Motif ID: En2

Z-value: 0.475


Transcription factors associated with En2:

Gene SymbolEntrez IDGene Name
En2 ENSMUSG00000039095.7 En2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
En2mm10_v2_chr5_+_28165690_28165717-0.203.3e-01Click!


Activity profile for motif En2.

activity profile for motif En2


Sorted Z-values histogram for motif En2

Sorted Z-values for motif En2



Network of associatons between targets according to the STRING database.



First level regulatory network of En2

PNG image of the network

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Top targets:


Showing 1 to 20 of 183 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_23574381 2.086 ENSMUST00000090776.4
 Hist1h2ad
histone cluster 1, H2ad
chr17_+_3397189 1.432 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr5_-_62766153 1.279 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr6_-_126645784 1.190 ENSMUST00000055168.3
 Kcna1
potassium voltage-gated channel, shaker-related subfamily, member 1
chr2_+_20737306 1.170 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chr13_+_23544052 1.144 ENSMUST00000075558.2
 Hist1h3f
histone cluster 1, H3f
chr5_-_84417359 1.059 ENSMUST00000113401.1
 Epha5
Eph receptor A5
chr2_+_116067213 0.848 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chrX_-_60893430 0.762 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr1_-_78968079 0.756 ENSMUST00000049117.5
 Gm5830
predicted pseudogene 5830
chr4_+_109978004 0.742 ENSMUST00000061187.3
 Dmrta2
doublesex and mab-3 related transcription factor like family A2
chr3_+_96268654 0.667 ENSMUST00000098843.2
 Hist2h3b
histone cluster 2, H3b
chr13_-_23574196 0.644 ENSMUST00000105106.1
 Hist1h2bf
histone cluster 1, H2bf
chr15_+_18818895 0.628 ENSMUST00000166873.2
 Cdh10
cadherin 10
chr16_+_45093611 0.607 ENSMUST00000099498.2
 Ccdc80
coiled-coil domain containing 80
chr2_+_62664279 0.599 ENSMUST00000028257.2
 Gca
grancalcin
chr4_-_14621805 0.572 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr2_-_173276144 0.523 ENSMUST00000139306.1
 Pmepa1
prostate transmembrane protein, androgen induced 1
chr4_-_14621494 0.486 ENSMUST00000149633.1
 Slc26a7
solute carrier family 26, member 7
chr9_-_96719549 0.474 ENSMUST00000128269.1
 Zbtb38
zinc finger and BTB domain containing 38

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 GO:0006342 chromatin silencing(GO:0006342)
0.4 1.2 GO:0050975 sensory perception of touch(GO:0050975)
0.2 1.1 GO:0019532 oxalate transport(GO:0019532)
0.1 1.1 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.0 1.1 GO:0051290 protein heterotetramerization(GO:0051290)
0.0 0.8 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.7 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.1 0.6 GO:0002227 innate immune response in mucosa(GO:0002227)
0.0 0.6 GO:0007530 sex determination(GO:0007530)
0.1 0.5 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.1 0.5 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.1 0.4 GO:0015808 L-alanine transport(GO:0015808)
0.0 0.4 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 0.3 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.1 0.3 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.1 0.3 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.1 0.3 GO:1904339 negative regulation of dopaminergic neuron differentiation(GO:1904339)
0.1 0.3 GO:2000564 CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.1 0.3 GO:0061055 myotome development(GO:0061055)
0.1 0.3 GO:0043415 positive regulation of skeletal muscle tissue regeneration(GO:0043415)

Gene overrepresentation in cellular_component category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.8 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 1.2 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 1.1 GO:0000786 nucleosome(GO:0000786)
0.0 1.1 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.9 GO:0072562 blood microparticle(GO:0072562)
0.0 0.6 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.5 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.4 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.3 GO:1990909 Wnt signalosome(GO:1990909)
0.0 0.2 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.2 GO:0044327 dendritic spine head(GO:0044327)
0.0 0.2 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.1 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 0.1 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.0 0.1 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.1 GO:0070688 MLL5-L complex(GO:0070688)
0.0 0.1 GO:0051286 cell tip(GO:0051286)
0.0 0.1 GO:0000836 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.6 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 1.2 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 1.1 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.1 1.1 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.9 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.8 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.6 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.6 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.6 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.6 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 0.5 GO:0008483 transaminase activity(GO:0008483)
0.0 0.5 GO:0070412 R-SMAD binding(GO:0070412)
0.1 0.4 GO:0015180 L-alanine transmembrane transporter activity(GO:0015180) L-proline transmembrane transporter activity(GO:0015193) alanine transmembrane transporter activity(GO:0022858)
0.0 0.3 GO:0015265 urea channel activity(GO:0015265)
0.0 0.3 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.3 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.0 0.3 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 0.3 GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor(GO:0052890)
0.1 0.2 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.2 GO:0047372 acylglycerol lipase activity(GO:0047372)