Motif ID: En1

Z-value: 0.871


Transcription factors associated with En1:

Gene SymbolEntrez IDGene Name
En1 ENSMUSG00000058665.7 En1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
En1mm10_v2_chr1_+_120602405_1206024180.154.5e-01Click!


Activity profile for motif En1.

activity profile for motif En1


Sorted Z-values histogram for motif En1

Sorted Z-values for motif En1



Network of associatons between targets according to the STRING database.



First level regulatory network of En1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_60144682 4.775 ENSMUST00000065383.4
 E330013P04Rik
RIKEN cDNA E330013P04 gene
chr14_+_67234620 4.126 ENSMUST00000176029.1
 Ebf2
early B cell factor 2
chr6_-_23248264 3.786 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr16_-_26989974 3.256 ENSMUST00000089832.4
 Gmnc
geminin coiled-coil domain containing
chr7_-_30973367 2.748 ENSMUST00000108116.3
 Lsr
lipolysis stimulated lipoprotein receptor
chr6_+_4755327 2.574 ENSMUST00000176551.1
 Peg10
paternally expressed 10
chr16_-_59555752 2.553 ENSMUST00000179383.1
ENSMUST00000044604.8
 Crybg3

beta-gamma crystallin domain containing 3

chr1_+_6487231 2.513 ENSMUST00000140079.1
ENSMUST00000131494.1
 St18

suppression of tumorigenicity 18

chr9_+_64117147 2.264 ENSMUST00000034969.7
 Lctl
lactase-like
chr17_-_70851189 2.261 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr12_+_109453455 2.205 ENSMUST00000109844.4
ENSMUST00000109842.2
ENSMUST00000109843.1
ENSMUST00000109846.4
ENSMUST00000173539.1
ENSMUST00000109841.2
 Dlk1





delta-like 1 homolog (Drosophila)





chr10_-_120899067 2.172 ENSMUST00000092143.5
 Msrb3
methionine sulfoxide reductase B3
chr13_-_71963713 2.108 ENSMUST00000077337.8
 Irx1
Iroquois related homeobox 1 (Drosophila)
chr16_-_45953565 1.756 ENSMUST00000134802.1
 Phldb2
pleckstrin homology-like domain, family B, member 2
chr16_-_45844303 1.679 ENSMUST00000036355.6
 Phldb2
pleckstrin homology-like domain, family B, member 2
chr19_+_23723279 1.671 ENSMUST00000067077.1
 Gm9938
predicted gene 9938
chr2_-_28916412 1.577 ENSMUST00000050776.2
ENSMUST00000113849.1
 Barhl1

BarH-like 1 (Drosophila)

chr4_-_116123618 1.577 ENSMUST00000102704.3
ENSMUST00000102705.3
 Rad54l

RAD54 like (S. cerevisiae)

chr17_-_84682932 1.564 ENSMUST00000066175.3
 Abcg5
ATP-binding cassette, sub-family G (WHITE), member 5
chr10_+_3872667 1.522 ENSMUST00000136671.1
ENSMUST00000042438.6
 Plekhg1

pleckstrin homology domain containing, family G (with RhoGef domain) member 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 144 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.1 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.6 3.9 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.6 3.8 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 3.6 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.1 3.3 GO:0006270 DNA replication initiation(GO:0006270)
0.9 2.7 GO:1904274 tricellular tight junction assembly(GO:1904274)
0.2 2.6 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211)
0.0 2.6 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.1 2.3 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.4 2.2 GO:0030091 protein repair(GO:0030091)
0.4 2.2 GO:0002553 histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553)
0.5 2.0 GO:0070829 heterochromatin maintenance(GO:0070829)
0.1 2.0 GO:0008340 determination of adult lifespan(GO:0008340)
0.0 1.9 GO:0002181 cytoplasmic translation(GO:0002181)
0.5 1.6 GO:0030300 regulation of intestinal cholesterol absorption(GO:0030300)
0.0 1.5 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.0 1.5 GO:0030901 midbrain development(GO:0030901)
0.2 1.4 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 1.4 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
0.1 1.4 GO:0045724 positive regulation of cilium assembly(GO:0045724)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 3.9 GO:0045180 basal cortex(GO:0045180)
0.5 2.7 GO:0061689 tricellular tight junction(GO:0061689)
0.0 2.6 GO:0005657 replication fork(GO:0005657)
0.1 2.4 GO:0000242 pericentriolar material(GO:0000242)
0.0 2.3 GO:0005814 centriole(GO:0005814)
0.2 2.2 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 2.1 GO:0000775 chromosome, centromeric region(GO:0000775)
0.0 1.8 GO:0005811 lipid particle(GO:0005811)
0.0 1.4 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.4 1.3 GO:1990047 spindle matrix(GO:1990047)
0.2 1.3 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 1.3 GO:0005903 brush border(GO:0005903)
0.1 1.0 GO:0045095 keratin filament(GO:0045095)
0.1 1.0 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 1.0 GO:0000145 exocyst(GO:0000145)
0.0 1.0 GO:0005882 intermediate filament(GO:0005882)
0.2 0.9 GO:0044611 nuclear pore inner ring(GO:0044611)
0.2 0.9 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.1 0.9 GO:0000243 commitment complex(GO:0000243)
0.1 0.9 GO:0042788 polysomal ribosome(GO:0042788)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 99 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.2 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.2 3.5 GO:0070410 co-SMAD binding(GO:0070410)
0.2 2.7 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
0.6 2.6 GO:0017116 single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116)
0.0 2.3 GO:0003729 mRNA binding(GO:0003729)
0.3 2.2 GO:0070191 methionine-R-sulfoxide reductase activity(GO:0070191)
0.0 1.9 GO:0008201 heparin binding(GO:0008201)
0.1 1.8 GO:0008422 beta-glucosidase activity(GO:0008422)
0.1 1.6 GO:0036310 annealing helicase activity(GO:0036310)
0.1 1.6 GO:0017127 cholesterol transporter activity(GO:0017127)
0.0 1.6 GO:0070063 RNA polymerase binding(GO:0070063)
0.0 1.5 GO:0101005 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.2 1.4 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.2 1.3 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.1 1.3 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 1.3 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 1.3 GO:0005484 SNAP receptor activity(GO:0005484)
0.2 1.2 GO:0042610 CD8 receptor binding(GO:0042610)
0.2 1.2 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 1.2 GO:0050431 transforming growth factor beta binding(GO:0050431)