Motif ID: E2f2_E2f5
Z-value: 5.393
Transcription factors associated with E2f2_E2f5:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
E2f2 | ENSMUSG00000018983.9 | E2f2 |
E2f5 | ENSMUSG00000027552.8 | E2f5 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
E2f2 | mm10_v2_chr4_+_136172367_136172395 | 0.97 | 2.9e-16 | Click! |
E2f5 | mm10_v2_chr3_+_14578609_14578687 | 0.88 | 3.0e-09 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
18.0 | 54.1 | GO:0032877 | positive regulation of DNA endoreduplication(GO:0032877) |
7.7 | 54.2 | GO:1990086 | lens fiber cell apoptotic process(GO:1990086) |
7.7 | 61.3 | GO:0033314 | mitotic DNA replication checkpoint(GO:0033314) |
6.0 | 77.5 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
5.6 | 16.7 | GO:0006285 | base-excision repair, AP site formation(GO:0006285) |
5.4 | 42.9 | GO:0035726 | common myeloid progenitor cell proliferation(GO:0035726) |
5.4 | 21.4 | GO:0007056 | spindle assembly involved in female meiosis(GO:0007056) |
5.3 | 21.2 | GO:0071139 | resolution of recombination intermediates(GO:0071139) |
5.3 | 21.0 | GO:0046655 | glycine biosynthetic process(GO:0006545) folic acid metabolic process(GO:0046655) |
5.0 | 19.9 | GO:0042276 | error-prone translesion synthesis(GO:0042276) |
5.0 | 29.8 | GO:0031936 | negative regulation of chromatin silencing(GO:0031936) |
4.6 | 36.8 | GO:0033504 | floor plate development(GO:0033504) |
4.4 | 17.7 | GO:0048304 | positive regulation of isotype switching to IgG isotypes(GO:0048304) |
4.3 | 102.5 | GO:0006270 | DNA replication initiation(GO:0006270) |
4.2 | 41.6 | GO:0009186 | deoxyribonucleoside diphosphate metabolic process(GO:0009186) |
4.1 | 24.6 | GO:0006287 | base-excision repair, gap-filling(GO:0006287) |
4.0 | 56.6 | GO:0090308 | regulation of methylation-dependent chromatin silencing(GO:0090308) |
3.7 | 18.6 | GO:0034421 | post-translational protein acetylation(GO:0034421) |
3.6 | 14.6 | GO:0098763 | mitotic cell cycle phase(GO:0098763) |
3.6 | 10.9 | GO:0035622 | intrahepatic bile duct development(GO:0035622) cholangiocyte proliferation(GO:1990705) |
3.3 | 13.3 | GO:0000076 | DNA replication checkpoint(GO:0000076) |
3.3 | 23.3 | GO:0019985 | translesion synthesis(GO:0019985) |
3.1 | 31.2 | GO:0032876 | negative regulation of DNA endoreduplication(GO:0032876) |
2.7 | 21.7 | GO:0016446 | somatic hypermutation of immunoglobulin genes(GO:0016446) |
2.7 | 10.7 | GO:0090069 | regulation of ribosome biogenesis(GO:0090069) |
2.5 | 20.2 | GO:1902916 | positive regulation of protein polyubiquitination(GO:1902916) |
2.4 | 14.6 | GO:1902969 | mitotic DNA replication(GO:1902969) |
2.2 | 33.4 | GO:0034501 | protein localization to kinetochore(GO:0034501) |
2.2 | 6.7 | GO:0035604 | orbitofrontal cortex development(GO:0021769) fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow(GO:0035602) fibroblast growth factor receptor signaling pathway involved in hemopoiesis(GO:0035603) fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow(GO:0035604) fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development(GO:0035607) coronal suture morphogenesis(GO:0060365) squamous basal epithelial stem cell differentiation involved in prostate gland acinus development(GO:0060529) |
2.2 | 20.0 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
2.2 | 12.9 | GO:0046602 | regulation of mitotic centrosome separation(GO:0046602) |
2.1 | 12.6 | GO:0097368 | establishment of Sertoli cell barrier(GO:0097368) |
2.0 | 8.1 | GO:0060266 | negative regulation of respiratory burst involved in inflammatory response(GO:0060266) negative regulation of respiratory burst(GO:0060268) |
1.9 | 9.7 | GO:0042148 | strand invasion(GO:0042148) |
1.8 | 5.5 | GO:0003349 | epicardium-derived cardiac endothelial cell differentiation(GO:0003349) |
1.7 | 8.7 | GO:0071947 | protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947) |
1.7 | 8.6 | GO:0036337 | Fas signaling pathway(GO:0036337) |
1.7 | 6.9 | GO:0061010 | gall bladder development(GO:0061010) |
1.7 | 5.1 | GO:0060821 | inactivation of X chromosome by DNA methylation(GO:0060821) |
1.6 | 4.7 | GO:0045819 | positive regulation of glycogen catabolic process(GO:0045819) |
