Motif ID: Egr1

Z-value: 3.396


Transcription factors associated with Egr1:

Gene SymbolEntrez IDGene Name
Egr1 ENSMUSG00000038418.7 Egr1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Egr1mm10_v2_chr18_+_34861200_348612150.077.3e-01Click!


Activity profile for motif Egr1.

activity profile for motif Egr1


Sorted Z-values histogram for motif Egr1

Sorted Z-values for motif Egr1



Network of associatons between targets according to the STRING database.



First level regulatory network of Egr1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_6065538 50.425 ENSMUST00000101585.3
ENSMUST00000066431.7
ENSMUST00000109815.2
ENSMUST00000109812.2
ENSMUST00000101586.2
ENSMUST00000093355.5
ENSMUST00000019133.4
 Camk2b






calcium/calmodulin-dependent protein kinase II, beta






chr4_+_127169131 22.283 ENSMUST00000046659.7
 Dlgap3
discs, large (Drosophila) homolog-associated protein 3
chr11_+_98348404 19.396 ENSMUST00000078694.6
 Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr5_-_139130159 16.431 ENSMUST00000129851.1
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr5_-_139129662 16.129 ENSMUST00000026973.7
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr11_-_6065737 15.834 ENSMUST00000002817.5
ENSMUST00000109813.2
ENSMUST00000090443.3
 Camk2b


calcium/calmodulin-dependent protein kinase II, beta


chr7_+_73740277 14.182 ENSMUST00000107456.2
 Fam174b
family with sequence similarity 174, member B
chr3_+_54156039 14.091 ENSMUST00000029311.6
 Trpc4
transient receptor potential cation channel, subfamily C, member 4
chrX_-_20920911 13.730 ENSMUST00000081893.6
ENSMUST00000115345.1
 Syn1

synapsin I

chr5_+_32136458 13.317 ENSMUST00000031017.9
 Fosl2
fos-like antigen 2
chr11_-_67922136 13.020 ENSMUST00000021288.3
ENSMUST00000108677.1
 Usp43

ubiquitin specific peptidase 43

chr4_+_124657646 12.868 ENSMUST00000053491.7
 Pou3f1
POU domain, class 3, transcription factor 1
chr14_-_102982630 12.744 ENSMUST00000184744.1
 KCTD12
mmu-mir-5130
chr5_+_137553517 12.155 ENSMUST00000136088.1
ENSMUST00000139395.1
ENSMUST00000136565.1
ENSMUST00000149292.1
ENSMUST00000125489.1
 Actl6b




actin-like 6B




chr13_-_100108337 11.851 ENSMUST00000180822.1
 BC001981
cDNA sequence BC001981
chr6_-_126645784 10.916 ENSMUST00000055168.3
 Kcna1
potassium voltage-gated channel, shaker-related subfamily, member 1
chr3_+_28263205 10.839 ENSMUST00000159236.2
 Tnik
TRAF2 and NCK interacting kinase
chr14_-_33447142 10.782 ENSMUST00000111944.3
ENSMUST00000022504.5
ENSMUST00000111945.2
 Mapk8


mitogen-activated protein kinase 8


chr1_-_56969827 10.780 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr7_-_27396542 10.538 ENSMUST00000108363.1
 Sptbn4
spectrin beta, non-erythrocytic 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 233 entries
Log-likelihood per target Total log-likelihoodTermDescription
22.1 66.3 GO:0032430 positive regulation of phospholipase A2 activity(GO:0032430) activation of meiosis involved in egg activation(GO:0060466)
2.6 31.0 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
1.4 20.5 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.6 19.8 GO:0032292 myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
6.5 19.4 GO:0007621 negative regulation of female receptivity(GO:0007621)
3.7 18.7 GO:0007256 activation of JNKK activity(GO:0007256)
5.8 17.4 GO:1900039 positive regulation of cellular response to hypoxia(GO:1900039)
0.9 16.3 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
0.2 15.1 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
1.0 14.4 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
1.7 13.9 GO:0005513 detection of calcium ion(GO:0005513)
0.5 13.6 GO:0061098 positive regulation of protein tyrosine kinase activity(GO:0061098)
0.3 13.3 GO:0032355 response to estradiol(GO:0032355)
0.3 13.1 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
2.0 12.2 GO:0032796 uropod organization(GO:0032796)
0.7 11.5 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
2.3 11.4 GO:0090292 nuclear migration along microfilament(GO:0031022) nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.1 11.2 GO:0099643 neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
3.6 10.9 GO:0050975 sensory perception of touch(GO:0050975)
2.7 10.8 GO:2000017 positive regulation of determination of dorsal identity(GO:2000017)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 115 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 67.3 GO:0051233 spindle midzone(GO:0051233)
0.2 55.7 GO:0045211 postsynaptic membrane(GO:0045211)
2.7 35.0 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.5 34.4 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 29.0 GO:0043025 neuronal cell body(GO:0043025)
0.2 27.2 GO:0055037 recycling endosome(GO:0055037)
0.5 25.4 GO:0034704 calcium channel complex(GO:0034704)
1.5 22.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 20.5 GO:0005794 Golgi apparatus(GO:0005794)
0.1 19.4 GO:0005769 early endosome(GO:0005769)
1.5 17.6 GO:0097449 astrocyte projection(GO:0097449)
0.5 16.8 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.7 15.8 GO:0032839 dendrite cytoplasm(GO:0032839)
2.6 15.4 GO:0008091 spectrin(GO:0008091)
0.6 13.7 GO:0000795 synaptonemal complex(GO:0000795)
0.5 13.4 GO:0001891 phagocytic cup(GO:0001891)
1.6 12.8 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
1.3 11.4 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1 11.2 GO:0005802 trans-Golgi network(GO:0005802)
0.6 10.9 GO:0044224 juxtaparanode region of axon(GO:0044224)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 174 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 71.9 GO:0043274 phospholipase binding(GO:0043274)
3.0 32.6 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
1.0 26.9 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.3 22.3 GO:0048306 calcium-dependent protein binding(GO:0048306)
2.2 21.7 GO:0019870 potassium channel inhibitor activity(GO:0019870)
6.5 19.4 GO:0031752 D3 dopamine receptor binding(GO:0031750) D5 dopamine receptor binding(GO:0031752)
0.5 17.3 GO:0001540 beta-amyloid binding(GO:0001540)
0.7 15.4 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.7 14.5 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
1.2 14.1 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.9 13.6 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.1 13.6 GO:0101005 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.1 13.6 GO:0016247 channel regulator activity(GO:0016247)
1.2 12.2 GO:0032036 myosin heavy chain binding(GO:0032036)
0.5 11.5 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.5 11.4 GO:0005521 lamin binding(GO:0005521)
1.2 10.9 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
1.3 10.8 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.2 10.5 GO:0030507 spectrin binding(GO:0030507)
1.7 10.3 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)