Motif ID: Egr4

Z-value: 0.900


Transcription factors associated with Egr4:

Gene SymbolEntrez IDGene Name
Egr4 ENSMUSG00000071341.3 Egr4



Activity profile for motif Egr4.

activity profile for motif Egr4


Sorted Z-values histogram for motif Egr4

Sorted Z-values for motif Egr4



Network of associatons between targets according to the STRING database.



First level regulatory network of Egr4

PNG image of the network

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Top targets:


Showing 1 to 20 of 114 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_70851189 5.291 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr2_-_102186322 3.207 ENSMUST00000111222.1
ENSMUST00000058790.5
 Ldlrad3

low density lipoprotein receptor class A domain containing 3

chr6_+_4747306 3.085 ENSMUST00000175823.1
ENSMUST00000176204.1
ENSMUST00000166678.1
 Peg10


paternally expressed 10


chr13_+_48261427 2.694 ENSMUST00000021810.1
 Id4
inhibitor of DNA binding 4
chr8_-_92355764 2.469 ENSMUST00000180102.1
ENSMUST00000179421.1
ENSMUST00000179222.1
ENSMUST00000179029.1
 4933436C20Rik



RIKEN cDNA 4933436C20 gene



chr4_+_86748526 2.423 ENSMUST00000082026.7
ENSMUST00000045512.8
 Dennd4c

DENN/MADD domain containing 4C

chr11_-_19018956 2.371 ENSMUST00000068264.7
ENSMUST00000144988.1
ENSMUST00000185131.1
 Meis1


Meis homeobox 1


chr19_+_25505618 2.319 ENSMUST00000025755.4
 Dmrt1
doublesex and mab-3 related transcription factor 1
chr9_+_65630552 2.154 ENSMUST00000055844.8
 Rbpms2
RNA binding protein with multiple splicing 2
chrX_-_143393893 2.147 ENSMUST00000166406.2
 Chrdl1
chordin-like 1
chr11_-_19018714 2.056 ENSMUST00000177417.1
 Meis1
Meis homeobox 1
chrX_-_20291728 1.957 ENSMUST00000115393.2
 Slc9a7
solute carrier family 9 (sodium/hydrogen exchanger), member 7
chr16_+_93883895 1.877 ENSMUST00000023666.4
ENSMUST00000117099.1
ENSMUST00000142316.1
 Chaf1b


chromatin assembly factor 1, subunit B (p60)


chr10_+_19591949 1.844 ENSMUST00000020188.6
 Ifngr1
interferon gamma receptor 1
chr19_-_50678642 1.836 ENSMUST00000072685.6
ENSMUST00000164039.2
 Sorcs1

VPS10 domain receptor protein SORCS 1

chr12_+_76370266 1.833 ENSMUST00000042779.3
 Zbtb1
zinc finger and BTB domain containing 1
chr6_-_28261907 1.714 ENSMUST00000115320.1
ENSMUST00000123098.1
ENSMUST00000115321.2
ENSMUST00000155494.1
 Zfp800



zinc finger protein 800



chr5_-_96161742 1.619 ENSMUST00000129646.1
ENSMUST00000113005.2
ENSMUST00000154500.1
ENSMUST00000141383.1
 Cnot6l



CCR4-NOT transcription complex, subunit 6-like



chr10_+_128232065 1.606 ENSMUST00000055539.4
ENSMUST00000105244.1
ENSMUST00000105243.2
ENSMUST00000125289.1
ENSMUST00000105242.1
 Timeless




timeless circadian clock 1




chr5_-_149051604 1.571 ENSMUST00000093196.4
 Hmgb1
high mobility group box 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 7.6 GO:0038092 nodal signaling pathway(GO:0038092)
0.2 4.4 GO:0035855 megakaryocyte development(GO:0035855)
0.0 3.1 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.7 2.7 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.4 2.7 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 2.3 GO:0070613 regulation of protein processing(GO:0070613)
0.1 2.1 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.1 2.1 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.1 1.9 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.5 1.8 GO:0002572 pro-T cell differentiation(GO:0002572)
0.3 1.7 GO:2000325 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.0 1.7 GO:0032869 cellular response to insulin stimulus(GO:0032869)
0.5 1.6 GO:0045819 positive regulation of glycogen catabolic process(GO:0045819)
0.2 1.6 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.1 1.6 GO:0042753 positive regulation of circadian rhythm(GO:0042753)
0.0 1.5 GO:0044030 regulation of DNA methylation(GO:0044030)
0.1 1.4 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.0 1.4 GO:0006783 heme biosynthetic process(GO:0006783)
0.3 1.3 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.1 1.3 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.0 GO:0005667 transcription factor complex(GO:0005667)
0.0 2.5 GO:0016607 nuclear speck(GO:0016607)
0.1 2.4 GO:0032593 insulin-responsive compartment(GO:0032593)
0.5 2.1 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.1 2.0 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 2.0 GO:0008180 COP9 signalosome(GO:0008180)
0.6 1.9 GO:0033186 CAF-1 complex(GO:0033186)
0.1 1.6 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 1.5 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 1.4 GO:0031011 Ino80 complex(GO:0031011)
0.1 1.3 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 1.2 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 1.1 GO:0030914 STAGA complex(GO:0030914)
0.1 1.0 GO:0089701 U2AF(GO:0089701)
0.0 1.0 GO:0010369 chromocenter(GO:0010369)
0.0 0.9 GO:1990391 DNA repair complex(GO:1990391)
0.0 0.8 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 0.7 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.1 0.7 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 0.6 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.8 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.2 5.3 GO:0070410 co-SMAD binding(GO:0070410)
0.0 4.0 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 2.8 GO:0042393 histone binding(GO:0042393)
0.3 2.7 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0 2.7 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 2.4 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 2.1 GO:0000400 four-way junction DNA binding(GO:0000400)
0.5 1.8 GO:0042015 interleukin-20 binding(GO:0042015)
0.1 1.8 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 1.7 GO:0032183 SUMO binding(GO:0032183)
0.5 1.6 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.1 1.6 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 1.5 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 1.5 GO:0035064 methylated histone binding(GO:0035064)
0.0 1.4 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 1.3 GO:0008143 poly(A) binding(GO:0008143)
0.4 1.2 GO:0043532 angiostatin binding(GO:0043532)
0.4 1.2 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.3 1.2 GO:0045131 pre-mRNA branch point binding(GO:0045131)