Motif ID: Ets2

Z-value: 1.341


Transcription factors associated with Ets2:

Gene SymbolEntrez IDGene Name
Ets2 ENSMUSG00000022895.8 Ets2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ets2mm10_v2_chr16_+_95702044_957020940.715.5e-05Click!


Activity profile for motif Ets2.

activity profile for motif Ets2


Sorted Z-values histogram for motif Ets2

Sorted Z-values for motif Ets2



Network of associatons between targets according to the STRING database.



First level regulatory network of Ets2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_5725639 10.273 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
 Dync1i1


dynein cytoplasmic 1 intermediate chain 1


chr6_+_5725812 8.390 ENSMUST00000115554.1
ENSMUST00000153942.1
 Dync1i1

dynein cytoplasmic 1 intermediate chain 1

chr15_-_66969616 8.008 ENSMUST00000170903.1
ENSMUST00000166420.1
ENSMUST00000005256.6
ENSMUST00000164070.1
 Ndrg1



N-myc downstream regulated gene 1



chr17_+_3397189 7.711 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr1_-_56969827 5.428 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr1_-_56969864 5.111 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr9_-_29411736 4.747 ENSMUST00000115236.1
 Ntm
neurotrimin
chr7_-_4546567 4.658 ENSMUST00000065957.5
 Syt5
synaptotagmin V
chr2_-_156392829 4.494 ENSMUST00000088578.2
 2900097C17Rik
RIKEN cDNA 2900097C17 gene
chr11_+_70647258 4.370 ENSMUST00000037534.7
 Rnf167
ring finger protein 167
chr5_-_44799643 3.929 ENSMUST00000070748.5
 Ldb2
LIM domain binding 2
chr1_+_185454803 3.812 ENSMUST00000061093.6
 Slc30a10
solute carrier family 30, member 10
chr4_+_128058962 3.714 ENSMUST00000184063.1
 Csmd2
CUB and Sushi multiple domains 2
chr2_-_5714490 3.687 ENSMUST00000044009.7
 Camk1d
calcium/calmodulin-dependent protein kinase ID
chr14_+_65969714 3.657 ENSMUST00000153460.1
 Clu
clusterin
chr7_+_44850393 3.652 ENSMUST00000136232.1
 Akt1s1
AKT1 substrate 1 (proline-rich)
chrX_+_170009892 3.311 ENSMUST00000180251.1
 Gm21887
predicted gene, 21887
chrX_+_163908982 3.251 ENSMUST00000069041.8
 Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr7_+_30413744 3.243 ENSMUST00000032800.9
 Tyrobp
TYRO protein tyrosine kinase binding protein
chr11_-_67922136 3.155 ENSMUST00000021288.3
ENSMUST00000108677.1
 Usp43

ubiquitin specific peptidase 43


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 186 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 21.1 GO:0047496 vesicle transport along microtubule(GO:0047496)
0.1 17.3 GO:0007266 Rho protein signal transduction(GO:0007266)
0.7 10.5 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.2 9.1 GO:0036465 synaptic vesicle recycling(GO:0036465)
0.8 8.0 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.2 6.3 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
0.0 5.8 GO:0043087 regulation of GTPase activity(GO:0043087)
0.5 4.3 GO:0002281 macrophage activation involved in immune response(GO:0002281)
0.1 4.1 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.1 4.1 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.1 4.1 GO:0060976 coronary vasculature development(GO:0060976)
0.2 4.0 GO:0045792 negative regulation of cell size(GO:0045792)
0.1 3.9 GO:0015914 phospholipid transport(GO:0015914)
0.1 3.9 GO:0007585 respiratory gaseous exchange(GO:0007585)
0.4 3.8 GO:0061088 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.6 3.7 GO:1902847 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of tau-protein kinase activity(GO:1902949)
0.5 3.7 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.1 3.5 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.3 3.2 GO:0048149 behavioral response to ethanol(GO:0048149)
0.8 3.1 GO:0060715 syncytiotrophoblast cell differentiation involved in labyrinthine layer development(GO:0060715)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 101 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 17.7 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 8.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.3 8.0 GO:0055038 recycling endosome membrane(GO:0055038)
0.2 7.4 GO:0030131 clathrin adaptor complex(GO:0030131)
0.1 6.4 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 5.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.5 5.1 GO:0071439 clathrin complex(GO:0071439)
0.3 4.7 GO:0031045 dense core granule(GO:0031045)
0.0 4.7 GO:0031225 anchored component of membrane(GO:0031225)
0.0 4.6 GO:0043209 myelin sheath(GO:0043209)
0.5 4.1 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.5 3.7 GO:0034366 spherical high-density lipoprotein particle(GO:0034366) neurofibrillary tangle(GO:0097418)
0.3 3.7 GO:0031931 TORC1 complex(GO:0031931)
0.3 3.7 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 3.7 GO:0000139 Golgi membrane(GO:0000139)
0.1 3.1 GO:0031430 M band(GO:0031430)
0.0 3.0 GO:0055037 recycling endosome(GO:0055037)
0.1 2.9 GO:0030673 axolemma(GO:0030673)
0.1 2.8 GO:0032279 asymmetric synapse(GO:0032279)
0.4 2.7 GO:0000235 astral microtubule(GO:0000235)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 119 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.7 18.7 GO:0045503 dynein light chain binding(GO:0045503)
0.1 13.2 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 10.6 GO:0030276 clathrin binding(GO:0030276)
0.2 9.7 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 8.7 GO:0008565 protein transporter activity(GO:0008565)
0.0 7.3 GO:0017124 SH3 domain binding(GO:0017124)
0.0 6.4 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
0.3 6.3 GO:0051787 misfolded protein binding(GO:0051787)
0.2 6.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 4.1 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 4.0 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.4 3.8 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 3.7 GO:0008432 JUN kinase binding(GO:0008432)
0.2 3.1 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 3.1 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.5 3.0 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 2.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 2.7 GO:0003774 motor activity(GO:0003774)
0.1 2.6 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.1 2.6 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)