Motif ID: Foxc1

Z-value: 0.746


Transcription factors associated with Foxc1:

Gene SymbolEntrez IDGene Name
Foxc1 ENSMUSG00000050295.2 Foxc1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxc1mm10_v2_chr13_+_31806627_318066500.213.1e-01Click!


Activity profile for motif Foxc1.

activity profile for motif Foxc1


Sorted Z-values histogram for motif Foxc1

Sorted Z-values for motif Foxc1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxc1

PNG image of the network

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Top targets:


Showing 1 to 20 of 165 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_53525703 2.314 ENSMUST00000081132.4
 Gm5449
predicted pseudogene 5449
chr19_+_60144682 1.245 ENSMUST00000065383.4
 E330013P04Rik
RIKEN cDNA E330013P04 gene
chrY_+_1010543 1.204 ENSMUST00000091197.3
 Eif2s3y
eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked
chr17_+_80944611 1.167 ENSMUST00000025092.4
 Tmem178
transmembrane protein 178
chr1_-_71653162 1.049 ENSMUST00000055226.6
 Fn1
fibronectin 1
chr1_+_107511489 1.010 ENSMUST00000064916.2
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr11_+_73160403 0.986 ENSMUST00000006104.3
 P2rx5
purinergic receptor P2X, ligand-gated ion channel, 5
chr1_+_107511416 0.959 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr17_-_70851710 0.943 ENSMUST00000166395.2
 Tgif1
TGFB-induced factor homeobox 1
chr7_-_75308373 0.886 ENSMUST00000085164.5
 Sv2b
synaptic vesicle glycoprotein 2 b
chr1_+_45311538 0.842 ENSMUST00000087883.6
 Col3a1
collagen, type III, alpha 1
chr15_-_66948419 0.784 ENSMUST00000167817.1
 Ndrg1
N-myc downstream regulated gene 1
chr1_+_72824482 0.773 ENSMUST00000047328.4
 Igfbp2
insulin-like growth factor binding protein 2
chr3_+_94377432 0.761 ENSMUST00000107292.1
 Rorc
RAR-related orphan receptor gamma
chr1_+_84839833 0.725 ENSMUST00000097672.3
 Fbxo36
F-box protein 36
chr3_+_94377505 0.709 ENSMUST00000098877.2
 Rorc
RAR-related orphan receptor gamma
chr13_+_23934434 0.679 ENSMUST00000072391.1
 Hist1h2aa
histone cluster 1, H2aa
chr17_+_3397189 0.672 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr6_+_47244359 0.648 ENSMUST00000060839.6
 Cntnap2
contactin associated protein-like 2
chr11_+_32300069 0.627 ENSMUST00000020535.1
 Hbq1a
hemoglobin, theta 1A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.0 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.2 1.5 GO:0072539 T-helper 17 cell differentiation(GO:0072539)
0.1 1.2 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.1 1.2 GO:0045671 negative regulation of osteoclast differentiation(GO:0045671)
0.2 1.1 GO:0043416 regulation of skeletal muscle tissue regeneration(GO:0043416)
0.3 1.0 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931) calcium-independent cell-matrix adhesion(GO:0007161)
0.1 1.0 GO:0042178 xenobiotic catabolic process(GO:0042178)
0.1 0.9 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.2 0.8 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1 0.8 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.0 0.8 GO:0042104 positive regulation of activated T cell proliferation(GO:0042104)
0.2 0.7 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
0.0 0.7 GO:0034390 smooth muscle cell apoptotic process(GO:0034390) regulation of smooth muscle cell apoptotic process(GO:0034391)
0.0 0.7 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.2 0.6 GO:0008582 regulation of synaptic growth at neuromuscular junction(GO:0008582)
0.1 0.6 GO:0071205 clustering of voltage-gated potassium channels(GO:0045163) protein localization to juxtaparanode region of axon(GO:0071205)
0.2 0.5 GO:1990046 positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046)
0.1 0.5 GO:0071475 cellular hyperosmotic salinity response(GO:0071475)
0.1 0.5 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601) regulation of wound healing, spreading of epidermal cells(GO:1903689)
0.0 0.5 GO:0070286 axonemal dynein complex assembly(GO:0070286)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 GO:0016234 inclusion body(GO:0016234)
0.3 1.0 GO:0005577 fibrinogen complex(GO:0005577)
0.1 1.0 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 1.0 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 0.8 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.7 GO:0030673 axolemma(GO:0030673)
0.1 0.5 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.0 0.5 GO:0042101 T cell receptor complex(GO:0042101)
0.1 0.4 GO:0042585 germinal vesicle(GO:0042585)
0.1 0.4 GO:0019815 B cell receptor complex(GO:0019815)
0.0 0.4 GO:0097433 dense body(GO:0097433)
0.0 0.4 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.0 0.4 GO:0032420 stereocilium(GO:0032420)
0.1 0.3 GO:1990037 Lewy body core(GO:1990037)
0.0 0.3 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.0 0.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.3 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.3 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.1 0.2 GO:0005899 insulin receptor complex(GO:0005899)
0.1 0.2 GO:0034457 Mpp10 complex(GO:0034457)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.4 1.5 GO:0008142 oxysterol binding(GO:0008142)
0.0 1.3 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 1.2 GO:0070410 co-SMAD binding(GO:0070410)
0.2 1.0 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.2 1.0 GO:0045340 mercury ion binding(GO:0045340)
0.1 1.0 GO:0070402 NADPH binding(GO:0070402)
0.1 0.8 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 0.8 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.8 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.8 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 0.7 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.7 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.6 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.2 0.5 GO:1901611 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
0.1 0.5 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0 0.5 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 0.4 GO:0035174 histone serine kinase activity(GO:0035174)
0.1 0.4 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.0 0.4 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)