Motif ID: Esrrb_Esrra

Z-value: 1.212

Transcription factors associated with Esrrb_Esrra:

Gene SymbolEntrez IDGene Name
Esrra ENSMUSG00000024955.7 Esrra
Esrrb ENSMUSG00000021255.11 Esrrb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Esrramm10_v2_chr19_-_6921804_69218340.831.5e-07Click!
Esrrbmm10_v2_chr12_+_86470109_86470122-0.077.4e-01Click!


Activity profile for motif Esrrb_Esrra.

activity profile for motif Esrrb_Esrra


Sorted Z-values histogram for motif Esrrb_Esrra

Sorted Z-values for motif Esrrb_Esrra



Network of associatons between targets according to the STRING database.



First level regulatory network of Esrrb_Esrra

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_141874870 10.835 ENSMUST00000182079.1
 Gm15294
predicted gene 15294
chr7_-_141429351 8.094 ENSMUST00000164387.1
ENSMUST00000137488.1
ENSMUST00000084436.3
 Cend1


cell cycle exit and neuronal differentiation 1


chr7_-_141429433 6.548 ENSMUST00000124444.1
 Cend1
cell cycle exit and neuronal differentiation 1
chr8_+_124793061 5.861 ENSMUST00000041106.7
 Trim67
tripartite motif-containing 67
chr8_+_124793013 5.829 ENSMUST00000167588.1
 Trim67
tripartite motif-containing 67
chr1_-_167393826 5.602 ENSMUST00000028005.2
 Mgst3
microsomal glutathione S-transferase 3
chr10_+_79716588 5.195 ENSMUST00000099513.1
ENSMUST00000020581.2
 Hcn2

hyperpolarization-activated, cyclic nucleotide-gated K+ 2

chr2_+_172345565 5.019 ENSMUST00000028995.4
 Fam210b
family with sequence similarity 210, member B
chr19_-_57314896 4.836 ENSMUST00000111524.1
 Ablim1
actin-binding LIM protein 1
chr1_+_181352618 4.793 ENSMUST00000161880.1
ENSMUST00000027795.7
 Cnih3

cornichon homolog 3 (Drosophila)

chr18_+_45268876 4.706 ENSMUST00000183850.1
ENSMUST00000066890.7
 Kcnn2

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2

chr2_+_178119166 4.623 ENSMUST00000108916.1
 Phactr3
phosphatase and actin regulator 3
chr11_+_7063423 4.506 ENSMUST00000020706.4
 Adcy1
adenylate cyclase 1
chr10_+_80264942 4.383 ENSMUST00000105362.1
ENSMUST00000105361.3
 Dazap1

DAZ associated protein 1

chr2_+_121357714 4.350 ENSMUST00000125812.1
ENSMUST00000078222.2
ENSMUST00000125221.1
ENSMUST00000150271.1
 Ckmt1



creatine kinase, mitochondrial 1, ubiquitous



chr9_+_44043384 4.308 ENSMUST00000114840.1
 Thy1
thymus cell antigen 1, theta
chr6_+_90550789 4.240 ENSMUST00000130418.1
ENSMUST00000032175.8
 Aldh1l1

aldehyde dehydrogenase 1 family, member L1

chr12_+_102554966 4.219 ENSMUST00000021610.5
 Chga
chromogranin A
chr2_+_178118975 4.186 ENSMUST00000108917.1
 Phactr3
phosphatase and actin regulator 3
chr11_+_98741805 4.127 ENSMUST00000064187.5
 Thra
thyroid hormone receptor alpha

