Motif ID: Brca1

Z-value: 0.716


Transcription factors associated with Brca1:

Gene SymbolEntrez IDGene Name
Brca1 ENSMUSG00000017146.6 Brca1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Brca1mm10_v2_chr11_-_101551837_1015518930.281.7e-01Click!


Activity profile for motif Brca1.

activity profile for motif Brca1


Sorted Z-values histogram for motif Brca1

Sorted Z-values for motif Brca1



Network of associatons between targets according to the STRING database.



First level regulatory network of Brca1

PNG image of the network

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Top targets:


Showing 1 to 20 of 178 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 6.590 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr19_+_55741810 2.299 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
 Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr11_+_44617310 2.216 ENSMUST00000081265.5
ENSMUST00000101326.3
ENSMUST00000109268.1
 Ebf1


early B cell factor 1


chr7_-_144939823 2.149 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr2_-_28916668 1.609 ENSMUST00000113847.1
 Barhl1
BarH-like 1 (Drosophila)
chr1_-_75278345 1.590 ENSMUST00000039534.4
 Resp18
regulated endocrine-specific protein 18
chr17_-_70853482 1.460 ENSMUST00000118283.1
 Tgif1
TGFB-induced factor homeobox 1
chr11_-_11890368 1.455 ENSMUST00000155690.1
 Ddc
dopa decarboxylase
chr10_-_42583628 1.276 ENSMUST00000019938.4
 Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr19_-_24225015 1.253 ENSMUST00000099558.4
 Tjp2
tight junction protein 2
chr2_-_105399286 1.203 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1
chr3_+_87906321 1.172 ENSMUST00000005017.8
 Hdgf
hepatoma-derived growth factor
chr2_-_9883993 1.152 ENSMUST00000114915.2
 9230102O04Rik
RIKEN cDNA 9230102O04 gene
chr12_-_10900296 1.026 ENSMUST00000085735.2
 Pgk1-rs7
phosphoglycerate kinase-1, related sequence-7
chr18_-_47333311 0.989 ENSMUST00000126684.1
ENSMUST00000156422.1
 Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

chr11_-_106998483 0.979 ENSMUST00000124541.1
 Kpna2
karyopherin (importin) alpha 2
chr13_-_95891905 0.966 ENSMUST00000068603.6
 Iqgap2
IQ motif containing GTPase activating protein 2
chr11_+_59306920 0.948 ENSMUST00000000128.3
ENSMUST00000108783.3
 Wnt9a

wingless-type MMTV integration site 9A

chr5_-_21701332 0.907 ENSMUST00000115217.1
ENSMUST00000060899.8
 Napepld

N-acyl phosphatidylethanolamine phospholipase D

chrX_+_71663665 0.903 ENSMUST00000070449.5
 Gpr50
G-protein-coupled receptor 50

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 6.6 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.3 2.3 GO:0048625 myoblast fate commitment(GO:0048625)
0.3 2.1 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.0 1.6 GO:0030901 midbrain development(GO:0030901)
0.2 1.5 GO:0098700 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842) neurotransmitter loading into synaptic vesicle(GO:0098700)
0.1 1.5 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.1 1.5 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.3 1.3 GO:1903011 negative regulation of bone development(GO:1903011)
0.3 1.3 GO:0021764 amygdala development(GO:0021764)
0.1 1.3 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.0 1.1 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 1.1 GO:0007019 microtubule depolymerization(GO:0007019)
0.1 1.0 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 1.0 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.1 1.0 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 1.0 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.2 0.9 GO:1903998 regulation of eating behavior(GO:1903998)
0.1 0.9 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903)
0.0 0.9 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.3 0.8 GO:0021557 oculomotor nerve development(GO:0021557) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.3 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 2.1 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.3 1.6 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 1.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.3 GO:0005921 gap junction(GO:0005921)
0.0 1.3 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 1.2 GO:0005643 nuclear pore(GO:0005643)
0.3 1.0 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.0 1.0 GO:0031941 filamentous actin(GO:0031941)
0.1 0.7 GO:0000125 PCAF complex(GO:0000125)
0.0 0.7 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 0.7 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 0.6 GO:1990635 proximal dendrite(GO:1990635)
0.1 0.6 GO:0001739 sex chromatin(GO:0001739)
0.1 0.6 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.6 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.6 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.1 0.5 GO:0030677 nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681)
0.1 0.5 GO:0042382 paraspeckles(GO:0042382)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.7 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.2 2.9 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.1 2.5 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 2.3 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 2.3 GO:0008432 JUN kinase binding(GO:0008432)
0.1 2.1 GO:0070064 proline-rich region binding(GO:0070064)
0.0 1.6 GO:0005109 frizzled binding(GO:0005109)
0.4 1.5 GO:0036468 aromatic-L-amino-acid decarboxylase activity(GO:0004058) L-dopa decarboxylase activity(GO:0036468)
0.4 1.3 GO:0003953 NAD+ nucleosidase activity(GO:0003953)
0.1 1.1 GO:0001222 transcription corepressor binding(GO:0001222)
0.1 1.0 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.1 1.0 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 1.0 GO:0030215 semaphorin receptor binding(GO:0030215)
0.3 0.9 GO:0008502 melatonin receptor activity(GO:0008502)
0.3 0.7 GO:0004630 phospholipase D activity(GO:0004630)
0.1 0.7 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.0 0.7 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.2 0.6 GO:0043515 kinetochore binding(GO:0043515)
0.1 0.6 GO:0034602 oxoglutarate dehydrogenase (NAD+) activity(GO:0034602)
0.0 0.6 GO:0031681 G-protein beta-subunit binding(GO:0031681)