Motif ID: Chd1_Pml

Z-value: 4.104

Transcription factors associated with Chd1_Pml:

Gene SymbolEntrez IDGene Name
Chd1 ENSMUSG00000023852.7 Chd1
Pml ENSMUSG00000036986.10 Pml

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Chd1mm10_v2_chr17_+_15704963_15704994-0.174.0e-01Click!
Pmlmm10_v2_chr9_-_58249702_58249791-0.164.3e-01Click!


Activity profile for motif Chd1_Pml.

activity profile for motif Chd1_Pml


Sorted Z-values histogram for motif Chd1_Pml

Sorted Z-values for motif Chd1_Pml



Network of associatons between targets according to the STRING database.



First level regulatory network of Chd1_Pml

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_84800024 31.670 ENSMUST00000126806.1
ENSMUST00000076715.6
 Nfix

nuclear factor I/X

chr15_-_66286224 31.143 ENSMUST00000070256.7
 Kcnq3
potassium voltage-gated channel, subfamily Q, member 3
chr8_-_84800344 26.306 ENSMUST00000099070.3
 Nfix
nuclear factor I/X
chr6_+_99692679 20.607 ENSMUST00000101122.1
 Gpr27
G protein-coupled receptor 27
chrX_+_170009659 18.679 ENSMUST00000179760.1
 Gm21887
predicted gene, 21887
chr4_-_120287349 18.506 ENSMUST00000102656.3
 Foxo6
forkhead box O6
chr16_-_67620880 17.809 ENSMUST00000114292.1
ENSMUST00000120898.1
 Cadm2

cell adhesion molecule 2

chr1_-_56972437 16.760 ENSMUST00000042857.7
 Satb2
special AT-rich sequence binding protein 2
chr11_-_6065737 16.683 ENSMUST00000002817.5
ENSMUST00000109813.2
ENSMUST00000090443.3
 Camk2b


calcium/calmodulin-dependent protein kinase II, beta


chr4_+_124657646 16.183 ENSMUST00000053491.7
 Pou3f1
POU domain, class 3, transcription factor 1
chr2_+_155775333 15.897 ENSMUST00000029141.5
 Mmp24
matrix metallopeptidase 24
chrX_+_170009892 15.789 ENSMUST00000180251.1
 Gm21887
predicted gene, 21887
chr9_-_98033181 15.746 ENSMUST00000035027.6
 Clstn2
calsyntenin 2
chr16_-_67620805 15.347 ENSMUST00000120594.1
 Cadm2
cell adhesion molecule 2
chr15_-_12321899 14.918 ENSMUST00000180521.1
 1810049J17Rik
RIKEN cDNA 1810049J17 gene
chr1_-_56971762 14.897 ENSMUST00000114415.3
 Satb2
special AT-rich sequence binding protein 2
chr11_-_6065538 14.575 ENSMUST00000101585.3
ENSMUST00000066431.7
ENSMUST00000109815.2
ENSMUST00000109812.2
ENSMUST00000101586.2
ENSMUST00000093355.5
ENSMUST00000019133.4
 Camk2b






calcium/calmodulin-dependent protein kinase II, beta






chr6_-_114042020 13.653 ENSMUST00000101045.3
 Atp2b2
ATPase, Ca++ transporting, plasma membrane 2
chr6_-_32588192 12.963 ENSMUST00000115096.2
 Plxna4
plexin A4
chr6_+_54816906 12.922 ENSMUST00000079869.6
 Znrf2
zinc and ring finger 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 895 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 87.9 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
5.1 71.2 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
1.9 50.3 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
3.1 49.9 GO:0060081 membrane hyperpolarization(GO:0060081)
2.5 40.5 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
2.4 35.7 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.3 32.9 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
10.8 32.3 GO:0060466 activation of meiosis involved in egg activation(GO:0060466)
1.8 30.5 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
2.0 30.1 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.2 27.3 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
1.0 26.9 GO:0060074 synapse maturation(GO:0060074)
7.3 21.9 GO:1900736 regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900736)
7.3 21.9 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.4 20.8 GO:0099643 neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
2.0 20.2 GO:0010459 negative regulation of heart rate(GO:0010459)
1.6 20.2 GO:0070842 aggresome assembly(GO:0070842)
2.5 19.7 GO:1900452 regulation of long term synaptic depression(GO:1900452)
0.9 19.7 GO:2000463 positive regulation of excitatory postsynaptic potential(GO:2000463)
0.9 19.7 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 283 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 210.8 GO:0016021 integral component of membrane(GO:0016021)
0.6 135.2 GO:0045211 postsynaptic membrane(GO:0045211)
1.9 67.3 GO:0032809 neuronal cell body membrane(GO:0032809)
1.1 66.9 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.2 56.3 GO:0005768 endosome(GO:0005768)
1.5 53.3 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.4 52.5 GO:0070382 exocytic vesicle(GO:0070382)
0.7 50.0 GO:0005905 clathrin-coated pit(GO:0005905)
1.8 49.8 GO:0043194 axon initial segment(GO:0043194)
1.2 47.0 GO:0048786 presynaptic active zone(GO:0048786)
0.3 36.7 GO:0031225 anchored component of membrane(GO:0031225)
0.4 36.2 GO:0055037 recycling endosome(GO:0055037)
1.1 34.5 GO:0051233 spindle midzone(GO:0051233)
0.5 31.8 GO:0043195 terminal bouton(GO:0043195)
0.5 28.1 GO:0043198 dendritic shaft(GO:0043198)
0.6 27.9 GO:0034704 calcium channel complex(GO:0034704)
0.4 27.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.5 24.2 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
2.4 23.8 GO:0044327 dendritic spine head(GO:0044327)
1.8 23.7 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 499 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.7 75.7 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.3 73.4 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
0.2 41.7 GO:0005096 GTPase activator activity(GO:0005096)
0.8 41.6 GO:0045499 chemorepellent activity(GO:0045499)
0.8 35.8 GO:0045296 cadherin binding(GO:0045296)
0.5 34.1 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.2 34.0 GO:0003714 transcription corepressor activity(GO:0003714)
1.4 32.8 GO:0043274 phospholipase binding(GO:0043274)
0.3 30.8 GO:0101005 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.1 29.0 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.3 27.1 GO:0016247 channel regulator activity(GO:0016247)
0.3 26.5 GO:0019210 kinase inhibitor activity(GO:0019210)
0.2 26.0 GO:0050839 cell adhesion molecule binding(GO:0050839)
1.9 24.6 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
1.8 24.6 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.6 24.4 GO:0030507 spectrin binding(GO:0030507)
0.6 23.0 GO:0001540 beta-amyloid binding(GO:0001540)
0.2 23.0 GO:0017124 SH3 domain binding(GO:0017124)
0.1 22.6 GO:0005509 calcium ion binding(GO:0005509)
0.2 21.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)