Motif ID: Foxo3

Z-value: 0.867


Transcription factors associated with Foxo3:

Gene SymbolEntrez IDGene Name
Foxo3 ENSMUSG00000048756.5 Foxo3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo3mm10_v2_chr10_-_42276744_422767630.884.8e-09Click!


Activity profile for motif Foxo3.

activity profile for motif Foxo3


Sorted Z-values histogram for motif Foxo3

Sorted Z-values for motif Foxo3



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxo3

PNG image of the network

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Top targets:


Showing 1 to 20 of 94 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_84773381 10.241 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr14_-_51913393 4.805 ENSMUST00000004673.7
ENSMUST00000111632.3
 Ndrg2

N-myc downstream regulated gene 2

chr2_+_124610573 4.377 ENSMUST00000103239.3
ENSMUST00000103240.2
 Sema6d

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D

chr7_-_103813913 3.727 ENSMUST00000098192.3
 Hbb-bt
hemoglobin, beta adult t chain
chr11_+_3332426 3.077 ENSMUST00000136474.1
 Pik3ip1
phosphoinositide-3-kinase interacting protein 1
chr10_+_112271123 2.957 ENSMUST00000092175.2
 Kcnc2
potassium voltage gated channel, Shaw-related subfamily, member 2
chr16_+_93683184 2.935 ENSMUST00000039620.6
 Cbr3
carbonyl reductase 3
chr10_+_40349265 2.667 ENSMUST00000044672.4
ENSMUST00000095743.2
 Cdk19

cyclin-dependent kinase 19

chr6_+_55836878 2.619 ENSMUST00000044729.6
 Ccdc129
coiled-coil domain containing 129
chr5_+_66968416 2.562 ENSMUST00000038188.7
 Limch1
LIM and calponin homology domains 1
chr11_+_85353156 2.465 ENSMUST00000108061.1
ENSMUST00000108062.1
ENSMUST00000108056.1
ENSMUST00000138423.1
ENSMUST00000074875.4
ENSMUST00000092821.3
 Bcas3





breast carcinoma amplified sequence 3





chr2_+_124610278 2.338 ENSMUST00000051419.8
ENSMUST00000077847.5
ENSMUST00000078621.5
ENSMUST00000076335.5
 Sema6d



sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D



chr11_-_60352869 2.253 ENSMUST00000095254.5
ENSMUST00000102683.4
ENSMUST00000093048.6
ENSMUST00000093046.6
ENSMUST00000064019.8
ENSMUST00000102682.4
 Tom1l2





target of myb1-like 2 (chicken)





chr1_+_24005505 2.151 ENSMUST00000181961.1
 Gm26524
predicted gene, 26524
chr7_+_82175156 2.116 ENSMUST00000180243.1
 Sh3gl3
SH3-domain GRB2-like 3
chrX_+_159697308 2.043 ENSMUST00000123433.1
 Sh3kbp1
SH3-domain kinase binding protein 1
chr5_+_66968559 1.994 ENSMUST00000127184.1
 Limch1
LIM and calponin homology domains 1
chr19_-_34255325 1.989 ENSMUST00000039631.8
 Acta2
actin, alpha 2, smooth muscle, aorta
chr2_+_136713444 1.906 ENSMUST00000028727.4
ENSMUST00000110098.3
 Snap25

synaptosomal-associated protein 25

chr4_-_87806276 1.785 ENSMUST00000148059.1
 Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 10.2 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.2 6.7 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.1 4.8 GO:0048662 negative regulation of smooth muscle cell proliferation(GO:0048662)
0.0 4.2 GO:0031032 actomyosin structure organization(GO:0031032)
0.2 3.7 GO:0042182 ketone catabolic process(GO:0042182)
0.4 3.1 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.3 3.1 GO:0007379 segment specification(GO:0007379)
0.4 3.0 GO:0071732 cellular response to nitric oxide(GO:0071732)
0.4 2.7 GO:0072321 chaperone-mediated protein transport(GO:0072321)
0.0 2.7 GO:0050729 positive regulation of inflammatory response(GO:0050729)
0.4 2.6 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.1 2.5 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.8 2.4 GO:1902524 negative regulation of interferon-alpha production(GO:0032687) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) negative regulation of interferon-beta biosynthetic process(GO:0045358) positive regulation of protein K48-linked ubiquitination(GO:1902524)
0.0 2.3 GO:0045839 negative regulation of mitotic nuclear division(GO:0045839)
0.1 2.0 GO:0014829 vascular smooth muscle contraction(GO:0014829)
0.1 1.9 GO:0099500 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.3 1.7 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.2 1.7 GO:0045075 interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.3 1.6 GO:1903726 negative regulation of phospholipid metabolic process(GO:1903726)
0.1 1.6 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 3.7 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 3.2 GO:0005769 early endosome(GO:0005769)
0.1 3.1 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 3.0 GO:0030673 axolemma(GO:0030673)
0.1 2.7 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 2.5 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.4 2.0 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 2.0 GO:0030139 endocytic vesicle(GO:0030139)
0.5 1.9 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.0 1.7 GO:0072562 blood microparticle(GO:0072562)
0.0 1.7 GO:0005901 caveola(GO:0005901)
0.0 1.0 GO:0000786 nucleosome(GO:0000786)
0.1 0.9 GO:0045179 apical cortex(GO:0045179)
0.1 0.9 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 0.7 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.6 GO:0005922 connexon complex(GO:0005922)
0.0 0.4 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 0.3 GO:0071565 nBAF complex(GO:0071565)
0.0 0.2 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.1 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.2 6.7 GO:0030215 semaphorin receptor binding(GO:0030215)
0.9 3.7 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
1.0 3.1 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.1 3.0 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
1.0 2.9 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.5 2.7 GO:0097001 ceramide binding(GO:0097001)
0.1 2.7 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.8 2.5 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.0 2.3 GO:0030276 clathrin binding(GO:0030276)
0.5 2.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.6 1.7 GO:0001851 complement component C3b binding(GO:0001851)
0.0 1.7 GO:0017124 SH3 domain binding(GO:0017124)
0.2 1.6 GO:0015245 fatty acid transporter activity(GO:0015245)
0.1 1.6 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 1.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.4 1.4 GO:0038049 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.1 1.4 GO:0004623 phospholipase A2 activity(GO:0004623)
0.1 1.3 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.0 1.3 GO:0008238 exopeptidase activity(GO:0008238)