Motif ID: Creb3

Z-value: 0.669


Transcription factors associated with Creb3:

Gene SymbolEntrez IDGene Name
Creb3 ENSMUSG00000028466.9 Creb3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Creb3mm10_v2_chr4_+_43562672_43562947-0.452.2e-02Click!


Activity profile for motif Creb3.

activity profile for motif Creb3


Sorted Z-values histogram for motif Creb3

Sorted Z-values for motif Creb3



Network of associatons between targets according to the STRING database.



First level regulatory network of Creb3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_144939823 2.653 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr11_-_94653964 2.131 ENSMUST00000039949.4
 Eme1
essential meiotic endonuclease 1 homolog 1 (S. pombe)
chr17_+_35439155 1.909 ENSMUST00000071951.6
ENSMUST00000078205.7
ENSMUST00000116598.3
ENSMUST00000076256.7
 H2-Q7



histocompatibility 2, Q region locus 7



chr5_+_120431770 1.753 ENSMUST00000031591.7
 Lhx5
LIM homeobox protein 5
chr4_+_3938888 1.502 ENSMUST00000121110.1
ENSMUST00000108386.1
ENSMUST00000149544.1
 Chchd7


coiled-coil-helix-coiled-coil-helix domain containing 7


chr2_-_105399286 1.463 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1
chr9_-_20976762 1.419 ENSMUST00000054197.5
 S1pr2
sphingosine-1-phosphate receptor 2
chr10_+_19356558 1.418 ENSMUST00000053225.5
 Olig3
oligodendrocyte transcription factor 3
chr2_-_23155864 1.399 ENSMUST00000028119.6
 Mastl
microtubule associated serine/threonine kinase-like
chr3_+_116878227 1.383 ENSMUST00000040260.6
 Frrs1
ferric-chelate reductase 1
chr7_-_45091713 1.359 ENSMUST00000141576.1
 Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr7_-_45092130 1.330 ENSMUST00000148175.1
 Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr2_+_119112793 1.327 ENSMUST00000140939.1
ENSMUST00000028795.3
 Rad51

RAD51 homolog

chr3_-_36571952 1.249 ENSMUST00000029270.3
 Ccna2
cyclin A2
chr4_-_117182623 1.228 ENSMUST00000065896.2
 Kif2c
kinesin family member 2C
chr10_+_127041931 1.211 ENSMUST00000006915.7
ENSMUST00000120542.1
 Mettl1

methyltransferase like 1

chr8_+_108714644 1.139 ENSMUST00000043896.8
 Zfhx3
zinc finger homeobox 3
chr1_+_74791516 1.125 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr18_+_84720019 1.094 ENSMUST00000161429.1
ENSMUST00000052501.1
 Fam69c

family with sequence similarity 69, member C

chrX_-_20291728 1.091 ENSMUST00000115393.2
 Slc9a7
solute carrier family 9 (sodium/hydrogen exchanger), member 7

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 100 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.3 GO:0032526 response to retinoic acid(GO:0032526)
0.4 2.7 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.4 2.1 GO:0072429 response to cell cycle checkpoint signaling(GO:0072396) response to DNA integrity checkpoint signaling(GO:0072402) response to DNA damage checkpoint signaling(GO:0072423) response to intra-S DNA damage checkpoint signaling(GO:0072429)
0.0 2.0 GO:0098780 mitophagy in response to mitochondrial depolarization(GO:0098779) response to mitochondrial depolarisation(GO:0098780)
0.0 1.9 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.3 1.8 GO:0021937 cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation(GO:0021937)
0.3 1.6 GO:0031860 telomeric 3' overhang formation(GO:0031860)
0.2 1.5 GO:1903298 regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903297) negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903298)
0.1 1.5 GO:0010664 negative regulation of striated muscle cell apoptotic process(GO:0010664)
0.5 1.4 GO:1901552 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.3 1.4 GO:0097475 motor neuron migration(GO:0097475) spinal cord motor neuron migration(GO:0097476)
0.2 1.4 GO:0007135 meiosis II(GO:0007135)
0.2 1.4 GO:0036265 RNA (guanine-N7)-methylation(GO:0036265)
0.3 1.3 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.1 1.3 GO:0006613 cotranslational protein targeting to membrane(GO:0006613)
0.3 1.2 GO:0070829 heterochromatin maintenance(GO:0070829)
0.2 1.2 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.0 1.2 GO:0048146 positive regulation of fibroblast proliferation(GO:0048146)
0.4 1.1 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.2 1.1 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.0 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.4 2.1 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.2 2.0 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 1.9 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 1.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.3 1.6 GO:0030870 Mre11 complex(GO:0030870)
0.0 1.4 GO:0005844 polysome(GO:0005844)
0.0 1.4 GO:0005811 lipid particle(GO:0005811)
0.1 1.3 GO:0000800 lateral element(GO:0000800)
0.4 1.2 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.2 1.2 GO:0001940 male pronucleus(GO:0001940)
0.0 1.2 GO:0035371 microtubule plus-end(GO:0035371)
0.0 1.1 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 1.1 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 1.0 GO:0097539 ciliary transition fiber(GO:0097539)
0.1 0.9 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.1 0.9 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.1 0.9 GO:0042555 MCM complex(GO:0042555)
0.1 0.9 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.9 GO:0010494 cytoplasmic stress granule(GO:0010494)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 84 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.7 GO:0070064 proline-rich region binding(GO:0070064)
0.1 2.4 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 2.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 2.1 GO:0004519 endonuclease activity(GO:0004519)
0.0 2.1 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 1.9 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.2 1.6 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 1.6 GO:0019905 syntaxin binding(GO:0019905)
0.3 1.4 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.2 1.4 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 1.4 GO:0005109 frizzled binding(GO:0005109)
0.2 1.3 GO:0000150 recombinase activity(GO:0000150)
0.1 1.3 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 1.3 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.4 1.2 GO:0008176 tRNA (guanine-N7-)-methyltransferase activity(GO:0008176)
0.4 1.2 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.2 1.2 GO:0070191 methionine-R-sulfoxide reductase activity(GO:0070191)
0.1 1.2 GO:0051010 microtubule plus-end binding(GO:0051010)
0.3 1.1 GO:0048408 epidermal growth factor binding(GO:0048408)
0.1 1.1 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)