Motif ID: Foxc2

Z-value: 0.565


Transcription factors associated with Foxc2:

Gene SymbolEntrez IDGene Name
Foxc2 ENSMUSG00000046714.6 Foxc2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxc2mm10_v2_chr8_+_121116163_1211161770.291.5e-01Click!


Activity profile for motif Foxc2.

activity profile for motif Foxc2


Sorted Z-values histogram for motif Foxc2

Sorted Z-values for motif Foxc2



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxc2

PNG image of the network

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Top targets:


Showing 1 to 20 of 126 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_84773381 4.515 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr17_+_70522083 2.870 ENSMUST00000148486.1
ENSMUST00000133717.1
 Dlgap1

discs, large (Drosophila) homolog-associated protein 1

chr9_+_53850243 2.653 ENSMUST00000048485.5
 Sln
sarcolipin
chr4_+_48049080 2.628 ENSMUST00000153369.1
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr11_+_32000452 2.129 ENSMUST00000020537.2
ENSMUST00000109409.1
 Nsg2

neuron specific gene family member 2

chr17_+_70522149 2.113 ENSMUST00000140728.1
 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr1_+_177444653 2.037 ENSMUST00000094276.3
 Zbtb18
zinc finger and BTB domain containing 18
chr17_+_20570362 1.770 ENSMUST00000095633.3
 Gm5145
predicted pseudogene 5145
chr10_+_60106452 1.683 ENSMUST00000165024.2
 Spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
chr2_-_62483637 1.492 ENSMUST00000136686.1
ENSMUST00000102733.3
 Gcg

glucagon

chr11_+_32000496 1.352 ENSMUST00000093219.3
 Nsg2
neuron specific gene family member 2
chr7_+_44849581 1.350 ENSMUST00000150335.1
ENSMUST00000107882.1
 Akt1s1

AKT1 substrate 1 (proline-rich)

chr2_-_45110336 1.337 ENSMUST00000028229.6
ENSMUST00000152232.1
 Zeb2

zinc finger E-box binding homeobox 2

chr16_-_74411292 1.327 ENSMUST00000117200.1
 Robo2
roundabout homolog 2 (Drosophila)
chrX_+_163911401 1.325 ENSMUST00000140845.1
 Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr13_+_42681513 1.325 ENSMUST00000149235.1
 Phactr1
phosphatase and actin regulator 1
chr5_+_16553488 1.289 ENSMUST00000030683.3
 Hgf
hepatocyte growth factor
chr11_+_77765588 1.272 ENSMUST00000164315.1
 Myo18a
myosin XVIIIA
chr3_+_68584154 1.257 ENSMUST00000182997.1
 Schip1
schwannomin interacting protein 1
chr1_-_97977233 1.194 ENSMUST00000161567.1
 Pam
peptidylglycine alpha-amidating monooxygenase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 5.0 GO:0070842 aggresome assembly(GO:0070842)
0.3 4.5 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.2 3.5 GO:0048268 clathrin coat assembly(GO:0048268)
0.2 3.1 GO:0045792 negative regulation of cell size(GO:0045792)
0.7 2.7 GO:1901894 regulation of calcium-transporting ATPase activity(GO:1901894)
0.9 2.6 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
0.0 2.0 GO:0021766 hippocampus development(GO:0021766)
0.2 1.8 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.2 1.7 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.2 1.7 GO:0007379 segment specification(GO:0007379)
0.2 1.5 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072366)
0.4 1.3 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.3 1.3 GO:0090164 asymmetric Golgi ribbon formation(GO:0090164)
0.2 1.3 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 1.3 GO:0001553 luteinization(GO:0001553)
0.0 1.3 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 1.3 GO:0060612 adipose tissue development(GO:0060612)
0.1 1.2 GO:0009404 toxin metabolic process(GO:0009404)
0.0 1.2 GO:0050919 negative chemotaxis(GO:0050919)
0.0 1.1 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.8 GO:0045211 postsynaptic membrane(GO:0045211)
0.3 3.1 GO:0031931 TORC1 complex(GO:0031931)
0.1 2.7 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 2.0 GO:0045171 intercellular bridge(GO:0045171)
0.0 1.7 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 1.4 GO:0016459 myosin complex(GO:0016459)
0.0 1.3 GO:0030673 axolemma(GO:0030673)
0.0 1.3 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 1.2 GO:0030667 secretory granule membrane(GO:0030667)
0.0 1.1 GO:0005901 caveola(GO:0005901)
0.0 1.0 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.9 GO:0031519 PcG protein complex(GO:0031519)
0.3 0.8 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.1 0.8 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 0.8 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.8 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 0.7 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.5 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.5 GO:0005605 basal lamina(GO:0005605)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 3.5 GO:0032051 clathrin light chain binding(GO:0032051)
0.2 2.6 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 1.7 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 1.5 GO:0005179 hormone activity(GO:0005179)
0.1 1.3 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 1.3 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.1 1.3 GO:0042056 chemoattractant activity(GO:0042056)
0.0 1.3 GO:0070412 R-SMAD binding(GO:0070412)
0.0 1.3 GO:0043531 ADP binding(GO:0043531)
0.4 1.2 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.1 1.1 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 1.1 GO:0001786 phosphatidylserine binding(GO:0001786)
0.2 1.0 GO:0071253 connexin binding(GO:0071253)
0.1 1.0 GO:0042287 MHC protein binding(GO:0042287)
0.0 1.0 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 0.9 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.2 0.8 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.1 0.8 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.8 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 0.8 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)