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 220 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.9 14.6 GO:0021933 radial glia guided migration of cerebellar granule cell(GO:0021933)
0.4 11.7 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.0 7.6 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.1 7.0 GO:0006342 chromatin silencing(GO:0006342)
0.1 6.1 GO:0032091 negative regulation of protein binding(GO:0032091)
0.1 5.7 GO:0048168 regulation of neuronal synaptic plasticity(GO:0048168)
1.0 5.2 GO:0070305 response to cGMP(GO:0070305) cellular response to cGMP(GO:0071321)
0.1 5.2 GO:0030032 lamellipodium assembly(GO:0030032)
0.2 5.1 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.8 4.9 GO:0046103 inosine biosynthetic process(GO:0046103)
0.2 4.8 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.5 4.5 GO:0071420 cellular response to histamine(GO:0071420)
0.3 4.5 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.7 4.3 GO:0046549 retinal cone cell development(GO:0046549)
1.4 4.2 GO:0042560 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
1.4 4.2 GO:1900736 regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900736)
0.2 4.2 GO:0051560 mitochondrial calcium ion homeostasis(GO:0051560)
1.4 4.1 GO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055)
1.4 4.1 GO:0071929 alpha-tubulin acetylation(GO:0071929)
0.0 4.1 GO:0007179 transforming growth factor beta receptor signaling pathway(GO:0007179)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 100 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.5 GO:0030027 lamellipodium(GO:0030027)
0.1 8.2 GO:0005844 polysome(GO:0005844)
0.1 8.1 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 7.0 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 6.8 GO:0070469 respiratory chain(GO:0070469)
0.4 5.2 GO:0072546 ER membrane protein complex(GO:0072546)
0.2 5.0 GO:0032590 dendrite membrane(GO:0032590)
0.6 4.9 GO:0001520 outer dense fiber(GO:0001520)
0.1 4.8 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 4.6 GO:0045211 postsynaptic membrane(GO:0045211)
0.8 4.2 GO:0042583 chromaffin granule(GO:0042583)
0.7 4.1 GO:0097427 microtubule bundle(GO:0097427)
0.1 4.1 GO:0031902 late endosome membrane(GO:0031902)
0.1 4.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 3.9 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 3.7 GO:0008021 synaptic vesicle(GO:0008021)
0.3 3.6 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
0.3 3.2 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.2 3.2 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.2 3.2 GO:0044300 cerebellar mossy fiber(GO:0044300)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 152 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 11.3 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.6 9.9 GO:0035613 RNA stem-loop binding(GO:0035613)
1.8 7.1 GO:0004111 creatine kinase activity(GO:0004111)
0.3 5.9 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.2 5.4 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 5.3 GO:0043851 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) rRNA methyltransferase activity(GO:0008649) rRNA (uridine-2'-O-)-methyltransferase activity(GO:0008650) rRNA (adenine-N6-)-methyltransferase activity(GO:0008988) rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383) selenocysteine methyltransferase activity(GO:0016205) rRNA (adenine) methyltransferase activity(GO:0016433) rRNA (cytosine) methyltransferase activity(GO:0016434) rRNA (guanine) methyltransferase activity(GO:0016435) rRNA (uridine) methyltransferase activity(GO:0016436) 1-phenanthrol methyltransferase activity(GO:0018707) protein-arginine N5-methyltransferase activity(GO:0019702) dimethylarsinite methyltransferase activity(GO:0034541) 4,5-dihydroxybenzo(a)pyrene methyltransferase activity(GO:0034807) 1-hydroxypyrene methyltransferase activity(GO:0034931) 1-hydroxy-6-methoxypyrene methyltransferase activity(GO:0034933) demethylmenaquinone methyltransferase activity(GO:0043770) cobalt-precorrin-6B C5-methyltransferase activity(GO:0043776) cobalt-precorrin-7 C15-methyltransferase activity(GO:0043777) cobalt-precorrin-5B C1-methyltransferase activity(GO:0043780) cobalt-precorrin-3 C17-methyltransferase activity(GO:0043782) dimethylamine methyltransferase activity(GO:0043791) hydroxyneurosporene-O-methyltransferase activity(GO:0043803) tRNA (adenine-57, 58-N(1)-) methyltransferase activity(GO:0043827) methylamine-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043833) trimethylamine methyltransferase activity(GO:0043834) methanol-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043851) monomethylamine methyltransferase activity(GO:0043852) P-methyltransferase activity(GO:0051994) Se-methyltransferase activity(GO:0051995) 2-phytyl-1,4-naphthoquinone methyltransferase activity(GO:0052624) tRNA (uracil-2'-O-)-methyltransferase activity(GO:0052665) tRNA (cytosine-2'-O-)-methyltransferase activity(GO:0052666) phosphomethylethanolamine N-methyltransferase activity(GO:0052667) tRNA (cytosine-3-)-methyltransferase activity(GO:0052735) rRNA (cytosine-2'-O-)-methyltransferase activity(GO:0070677) rRNA (cytosine-N4-)-methyltransferase activity(GO:0071424) trihydroxyferuloyl spermidine O-methyltransferase activity(GO:0080012)
1.0 5.2 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.2 5.1 GO:0005452 inorganic anion exchanger activity(GO:0005452)
1.2 4.7 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 4.7 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.8 4.5 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.1 4.5 GO:0019905 syntaxin binding(GO:0019905)
0.9 4.3 GO:0034235 GPI anchor binding(GO:0034235)
1.4 4.2 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.7 4.2 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
1.4 4.1 GO:0002153 steroid receptor RNA activator RNA binding(GO:0002153)
0.4 4.1 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 4.1 GO:0016247 channel regulator activity(GO:0016247)
0.1 4.0 GO:0019894 kinesin binding(GO:0019894)
0.1 3.9 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)