1.5 | 6.2 | GO:1904694 | negative regulation of vascular smooth muscle contraction(GO:1904694) |
1.5 | 5.9 | GO:0006297 | nucleotide-excision repair, DNA gap filling(GO:0006297) |
1.3 | 6.5 | GO:2000348 | regulation of CD40 signaling pathway(GO:2000348) |
1.3 | 5.1 | GO:2001032 | regulation of double-strand break repair via nonhomologous end joining(GO:2001032) |
1.2 | 3.7 | GO:0031627 | telomeric loop formation(GO:0031627) |
1.2 | 4.9 | GO:2000054 | negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054) |
1.2 | 3.5 | GO:0014835 | myoblast differentiation involved in skeletal muscle regeneration(GO:0014835) |
1.2 | 3.5 | GO:0019065 | receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509) |
1.2 | 56.7 | GO:0008156 | negative regulation of DNA replication(GO:0008156) |
1.2 | 3.5 | GO:0048352 | neural plate mediolateral regionalization(GO:0021998) mesoderm structural organization(GO:0048338) paraxial mesoderm structural organization(GO:0048352) lateral mesodermal cell fate commitment(GO:0048372) lateral mesodermal cell fate specification(GO:0048377) regulation of lateral mesodermal cell fate specification(GO:0048378) |
1.1 | 3.4 | GO:0036228 | protein targeting to nuclear inner membrane(GO:0036228) |
1.1 | 5.6 | GO:0003223 | ventricular compact myocardium morphogenesis(GO:0003223) |
1.1 | 15.4 | GO:1904816 | positive regulation of protein localization to chromosome, telomeric region(GO:1904816) |
1.1 | 8.8 | GO:0000212 | meiotic spindle organization(GO:0000212) |
1.1 | 3.2 | GO:0002184 | cytoplasmic translational termination(GO:0002184) |
1.1 | 5.3 | GO:0042518 | negative regulation of tyrosine phosphorylation of Stat3 protein(GO:0042518) |
1.1 | 10.5 | GO:0008063 | Toll signaling pathway(GO:0008063) |
1.0 | 28.3 | GO:0045662 | negative regulation of myoblast differentiation(GO:0045662) |
1.0 | 13.0 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
1.0 | 4.0 | GO:2000346 | negative regulation of hepatocyte proliferation(GO:2000346) |
1.0 | 4.8 | GO:0033567 | DNA replication, Okazaki fragment processing(GO:0033567) |
0.9 | 2.8 | GO:0003278 | apoptotic process involved in heart morphogenesis(GO:0003278) |
0.9 | 9.0 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
0.9 | 39.5 | GO:0043550 | regulation of lipid kinase activity(GO:0043550) |
0.9 | 3.5 | GO:0046125 | pyrimidine deoxyribonucleoside metabolic process(GO:0046125) |
0.8 | 7.6 | GO:0018095 | protein polyglutamylation(GO:0018095) |
0.8 | 5.0 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
0.8 | 8.1 | GO:0010457 | centriole-centriole cohesion(GO:0010457) |
0.8 | 5.5 | GO:0060501 | positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) |
0.8 | 2.3 | GO:1903984 | positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984) |
0.8 | 5.4 | GO:0070561 | vitamin D receptor signaling pathway(GO:0070561) |
0.8 | 6.9 | GO:1901030 | positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901030) |
0.7 | 7.0 | GO:0015884 | positive regulation of platelet activation(GO:0010572) folic acid transport(GO:0015884) |
0.6 | 8.4 | GO:0045647 | negative regulation of erythrocyte differentiation(GO:0045647) |
0.6 | 1.2 | GO:0010825 | positive regulation of centrosome duplication(GO:0010825) positive regulation of centrosome cycle(GO:0046607) |
0.6 | 3.0 | GO:0045605 | response to trichostatin A(GO:0035983) cellular response to trichostatin A(GO:0035984) negative regulation of epidermal cell differentiation(GO:0045605) |
0.6 | 1.1 | GO:0061074 | regulation of neural retina development(GO:0061074) |
0.5 | 1.6 | GO:0061085 | regulation of histone H3-K27 methylation(GO:0061085) positive regulation of histone H3-K27 methylation(GO:0061087) |
0.5 | 3.7 | GO:0001887 | selenium compound metabolic process(GO:0001887) |
0.5 | 1.6 | GO:0018214 | peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214) |
0.5 | 6.4 | GO:0046628 | positive regulation of insulin receptor signaling pathway(GO:0046628) |
0.5 | 1.9 | GO:0072697 | protein localization to cell cortex(GO:0072697) |
0.5 | 8.1 | GO:2000001 | regulation of DNA damage checkpoint(GO:2000001) |
0.5 | 4.3 | GO:0061088 | sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088) |
0.5 | 3.8 | GO:0035562 | negative regulation of chromatin binding(GO:0035562) |
