Motif ID: Etv4

Z-value: 0.968


Transcription factors associated with Etv4:

Gene SymbolEntrez IDGene Name
Etv4 ENSMUSG00000017724.8 Etv4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Etv4mm10_v2_chr11_-_101785252_101785371-0.203.3e-01Click!


Activity profile for motif Etv4.

activity profile for motif Etv4


Sorted Z-values histogram for motif Etv4

Sorted Z-values for motif Etv4



Network of associatons between targets according to the STRING database.



First level regulatory network of Etv4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_56133817 5.898 ENSMUST00000167545.1
 Sema6b
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr15_-_66969616 4.867 ENSMUST00000170903.1
ENSMUST00000166420.1
ENSMUST00000005256.6
ENSMUST00000164070.1
 Ndrg1



N-myc downstream regulated gene 1



chr6_+_5725639 4.154 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
 Dync1i1


dynein cytoplasmic 1 intermediate chain 1


chr15_-_66812593 3.262 ENSMUST00000100572.3
 Sla
src-like adaptor
chr17_+_3397189 3.227 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr6_+_115134899 3.003 ENSMUST00000009538.5
ENSMUST00000169345.1
 Syn2

synapsin II

chr9_-_29411736 2.839 ENSMUST00000115236.1
 Ntm
neurotrimin
chr7_+_45627482 2.828 ENSMUST00000057927.7
 Rasip1
Ras interacting protein 1
chr1_-_56969827 2.528 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr11_-_76509419 2.415 ENSMUST00000094012.4
 Abr
active BCR-related gene
chr17_+_35135174 2.378 ENSMUST00000166426.2
ENSMUST00000025250.7
 Bag6

BCL2-associated athanogene 6

chr6_+_8259288 2.349 ENSMUST00000159335.1
 Gm16039
predicted gene 16039
chr14_-_76556662 2.314 ENSMUST00000064517.7
 Serp2
stress-associated endoplasmic reticulum protein family member 2
chr3_+_95526777 2.278 ENSMUST00000015667.2
ENSMUST00000116304.2
 Ctss

cathepsin S

chr9_+_107935876 2.261 ENSMUST00000035700.8
 Camkv
CaM kinase-like vesicle-associated
chr17_+_74489492 2.227 ENSMUST00000024873.6
 Yipf4
Yip1 domain family, member 4
chr7_-_27181149 2.214 ENSMUST00000071986.6
ENSMUST00000121848.1
 Mia

melanoma inhibitory activity

chr1_-_56969864 2.165 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr13_+_83504032 2.152 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr13_+_109632760 2.142 ENSMUST00000135275.1
 Pde4d
phosphodiesterase 4D, cAMP specific

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 257 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 7.2 GO:0036506 maintenance of unfolded protein(GO:0036506) protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.1 5.9 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843)
0.0 5.4 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.4 4.4 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.1 4.2 GO:0047496 vesicle transport along microtubule(GO:0047496)
0.3 3.3 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.2 3.3 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.0 3.1 GO:0060976 coronary vasculature development(GO:0060976)
0.0 3.0 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
0.2 2.8 GO:0045792 negative regulation of cell size(GO:0045792)
0.1 2.8 GO:0010507 negative regulation of autophagy(GO:0010507)
0.6 2.5 GO:0060715 syncytiotrophoblast cell differentiation involved in labyrinthine layer development(GO:0060715)
0.0 2.5 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.5 2.4 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313)
0.5 2.3 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.7 2.2 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
0.2 2.2 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.2 2.2 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.2 2.2 GO:0010447 response to acidic pH(GO:0010447)
0.1 2.2 GO:0001893 maternal placenta development(GO:0001893)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 138 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 7.2 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.1 5.0 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 4.9 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 4.6 GO:0031225 anchored component of membrane(GO:0031225)
0.3 3.3 GO:0071439 clathrin complex(GO:0071439)
0.1 3.3 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 3.3 GO:0043204 perikaryon(GO:0043204)
0.0 3.2 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 3.0 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.3 2.8 GO:0031931 TORC1 complex(GO:0031931)
0.1 2.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 2.7 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.2 2.6 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 2.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.2 2.2 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 2.2 GO:0031430 M band(GO:0031430)
0.5 2.1 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.1 2.0 GO:0030673 axolemma(GO:0030673)
0.0 2.0 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 2.0 GO:0043198 dendritic shaft(GO:0043198)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 158 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.2 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.4 7.4 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.1 6.5 GO:0045296 cadherin binding(GO:0045296)
0.2 5.9 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 5.7 GO:0017124 SH3 domain binding(GO:0017124)
0.8 4.2 GO:0045503 dynein light chain binding(GO:0045503)
0.1 3.5 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.2 3.0 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.1 2.5 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.3 2.3 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.2 2.3 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.0 2.3 GO:0008083 growth factor activity(GO:0008083)
0.3 2.2 GO:0030375 thyroid hormone receptor coactivator activity(GO:0030375)
0.1 2.2 GO:0015026 coreceptor activity(GO:0015026)
0.1 2.2 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 2.2 GO:0035198 miRNA binding(GO:0035198)
0.1 2.2 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 2.2 GO:0043236 laminin binding(GO:0043236)
0.0 2.1 GO:0030276 clathrin binding(GO:0030276)
0.5 1.9 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)