Motif ID: Cux1

Z-value: 0.800


Transcription factors associated with Cux1:

Gene SymbolEntrez IDGene Name
Cux1 ENSMUSG00000029705.11 Cux1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Cux1mm10_v2_chr5_-_136567307_136567445-0.452.1e-02Click!


Activity profile for motif Cux1.

activity profile for motif Cux1


Sorted Z-values histogram for motif Cux1

Sorted Z-values for motif Cux1



Network of associatons between targets according to the STRING database.



First level regulatory network of Cux1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_103827922 6.737 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr11_+_78499087 5.146 ENSMUST00000017488.4
 Vtn
vitronectin
chr5_+_117841839 3.203 ENSMUST00000142742.2
 Nos1
nitric oxide synthase 1, neuronal
chr5_-_145201829 2.818 ENSMUST00000162220.1
ENSMUST00000031632.8
 Zkscan14

zinc finger with KRAB and SCAN domains 14

chr10_-_117282262 2.225 ENSMUST00000092163.7
 Lyz2
lysozyme 2
chr7_-_19166119 2.208 ENSMUST00000094790.3
 Gipr
gastric inhibitory polypeptide receptor
chr4_+_119814495 2.204 ENSMUST00000106307.2
 Hivep3
human immunodeficiency virus type I enhancer binding protein 3
chr7_-_140154712 1.861 ENSMUST00000059241.7
 Sprn
shadow of prion protein
chr5_-_122050102 1.836 ENSMUST00000154139.1
 Cux2
cut-like homeobox 2
chr7_+_44384098 1.618 ENSMUST00000118962.1
ENSMUST00000118831.1
 Syt3

synaptotagmin III

chr7_+_141461728 1.599 ENSMUST00000167491.1
ENSMUST00000165194.1
 Efcab4a

EF-hand calcium binding domain 4A

chr5_+_110544326 1.567 ENSMUST00000040001.7
 Galnt9
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9
chr5_+_66968559 1.493 ENSMUST00000127184.1
 Limch1
LIM and calponin homology domains 1
chr7_+_44384604 1.478 ENSMUST00000130707.1
ENSMUST00000130844.1
 Syt3

synaptotagmin III

chr7_+_44384803 1.427 ENSMUST00000120262.1
 Syt3
synaptotagmin III
chr7_-_19698383 1.423 ENSMUST00000173739.1
 Apoe
apolipoprotein E
chr7_+_96210107 1.417 ENSMUST00000138760.1
 Tenm4
teneurin transmembrane protein 4
chr6_+_41605482 1.408 ENSMUST00000114732.2
 Ephb6
Eph receptor B6
chr6_-_88875035 1.391 ENSMUST00000145944.1
 Podxl2
podocalyxin-like 2
chr1_-_83408190 1.386 ENSMUST00000160953.1
 Sphkap
SPHK1 interactor, AKAP domain containing

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 147 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 5.1 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.2 4.3 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.1 4.0 GO:0034605 cellular response to heat(GO:0034605)
0.8 3.2 GO:1901204 positive regulation of guanylate cyclase activity(GO:0031284) regulation of adrenergic receptor signaling pathway involved in heart process(GO:1901204)
0.3 3.0 GO:0071569 protein ufmylation(GO:0071569)
0.9 2.7 GO:2001139 negative regulation of postsynaptic membrane organization(GO:1901627) negative regulation of dendritic spine maintenance(GO:1902951) negative regulation of phospholipid efflux(GO:1902999) regulation of lipid transport across blood brain barrier(GO:1903000) negative regulation of lipid transport across blood brain barrier(GO:1903001) positive regulation of lipid transport across blood brain barrier(GO:1903002) negative regulation of phospholipid transport(GO:2001139)
0.1 2.6 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.2 2.5 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.1 2.5 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.1 2.4 GO:0022401 desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) negative adaptation of signaling pathway(GO:0022401)
0.0 2.4 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 2.2 GO:0031032 actomyosin structure organization(GO:0031032)
0.3 1.8 GO:2000323 negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.1 1.8 GO:0007614 short-term memory(GO:0007614)
0.1 1.7 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.4 1.4 GO:0032289 central nervous system myelin formation(GO:0032289)
0.4 1.4 GO:2000525 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.1 1.3 GO:0071420 cellular response to histamine(GO:0071420)
0.1 1.3 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.1 1.3 GO:0070914 UV-damage excision repair(GO:0070914)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 7.4 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
1.7 6.7 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.3 3.7 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 3.2 GO:0070382 exocytic vesicle(GO:0070382)
0.9 2.7 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.1 2.2 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 1.8 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 1.7 GO:0031225 anchored component of membrane(GO:0031225)
0.1 1.6 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 1.6 GO:0005604 basement membrane(GO:0005604)
0.0 1.4 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 1.3 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 1.3 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 1.3 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 1.3 GO:0030018 Z disc(GO:0030018)
0.1 1.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 1.2 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 1.2 GO:0009925 basal plasma membrane(GO:0009925)
0.0 1.2 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 1.1 GO:0005869 dynactin complex(GO:0005869)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 114 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 6.7 GO:0031720 haptoglobin binding(GO:0031720)
0.3 5.1 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.2 4.9 GO:0001786 phosphatidylserine binding(GO:0001786)
1.1 3.2 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 3.0 GO:0005516 calmodulin binding(GO:0005516)
0.2 2.8 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.9 2.7 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.1 2.6 GO:0031489 myosin V binding(GO:0031489)
0.4 2.2 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1 2.2 GO:0004890 GABA-A receptor activity(GO:0004890)
0.1 2.1 GO:0005003 ephrin receptor activity(GO:0005003)
0.0 1.6 GO:0035496 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980) O antigen polymerase activity(GO:0008755) lipopolysaccharide-1,6-galactosyltransferase activity(GO:0008921) cellulose synthase activity(GO:0016759) 9-phenanthrol UDP-glucuronosyltransferase activity(GO:0018715) 1-phenanthrol glycosyltransferase activity(GO:0018716) 9-phenanthrol glycosyltransferase activity(GO:0018717) 1,2-dihydroxy-phenanthrene glycosyltransferase activity(GO:0018718) phenanthrol glycosyltransferase activity(GO:0019112) alpha-1,2-galactosyltransferase activity(GO:0031278) dolichyl pyrophosphate Man7GlcNAc2 alpha-1,3-glucosyltransferase activity(GO:0033556) endogalactosaminidase activity(GO:0033931) lipopolysaccharide-1,5-galactosyltransferase activity(GO:0035496) dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity(GO:0042283) inositol phosphoceramide synthase activity(GO:0045140) alpha-(1->3)-fucosyltransferase activity(GO:0046920) indole-3-butyrate beta-glucosyltransferase activity(GO:0052638) salicylic acid glucosyltransferase (ester-forming) activity(GO:0052639) salicylic acid glucosyltransferase (glucoside-forming) activity(GO:0052640) benzoic acid glucosyltransferase activity(GO:0052641) chondroitin hydrolase activity(GO:0052757) dolichyl-pyrophosphate Man7GlcNAc2 alpha-1,6-mannosyltransferase activity(GO:0052824) cytokinin 9-beta-glucosyltransferase activity(GO:0080062)
0.0 1.5 GO:0051018 protein kinase A binding(GO:0051018)
0.0 1.5 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 1.4 GO:0017046 peptide hormone binding(GO:0017046)
0.0 1.4 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.2 1.3 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1 1.3 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 1.3 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 1.3 GO:0005245 voltage-gated calcium channel activity(GO:0005245)