Motif ID: E2f4

Z-value: 3.165


Transcription factors associated with E2f4:

Gene SymbolEntrez IDGene Name
E2f4 ENSMUSG00000014859.8 E2f4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f4mm10_v2_chr8_+_105297663_1052977420.883.7e-09Click!


Activity profile for motif E2f4.

activity profile for motif E2f4


Sorted Z-values histogram for motif E2f4

Sorted Z-values for motif E2f4



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f4

PNG image of the network

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Top targets:


Showing 1 to 20 of 185 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_134510999 16.436 ENSMUST00000105866.2
 Aunip
aurora kinase A and ninein interacting protein
chr4_-_132345686 15.671 ENSMUST00000030726.6
 Rcc1
regulator of chromosome condensation 1
chr4_-_132345715 15.437 ENSMUST00000084250.4
 Rcc1
regulator of chromosome condensation 1
chr19_+_6084983 15.259 ENSMUST00000025704.2
 Cdca5
cell division cycle associated 5
chr9_+_72438534 13.620 ENSMUST00000034746.8
 Mns1
meiosis-specific nuclear structural protein 1
chr14_-_47418407 13.416 ENSMUST00000043296.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr9_+_72438519 13.227 ENSMUST00000184604.1
 Mns1
meiosis-specific nuclear structural protein 1
chr1_-_169531343 12.537 ENSMUST00000028000.7
 Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr12_+_117843873 12.415 ENSMUST00000176735.1
ENSMUST00000177339.1
 Cdca7l

cell division cycle associated 7 like

chr1_-_189688074 12.314 ENSMUST00000171929.1
ENSMUST00000165962.1
 Cenpf

centromere protein F

chr4_-_116123618 11.810 ENSMUST00000102704.3
ENSMUST00000102705.3
 Rad54l

RAD54 like (S. cerevisiae)

chr11_-_101551837 11.566 ENSMUST00000017290.4
 Brca1
breast cancer 1
chr18_-_34751502 10.942 ENSMUST00000060710.7
 Cdc25c
cell division cycle 25C
chr1_-_169531447 10.921 ENSMUST00000111368.1
 Nuf2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr2_+_163054682 10.803 ENSMUST00000018005.3
 Mybl2
myeloblastosis oncogene-like 2
chr6_+_124830217 10.552 ENSMUST00000131847.1
ENSMUST00000151674.1
 Cdca3

cell division cycle associated 3

chr2_-_172940299 10.458 ENSMUST00000009143.7
 Bmp7
bone morphogenetic protein 7
chr18_+_34751803 9.988 ENSMUST00000181453.1
ENSMUST00000181641.1
 2010110K18Rik

RIKEN cDNA 2010110K18 gene

chr17_-_24251382 9.941 ENSMUST00000115390.3
 Ccnf
cyclin F
chr1_+_157412352 9.815 ENSMUST00000061537.5
 2810025M15Rik
RIKEN cDNA 2810025M15 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 106 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 41.9 GO:0007052 mitotic spindle organization(GO:0007052)
6.1 24.6 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
1.7 24.2 GO:0070986 left/right axis specification(GO:0070986)
0.8 23.5 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.9 20.0 GO:0008340 determination of adult lifespan(GO:0008340)
2.6 18.0 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.5 17.9 GO:0006270 DNA replication initiation(GO:0006270)
0.3 16.4 GO:0007051 spindle organization(GO:0007051)
5.1 15.3 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.5 13.1 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.5 12.3 GO:0051310 metaphase plate congression(GO:0051310)
3.9 11.6 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
1.0 11.1 GO:1902459 positive regulation of stem cell population maintenance(GO:1902459)
3.6 10.9 GO:0000087 mitotic M phase(GO:0000087)
3.5 10.5 GO:0072076 hyaluranon cable assembly(GO:0036118) nephrogenic mesenchyme development(GO:0072076) negative regulation of glomerular mesangial cell proliferation(GO:0072125) negative regulation of glomerulus development(GO:0090194) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
1.2 10.5 GO:0035881 amacrine cell differentiation(GO:0035881)
0.4 10.4 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
1.4 9.9 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
1.5 8.8 GO:0007144 female meiosis I(GO:0007144)
1.3 8.8 GO:0060623 regulation of chromosome condensation(GO:0060623)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 29.0 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.4 27.7 GO:0005882 intermediate filament(GO:0005882)
3.9 23.5 GO:0031262 Ndc80 complex(GO:0031262)
0.3 23.2 GO:0000922 spindle pole(GO:0000922)
0.0 22.6 GO:0005730 nucleolus(GO:0005730)
0.2 19.3 GO:0043198 dendritic shaft(GO:0043198)
1.7 18.2 GO:0031080 nuclear pore outer ring(GO:0031080)
1.7 15.3 GO:0008278 cohesin complex(GO:0008278)
0.1 14.9 GO:0000775 chromosome, centromeric region(GO:0000775)
0.2 14.6 GO:0005814 centriole(GO:0005814)
0.8 13.4 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 13.4 GO:0005667 transcription factor complex(GO:0005667)
1.1 12.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
1.2 11.6 GO:0070531 BRCA1-A complex(GO:0070531)
2.2 10.8 GO:0031523 Myb complex(GO:0031523)
0.2 10.4 GO:0005643 nuclear pore(GO:0005643)
0.0 10.4 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
1.7 10.0 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.2 9.4 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 9.2 GO:0031988 membrane-bounded vesicle(GO:0031988)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 35.9 GO:0042802 identical protein binding(GO:0042802)
4.4 31.1 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
4.1 24.6 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.0 21.1 GO:0003682 chromatin binding(GO:0003682)
0.1 16.7 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.1 14.3 GO:0042393 histone binding(GO:0042393)
0.3 12.3 GO:0045502 dynein binding(GO:0045502)
1.2 11.8 GO:0036310 annealing helicase activity(GO:0036310)
0.3 10.9 GO:0050699 WW domain binding(GO:0050699)
1.5 10.8 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
1.0 10.5 GO:0070700 BMP receptor binding(GO:0070700)
0.4 10.4 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.6 9.7 GO:0070182 DNA polymerase binding(GO:0070182)
0.2 9.5 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.2 9.4 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 9.0 GO:0003684 damaged DNA binding(GO:0003684)
1.7 8.6 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
1.7 8.6 GO:0000405 bubble DNA binding(GO:0000405)
0.1 8.5 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
1.2 8.2 GO:0015616 DNA translocase activity(GO:0015616)