Motif ID: Bhlhe40

Z-value: 0.416


Transcription factors associated with Bhlhe40:

Gene SymbolEntrez IDGene Name
Bhlhe40 ENSMUSG00000030103.5 Bhlhe40

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Bhlhe40mm10_v2_chr6_+_108660772_108660874-0.509.0e-03Click!


Activity profile for motif Bhlhe40.

activity profile for motif Bhlhe40


Sorted Z-values histogram for motif Bhlhe40

Sorted Z-values for motif Bhlhe40



Network of associatons between targets according to the STRING database.



First level regulatory network of Bhlhe40

PNG image of the network

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Top targets:


Showing 1 to 20 of 96 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_148039097 0.940 ENSMUST00000141283.1
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr1_-_75219245 0.617 ENSMUST00000079464.6
 Tuba4a
tubulin, alpha 4A
chr4_+_148039035 0.519 ENSMUST00000097788.4
 Mthfr
5,10-methylenetetrahydrofolate reductase
chrX_+_136270253 0.444 ENSMUST00000178632.1
ENSMUST00000053540.4
 Ngfrap1

nerve growth factor receptor (TNFRSF16) associated protein 1

chr4_-_137048695 0.425 ENSMUST00000049583.7
 Zbtb40
zinc finger and BTB domain containing 40
chr19_-_4201591 0.369 ENSMUST00000025740.6
 Rad9a
RAD9 homolog A
chr10_-_18023229 0.368 ENSMUST00000020002.7
 Abracl
ABRA C-terminal like
chr3_-_95106907 0.367 ENSMUST00000107233.2
 Pip5k1a
phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha
chr11_-_70239794 0.365 ENSMUST00000040428.3
 Rnasek
ribonuclease, RNase K
chr5_+_123252087 0.365 ENSMUST00000121964.1
 Wdr66
WD repeat domain 66
chrX_-_136203637 0.336 ENSMUST00000151592.1
ENSMUST00000131510.1
ENSMUST00000066819.4
 Tceal5


transcription elongation factor A (SII)-like 5


chr3_-_95106779 0.323 ENSMUST00000005768.7
ENSMUST00000107232.2
ENSMUST00000107236.2
 Pip5k1a


phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha


chr1_+_5083105 0.309 ENSMUST00000044369.7
 Atp6v1h
ATPase, H+ transporting, lysosomal V1 subunit H
chrX_+_136270302 0.308 ENSMUST00000113112.1
 Ngfrap1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr3_-_95882031 0.307 ENSMUST00000161994.1
 Gm129
predicted gene 129
chr11_+_97450136 0.305 ENSMUST00000107601.1
 Arhgap23
Rho GTPase activating protein 23
chr7_-_126583523 0.303 ENSMUST00000125508.1
ENSMUST00000147086.1
ENSMUST00000150587.1
 Cln3


ceroid lipofuscinosis, neuronal 3, juvenile (Batten, Spielmeyer-Vogt disease)


chr16_-_92466081 0.294 ENSMUST00000060005.8
 Rcan1
regulator of calcineurin 1
chr10_-_80139347 0.282 ENSMUST00000105369.1
 Dos
downstream of Stk11
chr8_+_111033890 0.280 ENSMUST00000034441.7
 Aars
alanyl-tRNA synthetase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 1.5 GO:0070829 heterochromatin maintenance(GO:0070829)
0.0 0.7 GO:0097178 ruffle assembly(GO:0097178)
0.0 0.6 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.4 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.0 0.4 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.0 0.4 GO:0009303 rRNA transcription(GO:0009303)
0.1 0.3 GO:0010845 positive regulation of reciprocal meiotic recombination(GO:0010845)
0.1 0.3 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.1 0.3 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
0.0 0.3 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.0 0.3 GO:0080111 DNA demethylation(GO:0080111)
0.0 0.3 GO:0097352 autophagosome maturation(GO:0097352)
0.1 0.2 GO:0002940 tRNA N2-guanine methylation(GO:0002940)
0.1 0.2 GO:1902219 regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902218) negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.1 0.2 GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.1 0.2 GO:0006407 rRNA export from nucleus(GO:0006407)
0.1 0.2 GO:0046032 ADP catabolic process(GO:0046032)
0.0 0.2 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.0 0.2 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0 0.2 GO:0015808 L-alanine transport(GO:0015808)

Gene overrepresentation in cellular_component category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.7 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.6 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 0.4 GO:0030896 checkpoint clamp complex(GO:0030896)
0.0 0.3 GO:0033503 HULC complex(GO:0033503)
0.0 0.3 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.1 0.2 GO:1990037 Lewy body core(GO:1990037)
0.0 0.2 GO:0044611 nuclear pore inner ring(GO:0044611)
0.0 0.2 GO:0033263 CORVET complex(GO:0033263)
0.0 0.1 GO:0043202 lysosomal lumen(GO:0043202)
0.0 0.1 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.0 0.1 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.0 0.1 GO:0061617 MICOS complex(GO:0061617)
0.0 0.1 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0 0.1 GO:0005641 nuclear envelope lumen(GO:0005641)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 1.5 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.0 0.8 GO:0005123 death receptor binding(GO:0005123)
0.1 0.7 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0 0.6 GO:0001056 RNA polymerase III activity(GO:0001056)
0.1 0.4 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.0 0.4 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 0.3 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.1 0.3 GO:0008311 double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311)
0.0 0.3 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.1 0.2 GO:0005128 erythropoietin receptor binding(GO:0005128)
0.1 0.2 GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597)
0.1 0.2 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.1 0.2 GO:0015173 hydrogen:amino acid symporter activity(GO:0005280) aromatic amino acid transmembrane transporter activity(GO:0015173)
0.1 0.2 GO:0000832 inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.0 0.2 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.2 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.2 GO:0047631 adenosine-diphosphatase activity(GO:0043262) ADP-ribose diphosphatase activity(GO:0047631)
0.0 0.2 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.1 GO:0004348 glucosylceramidase activity(GO:0004348)
0.0 0.1 GO:0001851 complement component C3b binding(GO:0001851) proteinase activated receptor binding(GO:0031871)