Motif ID: Foxo4

Z-value: 0.974


Transcription factors associated with Foxo4:

Gene SymbolEntrez IDGene Name
Foxo4 ENSMUSG00000042903.7 Foxo4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo4mm10_v2_chrX_+_101254528_1012545740.432.8e-02Click!


Activity profile for motif Foxo4.

activity profile for motif Foxo4


Sorted Z-values histogram for motif Foxo4

Sorted Z-values for motif Foxo4



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxo4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_50030735 3.427 ENSMUST00000071866.1
 Rpl13a-ps1
ribosomal protein 13A, pseudogene 1
chr13_-_8940977 3.362 ENSMUST00000071184.2
 Rpl10a-ps2
ribosomal protein L10A, pseudogene 2
chr4_-_97778042 2.053 ENSMUST00000146447.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr14_-_98169542 1.845 ENSMUST00000069334.7
ENSMUST00000071533.6
 Dach1

dachshund 1 (Drosophila)

chr4_+_8690399 1.825 ENSMUST00000127476.1
 Chd7
chromodomain helicase DNA binding protein 7
chr1_+_6487231 1.555 ENSMUST00000140079.1
ENSMUST00000131494.1
 St18

suppression of tumorigenicity 18

chr7_-_4778141 1.545 ENSMUST00000094892.5
 Il11
interleukin 11
chr2_-_175931051 1.543 ENSMUST00000108949.2
ENSMUST00000109018.2
 Gm8898

predicted gene 8898

chr7_-_89517576 1.527 ENSMUST00000041761.5
 Prss23
protease, serine, 23
chr6_+_95117740 1.431 ENSMUST00000032107.7
ENSMUST00000119582.1
 Kbtbd8

kelch repeat and BTB (POZ) domain containing 8

chr2_+_176521056 1.403 ENSMUST00000108997.2
ENSMUST00000178443.1
 Gm14431

predicted gene 14431

chr2_+_181767283 1.396 ENSMUST00000108757.2
 Myt1
myelin transcription factor 1
chr8_+_79639618 1.374 ENSMUST00000173078.1
ENSMUST00000173286.1
 Otud4

OTU domain containing 4

chr2_-_175141999 1.304 ENSMUST00000109062.1
ENSMUST00000109059.1
ENSMUST00000109060.1
 Gm14399


predicted gene 14399


chr2_+_175372436 1.235 ENSMUST00000131676.1
ENSMUST00000109048.2
ENSMUST00000109047.2
 Gm4723


predicted gene 4723


chr2_+_175469985 1.217 ENSMUST00000109042.3
ENSMUST00000109002.2
ENSMUST00000109043.2
ENSMUST00000143490.1
 Gm8923



predicted gene 8923



chr2_+_181767040 1.202 ENSMUST00000108756.1
 Myt1
myelin transcription factor 1
chr7_-_25250720 1.182 ENSMUST00000116343.2
ENSMUST00000045847.8
 Erf

Ets2 repressor factor

chr2_-_175703646 1.173 ENSMUST00000109027.2
ENSMUST00000179061.1
ENSMUST00000131041.1
 Gm4245


predicted gene 4245


chrX_+_134601179 1.113 ENSMUST00000074950.4
ENSMUST00000113203.1
ENSMUST00000113202.1
 Hnrnph2


heterogeneous nuclear ribonucleoprotein H2


chr2_+_176670522 1.108 ENSMUST00000121956.1
ENSMUST00000108985.2
 Gm14306

predicted gene 14306

chrX_+_134601271 1.091 ENSMUST00000050331.6
ENSMUST00000059297.5
 Hnrnph2

heterogeneous nuclear ribonucleoprotein H2

chr5_+_139543889 1.036 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr10_-_53638269 1.030 ENSMUST00000164393.1
 Fam184a
family with sequence similarity 184, member A
chr2_+_178023284 1.014 ENSMUST00000108925.3
ENSMUST00000108926.2
 Etohi1

