Motif ID: Foxi1_Foxo1

Z-value: 2.400

Transcription factors associated with Foxi1_Foxo1:

Gene SymbolEntrez IDGene Name
Foxi1 ENSMUSG00000047861.2 Foxi1
Foxo1 ENSMUSG00000044167.5 Foxo1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo1mm10_v2_chr3_+_52268337_52268388-0.039.0e-01Click!


Activity profile for motif Foxi1_Foxo1.

activity profile for motif Foxi1_Foxo1


Sorted Z-values histogram for motif Foxi1_Foxo1

Sorted Z-values for motif Foxi1_Foxo1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxi1_Foxo1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 29.667 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr17_-_70851710 19.716 ENSMUST00000166395.2
 Tgif1
TGFB-induced factor homeobox 1
chr3_-_52104891 11.305 ENSMUST00000121440.1
 Maml3
mastermind like 3 (Drosophila)
chr8_-_46294592 11.289 ENSMUST00000058636.7
 Helt
helt bHLH transcription factor
chr11_+_32276400 11.044 ENSMUST00000020531.2
 Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr18_-_47333311 10.693 ENSMUST00000126684.1
ENSMUST00000156422.1
 Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

chr6_+_53573364 10.625 ENSMUST00000047450.7
 Creb5
cAMP responsive element binding protein 5
chr16_-_22161450 10.359 ENSMUST00000115379.1
 Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr19_+_55741810 10.038 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
 Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr4_+_65124174 9.844 ENSMUST00000084501.3
 Pappa
pregnancy-associated plasma protein A
chr12_-_56535047 9.833 ENSMUST00000178477.2
 Nkx2-1
NK2 homeobox 1
chr16_+_30065333 9.658 ENSMUST00000023171.7
 Hes1
hairy and enhancer of split 1 (Drosophila)
chr12_+_109452833 9.501 ENSMUST00000056110.8
 Dlk1
delta-like 1 homolog (Drosophila)
chr3_+_134236483 8.838 ENSMUST00000181904.1
ENSMUST00000053048.9
 Cxxc4

CXXC finger 4

chr3_-_27153844 8.452 ENSMUST00000176242.2
ENSMUST00000176780.1
 Ect2

ect2 oncogene

chr3_-_27153861 8.347 ENSMUST00000108300.1
ENSMUST00000108298.2
 Ect2

ect2 oncogene

chr9_+_78615501 8.319 ENSMUST00000093812.4
 Cd109
CD109 antigen
chr12_+_52516077 8.169 ENSMUST00000110725.1
 Arhgap5
Rho GTPase activating protein 5
chr14_+_73237891 8.022 ENSMUST00000044405.6
 Lpar6
lysophosphatidic acid receptor 6
chr3_+_34649987 8.000 ENSMUST00000099151.2
 Sox2
SRY-box containing gene 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 461 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.9 29.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.5 28.7 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
1.6 28.2 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
1.0 22.1 GO:0006270 DNA replication initiation(GO:0006270)
2.4 21.4 GO:0048619 embryonic hindgut morphogenesis(GO:0048619)
1.1 20.6 GO:0038092 nodal signaling pathway(GO:0038092)
1.4 17.7 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
3.5 17.3 GO:0015671 oxygen transport(GO:0015671)
1.4 14.9 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.5 14.1 GO:0042462 eye photoreceptor cell development(GO:0042462)
1.2 13.4 GO:0060539 diaphragm development(GO:0060539)
1.0 12.8 GO:0034501 protein localization to kinetochore(GO:0034501)
1.1 12.5 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.1 12.1 GO:0000398 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.6 11.9 GO:0001967 suckling behavior(GO:0001967)
0.4 11.8 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
2.2 11.2 GO:0031052 programmed DNA elimination(GO:0031049) chromosome breakage(GO:0031052)
0.5 10.7 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.1 10.5 GO:0051028 mRNA transport(GO:0051028)
0.5 10.3 GO:0007638 mechanosensory behavior(GO:0007638)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 193 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 136.6 GO:0005634 nucleus(GO:0005634)
0.8 38.1 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
5.4 26.9 GO:0097149 centralspindlin complex(GO:0097149)
1.5 21.9 GO:0042555 MCM complex(GO:0042555)
0.1 20.7 GO:0005667 transcription factor complex(GO:0005667)
0.3 19.9 GO:0005902 microvillus(GO:0005902)
0.3 17.7 GO:0005871 kinesin complex(GO:0005871)
1.9 17.2 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.2 16.6 GO:0000776 kinetochore(GO:0000776)
0.2 15.3 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
1.6 12.6 GO:0005833 hemoglobin complex(GO:0005833)
0.1 11.7 GO:0016363 nuclear matrix(GO:0016363)
0.1 11.7 GO:0031513 nonmotile primary cilium(GO:0031513)
0.1 10.6 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
1.0 10.1 GO:0001939 female pronucleus(GO:0001939)
0.1 10.1 GO:0044798 nuclear transcription factor complex(GO:0044798)
1.6 9.7 GO:0031262 Ndc80 complex(GO:0031262)
3.1 9.3 GO:0070557 PCNA-p21 complex(GO:0070557)
0.2 9.0 GO:0043034 costamere(GO:0043034)
1.0 8.6 GO:0030478 actin cap(GO:0030478)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 319 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 59.1 GO:0003677 DNA binding(GO:0003677)
0.3 53.2 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
1.1 29.4 GO:0008432 JUN kinase binding(GO:0008432)
0.6 28.2 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.3 26.4 GO:0017048 Rho GTPase binding(GO:0017048)
0.5 24.3 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.7 20.3 GO:0070016 armadillo repeat domain binding(GO:0070016)
3.5 17.3 GO:0005344 oxygen transporter activity(GO:0005344)
0.1 15.6 GO:0051015 actin filament binding(GO:0051015)
0.1 15.4 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987)
0.0 12.6 GO:0005525 GTP binding(GO:0005525)
1.0 12.5 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.8 12.2 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.9 11.9 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.2 11.7 GO:0003684 damaged DNA binding(GO:0003684)
0.2 11.3 GO:0008186 ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.5 11.2 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.8 11.0 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.7 10.3 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.5 10.3 GO:0017049 GTP-Rho binding(GO:0017049)