0.4 | 6.4 | GO:0007095 | mitotic G2 DNA damage checkpoint(GO:0007095) |
0.4 | 1.9 | GO:0071557 | histone H3-K27 demethylation(GO:0071557) |
0.4 | 3.5 | GO:0036123 | histone H3-K9 dimethylation(GO:0036123) |
0.4 | 0.8 | GO:0033484 | nitric oxide homeostasis(GO:0033484) |
0.4 | 25.0 | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845) |
0.4 | 7.5 | GO:0034453 | microtubule anchoring(GO:0034453) |
0.4 | 3.3 | GO:0010587 | miRNA catabolic process(GO:0010587) |
0.4 | 1.1 | GO:1901254 | positive regulation of intracellular transport of viral material(GO:1901254) |
0.3 | 1.4 | GO:0043415 | positive regulation of skeletal muscle tissue regeneration(GO:0043415) |
0.3 | 3.8 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
0.3 | 4.4 | GO:0030238 | male sex determination(GO:0030238) Leydig cell differentiation(GO:0033327) |
0.3 | 0.7 | GO:0034184 | positive regulation of maintenance of sister chromatid cohesion(GO:0034093) positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184) |
0.3 | 5.1 | GO:0042407 | cristae formation(GO:0042407) |
0.3 | 2.8 | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway(GO:0048386) |
0.3 | 6.2 | GO:0007131 | reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825) |
0.3 | 0.9 | GO:2000015 | regulation of determination of dorsal identity(GO:2000015) |
0.3 | 2.1 | GO:0042984 | amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984) |
0.3 | 1.2 | GO:0071169 | establishment of protein localization to chromatin(GO:0071169) |
0.3 | 11.2 | GO:0032781 | positive regulation of ATPase activity(GO:0032781) |
0.3 | 1.3 | GO:0060056 | mammary gland involution(GO:0060056) |
0.3 | 15.3 | GO:0000725 | double-strand break repair via homologous recombination(GO:0000724) recombinational repair(GO:0000725) |
0.3 | 2.8 | GO:0080009 | mRNA methylation(GO:0080009) |
0.3 | 0.8 | GO:0006597 | spermine biosynthetic process(GO:0006597) |
0.3 | 2.8 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
0.3 | 0.5 | GO:0023035 | CD40 signaling pathway(GO:0023035) |
0.2 | 6.7 | GO:0040037 | negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037) |
0.2 | 4.9 | GO:0097150 | neuronal stem cell population maintenance(GO:0097150) |
0.2 | 1.7 | GO:1904251 | regulation of bile acid metabolic process(GO:1904251) |
0.2 | 0.9 | GO:0010826 | negative regulation of centrosome duplication(GO:0010826) negative regulation of centrosome cycle(GO:0046606) |
0.2 | 2.8 | GO:0060968 | regulation of gene silencing(GO:0060968) |
0.2 | 1.1 | GO:0006983 | ER overload response(GO:0006983) |
0.2 | 4.4 | GO:0036342 | post-anal tail morphogenesis(GO:0036342) |
0.2 | 1.0 | GO:0046784 | viral mRNA export from host cell nucleus(GO:0046784) |
0.2 | 1.0 | GO:0070535 | histone H2A K63-linked ubiquitination(GO:0070535) |
0.2 | 1.0 | GO:1900452 | regulation of long term synaptic depression(GO:1900452) |
0.2 | 3.0 | GO:0021796 | cerebral cortex regionalization(GO:0021796) |
0.2 | 4.6 | GO:0006284 | base-excision repair(GO:0006284) |
0.2 | 4.8 | GO:0007099 | centriole replication(GO:0007099) |
0.2 | 0.7 | GO:1904008 | cellular response to salt(GO:1902075) response to monosodium glutamate(GO:1904008) cellular response to monosodium glutamate(GO:1904009) |
0.2 | 4.5 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
0.2 | 2.7 | GO:2000772 | regulation of cellular senescence(GO:2000772) |
0.2 | 0.8 | GO:0072488 | nitrogen utilization(GO:0019740) ammonium transmembrane transport(GO:0072488) |
0.2 | 3.8 | GO:0021511 | spinal cord patterning(GO:0021511) |
0.2 | 2.3 | GO:0002021 | response to dietary excess(GO:0002021) |
0.2 | 0.5 | GO:0031990 | mRNA export from nucleus in response to heat stress(GO:0031990) |
0.2 | 2.4 | GO:0043486 | histone exchange(GO:0043486) |
0.1 | 1.8 | GO:0009143 | nucleoside triphosphate catabolic process(GO:0009143) |
0.1 | 0.6 | GO:0006685 | sphingomyelin catabolic process(GO:0006685) |
0.1 | 1.3 | GO:0070574 | cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574) |
0.1 | 0.4 | GO:0071929 | alpha-tubulin acetylation(GO:0071929) |
0.1 | 3.6 | GO:0032094 | response to food(GO:0032094) |
0.1 | 3.8 | GO:0030514 | negative regulation of BMP signaling pathway(GO:0030514) |
