Motif ID: Evx2

Z-value: 0.753


Transcription factors associated with Evx2:

Gene SymbolEntrez IDGene Name
Evx2 ENSMUSG00000001815.9 Evx2



Activity profile for motif Evx2.

activity profile for motif Evx2


Sorted Z-values histogram for motif Evx2

Sorted Z-values for motif Evx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Evx2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_168767136 4.667 ENSMUST00000029061.5
ENSMUST00000103074.1
 Sall4

sal-like 4 (Drosophila)

chr2_-_168767029 3.085 ENSMUST00000075044.3
 Sall4
sal-like 4 (Drosophila)
chrX_-_60893430 2.587 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr18_-_88927447 1.992 ENSMUST00000147313.1
 Socs6
suppressor of cytokine signaling 6
chrX_+_58030999 1.861 ENSMUST00000088631.4
ENSMUST00000088629.3
 Zic3

zinc finger protein of the cerebellum 3

chr4_-_132075250 1.768 ENSMUST00000105970.1
ENSMUST00000105975.1
 Epb4.1

erythrocyte protein band 4.1

chr13_+_51645232 1.553 ENSMUST00000075853.5
 Cks2
CDC28 protein kinase regulatory subunit 2
chr4_-_132345686 1.493 ENSMUST00000030726.6
 Rcc1
regulator of chromosome condensation 1
chr4_-_132345715 1.481 ENSMUST00000084250.4
 Rcc1
regulator of chromosome condensation 1
chr17_+_17402672 1.470 ENSMUST00000115576.2
 Lix1
limb expression 1 homolog (chicken)
chr2_+_119047116 1.468 ENSMUST00000152380.1
ENSMUST00000099542.2
 Casc5

cancer susceptibility candidate 5

chrX_+_58030622 1.444 ENSMUST00000088627.4
 Zic3
zinc finger protein of the cerebellum 3
chr14_+_62292475 1.438 ENSMUST00000166879.1
 Rnaseh2b
ribonuclease H2, subunit B
chr6_-_124779686 1.382 ENSMUST00000147669.1
ENSMUST00000128697.1
ENSMUST00000032218.3
ENSMUST00000112475.2
 Lrrc23



leucine rich repeat containing 23



chr10_-_8886033 1.381 ENSMUST00000015449.5
 Sash1
SAM and SH3 domain containing 1
chr2_+_119047129 1.379 ENSMUST00000153300.1
ENSMUST00000028799.5
 Casc5

cancer susceptibility candidate 5

chr7_-_126800354 1.271 ENSMUST00000106348.1
 Aldoa
aldolase A, fructose-bisphosphate
chr2_-_155074447 1.166 ENSMUST00000137242.1
ENSMUST00000054607.9
 Ahcy

S-adenosylhomocysteine hydrolase

chr4_+_109978004 1.164 ENSMUST00000061187.3
 Dmrta2
doublesex and mab-3 related transcription factor like family A2
chr2_+_91256813 1.101 ENSMUST00000144394.1
ENSMUST00000028694.5
ENSMUST00000168916.1
ENSMUST00000156919.1
 Pacsin3



protein kinase C and casein kinase substrate in neurons 3



chr15_+_34453285 1.072 ENSMUST00000060894.7
 BC030476
cDNA sequence BC030476
chr9_-_66514567 1.063 ENSMUST00000056890.8
 Fbxl22
F-box and leucine-rich repeat protein 22
chr2_+_91257323 1.045 ENSMUST00000111349.2
ENSMUST00000131711.1
 Pacsin3

protein kinase C and casein kinase substrate in neurons 3

chr4_-_129227883 1.038 ENSMUST00000106051.1
 C77080
expressed sequence C77080
chr5_-_98030727 1.013 ENSMUST00000031281.9
 Antxr2
anthrax toxin receptor 2
chr13_+_38204928 1.007 ENSMUST00000091641.5
ENSMUST00000178564.1
 Snrnp48

small nuclear ribonucleoprotein 48 (U11/U12)

chr7_+_51879041 0.993 ENSMUST00000107591.2
 Gas2
growth arrest specific 2
chr7_-_143460989 0.920 ENSMUST00000167912.1
ENSMUST00000037287.6
 Cdkn1c

cyclin-dependent kinase inhibitor 1C (P57)

chr9_+_47530173 0.873 ENSMUST00000114548.1
ENSMUST00000152459.1
ENSMUST00000143026.1
ENSMUST00000085909.2
ENSMUST00000114547.1
ENSMUST00000034581.3
 Cadm1





cell adhesion molecule 1





chr11_+_60537978 0.873 ENSMUST00000044250.3
 Alkbh5
alkB, alkylation repair homolog 5 (E. coli)
chrX_-_111536325 0.822 ENSMUST00000156639.1
 Rps6ka6
ribosomal protein S6 kinase polypeptide 6
chr19_+_47067721 0.683 ENSMUST00000026027.5
 Taf5
TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr4_+_140701466 0.683 ENSMUST00000038893.5
ENSMUST00000138808.1
 Rcc2

regulator of chromosome condensation 2

chr18_+_9958147 0.658 ENSMUST00000025137.7
 Thoc1
THO complex 1
chr14_+_48446128 0.550 ENSMUST00000124720.1
 Tmem260
transmembrane protein 260
chrX_-_57338598 0.480 ENSMUST00000033468.4
ENSMUST00000114736.1
 Arhgef6

Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6

chr7_+_27927592 0.469 ENSMUST00000181644.1
 Gm26891
predicted gene, 26891
chr17_-_47834682 0.434 ENSMUST00000066368.6
 Mdfi
MyoD family inhibitor
chr10_+_70175011 0.408 ENSMUST00000156001.1
ENSMUST00000135607.1
 Ccdc6

coiled-coil domain containing 6

chr8_-_31168699 0.385 ENSMUST00000033983.4
 Mak16
MAK16 homolog (S. cerevisiae)
chr12_-_98577940 0.373 ENSMUST00000110113.1
 Kcnk10
potassium channel, subfamily K, member 10
chr14_+_73173825 0.346 ENSMUST00000166875.1
 Rcbtb2
regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr9_-_85749308 0.301 ENSMUST00000039213.8
 Ibtk
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr6_-_69400097 0.292 ENSMUST00000177795.1
 Igkv4-62
immunoglobulin kappa variable 4-62
chr10_-_128525859 0.291 ENSMUST00000026427.6
 Esyt1
extended synaptotagmin-like protein 1
chr3_+_121291725 0.291 ENSMUST00000039442.7
 Alg14
asparagine-linked glycosylation 14
chr4_-_42661893 0.288 ENSMUST00000108006.3
 Il11ra2
interleukin 11 receptor, alpha chain 2
chr17_+_36837123 0.278 ENSMUST00000179968.1
ENSMUST00000130367.1
ENSMUST00000130801.1
ENSMUST00000144182.1
ENSMUST00000123715.1
ENSMUST00000053434.8
 Trim26





tripartite motif-containing 26





chr8_+_92855319 0.257 ENSMUST00000046290.1
 Lpcat2
lysophosphatidylcholine acyltransferase 2
chr12_+_52699297 0.224 ENSMUST00000095737.3
 Akap6
A kinase (PRKA) anchor protein 6
chr6_-_69284319 0.209 ENSMUST00000103349.1
 Igkv4-69
immunoglobulin kappa variable 4-69
chr13_-_67332525 0.195 ENSMUST00000168892.1
ENSMUST00000109735.2
 Zfp595

zinc finger protein 595

chr3_+_94837702 0.117 ENSMUST00000107266.1
ENSMUST00000042402.5
ENSMUST00000107269.1
 Pogz


pogo transposable element with ZNF domain


chr12_+_109545390 0.089 ENSMUST00000146701.1
 Meg3
maternally expressed 3
chr2_-_84715160 0.085 ENSMUST00000035840.5
 Zdhhc5
zinc finger, DHHC domain containing 5
chr14_-_59365410 0.073 ENSMUST00000161031.1
ENSMUST00000160425.1
 Phf11d

PHD finger protein 11D

chr2_+_154548888 0.051 ENSMUST00000045116.4
ENSMUST00000109709.3
 1700003F12Rik

RIKEN cDNA 1700003F12 gene

chr8_-_35495487 0.045 ENSMUST00000033927.6
 Eri1
exoribonuclease 1
chr4_+_100478806 0.029 ENSMUST00000133493.2
ENSMUST00000092730.3
ENSMUST00000106979.3
 Ube2u


ubiquitin-conjugating enzyme E2U (putative)


chr3_-_130709419 0.015 ENSMUST00000043937.7
 Ostc
oligosaccharyltransferase complex subunit
chr2_-_132247747 0.002 ENSMUST00000110163.1
ENSMUST00000180286.1
ENSMUST00000028816.2
 Tmem230


transmembrane protein 230



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.3 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.5 1.4 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.4 7.8 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.3 0.9 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.2 3.5 GO:0034501 protein localization to kinetochore(GO:0034501)
0.2 0.7 GO:0048296 isotype switching to IgA isotypes(GO:0048290) regulation of isotype switching to IgA isotypes(GO:0048296)
0.2 0.9 GO:0035553 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.1 1.2 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 2.6 GO:0007530 sex determination(GO:0007530)
0.1 1.3 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 2.1 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 1.4 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.1 1.2 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.1 0.8 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.1 0.3 GO:0046469 platelet activating factor biosynthetic process(GO:0006663) platelet activating factor metabolic process(GO:0046469)
0.1 1.5 GO:0097352 autophagosome maturation(GO:0097352)
0.1 0.2 GO:0032512 regulation of protein phosphatase type 2B activity(GO:0032512) positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.0 0.9 GO:0060065 uterus development(GO:0060065)
0.0 0.4 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 3.0 GO:0007052 mitotic spindle organization(GO:0007052)
0.0 2.0 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.4 GO:0060707 trophoblast giant cell differentiation(GO:0060707)
0.0 1.0 GO:1901998 toxin transport(GO:1901998)
0.0 1.5 GO:0007127 meiosis I(GO:0007127)
0.0 0.3 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.0 0.4 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.0 0.7 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.1 0.7 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.1 0.9 GO:0070852 cell body fiber(GO:0070852)
0.1 9.1 GO:0000792 heterochromatin(GO:0000792)
0.1 0.7 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 2.0 GO:0001772 immunological synapse(GO:0001772)
0.0 3.2 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 3.0 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 0.7 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 1.0 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.3 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 1.1 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.2 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.4 GO:0030687 preribosome, large subunit precursor(GO:0030687)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.0 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.2 0.9 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.2 1.3 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.2 1.4 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.2 1.2 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 2.1 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 0.3 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.1 0.3 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.1 2.6 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 0.9 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 1.6 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 1.4 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 0.4 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.2 GO:0043495 protein anchor(GO:0043495)
0.0 2.0 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 0.0 GO:0071207 histone pre-mRNA stem-loop binding(GO:0071207)
0.0 12.4 GO:0044212 transcription regulatory region DNA binding(GO:0044212)
0.0 0.7 GO:0048365 Rac GTPase binding(GO:0048365)