Motif ID: Fosl2_Bach2

Z-value: 1.026

Transcription factors associated with Fosl2_Bach2:

Gene SymbolEntrez IDGene Name
Bach2 ENSMUSG00000040270.10 Bach2
Fosl2 ENSMUSG00000029135.9 Fosl2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Fosl2mm10_v2_chr5_+_32136458_321365050.782.1e-06Click!
Bach2mm10_v2_chr4_+_32238713_322388040.212.9e-01Click!


Activity profile for motif Fosl2_Bach2.

activity profile for motif Fosl2_Bach2


Sorted Z-values histogram for motif Fosl2_Bach2

Sorted Z-values for motif Fosl2_Bach2



Network of associatons between targets according to the STRING database.



First level regulatory network of Fosl2_Bach2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_33907721 10.208 ENSMUST00000115161.1
ENSMUST00000062289.8
 Bend6

BEN domain containing 6

chr14_+_65968483 8.013 ENSMUST00000022616.6
 Clu
clusterin
chr7_+_126776939 6.301 ENSMUST00000038614.5
ENSMUST00000170882.1
ENSMUST00000106359.1
ENSMUST00000106357.1
ENSMUST00000145762.1
ENSMUST00000132643.1
ENSMUST00000106356.1
 Ypel3






yippee-like 3 (Drosophila)






chr6_+_17463927 5.296 ENSMUST00000115442.1
 Met
met proto-oncogene
chr6_+_124996681 4.926 ENSMUST00000032479.4
 Pianp
PILR alpha associated neural protein
chr3_+_55461758 4.913 ENSMUST00000070418.4
 Dclk1
doublecortin-like kinase 1
chr13_+_54949388 4.886 ENSMUST00000026994.7
ENSMUST00000109994.2
 Unc5a

unc-5 homolog A (C. elegans)

chr13_-_54611274 4.848 ENSMUST00000049575.7
 Cltb
clathrin, light polypeptide (Lcb)
chr9_-_20728219 4.764 ENSMUST00000034692.7
 Olfm2
olfactomedin 2
chr7_-_105482197 4.462 ENSMUST00000047040.2
 Prkcdbp
protein kinase C, delta binding protein
chr18_+_32938955 4.376 ENSMUST00000042868.4
 Camk4
calcium/calmodulin-dependent protein kinase IV
chr3_-_88503187 4.340 ENSMUST00000120377.1
 Lmna
lamin A
chr13_-_54611332 4.268 ENSMUST00000091609.4
 Cltb
clathrin, light polypeptide (Lcb)
chr3_-_88503331 4.213 ENSMUST00000029699.6
 Lmna
lamin A
chr8_+_95703037 3.852 ENSMUST00000073139.7
ENSMUST00000080666.7
 Ndrg4

N-myc downstream regulated gene 4

chr7_+_127244511 3.789 ENSMUST00000052509.4
 Zfp771
zinc finger protein 771
chr2_+_32628390 3.724 ENSMUST00000156578.1
 Ak1
adenylate kinase 1
chr18_+_37955544 3.721 ENSMUST00000070709.2
ENSMUST00000177058.1
ENSMUST00000169360.2
ENSMUST00000163591.2
ENSMUST00000091932.5
 Rell2




RELT-like 2




chr12_+_31265279 3.585 ENSMUST00000002979.8
ENSMUST00000170495.1
 Lamb1

laminin B1

chr6_-_124769548 3.552 ENSMUST00000149652.1
ENSMUST00000112476.1
ENSMUST00000004378.8
 Eno2


enolase 2, gamma neuronal



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 135 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 10.2 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.1 9.8 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
1.0 8.8 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
2.1 8.6 GO:1904177 regulation of adipose tissue development(GO:1904177)
1.3 8.0 GO:1902847 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of tau-protein kinase activity(GO:1902949)
1.6 6.5 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.7 6.5 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
1.6 6.3 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.6 4.9 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.1 4.9 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
1.5 4.5 GO:0043465 regulation of fermentation(GO:0043465) negative regulation of fermentation(GO:1901003)
1.1 4.5 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
0.7 4.5 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.5 4.5 GO:1902993 positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.4 3.9 GO:2001135 regulation of endocytic recycling(GO:2001135)
0.6 3.8 GO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804)
0.6 3.7 GO:0046103 ADP biosynthetic process(GO:0006172) inosine biosynthetic process(GO:0046103)
0.5 3.7 GO:0032261 purine nucleotide salvage(GO:0032261) IMP salvage(GO:0032264)
0.2 3.7 GO:0044804 nucleophagy(GO:0044804)
0.3 3.6 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 13.7 GO:0042734 presynaptic membrane(GO:0042734)
0.8 9.1 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
1.2 8.6 GO:0005638 lamin filament(GO:0005638)
1.1 8.0 GO:0034366 spherical high-density lipoprotein particle(GO:0034366) neurofibrillary tangle(GO:0097418)
0.0 7.2 GO:0016324 apical plasma membrane(GO:0016324)
0.1 7.1 GO:0005604 basement membrane(GO:0005604)
0.1 6.7 GO:0009925 basal plasma membrane(GO:0009925)
1.6 6.5 GO:0043259 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259)
0.1 4.9 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 4.9 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.1 4.8 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 4.7 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 3.9 GO:0045335 phagocytic vesicle(GO:0045335)
0.5 3.7 GO:0001520 outer dense fiber(GO:0001520)
0.7 3.6 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.2 3.3 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 3.3 GO:0043198 dendritic shaft(GO:0043198)
0.0 3.0 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 2.9 GO:0043679 axon terminus(GO:0043679)
0.6 2.6 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 100 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 10.2 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
1.0 9.1 GO:0032050 clathrin heavy chain binding(GO:0032050)
2.2 8.8 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.3 8.6 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.3 8.0 GO:0051787 misfolded protein binding(GO:0051787)
0.1 6.9 GO:0005080 protein kinase C binding(GO:0005080)
0.8 6.5 GO:0043208 glycosphingolipid binding(GO:0043208)
0.1 6.4 GO:0005518 collagen binding(GO:0005518)
0.1 6.1 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 5.9 GO:0017075 syntaxin-1 binding(GO:0017075)
0.2 5.8 GO:0042805 actinin binding(GO:0042805)
0.1 5.8 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 5.1 GO:0070412 R-SMAD binding(GO:0070412)
0.8 4.9 GO:0005042 netrin receptor activity(GO:0005042)
0.2 4.4 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 3.8 GO:0043531 ADP binding(GO:0043531)
0.5 3.7 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.3 3.7 GO:0004017 adenylate kinase activity(GO:0004017)
0.4 3.6 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.2 3.4 GO:0042608 T cell receptor binding(GO:0042608)