Motif ID: Foxo3

Z-value: 0.867


Transcription factors associated with Foxo3:

Gene SymbolEntrez IDGene Name
Foxo3 ENSMUSG00000048756.5 Foxo3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo3mm10_v2_chr10_-_42276744_422767630.884.8e-09Click!


Activity profile for motif Foxo3.

activity profile for motif Foxo3


Sorted Z-values histogram for motif Foxo3

Sorted Z-values for motif Foxo3



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxo3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_84773381 10.241 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr14_-_51913393 4.805 ENSMUST00000004673.7
ENSMUST00000111632.3
 Ndrg2

N-myc downstream regulated gene 2

chr2_+_124610573 4.377 ENSMUST00000103239.3
ENSMUST00000103240.2
 Sema6d

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D

chr7_-_103813913 3.727 ENSMUST00000098192.3
 Hbb-bt
hemoglobin, beta adult t chain
chr11_+_3332426 3.077 ENSMUST00000136474.1
 Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr10_+_112271123 2.957 ENSMUST00000092175.2
 Kcnc2
potassium voltage gated channel, Shaw-related subfamily, member 2
chr16_+_93683184 2.935 ENSMUST00000039620.6
 Cbr3
carbonyl reductase 3
chr10_+_40349265 2.667 ENSMUST00000044672.4
ENSMUST00000095743.2
 Cdk19

cyclin-dependent kinase 19

chr6_+_55836878 2.619 ENSMUST00000044729.6
 Ccdc129
coiled-coil domain containing 129
chr5_+_66968416 2.562 ENSMUST00000038188.7
 Limch1
LIM and calponin homology domains 1
chr11_+_85353156 2.465 ENSMUST00000108061.1
ENSMUST00000108062.1
ENSMUST00000108056.1
ENSMUST00000138423.1
ENSMUST00000074875.4
ENSMUST00000092821.3
 Bcas3





breast carcinoma amplified sequence 3





chr2_+_124610278 2.338 ENSMUST00000051419.8
ENSMUST00000077847.5
ENSMUST00000078621.5
ENSMUST00000076335.5
 Sema6d



sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D



chr11_-_60352869 2.253 ENSMUST00000095254.5
ENSMUST00000102683.4
ENSMUST00000093048.6
ENSMUST00000093046.6
ENSMUST00000064019.8
ENSMUST00000102682.4
 Tom1l2





target of myb1-like 2 (chicken)





chr1_+_24005505 2.151 ENSMUST00000181961.1
 Gm26524
predicted gene, 26524
chr7_+_82175156 2.116 ENSMUST00000180243.1
 Sh3gl3
SH3-domain GRB2-like 3
chrX_+_159697308 2.043 ENSMUST00000123433.1
 Sh3kbp1
SH3-domain kinase binding protein 1
chr5_+_66968559 1.994 ENSMUST00000127184.1
 Limch1
LIM and calponin homology domains 1
chr19_-_34255325 1.989 ENSMUST00000039631.8
 Acta2
actin, alpha 2, smooth muscle, aorta
chr2_+_136713444 1.906 ENSMUST00000028727.4
ENSMUST00000110098.3
 Snap25

synaptosomal-associated protein 25

chr4_-_87806276 1.785 ENSMUST00000148059.1
 Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr4_-_116405986 1.669 ENSMUST00000123072.1
ENSMUST00000144281.1
 Mast2

microtubule associated serine/threonine kinase 2

chr8_+_71568866 1.552 ENSMUST00000034267.4
 Slc27a1
solute carrier family 27 (fatty acid transporter), member 1
chr16_-_43979050 1.538 ENSMUST00000165648.1
ENSMUST00000036321.7
 Zdhhc23

zinc finger, DHHC domain containing 23

chr7_+_30291941 1.538 ENSMUST00000144508.1
 Clip3
CAP-GLY domain containing linker protein 3
chr11_-_101785252 1.450 ENSMUST00000164750.1
ENSMUST00000107176.1
ENSMUST00000017868.6
 Etv4


ets variant gene 4 (E1A enhancer binding protein, E1AF)


chr2_-_120245157 1.397 ENSMUST00000090071.4
 Pla2g4e
phospholipase A2, group IVE
chr19_-_42086338 1.364 ENSMUST00000051772.8
 Morn4
MORN repeat containing 4
chr2_-_51972990 1.355 ENSMUST00000145481.1
ENSMUST00000112705.2
 Nmi

