Motif ID: Esr2

Z-value: 2.181


Transcription factors associated with Esr2:

Gene SymbolEntrez IDGene Name
Esr2 ENSMUSG00000021055.7 Esr2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Esr2mm10_v2_chr12_-_76177251_76177265-0.262.0e-01Click!


Activity profile for motif Esr2.

activity profile for motif Esr2


Sorted Z-values histogram for motif Esr2

Sorted Z-values for motif Esr2



Network of associatons between targets according to the STRING database.



First level regulatory network of Esr2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_78499087 6.740 ENSMUST00000017488.4
 Vtn
vitronectin
chr11_-_6065538 6.174 ENSMUST00000101585.3
ENSMUST00000066431.7
ENSMUST00000109815.2
ENSMUST00000109812.2
ENSMUST00000101586.2
ENSMUST00000093355.5
ENSMUST00000019133.4
 Camk2b






calcium/calmodulin-dependent protein kinase II, beta






chr4_-_136892867 4.477 ENSMUST00000046332.5
 C1qc
complement component 1, q subcomponent, C chain
chr11_+_32296489 4.289 ENSMUST00000093207.3
 Hba-a2
hemoglobin alpha, adult chain 2
chr6_+_90550789 4.216 ENSMUST00000130418.1
ENSMUST00000032175.8
 Aldh1l1

aldehyde dehydrogenase 1 family, member L1

chr11_+_32283511 4.096 ENSMUST00000093209.3
 Hba-a1
hemoglobin alpha, adult chain 1
chrX_+_150547375 4.085 ENSMUST00000066337.6
ENSMUST00000112715.1
 Alas2

aminolevulinic acid synthase 2, erythroid

chr15_-_66801577 3.945 ENSMUST00000168589.1
 Sla
src-like adaptor
chr10_-_86732409 3.680 ENSMUST00000070435.4
 Fabp3-ps1
fatty acid binding protein 3, muscle and heart, pseudogene 1
chr5_+_35056813 3.412 ENSMUST00000101298.2
ENSMUST00000114270.1
ENSMUST00000133381.1
 Dok7


docking protein 7


chr14_-_31168587 3.400 ENSMUST00000036618.7
 Stab1
stabilin 1
chr8_+_70501116 3.385 ENSMUST00000127983.1
 Crlf1
cytokine receptor-like factor 1
chr9_-_106656081 3.297 ENSMUST00000023959.7
 Grm2
glutamate receptor, metabotropic 2
chr11_-_6065737 3.264 ENSMUST00000002817.5
ENSMUST00000109813.2
ENSMUST00000090443.3
 Camk2b


calcium/calmodulin-dependent protein kinase II, beta


chr4_-_134254076 3.190 ENSMUST00000060050.5
 Grrp1
glycine/arginine rich protein 1
chr17_-_35910032 3.184 ENSMUST00000141662.1
ENSMUST00000056034.6
ENSMUST00000077494.6
ENSMUST00000149277.1
ENSMUST00000061052.5
 Atat1




alpha tubulin acetyltransferase 1




chr15_+_80287234 3.150 ENSMUST00000160424.1
 Cacna1i
calcium channel, voltage-dependent, alpha 1I subunit
chr19_+_8617991 3.149 ENSMUST00000010250.2
 Slc22a6
solute carrier family 22 (organic anion transporter), member 6
chr13_+_83573577 3.034 ENSMUST00000185052.1
 Mef2c
myocyte enhancer factor 2C
chr10_-_81025521 2.995 ENSMUST00000144640.1
 Diras1
DIRAS family, GTP-binding RAS-like 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 790 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.5 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843)
3.1 9.4 GO:0032430 positive regulation of phospholipase A2 activity(GO:0032430)
0.2 9.4 GO:0048821 erythrocyte development(GO:0048821)
0.3 8.4 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.6 7.4 GO:0043589 skin morphogenesis(GO:0043589)
0.7 7.0 GO:0097421 liver regeneration(GO:0097421)
0.8 6.2 GO:0097460 ferrous iron import into cell(GO:0097460)
2.0 6.1 GO:0071929 alpha-tubulin acetylation(GO:0071929)
0.2 5.7 GO:0061098 positive regulation of protein tyrosine kinase activity(GO:0061098)
0.3 5.3 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.5 5.1 GO:0097688 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
1.0 5.0 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.3 5.0 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
0.2 5.0 GO:0032456 endocytic recycling(GO:0032456)
0.2 4.8 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
1.6 4.7 GO:2001139 negative regulation of postsynaptic membrane organization(GO:1901627) negative regulation of dendritic spine maintenance(GO:1902951) negative regulation of phospholipid efflux(GO:1902999) regulation of lipid transport across blood brain barrier(GO:1903000) negative regulation of lipid transport across blood brain barrier(GO:1903001) positive regulation of lipid transport across blood brain barrier(GO:1903002) negative regulation of phospholipid transport(GO:2001139)
0.4 4.7 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.2 4.4 GO:0022401 desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) negative adaptation of signaling pathway(GO:0022401)
0.4 4.3 GO:0036376 sodium ion export from cell(GO:0036376)
1.4 4.2 GO:0042560 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 304 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 27.6 GO:0016021 integral component of membrane(GO:0016021)
0.1 22.8 GO:0005768 endosome(GO:0005768)
0.3 16.7 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.2 15.4 GO:0072562 blood microparticle(GO:0072562)
0.1 14.3 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 14.0 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.1 12.1 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.2 10.5 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.3 10.3 GO:0051233 spindle midzone(GO:0051233)
0.2 9.3 GO:0034704 calcium channel complex(GO:0034704)
0.1 9.3 GO:0005884 actin filament(GO:0005884)
0.0 9.2 GO:0043005 neuron projection(GO:0043005)
2.1 8.4 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 8.3 GO:0031594 neuromuscular junction(GO:0031594)
1.6 8.2 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.1 8.1 GO:0070382 exocytic vesicle(GO:0070382)
0.7 7.3 GO:0044327 dendritic spine head(GO:0044327)
0.9 7.2 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.1 7.0 GO:0030173 integral component of Golgi membrane(GO:0030173)
2.2 6.7 GO:0005584 collagen type I trimer(GO:0005584)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 501 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 12.6 GO:0005096 GTPase activator activity(GO:0005096)
0.3 10.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.4 9.4 GO:0043274 phospholipase binding(GO:0043274)
0.2 9.1 GO:0005158 insulin receptor binding(GO:0005158)
0.5 9.0 GO:0005044 scavenger receptor activity(GO:0005044)
0.4 9.0 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.2 8.9 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 8.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.2 8.6 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
2.1 8.4 GO:0031720 haptoglobin binding(GO:0031720)
0.2 6.7 GO:0030552 cAMP binding(GO:0030552)
0.2 6.5 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 6.5 GO:0005539 glycosaminoglycan binding(GO:0005539)
0.9 6.2 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.0 5.8 GO:0003924 GTPase activity(GO:0003924)
0.1 5.6 GO:0030507 spectrin binding(GO:0030507)
1.4 5.5 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.1 5.4 GO:0017080 sodium channel regulator activity(GO:0017080)
0.2 5.1 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
1.2 4.8 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)