Motif ID: Egr3

Z-value: 0.630


Transcription factors associated with Egr3:

Gene SymbolEntrez IDGene Name
Egr3 ENSMUSG00000033730.3 Egr3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Egr3mm10_v2_chr14_+_70077375_70077445-0.039.0e-01Click!


Activity profile for motif Egr3.

activity profile for motif Egr3


Sorted Z-values histogram for motif Egr3

Sorted Z-values for motif Egr3



Network of associatons between targets according to the STRING database.



First level regulatory network of Egr3

PNG image of the network

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Top targets:


Showing 1 to 20 of 101 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_144896523 2.500 ENSMUST00000033389.5
 Fgf15
fibroblast growth factor 15
chr7_-_144939823 1.842 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr7_-_110061319 1.710 ENSMUST00000098110.2
 AA474408
expressed sequence AA474408
chr6_-_49214954 1.520 ENSMUST00000031838.7
 Igf2bp3
insulin-like growth factor 2 mRNA binding protein 3
chr8_+_62951361 1.519 ENSMUST00000119068.1
 Spock3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3
chr1_+_120340569 1.188 ENSMUST00000037286.8
 C1ql2
complement component 1, q subcomponent-like 2
chr3_+_129213920 1.102 ENSMUST00000042587.10
 Pitx2
paired-like homeodomain transcription factor 2
chrX_+_36195968 1.032 ENSMUST00000115256.1
 Zcchc12
zinc finger, CCHC domain containing 12
chr9_-_55048544 1.017 ENSMUST00000034854.6
 Chrnb4
cholinergic receptor, nicotinic, beta polypeptide 4
chrX_-_162159717 1.012 ENSMUST00000087085.3
 Nhs
Nance-Horan syndrome (human)
chr10_-_68278713 0.949 ENSMUST00000020106.7
 Arid5b
AT rich interactive domain 5B (MRF1-like)
chr11_+_98937669 0.926 ENSMUST00000107475.2
ENSMUST00000068133.3
 Rara

retinoic acid receptor, alpha

chr2_-_148045891 0.855 ENSMUST00000109964.1
 Foxa2
forkhead box A2
chr7_-_119184374 0.839 ENSMUST00000084650.4
 Gpr139
G protein-coupled receptor 139
chr4_+_57637816 0.747 ENSMUST00000150412.1
 Gm20459
predicted gene 20459
chr18_-_41951187 0.645 ENSMUST00000070949.4
 Prelid2
PRELI domain containing 2
chr9_-_75409951 0.606 ENSMUST00000049355.10
 Mapk6
mitogen-activated protein kinase 6
chr2_-_65529275 0.603 ENSMUST00000126837.1
 Scn3a
sodium channel, voltage-gated, type III, alpha
chr13_-_41847626 0.570 ENSMUST00000121404.1
 Adtrp
androgen dependent TFPI regulating protein
chr13_-_41847482 0.531 ENSMUST00000072012.3
 Adtrp
androgen dependent TFPI regulating protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 2.5 GO:0070858 negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
0.0 1.9 GO:0051028 mRNA transport(GO:0051028)
0.3 1.8 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.2 1.5 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.3 1.1 GO:0055009 extraocular skeletal muscle development(GO:0002074) atrial cardiac muscle tissue development(GO:0003228) pulmonary myocardium development(GO:0003350) subthalamus development(GO:0021539) subthalamic nucleus development(GO:0021763) atrial cardiac muscle tissue morphogenesis(GO:0055009) left lung morphogenesis(GO:0060460) pulmonary vein morphogenesis(GO:0060577) superior vena cava morphogenesis(GO:0060578)
0.3 1.0 GO:0060084 synaptic transmission involved in micturition(GO:0060084)
0.2 1.0 GO:2000325 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.0 1.0 GO:0002088 lens development in camera-type eye(GO:0002088)
0.3 0.9 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.3 0.9 GO:0045014 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594)
0.1 0.9 GO:0060613 fat pad development(GO:0060613)
0.1 0.9 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.1 0.8 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 0.8 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.0 0.8 GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway(GO:0007200)
0.1 0.6 GO:0046684 response to pyrethroid(GO:0046684)
0.0 0.6 GO:0015914 phospholipid transport(GO:0015914)
0.2 0.5 GO:0010757 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) negative regulation of plasminogen activation(GO:0010757) regulation of vascular wound healing(GO:0061043) regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.1 0.5 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 0.5 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 1.2 GO:0005581 collagen trimer(GO:0005581)
0.1 1.0 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.9 GO:0000780 condensed nuclear chromosome, centromeric region(GO:0000780)
0.0 0.9 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 0.8 GO:0031209 SCAR complex(GO:0031209)
0.0 0.6 GO:0032156 septin cytoskeleton(GO:0032156)
0.0 0.6 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 0.5 GO:0042583 chromaffin granule(GO:0042583)
0.0 0.5 GO:0031430 M band(GO:0031430)
0.1 0.4 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.4 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.4 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.4 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 0.3 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.0 0.3 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.2 GO:0042825 TAP complex(GO:0042825)
0.0 0.2 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.1 GO:0031417 NatC complex(GO:0031417)
0.0 0.1 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.5 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.2 2.4 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 1.8 GO:0070064 proline-rich region binding(GO:0070064)
0.1 1.5 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 1.5 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 1.0 GO:0004889 acetylcholine-activated cation-selective channel activity(GO:0004889)
0.0 1.0 GO:0032183 SUMO binding(GO:0032183)
0.1 0.9 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.0 0.9 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.8 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 0.8 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.8 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.8 GO:0008146 sulfotransferase activity(GO:0008146)
0.0 0.8 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 0.6 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.0 0.6 GO:0031402 sodium ion binding(GO:0031402)
0.0 0.5 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.4 GO:0030957 Tat protein binding(GO:0030957)
0.1 0.3 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)