0.1 | 1.7 | GO:0007130 | synaptonemal complex assembly(GO:0007130) |
0.1 | 0.7 | GO:0045654 | positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534) |
0.1 | 2.4 | GO:0042753 | positive regulation of circadian rhythm(GO:0042753) |
0.1 | 2.9 | GO:0007340 | acrosome reaction(GO:0007340) |
0.1 | 3.5 | GO:0030488 | tRNA methylation(GO:0030488) |
0.1 | 2.8 | GO:0046580 | negative regulation of Ras protein signal transduction(GO:0046580) |
0.1 | 4.5 | GO:0007569 | cell aging(GO:0007569) |
0.1 | 1.4 | GO:0048026 | positive regulation of mRNA splicing, via spliceosome(GO:0048026) |
0.1 | 1.6 | GO:0040034 | regulation of development, heterochronic(GO:0040034) |
0.1 | 0.8 | GO:0007020 | microtubule nucleation(GO:0007020) |
0.1 | 14.2 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
0.1 | 1.3 | GO:0001731 | formation of translation preinitiation complex(GO:0001731) |
0.1 | 12.2 | GO:0048511 | rhythmic process(GO:0048511) |
0.1 | 5.4 | GO:0043966 | histone H3 acetylation(GO:0043966) |
0.1 | 1.1 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
0.1 | 0.2 | GO:0033092 | positive regulation of immature T cell proliferation in thymus(GO:0033092) |
0.1 | 2.4 | GO:0048477 | oogenesis(GO:0048477) |
0.1 | 6.1 | GO:0007548 | sex differentiation(GO:0007548) |
0.1 | 0.5 | GO:0007197 | gastric acid secretion(GO:0001696) adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207) |
0.1 | 1.1 | GO:0000291 | nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291) |
0.1 | 0.3 | GO:0030242 | pexophagy(GO:0030242) |
0.1 | 1.1 | GO:0016926 | protein desumoylation(GO:0016926) |
0.1 | 0.5 | GO:1990118 | sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
0.1 | 2.0 | GO:0001921 | positive regulation of receptor recycling(GO:0001921) |
0.1 | 0.4 | GO:0009249 | protein lipoylation(GO:0009249) |
0.1 | 11.8 | GO:0018108 | peptidyl-tyrosine phosphorylation(GO:0018108) |
0.1 | 2.0 | GO:0060135 | maternal process involved in female pregnancy(GO:0060135) |
0.1 | 4.0 | GO:0001885 | endothelial cell development(GO:0001885) |
0.1 | 4.4 | GO:0051225 | spindle assembly(GO:0051225) |
0.1 | 1.6 | GO:0033962 | cytoplasmic mRNA processing body assembly(GO:0033962) |
0.1 | 7.9 | GO:0006260 | DNA replication(GO:0006260) |
0.1 | 2.5 | GO:0097194 | execution phase of apoptosis(GO:0097194) |
0.1 | 4.5 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
0.0 | 1.8 | GO:0008333 | endosome to lysosome transport(GO:0008333) |
0.0 | 0.8 | GO:0043968 | histone H2A acetylation(GO:0043968) |
0.0 | 1.8 | GO:0043666 | regulation of phosphoprotein phosphatase activity(GO:0043666) |
0.0 | 0.6 | GO:0060628 | regulation of ER to Golgi vesicle-mediated transport(GO:0060628) |
0.0 | 33.9 | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter(GO:0045944) |
0.0 | 0.2 | GO:0009048 | dosage compensation(GO:0007549) dosage compensation by inactivation of X chromosome(GO:0009048) |
0.0 | 1.7 | GO:0009952 | anterior/posterior pattern specification(GO:0009952) |
0.0 | 0.3 | GO:0070373 | negative regulation of ERK1 and ERK2 cascade(GO:0070373) |
0.0 | 1.5 | GO:0051090 | regulation of sequence-specific DNA binding transcription factor activity(GO:0051090) |
0.0 | 0.3 | GO:0006103 | 2-oxoglutarate metabolic process(GO:0006103) |
0.0 | 3.3 | GO:0006468 | protein phosphorylation(GO:0006468) |
0.0 | 3.2 | GO:0006915 | apoptotic process(GO:0006915) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
9.3 | 46.6 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
8.7 | 26.2 | GO:0005658 | alpha DNA polymerase:primase complex(GO:0005658) |
7.9 | 118.1 | GO:0042555 | MCM complex(GO:0042555) |
7.1 | 7.1 | GO:0031298 | replication fork protection complex(GO:0031298) |
5.3 | 26.4 | GO:0008622 | epsilon DNA polymerase complex(GO:0008622) |
3.1 | 15.7 | GO:0035189 | Rb-E2F complex(GO:0035189) |
2.8 | 28.3 | GO:0000800 | lateral element(GO:0000800) |
2.8 | 8.4 | GO:0036387 | nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387) |
2.7 | 8.2 | GO:0035061 | interchromatin granule(GO:0035061) |
2.6 | 15.6 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
2.6 | 7.8 | GO:0043625 | delta DNA polymerase complex(GO:0043625) |
2.3 | 18.6 | GO:0031390 | Ctf18 RFC-like complex(GO:0031390) |