N-myc (and STAT) interactor

chr3_+_63295815 1.320 ENSMUST00000029400.1
 Mme
membrane metallo endopeptidase
chr4_-_87806296 1.314 ENSMUST00000126353.1
ENSMUST00000149357.1
 Mllt3

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

chr18_+_37513652 1.309 ENSMUST00000061405.4
 Pcdhb21
protocadherin beta 21
chr3_-_30793549 1.264 ENSMUST00000180833.1
 4933429H19Rik
RIKEN cDNA 4933429H19 gene
chr1_+_75142775 1.187 ENSMUST00000097694.4
 Fam134a
family with sequence similarity 134, member A
chr16_-_22439719 1.175 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr10_-_93310963 1.117 ENSMUST00000151153.1
 Elk3
ELK3, member of ETS oncogene family
chr7_+_30291659 1.115 ENSMUST00000014065.8
ENSMUST00000150892.1
ENSMUST00000126216.1
 Clip3


CAP-GLY domain containing linker protein 3


chr4_-_91376433 1.091 ENSMUST00000107109.2
ENSMUST00000107111.2
ENSMUST00000107120.1
 Elavl2


ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)


chr18_-_74961252 1.071 ENSMUST00000066532.4
 Lipg
lipase, endothelial
chr10_-_63421739 1.066 ENSMUST00000054760.4
 Gm7075
predicted gene 7075
chr2_-_51973219 1.063 ENSMUST00000028314.2
 Nmi
N-myc (and STAT) interactor
chrX_+_85574018 1.055 ENSMUST00000048250.3
ENSMUST00000137438.1
ENSMUST00000146063.1
 Tab3


TGF-beta activated kinase 1/MAP3K7 binding protein 3


chr1_-_140183404 1.048 ENSMUST00000066859.6
ENSMUST00000111976.2
 Cfh

complement component factor h

chr12_-_84698769 1.025 ENSMUST00000095550.2
 Syndig1l
synapse differentiation inducing 1 like
chr4_-_91376490 1.009 ENSMUST00000107124.3
 Elavl2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr2_-_7081256 1.006 ENSMUST00000183209.1
 Celf2
CUGBP, Elav-like family member 2
chr10_-_93311073 0.983 ENSMUST00000008542.5
 Elk3
ELK3, member of ETS oncogene family
chr7_+_113765998 0.971 ENSMUST00000046687.9
 Spon1
spondin 1, (f-spondin) extracellular matrix protein
chr13_-_23622502 0.961 ENSMUST00000062045.2
 Hist1h1e
histone cluster 1, H1e
chr8_-_41016295 0.951 ENSMUST00000131965.1
 Mtus1
mitochondrial tumor suppressor 1
chr3_-_146770218 0.875 ENSMUST00000106137.1
 Prkacb
protein kinase, cAMP dependent, catalytic, beta
chr4_-_155345696 0.870 ENSMUST00000103178.4
 Prkcz
protein kinase C, zeta
chr7_+_24907618 0.834 ENSMUST00000151121.1
 Arhgef1
Rho guanine nucleotide exchange factor (GEF) 1
chr7_+_113766119 0.815 ENSMUST00000084696.4
 Spon1
spondin 1, (f-spondin) extracellular matrix protein
chr14_-_121698417 0.780 ENSMUST00000040700.7
 Dock9
dedicator of cytokinesis 9
chr17_+_24840108 0.771 ENSMUST00000164251.1
 Hagh
hydroxyacyl glutathione hydrolase
chr18_-_39489776 0.740 ENSMUST00000025300.6
 Nr3c1
nuclear receptor subfamily 3, group C, member 1
chr2_-_91710519 0.727 ENSMUST00000028678.8
ENSMUST00000076803.5
 Atg13

autophagy related 13

chr5_-_137531204 0.726 ENSMUST00000150063.2
 Gnb2
guanine nucleotide binding protein (G protein), beta 2
chr1_-_75142360 0.715 ENSMUST00000041213.5
 Cnppd1
cyclin Pas1/PHO80 domain containing 1
chr18_-_39489880 0.687 ENSMUST00000152853.1
 Nr3c1
nuclear receptor subfamily 3, group C, member 1
chr8_-_41016749 0.675 ENSMUST00000117735.1
 Mtus1
mitochondrial tumor suppressor 1
chr1_-_140183283 0.662 ENSMUST00000111977.1
 Cfh
complement component factor h
chr19_-_19111181 0.644 ENSMUST00000112832.1
 Rorb
RAR-related orphan receptor beta
chr9_+_114731177 0.644 ENSMUST00000035007.8
 Cmtm6
CKLF-like MARVEL transmembrane domain containing 6
chr14_-_57133585 0.623 ENSMUST00000039380.8
 Gjb6
gap junction protein, beta 6
chr1_+_36511867 0.563 ENSMUST00000001166.7
ENSMUST00000097776.3
 Cnnm3

