Motif ID: E2f3

Z-value: 1.782


Transcription factors associated with E2f3:

Gene SymbolEntrez IDGene Name
E2f3 ENSMUSG00000016477.11 E2f3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f3mm10_v2_chr13_-_29984219_299843530.791.7e-06Click!


Activity profile for motif E2f3.

activity profile for motif E2f3


Sorted Z-values histogram for motif E2f3

Sorted Z-values for motif E2f3



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_46450892 13.001 ENSMUST00000102926.4
 Anp32b
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr7_-_137314394 9.461 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3



chrX_-_51205773 5.947 ENSMUST00000114875.1
 Mbnl3
muscleblind-like 3 (Drosophila)
chr12_-_69228167 5.483 ENSMUST00000021359.5
 Pole2
polymerase (DNA directed), epsilon 2 (p59 subunit)
chr7_+_13278778 5.449 ENSMUST00000098814.4
ENSMUST00000146998.1
ENSMUST00000185145.1
 Lig1


ligase I, DNA, ATP-dependent


chr18_+_11657349 5.332 ENSMUST00000047322.6
 Rbbp8
retinoblastoma binding protein 8
chr11_-_101551837 5.158 ENSMUST00000017290.4
 Brca1
breast cancer 1
chr2_-_127133909 5.013 ENSMUST00000110387.3
 Ncaph
non-SMC condensin I complex, subunit H
chr2_+_109280738 4.840 ENSMUST00000028527.7
 Kif18a
kinesin family member 18A
chr3_+_59006978 4.814 ENSMUST00000040325.7
ENSMUST00000164225.1
ENSMUST00000040846.8
ENSMUST00000029393.8
 Med12l



mediator of RNA polymerase II transcription, subunit 12 homolog (yeast)-like



chr19_+_41482632 4.757 ENSMUST00000067795.5
 Lcor
ligand dependent nuclear receptor corepressor
chr12_+_24708241 4.630 ENSMUST00000020980.5
 Rrm2
ribonucleotide reductase M2
chr10_+_20347788 4.281 ENSMUST00000169712.1
 Mtfr2
mitochondrial fission regulator 2
chr3_+_69004969 4.212 ENSMUST00000136502.1
ENSMUST00000107803.1
 Smc4

structural maintenance of chromosomes 4

chr5_+_114568016 4.090 ENSMUST00000043650.7
 Fam222a
family with sequence similarity 222, member A
chr3_+_41742615 4.086 ENSMUST00000146165.1
ENSMUST00000119572.1
ENSMUST00000108065.2
ENSMUST00000120167.1
ENSMUST00000026867.7
ENSMUST00000026868.7
 D3Ertd751e





DNA segment, Chr 3, ERATO Doi 751, expressed





chr13_+_117220584 4.082 ENSMUST00000022242.7
 Emb
embigin
chr16_-_78376758 4.030 ENSMUST00000023570.7
 Btg3
B cell translocation gene 3
chr15_+_102296256 3.786 ENSMUST00000064924.4
 Espl1
extra spindle poles-like 1 (S. cerevisiae)
chr9_+_64281575 3.776 ENSMUST00000034964.6
 Tipin
timeless interacting protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 126 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 14.8 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.3 9.4 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
1.6 8.0 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.7 5.9 GO:0033504 floor plate development(GO:0033504)
0.4 5.7 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
1.4 5.6 GO:0035624 mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025) receptor transactivation(GO:0035624) epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway(GO:0035625) response to high density lipoprotein particle(GO:0055099)
1.4 5.5 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.8 5.4 GO:0033567 DNA replication, Okazaki fragment processing(GO:0033567)
1.1 5.3 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.2 5.3 GO:0046677 response to antibiotic(GO:0046677)
1.7 5.2 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.6 5.0 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.4 4.8 GO:0072520 seminiferous tubule development(GO:0072520)
0.5 4.6 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.6 4.5 GO:0031053 primary miRNA processing(GO:0031053)
0.1 4.3 GO:0000266 mitochondrial fission(GO:0000266)
0.2 4.1 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.2 4.0 GO:0090161 Golgi ribbon formation(GO:0090161)
0.4 3.9 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.0 3.9 GO:0045930 negative regulation of mitotic cell cycle(GO:0045930)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 74 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 13.0 GO:0000796 condensin complex(GO:0000796)
0.1 7.5 GO:0016607 nuclear speck(GO:0016607)
0.0 7.3 GO:0000785 chromatin(GO:0000785)
0.1 6.5 GO:0005814 centriole(GO:0005814)
0.2 6.2 GO:0016592 mediator complex(GO:0016592)
1.1 5.5 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.1 5.3 GO:0017053 transcriptional repressor complex(GO:0017053)
0.5 5.2 GO:0070531 BRCA1-A complex(GO:0070531)
0.1 5.0 GO:0032587 ruffle membrane(GO:0032587)
0.7 4.8 GO:0005828 kinetochore microtubule(GO:0005828)
0.9 4.6 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.4 4.5 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.2 4.0 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 3.8 GO:0072686 mitotic spindle(GO:0072686)
0.0 3.1 GO:0016605 PML body(GO:0016605)
0.4 3.0 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 3.0 GO:0005694 chromosome(GO:0005694)
0.3 2.9 GO:0071439 clathrin complex(GO:0071439)
0.2 2.9 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 2.9 GO:0016580 Sin3 complex(GO:0016580)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 91 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 12.9 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 7.2 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.0 6.9 GO:0046982 protein heterodimerization activity(GO:0046982)
0.1 6.6 GO:0003684 damaged DNA binding(GO:0003684)
0.7 5.6 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.7 5.5 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.2 5.5 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.9 5.4 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.3 4.8 GO:0051010 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) microtubule plus-end binding(GO:0051010)
0.9 4.6 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.1 4.6 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.9 4.5 GO:0001069 regulatory region RNA binding(GO:0001069)
0.0 4.1 GO:0008134 transcription factor binding(GO:0008134)
0.2 3.8 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.2 3.7 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.2 3.7 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 3.4 GO:0008022 protein C-terminus binding(GO:0008022)
0.1 3.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 3.2 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.2 2.9 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)