2.1 | 10.7 | GO:0001651 | dense fibrillar component(GO:0001651) |
1.8 | 5.5 | GO:0000811 | GINS complex(GO:0000811) DNA replication preinitiation complex(GO:0031261) |
1.7 | 5.2 | GO:0070557 | PCNA-p21 complex(GO:0070557) |
1.6 | 15.8 | GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex(GO:0031464) |
1.5 | 12.2 | GO:0001673 | male germ cell nucleus(GO:0001673) |
1.4 | 71.0 | GO:0005657 | replication fork(GO:0005657) |
1.2 | 8.4 | GO:0032300 | mismatch repair complex(GO:0032300) |
1.2 | 7.1 | GO:0070776 | H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776) |
1.2 | 3.5 | GO:0043527 | tRNA methyltransferase complex(GO:0043527) |
1.1 | 3.2 | GO:0018444 | translation release factor complex(GO:0018444) |
0.9 | 1.7 | GO:0000801 | central element(GO:0000801) |
0.7 | 5.1 | GO:0001740 | Barr body(GO:0001740) |
0.7 | 10.5 | GO:0035631 | CD40 receptor complex(GO:0035631) |
0.7 | 3.5 | GO:0033553 | rDNA heterochromatin(GO:0033553) |
0.7 | 3.4 | GO:0044611 | nuclear pore inner ring(GO:0044611) |
0.7 | 5.4 | GO:0016580 | Sin3 complex(GO:0016580) |
0.6 | 8.3 | GO:0043240 | Fanconi anaemia nuclear complex(GO:0043240) |
0.6 | 3.8 | GO:0000444 | MIS12/MIND type complex(GO:0000444) |
0.6 | 3.7 | GO:0070187 | telosome(GO:0070187) |
0.6 | 5.1 | GO:0061617 | MICOS complex(GO:0061617) |
0.6 | 4.4 | GO:0070652 | HAUS complex(GO:0070652) |
0.6 | 11.0 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
0.5 | 3.5 | GO:0070695 | FHF complex(GO:0070695) |
0.5 | 5.2 | GO:1904115 | axon cytoplasm(GO:1904115) |
0.5 | 29.3 | GO:0005871 | kinesin complex(GO:0005871) |
0.4 | 45.1 | GO:0005814 | centriole(GO:0005814) |
0.4 | 29.3 | GO:0072686 | mitotic spindle(GO:0072686) |
0.4 | 2.8 | GO:0036396 | MIS complex(GO:0036396) mRNA editing complex(GO:0045293) |
0.4 | 1.5 | GO:0001652 | granular component(GO:0001652) |
0.4 | 1.1 | GO:0005785 | signal recognition particle receptor complex(GO:0005785) |
0.4 | 1.1 | GO:0031251 | PAN complex(GO:0031251) |
0.4 | 1.1 | GO:0042025 | viral replication complex(GO:0019034) host cell nucleus(GO:0042025) host cell nuclear part(GO:0044094) |
0.3 | 1.3 | GO:0016012 | sarcoglycan complex(GO:0016012) |
0.3 | 134.3 | GO:0005667 | transcription factor complex(GO:0005667) |
0.3 | 2.2 | GO:0030677 | nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681) |
0.3 | 20.2 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
0.3 | 3.5 | GO:0030122 | AP-2 adaptor complex(GO:0030122) |
0.3 | 1.4 | GO:0005683 | U7 snRNP(GO:0005683) |
0.3 | 6.4 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
0.3 | 1.3 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
0.2 | 41.2 | GO:0000775 | chromosome, centromeric region(GO:0000775) |
0.2 | 1.4 | GO:0044530 | supraspliceosomal complex(GO:0044530) |
0.2 | 15.7 | GO:0016605 | PML body(GO:0016605) |
0.2 | 2.8 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
0.2 | 0.6 | GO:0090543 | Flemming body(GO:0090543) |
0.2 | 0.8 | GO:0032777 | Piccolo NuA4 histone acetyltransferase complex(GO:0032777) |
0.2 | 4.5 | GO:0002102 | podosome(GO:0002102) |
0.2 | 5.5 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
0.2 | 2.8 | GO:0097470 | ribbon synapse(GO:0097470) |
0.2 | 10.0 | GO:0000793 | condensed chromosome(GO:0000793) |
0.2 | 1.9 | GO:0044666 | MLL3/4 complex(GO:0044666) |
0.2 | 8.7 | GO:0000922 | spindle pole(GO:0000922) |
0.1 | 1.7 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
0.1 | 8.5 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
0.1 | 3.6 | GO:0016363 | nuclear matrix(GO:0016363) |
0.1 | 1.7 | GO:0035861 | site of double-strand break(GO:0035861) |
0.1 | 1.0 | GO:0000347 | THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) |
0.1 | 1.1 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
0.1 | 0.7 | GO:0005638 | lamin filament(GO:0005638) |
0.1 | 4.5 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
0.1 | 175.1 | GO:0005654 | nucleoplasm(GO:0005654) |
0.1 | 2.0 | GO:0030665 | clathrin-coated vesicle membrane(GO:0030665) |
0.1 | 1.8 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
0.1 | 0.9 | GO:0036038 | MKS complex(GO:0036038) |
0.1 | 1.2 | GO:0034451 | centriolar satellite(GO:0034451) |
