Motif ID: Ezh2_Atf2_Ikzf1

Z-value: 2.128

Transcription factors associated with Ezh2_Atf2_Ikzf1:

Gene SymbolEntrez IDGene Name
Atf2 ENSMUSG00000027104.12 Atf2
Ezh2 ENSMUSG00000029687.10 Ezh2
Ikzf1 ENSMUSG00000018654.11 Ikzf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Atf2mm10_v2_chr2_-_73892588_738926160.544.8e-03Click!
Ezh2mm10_v2_chr6_-_47594967_47595047-0.491.0e-02Click!


Activity profile for motif Ezh2_Atf2_Ikzf1.

activity profile for motif Ezh2_Atf2_Ikzf1


Sorted Z-values histogram for motif Ezh2_Atf2_Ikzf1

Sorted Z-values for motif Ezh2_Atf2_Ikzf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Ezh2_Atf2_Ikzf1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_141524379 11.016 ENSMUST00000032362.9
 Slco1c1
solute carrier organic anion transporter family, member 1c1
chr9_-_117252450 10.621 ENSMUST00000111773.3
ENSMUST00000068962.7
ENSMUST00000044901.7
 Rbms3


RNA binding motif, single stranded interacting protein


chr14_-_79771305 10.017 ENSMUST00000039568.5
 Pcdh8
protocadherin 8
chr9_+_27790947 9.229 ENSMUST00000115243.2
 Opcml
opioid binding protein/cell adhesion molecule-like
chr16_+_45094036 8.771 ENSMUST00000061050.5
 Ccdc80
coiled-coil domain containing 80
chr16_+_45093611 8.011 ENSMUST00000099498.2
 Ccdc80
coiled-coil domain containing 80
chr10_-_102490418 8.004 ENSMUST00000020040.3
 Nts
neurotensin
chr8_+_57455898 7.390 ENSMUST00000034023.3
 Scrg1
scrapie responsive gene 1
chr1_-_154725920 7.073 ENSMUST00000004214.8
 Cacna1e
calcium channel, voltage-dependent, R type, alpha 1E subunit
chr19_+_26623419 7.004 ENSMUST00000176584.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr2_+_152081529 6.511 ENSMUST00000064061.3
 Scrt2
scratch homolog 2, zinc finger protein (Drosophila)
chr13_+_42709482 6.427 ENSMUST00000066928.5
ENSMUST00000148891.1
 Phactr1

phosphatase and actin regulator 1

chr19_-_28911879 6.286 ENSMUST00000179171.1
 AC163993.1
AC163993.1
chr12_-_78980758 6.232 ENSMUST00000174072.1
 Tmem229b
transmembrane protein 229B
chr1_-_56978534 5.884 ENSMUST00000177282.1
 Satb2
special AT-rich sequence binding protein 2
chr4_-_82505749 5.866 ENSMUST00000107245.2
ENSMUST00000107246.1
 Nfib

nuclear factor I/B

chr1_-_169747634 5.688 ENSMUST00000027991.5
ENSMUST00000111357.1
 Rgs4

regulator of G-protein signaling 4

chr2_+_4300462 5.678 ENSMUST00000175669.1
 Frmd4a
FERM domain containing 4A
chr3_-_82145865 5.624 ENSMUST00000048976.6
 Gucy1a3
guanylate cyclase 1, soluble, alpha 3
chr1_-_56969827 5.498 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 366 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 22.4 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2 15.1 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.4 14.9 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.8 12.4 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
2.7 11.0 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
1.1 10.8 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.5 10.8 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.1 10.3 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.3 9.9 GO:0001919 regulation of receptor recycling(GO:0001919)
0.2 9.6 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
1.0 9.2 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.3 9.1 GO:0035640 exploration behavior(GO:0035640)
1.7 8.7 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.3 8.2 GO:2000463 positive regulation of excitatory postsynaptic potential(GO:2000463)
0.6 8.0 GO:0021540 corpus callosum morphogenesis(GO:0021540)
0.2 7.8 GO:2001222 regulation of neuron migration(GO:2001222)
0.1 7.6 GO:0001578 microtubule bundle formation(GO:0001578)
0.2 7.4 GO:0008542 visual learning(GO:0008542)
2.4 7.3 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.7 6.7 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 160 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 37.2 GO:0016021 integral component of membrane(GO:0016021)
0.4 25.8 GO:0042734 presynaptic membrane(GO:0042734)
0.1 24.7 GO:0045211 postsynaptic membrane(GO:0045211)
1.2 19.5 GO:0005614 interstitial matrix(GO:0005614)
0.4 15.3 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 14.2 GO:0000118 histone deacetylase complex(GO:0000118)
0.6 12.6 GO:0016514 SWI/SNF complex(GO:0016514)
0.6 12.6 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.2 12.4 GO:0030315 T-tubule(GO:0030315)
0.0 9.9 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 9.1 GO:0044306 neuron projection terminus(GO:0044306)
0.5 8.7 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.7 8.2 GO:0043083 synaptic cleft(GO:0043083)
0.0 8.0 GO:0043209 myelin sheath(GO:0043209)
0.8 7.4 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 6.8 GO:0043204 perikaryon(GO:0043204)
0.7 6.7 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 6.5 GO:0031225 anchored component of membrane(GO:0031225)
0.2 6.0 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.4 5.9 GO:0032279 asymmetric synapse(GO:0032279)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 260 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 23.6 GO:0005509 calcium ion binding(GO:0005509)
0.6 16.3 GO:0001968 fibronectin binding(GO:0001968)
0.8 13.7 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.0 11.3 GO:0015631 tubulin binding(GO:0015631)
2.8 11.0 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.5 10.9 GO:0005184 neuropeptide hormone activity(GO:0005184)
1.5 10.5 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.9 10.3 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 9.4 GO:0017124 SH3 domain binding(GO:0017124)
0.6 9.0 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.5 8.7 GO:0004890 GABA-A receptor activity(GO:0004890)
0.3 8.3 GO:0017075 syntaxin-1 binding(GO:0017075)
0.2 8.1 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.3 7.5 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.1 7.2 GO:0005516 calmodulin binding(GO:0005516)
0.9 6.9 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.7 6.7 GO:0004383 guanylate cyclase activity(GO:0004383)
1.3 6.5 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
1.6 6.3 GO:0004111 creatine kinase activity(GO:0004111)
0.1 6.1 GO:0003730 mRNA 3'-UTR binding(GO:0003730)