Motif ID: E2f2_E2f5

Z-value: 5.393

Transcription factors associated with E2f2_E2f5:

Gene SymbolEntrez IDGene Name
E2f2 ENSMUSG00000018983.9 E2f2
E2f5 ENSMUSG00000027552.8 E2f5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f2mm10_v2_chr4_+_136172367_1361723950.972.9e-16Click!
E2f5mm10_v2_chr3_+_14578609_145786870.883.0e-09Click!


Activity profile for motif E2f2_E2f5.

activity profile for motif E2f2_E2f5


Sorted Z-values histogram for motif E2f2_E2f5

Sorted Z-values for motif E2f2_E2f5



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f2_E2f5

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_139543889 42.940 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr2_-_157204483 40.938 ENSMUST00000029170.7
 Rbl1
retinoblastoma-like 1 (p107)
chr4_+_136172367 38.521 ENSMUST00000061721.5
 E2f2
E2F transcription factor 2
chr7_-_137314394 37.167 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3



chr4_+_126556935 33.046 ENSMUST00000048391.8
 Clspn
claspin
chr15_-_58135047 29.782 ENSMUST00000038194.3
 Atad2
ATPase family, AAA domain containing 2
chr4_+_126556994 28.288 ENSMUST00000147675.1
 Clspn
claspin
chr13_-_24761861 28.027 ENSMUST00000006898.3
ENSMUST00000110382.2
 Gmnn

geminin

chr12_+_24708241 27.475 ENSMUST00000020980.5
 Rrm2
ribonucleotide reductase M2
chr17_+_56304313 27.255 ENSMUST00000113035.1
ENSMUST00000113039.2
ENSMUST00000142387.1
 Uhrf1


ubiquitin-like, containing PHD and RING finger domains, 1


chr9_+_122951051 26.715 ENSMUST00000040717.5
 Kif15
kinesin family member 15
chr10_+_110745433 26.234 ENSMUST00000174857.1
ENSMUST00000073781.5
ENSMUST00000173471.1
ENSMUST00000173634.1
 E2f7



E2F transcription factor 7



chr13_-_24761440 26.180 ENSMUST00000176890.1
ENSMUST00000175689.1
 Gmnn

geminin

chr6_+_4747306 25.387 ENSMUST00000175823.1
ENSMUST00000176204.1
ENSMUST00000166678.1
 Peg10


paternally expressed 10


chr2_-_113848655 24.682 ENSMUST00000102545.1
ENSMUST00000110948.1
 Arhgap11a

Rho GTPase activating protein 11A

chr2_-_113848601 22.737 ENSMUST00000110949.2
 Arhgap11a
Rho GTPase activating protein 11A
chr8_+_75109528 22.466 ENSMUST00000164309.1
 Mcm5
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chr10_-_5805412 21.427 ENSMUST00000019907.7
 Fbxo5
F-box protein 5
chr1_-_20820213 21.343 ENSMUST00000053266.9
 Mcm3
minichromosome maintenance deficient 3 (S. cerevisiae)
chrX_-_93632113 21.140 ENSMUST00000006856.2
 Pola1
polymerase (DNA directed), alpha 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 182 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.3 102.5 GO:0006270 DNA replication initiation(GO:0006270)
6.0 77.5 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
7.7 61.3 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
1.2 56.7 GO:0008156 negative regulation of DNA replication(GO:0008156)
4.0 56.6 GO:0090308 regulation of methylation-dependent chromatin silencing(GO:0090308)
7.7 54.2 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
18.0 54.1 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
5.4 42.9 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
4.2 41.6 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.9 39.5 GO:0043550 regulation of lipid kinase activity(GO:0043550)
4.6 36.8 GO:0033504 floor plate development(GO:0033504)
0.0 33.9 GO:0045944 positive regulation of transcription from RNA polymerase II promoter(GO:0045944)
2.2 33.4 GO:0034501 protein localization to kinetochore(GO:0034501)
3.1 31.2 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
5.0 29.8 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
1.0 28.3 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.4 25.0 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
4.1 24.6 GO:0006287 base-excision repair, gap-filling(GO:0006287)
3.3 23.3 GO:0019985 translesion synthesis(GO:0019985)
2.7 21.7 GO:0016446 somatic hypermutation of immunoglobulin genes(GO:0016446)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 91 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 175.1 GO:0005654 nucleoplasm(GO:0005654)
0.0 173.5 GO:0005634 nucleus(GO:0005634)
0.3 134.3 GO:0005667 transcription factor complex(GO:0005667)
7.9 118.1 GO:0042555 MCM complex(GO:0042555)
1.4 71.0 GO:0005657 replication fork(GO:0005657)
9.3 46.6 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.4 45.1 GO:0005814 centriole(GO:0005814)
0.2 41.2 GO:0000775 chromosome, centromeric region(GO:0000775)
0.1 31.1 GO:0005730 nucleolus(GO:0005730)
0.5 29.3 GO:0005871 kinesin complex(GO:0005871)
0.4 29.3 GO:0072686 mitotic spindle(GO:0072686)
2.8 28.3 GO:0000800 lateral element(GO:0000800)
5.3 26.4 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
8.7 26.2 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.3 20.2 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
2.3 18.6 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
1.6 15.8 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
3.1 15.7 GO:0035189 Rb-E2F complex(GO:0035189)
0.2 15.7 GO:0016605 PML body(GO:0016605)
2.6 15.6 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 121 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 107.6 GO:0001047 core promoter binding(GO:0001047)
1.1 67.1 GO:0003678 DNA helicase activity(GO:0003678)
0.2 67.1 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
10.2 61.3 GO:0010997 anaphase-promoting complex binding(GO:0010997)
6.8 54.5 GO:0003688 DNA replication origin binding(GO:0003688)
3.0 53.6 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.2 49.3 GO:0005096 GTPase activator activity(GO:0005096)
15.6 46.9 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
9.3 46.6 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
1.7 45.1 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.5 43.1 GO:0070491 repressing transcription factor binding(GO:0070491)
0.2 37.6 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.1 35.1 GO:0044212 transcription regulatory region DNA binding(GO:0044212)
0.2 30.7 GO:0042393 histone binding(GO:0042393)
4.4 30.5 GO:0000150 recombinase activity(GO:0000150)
0.4 29.3 GO:0003777 microtubule motor activity(GO:0003777)
3.5 24.6 GO:0003896 DNA primase activity(GO:0003896)
0.1 22.5 GO:0003682 chromatin binding(GO:0003682)
1.4 22.0 GO:0004844 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
7.0 21.0 GO:0051870 methotrexate binding(GO:0051870)