cyclin M3

chr11_+_60353324 0.560 ENSMUST00000070805.6
ENSMUST00000094140.2
ENSMUST00000108723.2
ENSMUST00000108722.4
 Lrrc48



leucine rich repeat containing 48



chr4_-_134915010 0.502 ENSMUST00000105863.1
ENSMUST00000030626.5
 Tmem50a

transmembrane protein 50A

chr11_-_48946148 0.421 ENSMUST00000104958.1
 Psme2b
protease (prosome, macropain) activator subunit 2B
chr11_+_29463735 0.412 ENSMUST00000155854.1
 Ccdc88a
coiled coil domain containing 88A
chr1_+_66386968 0.405 ENSMUST00000145419.1
 Map2
microtubule-associated protein 2
chr10_+_88201223 0.388 ENSMUST00000182619.1
 Ccdc53
coiled-coil domain containing 53
chr6_-_83831736 0.353 ENSMUST00000058383.8
 Paip2b
poly(A) binding protein interacting protein 2B
chr8_-_122476036 0.320 ENSMUST00000014614.3
 Rnf166
ring finger protein 166
chr14_+_84443553 0.319 ENSMUST00000071370.5
 Pcdh17
protocadherin 17
chr2_+_76675265 0.281 ENSMUST00000111920.1
 Plekha3
pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 3
chr7_+_29309429 0.277 ENSMUST00000137848.1
 Dpf1
D4, zinc and double PHD fingers family 1
chr11_+_19924403 0.255 ENSMUST00000093298.5
 Spred2
sprouty-related, EVH1 domain containing 2
chr10_+_97565436 0.249 ENSMUST00000038160.4
 Lum
lumican
chr13_+_60602182 0.222 ENSMUST00000044083.7
 Dapk1
death associated protein kinase 1
chr5_-_137531952 0.179 ENSMUST00000140139.1
 Gnb2
guanine nucleotide binding protein (G protein), beta 2
chr5_-_17888884 0.175 ENSMUST00000169095.1
 Cd36
CD36 antigen
chr8_-_25785154 0.162 ENSMUST00000038498.8
 Bag4
BCL2-associated athanogene 4
chr10_+_96616998 0.145 ENSMUST00000038377.7
 Btg1
B cell translocation gene 1, anti-proliferative
chr7_-_30559828 0.138 ENSMUST00000108164.1
 Lin37
lin-37 homolog (C. elegans)
chr14_+_30879257 0.108 ENSMUST00000040715.6
 Mustn1
musculoskeletal, embryonic nuclear protein 1
chr8_+_58912257 0.096 ENSMUST00000160055.1
 BC030500
cDNA sequence BC030500
chr7_+_130692532 0.092 ENSMUST00000033141.6
 Tacc2
transforming, acidic coiled-coil containing protein 2
chr5_+_65131184 0.065 ENSMUST00000031089.5
ENSMUST00000101191.3
 Klhl5

kelch-like 5

chr11_+_19924354 0.034 ENSMUST00000093299.6
 Spred2
sprouty-related, EVH1 domain containing 2
chr12_+_38780817 0.030 ENSMUST00000160856.1
 Etv1
ets variant gene 1
chr1_-_74284636 0.013 ENSMUST00000178235.1
ENSMUST00000006462.7
 Aamp

angio-associated migratory protein

chr5_-_151190154 0.008 ENSMUST00000062015.8
ENSMUST00000110483.2
 Stard13

StAR-related lipid transfer (START) domain containing 13

chr1_+_74284930 0.004 ENSMUST00000113805.1
ENSMUST00000027370.6
ENSMUST00000087226.4
 Pnkd


