Motif ID: Esr1

Z-value: 1.086


Transcription factors associated with Esr1:

Gene SymbolEntrez IDGene Name
Esr1 ENSMUSG00000019768.10 Esr1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Esr1mm10_v2_chr10_+_4710119_47101660.077.5e-01Click!


Activity profile for motif Esr1.

activity profile for motif Esr1


Sorted Z-values histogram for motif Esr1

Sorted Z-values for motif Esr1



Network of associatons between targets according to the STRING database.



First level regulatory network of Esr1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_77113676 3.773 ENSMUST00000072755.4
ENSMUST00000105409.1
 Col18a1

collagen, type XVIII, alpha 1

chr7_-_30973367 3.203 ENSMUST00000108116.3
 Lsr
lipolysis stimulated lipoprotein receptor
chr7_-_30973399 3.193 ENSMUST00000098553.4
ENSMUST00000147431.1
 Lsr

lipolysis stimulated lipoprotein receptor

chr4_+_124986430 3.121 ENSMUST00000030687.7
 Rspo1
R-spondin homolog (Xenopus laevis)
chr7_-_30973464 3.113 ENSMUST00000001279.8
 Lsr
lipolysis stimulated lipoprotein receptor
chr7_+_144915100 3.056 ENSMUST00000128057.1
 Oraov1
oral cancer overexpressed 1
chr2_-_166155272 2.945 ENSMUST00000088086.3
 Sulf2
sulfatase 2
chr18_+_74442500 2.783 ENSMUST00000074157.6
 Myo5b
myosin VB
chr18_+_74442551 2.678 ENSMUST00000121875.1
 Myo5b
myosin VB
chr11_-_115612491 2.587 ENSMUST00000106507.2
 Mif4gd
MIF4G domain containing
chr9_-_63711969 2.548 ENSMUST00000154323.1
 Smad3
SMAD family member 3
chr6_+_66535390 2.515 ENSMUST00000116605.1
 Mad2l1
MAD2 mitotic arrest deficient-like 1
chr2_+_109917639 2.488 ENSMUST00000046548.7
ENSMUST00000111037.2
 Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr8_+_84021444 2.403 ENSMUST00000055077.6
 Palm3
paralemmin 3
chr6_-_125165707 2.342 ENSMUST00000118875.1
 Gapdh
glyceraldehyde-3-phosphate dehydrogenase
chr4_+_89688196 2.255 ENSMUST00000052478.2
 Dmrta1
doublesex and mab-3 related transcription factor like family A1
chr12_+_109747903 2.098 ENSMUST00000183084.1
ENSMUST00000182300.1
 Mirg

miRNA containing gene

chr2_+_122147680 2.071 ENSMUST00000102476.4
 B2m
beta-2 microglobulin
chr14_+_50944499 2.060 ENSMUST00000178092.1
 Pnp
purine-nucleoside phosphorylase
chr9_-_64253617 2.025 ENSMUST00000005066.8
 Map2k1
mitogen-activated protein kinase kinase 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 244 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.2 9.5 GO:1904274 tricellular tight junction assembly(GO:1904274)
1.5 6.1 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
1.4 5.5 GO:0032439 endosome localization(GO:0032439)
0.3 4.7 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.6 4.5 GO:1904667 negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.4 4.3 GO:2000254 regulation of male germ cell proliferation(GO:2000254)
0.3 3.5 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
1.1 3.2 GO:0044778 meiotic DNA integrity checkpoint(GO:0044778)
0.1 3.2 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.7 2.9 GO:0014846 esophagus smooth muscle contraction(GO:0014846) glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.6 2.9 GO:0019659 lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.0 2.9 GO:0051225 spindle assembly(GO:0051225)
0.9 2.8 GO:0015938 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034)
0.7 2.8 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
0.3 2.8 GO:0008063 Toll signaling pathway(GO:0008063)
0.2 2.8 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.6 2.6 GO:0032901 positive regulation of neurotrophin production(GO:0032901)
0.8 2.5 GO:0044413 evasion or tolerance of host defenses by virus(GO:0019049) positive regulation of transforming growth factor beta3 production(GO:0032916) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.8 2.5 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.8 2.3 GO:0018298 protein-chromophore linkage(GO:0018298)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 122 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 9.5 GO:0061689 tricellular tight junction(GO:0061689)
1.0 6.8 GO:0097452 GAIT complex(GO:0097452)
0.5 6.5 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 5.7 GO:0005643 nuclear pore(GO:0005643)
0.0 5.6 GO:0005667 transcription factor complex(GO:0005667)
0.9 5.5 GO:0045179 apical cortex(GO:0045179)
0.4 5.3 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 4.8 GO:0005581 collagen trimer(GO:0005581)
0.1 3.3 GO:0005871 kinesin complex(GO:0005871)
0.5 3.2 GO:0030896 checkpoint clamp complex(GO:0030896)
0.0 3.0 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 2.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.5 2.5 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 2.4 GO:0016234 inclusion body(GO:0016234)
0.0 2.4 GO:0001669 acrosomal vesicle(GO:0001669)
0.7 2.0 GO:0005588 collagen type V trimer(GO:0005588)
0.4 1.9 GO:0033093 Weibel-Palade body(GO:0033093)
0.3 1.7 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.2 1.7 GO:0042611 MHC protein complex(GO:0042611)
0.0 1.7 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 186 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 9.9 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
0.1 9.1 GO:0003774 motor activity(GO:0003774)
2.0 6.1 GO:0035605 peptidyl-cysteine S-nitrosylase activity(GO:0035605)
0.0 4.2 GO:0003729 mRNA binding(GO:0003729)
0.0 3.8 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.6 3.5 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.2 3.2 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.7 2.9 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.6 2.9 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.9 2.8 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.4 2.6 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.3 2.6 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
0.0 2.6 GO:0000049 tRNA binding(GO:0000049)
0.5 2.5 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 2.5 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.1 2.4 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.8 2.3 GO:0009881 photoreceptor activity(GO:0009881)
0.3 2.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.2 2.3 GO:0008413 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity(GO:0008413)
0.7 2.1 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)