 1 (beta-1,4-mannosyltransferase)

chr4_-_48473403 0.100 ENSMUST00000164866.1
ENSMUST00000030030.8
 Tex10

testis expressed gene 10

chr2_-_160619971 0.093 ENSMUST00000109473.1
 Gm14221
predicted gene 14221
chr2_+_30286406 0.092 ENSMUST00000138666.1
ENSMUST00000113634.2
 Nup188

nucleoporin 188

chr9_-_44361625 0.092 ENSMUST00000034644.8
 Vps11
vacuolar protein sorting 11 (yeast)
chr11_+_3649494 0.087 ENSMUST00000093389.2
 Morc2a
microrchidia 2A
chr2_+_121449362 0.082 ENSMUST00000110615.1
ENSMUST00000099475.5
 Serf2

small EDRK-rich factor 2

chr4_-_148038769 0.076 ENSMUST00000030879.5
ENSMUST00000137724.1
 Clcn6

chloride channel 6

chr2_+_30286383 0.075 ENSMUST00000064447.5
 Nup188
nucleoporin 188
chrX_-_134600976 0.070 ENSMUST00000033621.6
 Gla
galactosidase, alpha
chr5_+_104046980 0.069 ENSMUST00000134313.1
 Nudt9
nudix (nucleoside diphosphate linked moiety X)-type motif 9
chr16_+_8830093 0.069 ENSMUST00000023150.5
 1810013L24Rik
RIKEN cDNA 1810013L24 gene
chr5_-_135078224 0.069 ENSMUST00000067935.4
ENSMUST00000076203.2
 Vps37d

vacuolar protein sorting 37D (yeast)

chr11_+_75348433 0.066 ENSMUST00000044530.2
 Smyd4
SET and MYND domain containing 4
chr5_+_104046869 0.064 ENSMUST00000031250.7
 Nudt9
nudix (nucleoside diphosphate linked moiety X)-type motif 9
chr3_-_90052463 0.061 ENSMUST00000029553.9
ENSMUST00000064639.8
ENSMUST00000090908.6
 Ubap2l


ubiquitin associated protein 2-like


chrX_+_134601179 0.059 ENSMUST00000074950.4
ENSMUST00000113203.1
ENSMUST00000113202.1
 Hnrnph2


heterogeneous nuclear ribonucleoprotein H2


chr3_-_95882232 0.057 ENSMUST00000161866.1
 Gm129
predicted gene 129
chr7_-_90475971 0.055 ENSMUST00000032843.7
 Tmem126b
transmembrane protein 126B
chr11_-_75348261 0.053 ENSMUST00000000767.5
ENSMUST00000092907.5
 Rpa1

replication protein A1

chr7_+_128744870 0.053 ENSMUST00000042942.8
 Sec23ip
Sec23 interacting protein
chr2_-_37703845 0.045 ENSMUST00000155237.1
 Strbp
spermatid perinuclear RNA binding protein
chr4_-_118489755 0.045 ENSMUST00000184261.1
 Tie1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr19_-_7241216 0.036 ENSMUST00000025675.9
 Naa40
N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae)
chr5_+_104046526 0.035 ENSMUST00000150226.1
 Nudt9
nudix (nucleoside diphosphate linked moiety X)-type motif 9
chr11_-_75454656 0.031 ENSMUST00000173320.1
 Wdr81
WD repeat domain 81
chr14_-_50924626 0.021 ENSMUST00000160375.1
ENSMUST00000162177.1
ENSMUST00000159292.1
 Osgep


O-sialoglycoprotein endopeptidase


chr3_+_85574109 0.019 ENSMUST00000127348.1
ENSMUST00000107672.1
ENSMUST00000107674.1
 Pet112


PET112 homolog (S. cerevisiae)


chr8_+_25601591 0.016 ENSMUST00000155861.1
 Whsc1l1
Wolf-Hirschhorn syndrome candidate 1-like 1 (human)
chr16_+_5050012 0.013 ENSMUST00000052449.5
 Ubn1
ubinuclein 1
chr4_-_141790891 0.007 ENSMUST00000038014.4
ENSMUST00000153880.1
 Dnajc16

