Motif ID: E2f1

Z-value: 7.069


Transcription factors associated with E2f1:

Gene SymbolEntrez IDGene Name
E2f1 ENSMUSG00000027490.11 E2f1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f1mm10_v2_chr2_-_154569720_1545697990.941.5e-12Click!


Activity profile for motif E2f1.

activity profile for motif E2f1


Sorted Z-values histogram for motif E2f1

Sorted Z-values for motif E2f1



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_60893430 33.659 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr10_-_120476469 33.209 ENSMUST00000072777.7
ENSMUST00000159699.1
 Hmga2

high mobility group AT-hook 2

chr15_-_98004695 30.029 ENSMUST00000023123.8
 Col2a1
collagen, type II, alpha 1
chr17_+_56303396 27.617 ENSMUST00000113038.1
 Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr15_-_98004634 27.547 ENSMUST00000131560.1
ENSMUST00000088355.5
 Col2a1

collagen, type II, alpha 1

chr14_-_47276790 26.576 ENSMUST00000111792.1
ENSMUST00000111791.1
ENSMUST00000111790.1
 Wdhd1


WD repeat and HMG-box DNA binding protein 1


chr17_+_56303321 25.706 ENSMUST00000001258.8
 Uhrf1
ubiquitin-like, containing PHD and RING finger domains, 1
chr4_+_126556935 25.456 ENSMUST00000048391.8
 Clspn
claspin
chr1_-_20820213 25.358 ENSMUST00000053266.9
 Mcm3
minichromosome maintenance deficient 3 (S. cerevisiae)
chr13_-_47106176 24.755 ENSMUST00000021807.6
ENSMUST00000135278.1
 Dek

DEK oncogene (DNA binding)

chr13_-_47105790 24.512 ENSMUST00000129352.1
 Dek
DEK oncogene (DNA binding)
chr5_+_45669907 24.171 ENSMUST00000117396.1
 Ncapg
non-SMC condensin I complex, subunit G
chr11_+_98907801 22.900 ENSMUST00000092706.6
 Cdc6
cell division cycle 6
chr2_+_163054682 21.809 ENSMUST00000018005.3
 Mybl2
myeloblastosis oncogene-like 2
chr7_+_13278778 21.388 ENSMUST00000098814.4
ENSMUST00000146998.1
ENSMUST00000185145.1
 Lig1


ligase I, DNA, ATP-dependent


chr15_+_55557399 21.202 ENSMUST00000022998.7
 Mtbp
Mdm2, transformed 3T3 cell double minute p53 binding protein
chr1_-_191575534 20.848 ENSMUST00000027933.5
 Dtl
denticleless homolog (Drosophila)
chr10_-_128704978 20.454 ENSMUST00000026416.7
ENSMUST00000026415.7
 Cdk2

cyclin-dependent kinase 2

chr12_+_24708241 20.411 ENSMUST00000020980.5
 Rrm2
ribonucleotide reductase M2
chr4_+_126556994 20.173 ENSMUST00000147675.1
 Clspn
claspin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 498 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.3 168.2 GO:0006270 DNA replication initiation(GO:0006270)
5.5 82.7 GO:0010216 maintenance of DNA methylation(GO:0010216)
0.4 79.0 GO:0006260 DNA replication(GO:0006260)
17.2 68.9 GO:2001032 regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
6.6 65.8 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
3.8 61.3 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
10.6 52.9 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
5.7 45.6 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
3.4 44.8 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.9 40.2 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
3.3 39.7 GO:0019985 translesion synthesis(GO:0019985)
13.1 39.4 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
0.2 38.8 GO:0007067 mitotic nuclear division(GO:0007067)
7.0 34.9 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)
0.2 33.1 GO:0006281 DNA repair(GO:0006281)
2.7 32.9 GO:2000381 negative regulation of mesoderm development(GO:2000381)
2.5 32.9 GO:0034501 protein localization to kinetochore(GO:0034501)
6.3 31.6 GO:0046601 positive regulation of centriole replication(GO:0046601)
3.9 31.1 GO:0033504 floor plate development(GO:0033504)
1.8 30.8 GO:0007530 sex determination(GO:0007530)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 230 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 421.8 GO:0005634 nucleus(GO:0005634)
0.3 156.6 GO:0005694 chromosome(GO:0005694)
2.0 128.2 GO:0005657 replication fork(GO:0005657)
0.6 98.1 GO:0000775 chromosome, centromeric region(GO:0000775)
6.4 96.7 GO:0042555 MCM complex(GO:0042555)
0.1 63.7 GO:0005730 nucleolus(GO:0005730)
4.6 60.4 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.8 59.6 GO:0005814 centriole(GO:0005814)
10.3 51.3 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
5.9 47.0 GO:0098536 deuterosome(GO:0098536)
0.2 37.8 GO:0009897 external side of plasma membrane(GO:0009897)
5.1 35.8 GO:0000796 condensin complex(GO:0000796)
0.2 33.4 GO:0031965 nuclear membrane(GO:0031965)
0.4 31.7 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
5.2 31.2 GO:0005663 DNA replication factor C complex(GO:0005663)
5.0 30.1 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.1 30.1 GO:0005667 transcription factor complex(GO:0005667)
3.0 29.6 GO:0001739 sex chromatin(GO:0001739)
0.7 29.0 GO:0034707 chloride channel complex(GO:0034707)
2.9 28.6 GO:0000805 X chromosome(GO:0000805)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 326 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 101.4 GO:0042393 histone binding(GO:0042393)
1.6 86.2 GO:0003678 DNA helicase activity(GO:0003678)
0.5 79.4 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.7 68.5 GO:0004386 helicase activity(GO:0004386)
20.3 60.9 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
3.8 57.6 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.2 57.5 GO:0008022 protein C-terminus binding(GO:0008022)
0.2 54.7 GO:0003682 chromatin binding(GO:0003682)
10.3 51.3 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.9 45.9 GO:0035064 methylated histone binding(GO:0035064)
4.1 45.2 GO:0003680 AT DNA binding(GO:0003680)
0.8 44.9 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
7.4 44.7 GO:0010997 anaphase-promoting complex binding(GO:0010997)
1.2 43.8 GO:0070063 RNA polymerase binding(GO:0070063)
0.0 41.5 GO:0044822 poly(A) RNA binding(GO:0044822)
3.7 40.2 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
1.0 33.7 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.8 33.5 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
1.2 32.7 GO:0017025 TBP-class protein binding(GO:0017025)
1.5 29.7 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)