Motif ID: Foxa2_Foxa1

Z-value: 1.871

Transcription factors associated with Foxa2_Foxa1:

Gene SymbolEntrez IDGene Name
Foxa1 ENSMUSG00000035451.6 Foxa1
Foxa2 ENSMUSG00000037025.5 Foxa2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxa1mm10_v2_chr12_-_57546121_575461410.242.3e-01Click!
Foxa2mm10_v2_chr2_-_148046896_1480469910.125.8e-01Click!


Activity profile for motif Foxa2_Foxa1.

activity profile for motif Foxa2_Foxa1


Sorted Z-values histogram for motif Foxa2_Foxa1

Sorted Z-values for motif Foxa2_Foxa1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxa2_Foxa1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_48662740 12.637 ENSMUST00000122009.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr17_-_70851710 12.325 ENSMUST00000166395.2
 Tgif1
TGFB-induced factor homeobox 1
chr6_+_5390387 10.208 ENSMUST00000183358.1
 Asb4
ankyrin repeat and SOCS box-containing 4
chr12_-_56535047 9.727 ENSMUST00000178477.2
 Nkx2-1
NK2 homeobox 1
chr14_+_73237891 9.291 ENSMUST00000044405.6
 Lpar6
lysophosphatidic acid receptor 6
chr4_-_58499398 8.898 ENSMUST00000107570.1
 Lpar1
lysophosphatidic acid receptor 1
chr4_+_11191726 8.138 ENSMUST00000029866.9
ENSMUST00000108324.3
 Ccne2

cyclin E2

chr2_+_14873656 7.418 ENSMUST00000114718.1
ENSMUST00000114719.1
 Cacnb2

calcium channel, voltage-dependent, beta 2 subunit

chr18_-_47333311 7.407 ENSMUST00000126684.1
ENSMUST00000156422.1
 Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

chr1_+_12718496 6.518 ENSMUST00000088585.3
 Sulf1
sulfatase 1
chr1_-_138619687 6.394 ENSMUST00000027642.2
 Nek7
NIMA (never in mitosis gene a)-related expressed kinase 7
chr13_-_60177357 6.372 ENSMUST00000065086.4
 Gas1
growth arrest specific 1
chr4_+_11191354 5.811 ENSMUST00000170901.1
 Ccne2
cyclin E2
chr12_-_99883429 5.768 ENSMUST00000046485.3
 Efcab11
EF-hand calcium binding domain 11
chr2_+_25180737 5.760 ENSMUST00000104999.2
 Nrarp
Notch-regulated ankyrin repeat protein
chr18_-_60501983 5.349 ENSMUST00000042710.6
 Smim3
small integral membrane protein 3
chr2_-_70825726 5.202 ENSMUST00000038584.8
 Tlk1
tousled-like kinase 1
chr2_-_172940299 5.010 ENSMUST00000009143.7
 Bmp7
bone morphogenetic protein 7
chr17_+_29090969 4.987 ENSMUST00000119901.1
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr12_+_71016658 4.530 ENSMUST00000125125.1
 Arid4a
AT rich interactive domain 4A (RBP1-like)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 141 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 17.0 GO:0006270 DNA replication initiation(GO:0006270)
0.9 13.9 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
4.2 12.6 GO:0021759 globus pallidus development(GO:0021759)
3.2 12.6 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
1.1 12.1 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
1.0 10.2 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.5 10.0 GO:0007638 mechanosensory behavior(GO:0007638)
0.9 9.5 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
2.2 8.9 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.7 8.0 GO:0060539 diaphragm development(GO:0060539)
2.5 7.4 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.4 7.4 GO:2001224 positive regulation of neuron migration(GO:2001224)
1.1 6.9 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.6 6.5 GO:0060686 negative regulation of prostatic bud formation(GO:0060686)
0.7 6.4 GO:0090399 replicative senescence(GO:0090399)
0.6 6.4 GO:0042473 outer ear morphogenesis(GO:0042473)
0.3 6.4 GO:1904355 positive regulation of telomere capping(GO:1904355)
0.2 6.1 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.5 5.8 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
1.1 5.6 GO:0031860 telomeric 3' overhang formation(GO:0031860)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 13.3 GO:0005667 transcription factor complex(GO:0005667)
0.1 10.7 GO:0030426 growth cone(GO:0030426)
2.6 10.2 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.9 10.1 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.1 10.1 GO:0031225 anchored component of membrane(GO:0031225)
0.1 8.9 GO:0043198 dendritic shaft(GO:0043198)
0.7 7.4 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 6.5 GO:0005887 integral component of plasma membrane(GO:0005887)
0.9 5.6 GO:0030870 Mre11 complex(GO:0030870)
0.2 5.6 GO:0046658 anchored component of plasma membrane(GO:0046658)
1.7 5.0 GO:0070557 PCNA-p21 complex(GO:0070557)
0.6 5.0 GO:0030478 actin cap(GO:0030478)
0.0 4.8 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 4.6 GO:0005719 nuclear euchromatin(GO:0005719)
0.5 3.8 GO:0001940 male pronucleus(GO:0001940)
0.4 3.2 GO:0033269 internode region of axon(GO:0033269)
0.1 3.1 GO:0005871 kinesin complex(GO:0005871)
0.2 3.0 GO:0042555 MCM complex(GO:0042555)
0.0 3.0 GO:0030496 midbody(GO:0030496)
0.1 2.7 GO:0001772 immunological synapse(GO:0001772)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 102 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 38.4 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.4 18.9 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
1.3 15.1 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.6 12.3 GO:0070410 co-SMAD binding(GO:0070410)
2.0 11.9 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.4 10.2 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 8.2 GO:0004930 G-protein coupled receptor activity(GO:0004930)
1.5 7.4 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.1 7.2 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
1.3 6.5 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.6 5.6 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.2 5.5 GO:0005521 lamin binding(GO:0005521)
0.1 5.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 5.1 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.5 5.0 GO:0070700 BMP receptor binding(GO:0070700)
1.5 4.4 GO:0016015 morphogen activity(GO:0016015)
0.0 4.1 GO:0051015 actin filament binding(GO:0051015)
1.0 4.0 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 3.5 GO:0005096 GTPase activator activity(GO:0005096)
0.2 3.2 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)