Motif ID: Dlx5_Dlx4

Z-value: 1.307

Transcription factors associated with Dlx5_Dlx4:

Gene SymbolEntrez IDGene Name
Dlx4 ENSMUSG00000020871.7 Dlx4
Dlx5 ENSMUSG00000029755.9 Dlx5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dlx5mm10_v2_chr6_-_6882068_68820920.048.3e-01Click!


Activity profile for motif Dlx5_Dlx4.

activity profile for motif Dlx5_Dlx4


Sorted Z-values histogram for motif Dlx5_Dlx4

Sorted Z-values for motif Dlx5_Dlx4



Network of associatons between targets according to the STRING database.



First level regulatory network of Dlx5_Dlx4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_81843699 4.835 ENSMUST00000092020.2
 Gm8444
predicted gene 8444
chr7_-_25882407 4.422 ENSMUST00000163316.2
 Gm6434
predicted gene 6434
chr5_-_84417359 3.363 ENSMUST00000113401.1
 Epha5
Eph receptor A5
chr1_-_175979114 2.983 ENSMUST00000104983.1
 B020018G12Rik
RIKEN cDNA B020018G12 gene
chrX_+_56787701 2.791 ENSMUST00000151033.1
 Fhl1
four and a half LIM domains 1
chr1_-_5019342 2.690 ENSMUST00000002533.8
 Rgs20
regulator of G-protein signaling 20
chr8_-_4779513 2.531 ENSMUST00000022945.7
 Shcbp1
Shc SH2-domain binding protein 1
chr4_+_105789869 2.474 ENSMUST00000184254.1
 Gm12728
predicted gene 12728
chr3_-_19264959 2.273 ENSMUST00000121951.1
 Pde7a
phosphodiesterase 7A
chr8_+_23411490 2.104 ENSMUST00000033952.7
 Sfrp1
secreted frizzled-related protein 1
chr9_-_36726374 2.033 ENSMUST00000172702.2
ENSMUST00000172742.1
ENSMUST00000034625.5
 Chek1


checkpoint kinase 1


chr12_-_55014329 2.010 ENSMUST00000172875.1
 Baz1a
bromodomain adjacent to zinc finger domain 1A
chr9_-_16378231 1.857 ENSMUST00000082170.5
 Fat3
FAT tumor suppressor homolog 3 (Drosophila)
chr19_-_34255325 1.794 ENSMUST00000039631.8
 Acta2
actin, alpha 2, smooth muscle, aorta
chrX_+_56786527 1.792 ENSMUST00000144600.1
 Fhl1
four and a half LIM domains 1
chr9_-_66514567 1.687 ENSMUST00000056890.8
 Fbxl22
F-box and leucine-rich repeat protein 22
chr2_-_121235689 1.656 ENSMUST00000142400.1
 Trp53bp1
transformation related protein 53 binding protein 1
chr8_-_57653023 1.646 ENSMUST00000034021.5
 Galnt7
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7
chr9_+_95857597 1.627 ENSMUST00000034980.7
 Atr
ataxia telangiectasia and Rad3 related
chrM_+_9870 1.619 ENSMUST00000084013.1
 mt-Nd4l
mitochondrially encoded NADH dehydrogenase 4L

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 185 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.5 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.1 3.9 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.3 3.4 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.1 3.4 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.3 2.7 GO:0090244 Wnt signaling pathway involved in somitogenesis(GO:0090244)
0.2 2.7 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.1 2.6 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 2.5 GO:0006342 chromatin silencing(GO:0006342)
0.7 2.1 GO:1904956 regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.0 2.1 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.3 2.0 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
0.1 1.9 GO:0010842 retina layer formation(GO:0010842)
0.1 1.7 GO:0014829 vascular smooth muscle contraction(GO:0014829)
0.5 1.6 GO:1904884 telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.0 1.6 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 1.6 GO:0000077 DNA damage checkpoint(GO:0000077) DNA integrity checkpoint(GO:0031570)
0.2 1.5 GO:0006570 tyrosine metabolic process(GO:0006570)
0.2 1.5 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.2 1.5 GO:0030035 microspike assembly(GO:0030035)
0.0 1.5 GO:0019228 neuronal action potential(GO:0019228)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.5 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 3.9 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 3.8 GO:0070469 respiratory chain(GO:0070469)
0.0 3.4 GO:0005657 replication fork(GO:0005657)
0.0 3.0 GO:0000776 kinetochore(GO:0000776)
0.1 2.9 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 2.6 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 2.3 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 2.2 GO:0000786 nucleosome(GO:0000786)
0.1 2.1 GO:0035371 microtubule plus-end(GO:0035371)
0.4 2.0 GO:0008623 CHRAC(GO:0008623)
0.0 2.0 GO:0030175 filopodium(GO:0030175)
0.4 1.8 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.1 1.6 GO:0001741 XY body(GO:0001741)
0.1 1.5 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 1.4 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.3 1.3 GO:0036449 microtubule minus-end(GO:0036449)
0.0 1.2 GO:0005871 kinesin complex(GO:0005871)
0.0 1.2 GO:0031594 neuromuscular junction(GO:0031594)
0.3 1.1 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 111 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.9 GO:0042393 histone binding(GO:0042393)
0.0 3.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 3.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 3.5 GO:0044325 ion channel binding(GO:0044325)
0.4 3.4 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.1 2.5 GO:0042169 SH2 domain binding(GO:0042169)
0.1 2.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.7 2.0 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.0 2.0 GO:0042162 telomeric DNA binding(GO:0042162)
0.1 1.9 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 1.9 GO:0005516 calmodulin binding(GO:0005516)
0.3 1.6 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.3 1.6 GO:0032405 MutLalpha complex binding(GO:0032405) MutSalpha complex binding(GO:0032407)
0.1 1.6 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 1.6 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.0 1.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 1.5 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.2 1.5 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 1.5 GO:0008186 ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.2 1.3 GO:0004984 olfactory receptor activity(GO:0004984)