Motif ID: Etv3_Erf_Fev_Elk4_Elk1_Elk3

Z-value: 0.807

Transcription factors associated with Etv3_Erf_Fev_Elk4_Elk1_Elk3:

Gene SymbolEntrez IDGene Name
Elk1 ENSMUSG00000009406.7 Elk1
Elk3 ENSMUSG00000008398.8 Elk3
Elk4 ENSMUSG00000026436.9 Elk4
Erf ENSMUSG00000040857.9 Erf
Etv3 ENSMUSG00000003382.12 Etv3
Fev ENSMUSG00000055197.4 Fev

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Erfmm10_v2_chr7_-_25250720_25250761-0.751.2e-05Click!
Elk1mm10_v2_chrX_-_20950597_209506130.741.3e-05Click!
Etv3mm10_v2_chr3_+_87525572_87525643-0.461.9e-02Click!
Elk3mm10_v2_chr10_-_93310963_933109890.213.0e-01Click!
Elk4mm10_v2_chr1_+_132007606_132007634-0.213.1e-01Click!


Activity profile for motif Etv3_Erf_Fev_Elk4_Elk1_Elk3.

activity profile for motif Etv3_Erf_Fev_Elk4_Elk1_Elk3


Sorted Z-values histogram for motif Etv3_Erf_Fev_Elk4_Elk1_Elk3

Sorted Z-values for motif Etv3_Erf_Fev_Elk4_Elk1_Elk3



Network of associatons between targets according to the STRING database.



First level regulatory network of Etv3_Erf_Fev_Elk4_Elk1_Elk3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_156312470 4.098 ENSMUST00000079125.6
 Scand1
SCAN domain-containing 1
chr2_+_168230597 3.868 ENSMUST00000099071.3
 Mocs3
molybdenum cofactor synthesis 3
chr2_-_156392829 3.615 ENSMUST00000088578.2
 2900097C17Rik
RIKEN cDNA 2900097C17 gene
chr9_-_29411736 3.263 ENSMUST00000115236.1
 Ntm
neurotrimin
chr2_+_91650169 3.208 ENSMUST00000090614.4
 Arhgap1
Rho GTPase activating protein 1
chr17_+_35135174 3.187 ENSMUST00000166426.2
ENSMUST00000025250.7
 Bag6

BCL2-associated athanogene 6

chr11_+_70647258 3.181 ENSMUST00000037534.7
 Rnf167
ring finger protein 167
chr2_+_91650116 3.154 ENSMUST00000111331.2
 Arhgap1
Rho GTPase activating protein 1
chr7_+_44850393 2.897 ENSMUST00000136232.1
 Akt1s1
AKT1 substrate 1 (proline-rich)
chr6_+_8259288 2.852 ENSMUST00000159335.1
 Gm16039
predicted gene 16039
chr7_-_4546567 2.831 ENSMUST00000065957.5
 Syt5
synaptotagmin V
chr7_+_122067164 2.822 ENSMUST00000033158.4
 Ubfd1
ubiquitin family domain containing 1
chr17_+_33955902 2.759 ENSMUST00000173196.2
 Vps52
vacuolar protein sorting 52 (yeast)
chr17_+_35135196 2.736 ENSMUST00000172571.1
ENSMUST00000173491.1
 Bag6

BCL2-associated athanogene 6

chr14_-_76556662 2.618 ENSMUST00000064517.7
 Serp2
stress-associated endoplasmic reticulum protein family member 2
chr11_-_42182924 2.503 ENSMUST00000020707.5
ENSMUST00000132971.1
 Gabra1

gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1

chr11_+_6200029 2.486 ENSMUST00000181545.1
 A730071L15Rik
RIKEN cDNA A730071L15Rik gene
chr17_+_33955812 2.395 ENSMUST00000025178.9
ENSMUST00000114330.2
 Vps52

vacuolar protein sorting 52 (yeast)

chr6_+_125009232 2.374 ENSMUST00000112428.1
 Zfp384
zinc finger protein 384
chr6_+_8259327 2.300 ENSMUST00000159378.1
 Gm16039
predicted gene 16039

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 360 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 9.2 GO:0036506 maintenance of unfolded protein(GO:0036506) protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.4 6.8 GO:0045792 negative regulation of cell size(GO:0045792)
0.1 6.2 GO:0036465 synaptic vesicle recycling(GO:0036465)
1.7 5.2 GO:0048611 ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611)
0.4 4.5 GO:0051103 DNA ligation involved in DNA repair(GO:0051103)
0.0 4.1 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.0 4.1 GO:0043087 regulation of GTPase activity(GO:0043087)
0.3 4.0 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
1.0 3.9 GO:0018307 enzyme active site formation(GO:0018307)
0.1 3.8 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 3.8 GO:0050714 positive regulation of protein secretion(GO:0050714)
0.2 3.6 GO:0002076 osteoblast development(GO:0002076)
0.2 3.4 GO:0060363 cranial suture morphogenesis(GO:0060363)
0.1 3.2 GO:0035904 aorta development(GO:0035904)
0.0 3.0 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.3 2.9 GO:0071420 cellular response to histamine(GO:0071420)
0.1 2.9 GO:0045761 regulation of adenylate cyclase activity(GO:0045761)
0.3 2.7 GO:0019348 dolichol metabolic process(GO:0019348)
0.1 2.7 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.4 2.5 GO:0044034 negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 166 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 9.2 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.2 8.9 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 8.7 GO:0005794 Golgi apparatus(GO:0005794)
0.2 7.1 GO:0000407 pre-autophagosomal structure(GO:0000407)
1.3 6.5 GO:1990745 EARP complex(GO:1990745)
0.0 5.9 GO:0001726 ruffle(GO:0001726)
0.5 5.8 GO:0031931 TORC1 complex(GO:0031931)
0.0 5.6 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.9 4.5 GO:0032807 DNA ligase IV complex(GO:0032807)
0.1 4.4 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 3.9 GO:0031225 anchored component of membrane(GO:0031225)
0.0 3.9 GO:0005769 early endosome(GO:0005769)
0.0 3.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.4 3.6 GO:0071439 clathrin complex(GO:0071439)
0.3 3.5 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.4 3.4 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 3.2 GO:0005802 trans-Golgi network(GO:0005802)
0.1 3.0 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.2 2.9 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.2 2.8 GO:0031045 dense core granule(GO:0031045)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 222 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 12.4 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
0.1 11.0 GO:0017124 SH3 domain binding(GO:0017124)
0.5 10.0 GO:0070628 proteasome binding(GO:0070628)
0.1 6.6 GO:0008565 protein transporter activity(GO:0008565)
0.1 6.3 GO:0030276 clathrin binding(GO:0030276)
0.1 6.1 GO:0019905 syntaxin binding(GO:0019905)
0.8 3.9 GO:0004792 thiosulfate sulfurtransferase activity(GO:0004792)
0.1 3.3 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 3.0 GO:0008179 adenylate cyclase binding(GO:0008179)
0.2 2.9 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 2.9 GO:0051015 actin filament binding(GO:0051015)
0.5 2.6 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.5 2.4 GO:0071253 connexin binding(GO:0071253)
0.1 2.4 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.1 2.4 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 2.4 GO:0003779 actin binding(GO:0003779)
0.2 2.3 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0 2.3 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 2.2 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 2.2 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)