DnaJ (Hsp40) homolog, subfamily C, member 16

chr2_+_84839395 0.007 ENSMUST00000146816.1
ENSMUST00000028469.7
 Slc43a1

solute carrier family 43, member 1

chrX_+_134601271 0.006 ENSMUST00000050331.6
ENSMUST00000059297.5
 Hnrnph2

heterogeneous nuclear ribonucleoprotein H2

chr5_-_91963068 0.003 ENSMUST00000031345.8
 Rchy1
ring finger and CHY zinc finger domain containing 1
chr6_+_17693905 0.001 ENSMUST00000115420.1
 St7
suppression of tumorigenicity 7

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.5 GO:0070829 heterochromatin maintenance(GO:0070829)
0.1 0.3 GO:0010845 positive regulation of reciprocal meiotic recombination(GO:0010845)
0.1 0.3 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.1 0.2 GO:0002940 tRNA N2-guanine methylation(GO:0002940)
0.1 0.2 GO:1902219 regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902218) negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.1 0.3 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
0.1 0.2 GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.1 0.2 GO:0006407 rRNA export from nucleus(GO:0006407)
0.1 0.2 GO:0046032 ADP catabolic process(GO:0046032)
0.0 0.1 GO:2000508 regulation of dendritic cell chemotaxis(GO:2000508) positive regulation of dendritic cell chemotaxis(GO:2000510)
0.0 0.4 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.4 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.0 0.2 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.0 0.2 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0 0.2 GO:0015808 L-alanine transport(GO:0015808)
0.0 0.1 GO:0002922 positive regulation of humoral immune response(GO:0002922) progesterone receptor signaling pathway(GO:0050847)
0.0 0.2 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.7 GO:0097178 ruffle assembly(GO:0097178)
0.0 0.6 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.3 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.0 0.3 GO:0080111 DNA demethylation(GO:0080111)
0.0 0.1 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.3 GO:0097352 autophagosome maturation(GO:0097352)
0.0 0.1 GO:0035542 endosomal vesicle fusion(GO:0034058) regulation of SNARE complex assembly(GO:0035542)
0.0 0.2 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.4 GO:0009303 rRNA transcription(GO:0009303)
0.0 0.2 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.0 0.1 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.0 0.1 GO:0006622 protein targeting to lysosome(GO:0006622)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:1990037 Lewy body core(GO:1990037)
0.1 0.4 GO:0030896 checkpoint clamp complex(GO:0030896)
0.0 0.3 GO:0033503 HULC complex(GO:0033503)
0.0 0.7 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.1 GO:0043202 lysosomal lumen(GO:0043202)
0.0 0.2 GO:0044611 nuclear pore inner ring(GO:0044611)
0.0 0.2 GO:0033263 CORVET complex(GO:0033263)
0.0 0.6 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.1 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.0 0.3 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0 0.1 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.0 0.1 GO:0061617 MICOS complex(GO:0061617)
0.0 0.1 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0 0.1 GO:0005641 nuclear envelope lumen(GO:0005641)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.1 0.3 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.1 0.3 GO:0008311 double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311)
0.1 0.4 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.1 0.7 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.1 0.2 GO:0005128 erythropoietin receptor binding(GO:0005128)
0.1 0.2 GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597)
0.1 0.2 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.1 0.2 GO:0015173 hydrogen:amino acid symporter activity(GO:0005280) aromatic amino acid transmembrane transporter activity(GO:0015173)
0.1 0.2 GO:0000832 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.0 0.3 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.1 GO:0004348 glucosylceramidase activity(GO:0004348)
0.0 0.1 GO:0001851 complement component C3b binding(GO:0001851) proteinase activated receptor binding(GO:0031871)
0.0 0.1 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0 0.8 GO:0005123 death receptor binding(GO:0005123)
0.0 0.6 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 0.2 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.2 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.2 GO:0047631 adenosine-diphosphatase activity(GO:0043262) ADP-ribose diphosphatase activity(GO:0047631)
0.0 0.1 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.2 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.4 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.1 GO:0016936 galactoside binding(GO:0016936)