Motif ID: Clock

Z-value: 0.488


Transcription factors associated with Clock:

Gene SymbolEntrez IDGene Name
Clock ENSMUSG00000029238.8 Clock

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Clockmm10_v2_chr5_-_76304474_763045480.601.2e-03Click!


Activity profile for motif Clock.

activity profile for motif Clock


Sorted Z-values histogram for motif Clock

Sorted Z-values for motif Clock



Network of associatons between targets according to the STRING database.



First level regulatory network of Clock

PNG image of the network

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Top targets:


Showing 1 to 20 of 153 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_144939823 1.132 ENSMUST00000093962.4
Ccnd1
cyclin D1
chr14_-_20181773 1.124 ENSMUST00000024011.8
Kcnk5
potassium channel, subfamily K, member 5
chr15_+_72913357 1.041 ENSMUST00000166418.2
Gm3150
predicted gene 3150
chrX_+_36328353 1.036 ENSMUST00000016383.3
Lonrf3
LON peptidase N-terminal domain and ring finger 3
chr16_+_32608973 0.938 ENSMUST00000120680.1
Tfrc
transferrin receptor
chr1_-_186705980 0.881 ENSMUST00000045288.8
Tgfb2
transforming growth factor, beta 2
chr4_-_82705735 0.835 ENSMUST00000155821.1
Nfib
nuclear factor I/B
chr2_+_164769892 0.827 ENSMUST00000088248.6
ENSMUST00000001439.6
Ube2c

ubiquitin-conjugating enzyme E2C

chr1_-_82291370 0.798 ENSMUST00000069799.2
Irs1
insulin receptor substrate 1
chr4_-_97778042 0.798 ENSMUST00000146447.1
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr5_-_76951560 0.732 ENSMUST00000140076.1
Ppat
phosphoribosyl pyrophosphate amidotransferase
chr10_+_22158566 0.726 ENSMUST00000181645.1
ENSMUST00000105522.2
Raet1e
H60b
retinoic acid early transcript 1E
histocompatibility 60b
chr3_+_41564880 0.640 ENSMUST00000168086.1
Phf17
PHD finger protein 17
chr6_+_108660772 0.631 ENSMUST00000163617.1
Bhlhe40
basic helix-loop-helix family, member e40
chr1_+_59684949 0.622 ENSMUST00000027174.3
Nop58
NOP58 ribonucleoprotein
chr2_+_160645881 0.610 ENSMUST00000109468.2
Top1
topoisomerase (DNA) I
chr6_+_108660616 0.600 ENSMUST00000032194.4
Bhlhe40
basic helix-loop-helix family, member e40
chr17_-_35000848 0.598 ENSMUST00000166828.3
D17H6S56E-5
DNA segment, Chr 17, human D6S56E 5
chr18_+_35553401 0.572 ENSMUST00000181664.1
Snhg4
small nucleolar RNA host gene 4 (non-protein coding)
chr5_+_93093428 0.570 ENSMUST00000074733.7
Sept11
septin 11

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.3 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.1 1.1 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 1.0 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.3 0.9 GO:0048818 positive regulation of hair follicle maturation(GO:0048818) positive regulation of catagen(GO:0051795) regulation of epithelial to mesenchymal transition involved in endocardial cushion formation(GO:1905005)
0.1 0.9 GO:0033572 transferrin transport(GO:0033572)
0.0 0.9 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.2 0.8 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.2 0.8 GO:0010993 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.2 0.8 GO:0090273 regulation of somatostatin secretion(GO:0090273)
0.1 0.7 GO:0006543 glutamine catabolic process(GO:0006543)
0.1 0.7 GO:0048254 snoRNA localization(GO:0048254)
0.1 0.6 GO:0046084 adenine metabolic process(GO:0046083) adenine biosynthetic process(GO:0046084)
0.1 0.6 GO:0006265 DNA topological change(GO:0006265)
0.0 0.6 GO:0001913 T cell mediated cytotoxicity(GO:0001913)
0.1 0.5 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.1 0.5 GO:0090209 negative regulation of triglyceride metabolic process(GO:0090209)
0.1 0.4 GO:0002842 T cell mediated immune response to tumor cell(GO:0002424) regulation of T cell mediated immune response to tumor cell(GO:0002840) positive regulation of T cell mediated immune response to tumor cell(GO:0002842)
0.1 0.4 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 0.4 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.1 0.4 GO:0070460 thyroid-stimulating hormone secretion(GO:0070460)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.1 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 0.9 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.3 0.8 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.8 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.8 GO:0005680 anaphase-promoting complex(GO:0005680)
0.2 0.7 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.1 0.6 GO:0001651 dense fibrillar component(GO:0001651)
0.1 0.6 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.1 0.4 GO:0043259 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259)
0.1 0.4 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 0.4 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 0.3 GO:0031088 platelet dense granule membrane(GO:0031088)
0.1 0.3 GO:0031084 BLOC-2 complex(GO:0031084)
0.0 0.3 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.1 0.2 GO:0008537 proteasome activator complex(GO:0008537)
0.0 0.1 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.0 0.1 GO:0000125 PCAF complex(GO:0000125)
0.0 0.1 GO:0070761 pre-snoRNP complex(GO:0070761)
0.0 0.1 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.0 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.4 GO:0070064 proline-rich region binding(GO:0070064)
0.2 1.2 GO:0043426 MRF binding(GO:0043426)
0.1 1.1 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 1.0 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.3 0.9 GO:0004998 transferrin receptor activity(GO:0004998)
0.2 0.9 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 0.9 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.1 0.8 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.8 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 0.7 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.1 0.7 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.7 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.7 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 0.6 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.0 0.6 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 0.4 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.1 0.4 GO:0043559 insulin binding(GO:0043559)
0.0 0.4 GO:0043208 glycosphingolipid binding(GO:0043208)
0.0 0.4 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.4 GO:0008758 thiamine-pyrophosphatase activity(GO:0004787) UDP-2,3-diacylglucosamine hydrolase activity(GO:0008758) dATP pyrophosphohydrolase activity(GO:0008828) dihydroneopterin monophosphate phosphatase activity(GO:0019176) dihydroneopterin triphosphate pyrophosphohydrolase activity(GO:0019177) dTTP diphosphatase activity(GO:0036218) phosphocholine hydrolase activity(GO:0044606)