0.1 | 3.5 | GO:0005901 | caveola(GO:0005901) |
0.1 | 1.7 | GO:0005637 | nuclear inner membrane(GO:0005637) |
0.1 | 7.0 | GO:0030027 | lamellipodium(GO:0030027) |
0.1 | 31.1 | GO:0005730 | nucleolus(GO:0005730) |
0.1 | 1.0 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
0.0 | 2.9 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
0.0 | 11.1 | GO:0000139 | Golgi membrane(GO:0000139) |
0.0 | 0.2 | GO:0016342 | catenin complex(GO:0016342) |
0.0 | 173.5 | GO:0005634 | nucleus(GO:0005634) |
0.0 | 0.3 | GO:0030008 | TRAPP complex(GO:0030008) |
0.0 | 0.6 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
0.0 | 4.2 | GO:0005925 | focal adhesion(GO:0005925) |
0.0 | 0.2 | GO:0044232 | organelle membrane contact site(GO:0044232) |
0.0 | 0.5 | GO:0001669 | acrosomal vesicle(GO:0001669) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
15.6 | 46.9 | GO:0044729 | hemi-methylated DNA-binding(GO:0044729) |
10.2 | 61.3 | GO:0010997 | anaphase-promoting complex binding(GO:0010997) |
9.3 | 46.6 | GO:0061731 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
7.0 | 21.0 | GO:0051870 | methotrexate binding(GO:0051870) |
6.8 | 54.5 | GO:0003688 | DNA replication origin binding(GO:0003688) |
4.6 | 18.3 | GO:0034481 | chondroitin sulfotransferase activity(GO:0034481) |
4.4 | 30.5 | GO:0000150 | recombinase activity(GO:0000150) |
3.8 | 15.0 | GO:0048256 | flap endonuclease activity(GO:0048256) |
3.6 | 14.5 | GO:0008821 | crossover junction endodeoxyribonuclease activity(GO:0008821) |
3.5 | 24.6 | GO:0003896 | DNA primase activity(GO:0003896) |
3.0 | 3.0 | GO:0032137 | guanine/thymine mispair binding(GO:0032137) |
3.0 | 12.0 | GO:0036033 | mediator complex binding(GO:0036033) |
3.0 | 53.6 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
2.7 | 13.5 | GO:0032135 | DNA insertion or deletion binding(GO:0032135) |
2.6 | 7.8 | GO:0035402 | histone kinase activity (H3-T11 specific)(GO:0035402) |
2.1 | 8.5 | GO:0071987 | WD40-repeat domain binding(GO:0071987) |
1.8 | 10.7 | GO:0042134 | rRNA primary transcript binding(GO:0042134) |
1.7 | 8.7 | GO:1990380 | Lys48-specific deubiquitinase activity(GO:1990380) |
1.7 | 18.6 | GO:0003689 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
1.7 | 45.1 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
1.6 | 4.7 | GO:0000402 | open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402) |
1.4 | 22.0 | GO:0004844 | uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506) |
1.4 | 6.8 | GO:0004430 | 1-phosphatidylinositol 4-kinase activity(GO:0004430) |
1.3 | 15.9 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
1.3 | 20.1 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
1.2 | 14.9 | GO:0031996 | thioesterase binding(GO:0031996) |
1.2 | 7.5 | GO:0003910 | DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910) |
1.2 | 8.6 | GO:0032184 | SUMO polymer binding(GO:0032184) |
1.1 | 4.4 | GO:0045131 | pre-mRNA branch point binding(GO:0045131) |
1.1 | 5.5 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
1.1 | 12.9 | GO:0070182 | DNA polymerase binding(GO:0070182) |
1.1 | 67.1 | GO:0003678 | DNA helicase activity(GO:0003678) |
0.9 | 3.5 | GO:0019136 | deoxynucleoside kinase activity(GO:0019136) |
0.8 | 7.0 | GO:0008517 | folic acid transporter activity(GO:0008517) |
0.7 | 6.7 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
0.7 | 3.3 | GO:0050265 | RNA uridylyltransferase activity(GO:0050265) |
0.6 | 3.7 | GO:0003691 | double-stranded telomeric DNA binding(GO:0003691) |
0.6 | 107.6 | GO:0001047 | core promoter binding(GO:0001047) |
0.6 | 3.5 | GO:0051525 | NFAT protein binding(GO:0051525) |
0.6 | 3.5 | GO:0046974 | histone methyltransferase activity (H3-K9 specific)(GO:0046974) |
0.6 | 3.5 | GO:0098821 | BMP receptor activity(GO:0098821) |
0.6 | 1.7 | GO:0050510 | N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510) |
0.5 | 43.1 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
0.5 | 1.9 | GO:0071558 | histone demethylase activity (H3-K27 specific)(GO:0071558) |
0.5 | 1.4 | GO:0071208 | histone pre-mRNA DCP binding(GO:0071208) |
0.5 | 3.7 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
0.5 | 3.6 | GO:0001618 | virus receptor activity(GO:0001618) |
