Motif ID: Emx1_Emx2

Z-value: 0.623

Transcription factors associated with Emx1_Emx2:

Gene SymbolEntrez IDGene Name
Emx1 ENSMUSG00000033726.8 Emx1
Emx2 ENSMUSG00000043969.4 Emx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Emx1mm10_v2_chr6_+_85187438_851875100.572.3e-03Click!
Emx2mm10_v2_chr19_+_59458372_59458450-0.413.8e-02Click!


Activity profile for motif Emx1_Emx2.

activity profile for motif Emx1_Emx2


Sorted Z-values histogram for motif Emx1_Emx2

Sorted Z-values for motif Emx1_Emx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Emx1_Emx2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 152 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_82505749 4.375 ENSMUST00000107245.2
ENSMUST00000107246.1
 Nfib

nuclear factor I/B

chr4_-_82505707 4.168 ENSMUST00000107248.1
ENSMUST00000107247.1
 Nfib

nuclear factor I/B

chr4_-_82505274 3.687 ENSMUST00000050872.8
ENSMUST00000064770.2
 Nfib

nuclear factor I/B

chr7_-_103827922 2.217 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr17_-_31636631 2.184 ENSMUST00000135425.1
ENSMUST00000151718.1
ENSMUST00000155814.1
 Cbs


cystathionine beta-synthase


chr1_-_158356258 1.976 ENSMUST00000004133.8
 Brinp2
bone morphogenic protein/retinoic acid inducible neural-specific 2
chr10_+_81257277 1.680 ENSMUST00000117488.1
ENSMUST00000105328.3
ENSMUST00000121205.1
 Matk


megakaryocyte-associated tyrosine kinase


chr17_-_36032682 1.429 ENSMUST00000102678.4
 H2-T23
histocompatibility 2, T region locus 23
chr4_+_118961578 1.292 ENSMUST00000058651.4
 Lao1
L-amino acid oxidase 1
chr9_-_20728219 1.284 ENSMUST00000034692.7
 Olfm2
olfactomedin 2
chr10_+_90071095 1.278 ENSMUST00000183109.1
 Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr14_+_58893465 1.141 ENSMUST00000079960.1
 Rpl13-ps3
ribosomal protein L13, pseudogene 3
chr15_+_99006056 1.121 ENSMUST00000079818.3
 Gm8973
predicted gene 8973
chr6_-_144209448 0.982 ENSMUST00000077160.5
 Sox5
SRY-box containing gene 5
chr2_-_93452679 0.979 ENSMUST00000111257.1
ENSMUST00000145553.1
 Cd82

CD82 antigen

chr6_-_144209558 0.935 ENSMUST00000111749.1
ENSMUST00000170367.2
 Sox5

SRY-box containing gene 5

chr6_-_144209471 0.905 ENSMUST00000038815.7
 Sox5
SRY-box containing gene 5
chr2_-_5676046 0.871 ENSMUST00000114987.3
 Camk1d
calcium/calmodulin-dependent protein kinase ID
chr3_+_121953213 0.866 ENSMUST00000037958.7
ENSMUST00000128366.1
 Arhgap29

Rho GTPase activating protein 29

chr1_+_32172711 0.862 ENSMUST00000027226.5
 Khdrbs2
KH domain containing, RNA binding, signal transduction associated 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.1 12.2 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.3 2.3 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.7 2.2 GO:0019343 cysteine biosynthetic process via cystathionine(GO:0019343) cysteine biosynthetic process(GO:0019344)
0.0 2.0 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 1.7 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.5 1.4 GO:2000564 CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.1 1.3 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.1 1.3 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.0 1.3 GO:0009063 cellular amino acid catabolic process(GO:0009063)
0.1 0.9 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.3 0.8 GO:0060060 post-embryonic retina morphogenesis in camera-type eye(GO:0060060)
0.1 0.8 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.4 0.7 GO:0021730 trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740)
0.2 0.7 GO:0048388 endosomal lumen acidification(GO:0048388)
0.1 0.7 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.0 0.7 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.2 0.6 GO:0097155 fasciculation of sensory neuron axon(GO:0097155)
0.1 0.6 GO:0045200 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.1 0.6 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.1 0.6 GO:0045607 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 12.2 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 2.3 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.6 2.2 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 1.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 1.4 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 1.3 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.2 0.7 GO:0043512 inhibin A complex(GO:0043512)
0.0 0.6 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.6 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.5 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.4 GO:0005922 connexon complex(GO:0005922)
0.0 0.4 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.4 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 0.3 GO:1990075 kinesin II complex(GO:0016939) periciliary membrane compartment(GO:1990075)
0.0 0.3 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.2 GO:0044294 dendritic growth cone(GO:0044294)
0.0 0.2 GO:0005638 lamin filament(GO:0005638)
0.0 0.2 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 0.2 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.2 GO:0030915 Smc5-Smc6 complex(GO:0030915)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 12.2 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.7 2.2 GO:0098809 nitrite reductase activity(GO:0098809)
0.6 2.2 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.0 1.7 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.2 1.4 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.4 1.3 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.0 1.3 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 1.0 GO:0015250 water channel activity(GO:0015250)
0.0 0.9 GO:0008143 poly(A) binding(GO:0008143)
0.0 0.9 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 0.8 GO:0051400 BH domain binding(GO:0051400)
0.0 0.8 GO:0070888 E-box binding(GO:0070888)
0.1 0.7 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 0.6 GO:0042296 ISG15 transferase activity(GO:0042296)
0.1 0.6 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 0.6 GO:0043015 cAMP binding(GO:0030552) gamma-tubulin binding(GO:0043015)
0.0 0.6 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 0.5 GO:0016920 pyroglutamyl-peptidase activity(GO:0016920)
0.0 0.5 GO:0043522 leucine zipper domain binding(GO:0043522)
0.1 0.4 GO:0052630 CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity(GO:0043338) phospholactate guanylyltransferase activity(GO:0043814) ATP:coenzyme F420 adenylyltransferase activity(GO:0043910) UDP-N-acetylgalactosamine diphosphorylase activity(GO:0052630)