Motif ID: E2f6

Z-value: 1.575


Transcription factors associated with E2f6:

Gene SymbolEntrez IDGene Name
E2f6 ENSMUSG00000057469.7 E2f6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f6mm10_v2_chr12_+_16810940_168109780.919.4e-11Click!


Activity profile for motif E2f6.

activity profile for motif E2f6


Sorted Z-values histogram for motif E2f6

Sorted Z-values for motif E2f6



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f6

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_48261427 6.103 ENSMUST00000021810.1
 Id4
inhibitor of DNA binding 4
chr15_-_98004695 5.722 ENSMUST00000023123.8
 Col2a1
collagen, type II, alpha 1
chr15_-_98004634 5.171 ENSMUST00000131560.1
ENSMUST00000088355.5
 Col2a1

collagen, type II, alpha 1

chrX_-_60893430 5.141 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr7_-_38107490 4.987 ENSMUST00000108023.3
 Ccne1
cyclin E1
chr19_-_45742873 4.593 ENSMUST00000026241.5
ENSMUST00000026240.7
ENSMUST00000111928.1
 Fgf8


fibroblast growth factor 8


chr2_-_64097994 4.513 ENSMUST00000131615.2
 Fign
fidgetin
chr13_-_29984219 4.163 ENSMUST00000146092.1
 E2f3
E2F transcription factor 3
chr7_+_102441685 4.048 ENSMUST00000033283.9
 Rrm1
ribonucleotide reductase M1
chr17_-_35516780 3.975 ENSMUST00000160885.1
ENSMUST00000159009.1
ENSMUST00000161012.1
 Tcf19


transcription factor 19


chr2_+_71389239 3.814 ENSMUST00000028408.2
 Hat1
histone aminotransferase 1
chr2_+_164562579 3.770 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2


chr5_+_139543889 3.748 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chrX_-_162159717 3.687 ENSMUST00000087085.3
 Nhs
Nance-Horan syndrome (human)
chr7_+_13278778 3.515 ENSMUST00000098814.4
ENSMUST00000146998.1
ENSMUST00000185145.1
 Lig1


ligase I, DNA, ATP-dependent


chr13_-_111808938 3.413 ENSMUST00000109267.2
 Map3k1
mitogen-activated protein kinase kinase kinase 1
chr4_+_11191726 3.357 ENSMUST00000029866.9
ENSMUST00000108324.3
 Ccne2

cyclin E2

chr3_-_66981279 3.357 ENSMUST00000162098.2
 Shox2
short stature homeobox 2
chr4_+_126556935 3.324 ENSMUST00000048391.8
 Clspn
claspin
chr9_+_65890237 3.324 ENSMUST00000045802.6
 2810417H13Rik
RIKEN cDNA 2810417H13 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 413 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 17.0 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.5 14.0 GO:0006270 DNA replication initiation(GO:0006270)
0.7 9.4 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
2.0 7.9 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.6 7.9 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.5 7.4 GO:0051383 kinetochore organization(GO:0051383)
1.8 7.1 GO:0015888 thiamine transport(GO:0015888)
0.8 6.8 GO:0044027 hypermethylation of CpG island(GO:0044027)
2.1 6.4 GO:0030421 defecation(GO:0030421)
0.8 6.4 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.6 6.1 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.2 6.0 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
1.4 5.5 GO:2000525 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
1.1 5.5 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.6 5.3 GO:0060836 lymphatic endothelial cell differentiation(GO:0060836)
0.1 5.2 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
1.7 5.0 GO:0072180 mesenchymal cell proliferation involved in ureteric bud development(GO:0072138) mesonephric duct development(GO:0072177) mesonephric duct morphogenesis(GO:0072180)
0.7 4.8 GO:0033567 DNA replication, Okazaki fragment processing(GO:0033567)
0.3 4.7 GO:0007530 sex determination(GO:0007530)
2.3 4.6 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 182 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 15.3 GO:0000791 euchromatin(GO:0000791)
0.9 12.3 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
1.9 9.4 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0 8.8 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 7.9 GO:0005844 polysome(GO:0005844)
0.2 7.4 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 7.0 GO:0005730 nucleolus(GO:0005730)
0.1 6.8 GO:0032432 actin filament bundle(GO:0032432)
0.1 5.6 GO:0016592 mediator complex(GO:0016592)
0.1 5.6 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.1 5.5 GO:0005884 actin filament(GO:0005884)
0.2 5.2 GO:0016580 Sin3 complex(GO:0016580)
0.3 4.7 GO:0005662 DNA replication factor A complex(GO:0005662)
0.2 4.3 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 4.0 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.2 3.9 GO:0071564 npBAF complex(GO:0071564)
0.5 3.8 GO:0097452 GAIT complex(GO:0097452)
0.3 3.7 GO:0043596 nuclear replication fork(GO:0043596)
0.3 3.7 GO:0042555 MCM complex(GO:0042555)
0.6 3.5 GO:0005663 DNA replication factor C complex(GO:0005663)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 250 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.8 GO:0005178 integrin binding(GO:0005178)
0.7 11.1 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 9.9 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
1.9 9.4 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.3 8.7 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.2 7.8 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.2 7.7 GO:0070063 RNA polymerase binding(GO:0070063)
0.1 7.5 GO:0001047 core promoter binding(GO:0001047)
0.9 7.4 GO:0051718 DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
2.4 7.1 GO:0015234 thiamine transmembrane transporter activity(GO:0015234) thiamine uptake transmembrane transporter activity(GO:0015403)
1.1 6.6 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.2 6.4 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.3 6.2 GO:0008266 poly(U) RNA binding(GO:0008266)
0.4 5.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.2 5.9 GO:0071837 HMG box domain binding(GO:0071837)
0.1 5.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 5.1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.8 5.0 GO:0043426 MRF binding(GO:0043426)
0.1 4.9 GO:0070888 E-box binding(GO:0070888)
0.4 4.8 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)