paroxysmal nonkinesiogenic dyskinesia



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:1902524 negative regulation of interferon-alpha production(GO:0032687) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) negative regulation of interferon-beta biosynthetic process(GO:0045358) positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.7 10.2 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.4 1.3 GO:0071492 cellular response to UV-A(GO:0071492)
0.4 3.1 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.4 2.7 GO:0072321 chaperone-mediated protein transport(GO:0072321)
0.4 2.6 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.4 3.0 GO:0071732 cellular response to nitric oxide(GO:0071732)
0.4 1.1 GO:0010986 positive regulation of lipoprotein particle clearance(GO:0010986)
0.3 1.6 GO:1903726 negative regulation of phospholipid metabolic process(GO:1903726)
0.3 3.1 GO:0007379 segment specification(GO:0007379)
0.3 1.4 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.3 1.7 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.2 6.7 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.2 3.7 GO:0042182 ketone catabolic process(GO:0042182)
0.2 0.9 GO:2000551 regulation of T-helper 2 cell cytokine production(GO:2000551) positive regulation of T-helper 2 cell cytokine production(GO:2000553)
0.2 1.7 GO:0045075 interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.1 1.0 GO:0016584 nucleosome positioning(GO:0016584)
0.1 2.5 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.1 4.8 GO:0048662 negative regulation of smooth muscle cell proliferation(GO:0048662)
0.1 1.6 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.1 0.6 GO:0046549 retinal cone cell development(GO:0046549)
0.1 1.9 GO:0099500 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.1 0.2 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.1 2.0 GO:0014829 vascular smooth muscle contraction(GO:0014829)
0.1 0.9 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.1 0.2 GO:0070543 response to linoleic acid(GO:0070543)
0.0 1.3 GO:0018345 protein palmitoylation(GO:0018345)
0.0 2.7 GO:0050729 positive regulation of inflammatory response(GO:0050729)
0.0 0.2 GO:0090365 regulation of mRNA modification(GO:0090365)
0.0 1.4 GO:0009395 phospholipid catabolic process(GO:0009395)
0.0 2.3 GO:0045839 negative regulation of mitotic nuclear division(GO:0045839)
0.0 0.1 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.0 0.3 GO:2000807 regulation of synaptic vesicle clustering(GO:2000807)
0.0 0.4 GO:0032148 activation of protein kinase B activity(GO:0032148)
0.0 0.3 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0 1.0 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 4.2 GO:0031032 actomyosin structure organization(GO:0031032)
0.0 0.4 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 0.2 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.0 0.1 GO:0035988 chondrocyte proliferation(GO:0035988)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.7 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.5 1.9 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.4 2.0 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.2 0.7 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.1 0.9 GO:0045179 apical cortex(GO:0045179)
0.1 2.5 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 3.0 GO:0030673 axolemma(GO:0030673)
0.1 2.7 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 3.1 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 0.9 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.4 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 0.6 GO:0005922 connexon complex(GO:0005922)
0.0 0.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.2 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 1.7 GO:0072562 blood microparticle(GO:0072562)
0.0 2.0 GO:0030139 endocytic vesicle(GO:0030139)
0.0 3.2 GO:0005769 early endosome(GO:0005769)
0.0 1.7 GO:0005901 caveola(GO:0005901)
0.0 1.0 GO:0000786 nucleosome(GO:0000786)
0.0 0.3 GO:0071565 nBAF complex(GO:0071565)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.1 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
1.0 2.9 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.9 3.7 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.8 2.5 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.6 1.7 GO:0001851 complement component C3b binding(GO:0001851)
0.5 2.7 GO:0097001 ceramide binding(GO:0097001)
0.5 2.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.4 1.4 GO:0038049 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.3 1.1 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.2 0.6 GO:0008502 melatonin receptor activity(GO:0008502)
0.2 6.7 GO:0030215 semaphorin receptor binding(GO:0030215)
0.2 1.6 GO:0015245 fatty acid transporter activity(GO:0015245)
0.1 0.9 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 3.0 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 1.4 GO:0004623 phospholipase A2 activity(GO:0004623)
0.1 0.8 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.1 1.6 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 0.2 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.1 2.7 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.1 0.4 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 1.3 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.0 0.3 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.9 GO:0043274 phospholipase binding(GO:0043274)
0.0 2.3 GO:0030276 clathrin binding(GO:0030276)
0.0 0.4 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 9.1 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.4 GO:0043422 protein kinase B binding(GO:0043422)
0.0 0.3 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.9 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 1.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 1.3 GO:0008238 exopeptidase activity(GO:0008238)
0.0 1.7 GO:0017124 SH3 domain binding(GO:0017124)