0.4 | 29.3 | GO:0003777 | microtubule motor activity(GO:0003777) |
0.4 | 5.4 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
0.4 | 2.7 | GO:0002151 | G-quadruplex RNA binding(GO:0002151) |
0.4 | 8.3 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
0.4 | 3.2 | GO:0003747 | translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079) |
0.3 | 1.7 | GO:0004594 | pantothenate kinase activity(GO:0004594) |
0.3 | 0.3 | GO:0016751 | S-succinyltransferase activity(GO:0016751) |
0.3 | 13.5 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
0.3 | 5.1 | GO:0070411 | I-SMAD binding(GO:0070411) |
0.3 | 10.9 | GO:0051059 | NF-kappaB binding(GO:0051059) |
0.3 | 18.2 | GO:0035064 | methylated histone binding(GO:0035064) |
0.3 | 6.9 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |
0.3 | 8.4 | GO:0070888 | E-box binding(GO:0070888) |
0.3 | 1.8 | GO:0047429 | nucleoside-triphosphate diphosphatase activity(GO:0047429) |
0.3 | 4.3 | GO:0008599 | protein phosphatase type 1 regulator activity(GO:0008599) |
0.2 | 30.7 | GO:0042393 | histone binding(GO:0042393) |
0.2 | 3.6 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
0.2 | 1.3 | GO:0071074 | eukaryotic initiation factor eIF2 binding(GO:0071074) |
0.2 | 1.1 | GO:0005047 | signal recognition particle binding(GO:0005047) |
0.2 | 9.9 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
0.2 | 5.6 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
0.2 | 67.1 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
0.2 | 2.2 | GO:0004526 | ribonuclease P activity(GO:0004526) |
0.2 | 37.6 | GO:0043565 | sequence-specific DNA binding(GO:0043565) |
0.2 | 4.0 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
0.2 | 2.8 | GO:0042974 | retinoic acid receptor binding(GO:0042974) |
0.2 | 18.3 | GO:0004386 | helicase activity(GO:0004386) |
0.2 | 2.3 | GO:0031386 | protein tag(GO:0031386) |
0.2 | 49.3 | GO:0005096 | GTPase activator activity(GO:0005096) |
0.2 | 14.2 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
0.2 | 15.0 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
0.2 | 0.5 | GO:0016934 | extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934) |
0.1 | 3.3 | GO:0036002 | pre-mRNA binding(GO:0036002) |
0.1 | 0.4 | GO:0010484 | H3 histone acetyltransferase activity(GO:0010484) |
0.1 | 8.2 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
0.1 | 22.5 | GO:0003682 | chromatin binding(GO:0003682) |
0.1 | 1.6 | GO:0016929 | SUMO-specific protease activity(GO:0016929) |
0.1 | 8.2 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
0.1 | 1.3 | GO:0043747 | protein-N-terminal asparagine amidohydrolase activity(GO:0008418) UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity(GO:0008759) iprodione amidohydrolase activity(GO:0018748) (3,5-dichlorophenylurea)acetate amidohydrolase activity(GO:0018749) 4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity(GO:0034571) didemethylisoproturon amidohydrolase activity(GO:0034573) N-isopropylacetanilide amidohydrolase activity(GO:0034576) N-cyclohexylformamide amidohydrolase activity(GO:0034781) isonicotinic acid hydrazide hydrolase activity(GO:0034876) cis-aconitamide amidase activity(GO:0034882) gamma-N-formylaminovinylacetate hydrolase activity(GO:0034885) N2-acetyl-L-lysine deacetylase activity(GO:0043747) O-succinylbenzoate synthase activity(GO:0043748) indoleacetamide hydrolase activity(GO:0043864) N-acetylcitrulline deacetylase activity(GO:0043909) N-acetylgalactosamine-6-phosphate deacetylase activity(GO:0047419) diacetylchitobiose deacetylase activity(GO:0052773) chitooligosaccharide deacetylase activity(GO:0052790) |
0.1 | 1.6 | GO:0048038 | quinone binding(GO:0048038) |
0.1 | 2.3 | GO:0016864 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
0.1 | 4.0 | GO:0031593 | polyubiquitin binding(GO:0031593) |
0.1 | 35.1 | GO:0044212 | transcription regulatory region DNA binding(GO:0044212) |
0.1 | 3.8 | GO:0005160 | transforming growth factor beta receptor binding(GO:0005160) |
0.1 | 1.9 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
0.1 | 4.5 | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity(GO:0003755) |
0.1 | 2.0 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
0.1 | 3.1 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
0.1 | 17.6 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
0.1 | 0.6 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
0.1 | 0.5 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
0.1 | 9.7 | GO:0070739 | protein-glutamic acid ligase activity(GO:0070739) |
0.1 | 0.9 | GO:0031005 | filamin binding(GO:0031005) |
0.1 | 0.5 | GO:0005451 | monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386) |
0.1 | 1.1 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
0.1 | 2.8 | GO:0050840 | extracellular matrix binding(GO:0050840) |
0.1 | 2.1 | GO:0004772 | sterol O-acyltransferase activity(GO:0004772) |
0.1 | 5.6 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
0.1 | 1.1 | GO:0005112 | Notch binding(GO:0005112) |
0.0 | 0.2 | GO:0031730 | CCR5 chemokine receptor binding(GO:0031730) |
0.0 | 1.3 | GO:0030332 | cyclin binding(GO:0030332) |
0.0 | 0.8 | GO:0008519 | ammonium transmembrane transporter activity(GO:0008519) |
0.0 | 0.7 | GO:0008432 | JUN kinase binding(GO:0008432) |
0.0 | 6.2 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
0.0 | 1.5 | GO:0002039 | p53 binding(GO:0002039) |
0.0 | 1.1 | GO:0045182 | translation regulator activity(GO:0045182) |
0.0 | 6.5 | GO:0031625 | ubiquitin protein ligase binding(GO:0031625) |
0.0 | 0.2 | GO:0045294 | alpha-catenin binding(GO:0045294) |
0.0 | 0.9 | GO:0008536 | Ran GTPase binding(GO:0008536) |
0.0 | 1.1 | GO:0043851 | rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) tRNA (guanine-N2-)-methyltransferase activity(GO:0004809) rRNA methyltransferase activity(GO:0008649) rRNA (uridine-2'-O-)-methyltransferase activity(GO:0008650) rRNA (adenine-N6-)-methyltransferase activity(GO:0008988) DNA-methyltransferase activity(GO:0009008) rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383) selenocysteine methyltransferase activity(GO:0016205) tRNA (cytosine) methyltransferase activity(GO:0016427) tRNA (cytosine-5-)-methyltransferase activity(GO:0016428) rRNA (adenine) methyltransferase activity(GO:0016433) rRNA (cytosine) methyltransferase activity(GO:0016434) rRNA (guanine) methyltransferase activity(GO:0016435) rRNA (uridine) methyltransferase activity(GO:0016436) 1-phenanthrol methyltransferase activity(GO:0018707) protein-arginine N5-methyltransferase activity(GO:0019702) dimethylarsinite methyltransferase activity(GO:0034541) 4,5-dihydroxybenzo(a)pyrene methyltransferase activity(GO:0034807) 1-hydroxypyrene methyltransferase activity(GO:0034931) 1-hydroxy-6-methoxypyrene methyltransferase activity(GO:0034933) demethylmenaquinone methyltransferase activity(GO:0043770) cobalt-precorrin-6B C5-methyltransferase activity(GO:0043776) cobalt-precorrin-7 C15-methyltransferase activity(GO:0043777) cobalt-precorrin-5B C1-methyltransferase activity(GO:0043780) cobalt-precorrin-3 C17-methyltransferase activity(GO:0043782) dimethylamine methyltransferase activity(GO:0043791) hydroxyneurosporene-O-methyltransferase activity(GO:0043803) tRNA (adenine-57, 58-N(1)-) methyltransferase activity(GO:0043827) methylamine-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043833) trimethylamine methyltransferase activity(GO:0043834) methanol-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043851) monomethylamine methyltransferase activity(GO:0043852) P-methyltransferase activity(GO:0051994) Se-methyltransferase activity(GO:0051995) 2-phytyl-1,4-naphthoquinone methyltransferase activity(GO:0052624) tRNA (uracil-2'-O-)-methyltransferase activity(GO:0052665) tRNA (cytosine-2'-O-)-methyltransferase activity(GO:0052666) phosphomethylethanolamine N-methyltransferase activity(GO:0052667) tRNA (cytosine-3-)-methyltransferase activity(GO:0052735) rRNA (cytosine-2'-O-)-methyltransferase activity(GO:0070677) rRNA (cytosine-N4-)-methyltransferase activity(GO:0071424) trihydroxyferuloyl spermidine O-methyltransferase activity(GO:0080012) |
0.0 | 6.7 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
0.0 | 1.9 | GO:0030674 | protein binding, bridging(GO:0030674) |
0.0 | 0.9 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
0.0 | 0.8 | GO:0016765 | transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765) |