ethanol induced 1

chr11_-_102579461 0.967 ENSMUST00000107081.1
 Gm11627
predicted gene 11627
chr2_-_175338197 0.930 ENSMUST00000121393.2
 Gm4631
predicted gene 4631
chr8_-_47352348 0.924 ENSMUST00000110367.2
 Stox2
storkhead box 2
chr2_-_175206899 0.884 ENSMUST00000109055.1
ENSMUST00000099028.3
ENSMUST00000109056.1
ENSMUST00000109058.2
 Gm14391



predicted gene 14391



chr5_-_135545108 0.839 ENSMUST00000060311.8
 Hip1
huntingtin interacting protein 1
chr2_+_177000956 0.835 ENSMUST00000108975.2
ENSMUST00000156844.1
 Gm14419

predicted gene 14419

chr17_-_51831884 0.830 ENSMUST00000124222.1
 Satb1
special AT-rich sequence binding protein 1
chr8_-_77517898 0.824 ENSMUST00000076316.4
 Arhgap10
Rho GTPase activating protein 10
chr6_+_42286709 0.798 ENSMUST00000163936.1
 Clcn1
chloride channel 1
chr6_+_42286676 0.795 ENSMUST00000031894.6
 Clcn1
chloride channel 1
chr11_-_33163072 0.780 ENSMUST00000093201.6
ENSMUST00000101375.4
ENSMUST00000109354.3
ENSMUST00000075641.3
 Npm1



nucleophosmin 1



chr2_+_175965331 0.744 ENSMUST00000109007.1
ENSMUST00000174416.1
 Gm2026

predicted gene 2026

chr6_+_56714891 0.737 ENSMUST00000031805.8
 Avl9
AVL9 homolog (S. cerevisiase)
chr17_-_23745829 0.731 ENSMUST00000046525.8
 Kremen2
kringle containing transmembrane protein 2
chr8_-_45410539 0.722 ENSMUST00000034056.4
ENSMUST00000167106.1
 Tlr3

toll-like receptor 3

chr8_+_26119361 0.686 ENSMUST00000014022.8
ENSMUST00000153528.1
ENSMUST00000131138.1
ENSMUST00000110575.1
 Rnf170



ring finger protein 170



chr11_-_77078404 0.684 ENSMUST00000102494.1
 Ccdc55
coiled-coil domain containing 55
chrX_-_134600976 0.680 ENSMUST00000033621.6
 Gla
galactosidase, alpha
chr2_+_176798612 0.669 ENSMUST00000118012.2
 Gm14295
predicted gene 14295
chr16_-_64771146 0.651 ENSMUST00000076991.6
 4930453N24Rik
RIKEN cDNA 4930453N24 gene
chr2_-_178078425 0.649 ENSMUST00000108924.2
ENSMUST00000131702.1
ENSMUST00000108923.1
 Zfp931


zinc finger protein 931


chr19_-_5796924 0.646 ENSMUST00000174808.1
 Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chr2_-_144011202 0.620 ENSMUST00000016072.5
ENSMUST00000037875.5
 Rrbp1

ribosome binding protein 1

chr2_-_176486773 0.615 ENSMUST00000120959.1
ENSMUST00000120521.1
 Gm14434

predicted gene 14434

chr7_-_4524229 0.613 ENSMUST00000154913.1
 Tnni3
troponin I, cardiac 3
chr2_-_175435782 0.607 ENSMUST00000152941.1
ENSMUST00000109045.2
 Gm4724

predicted gene 4724

chr2_+_175869219 0.602 ENSMUST00000109011.1
 Gm6710
predicted gene 6710
chr2_-_176636318 0.585 ENSMUST00000108990.2
ENSMUST00000119149.1
ENSMUST00000117267.1
 Gm14308


predicted gene 14308


chr2_-_177957239 0.568 ENSMUST00000108928.1
ENSMUST00000108932.1
ENSMUST00000108930.2
 Gm14326


predicted gene 14326


chr2_+_176708328 0.564 ENSMUST00000108981.2
ENSMUST00000108980.2
 Gm14305

predicted gene 14305

chr17_+_78508063 0.552 ENSMUST00000024880.9
 Vit
vitrin
chr4_+_97777606 0.552 ENSMUST00000075448.6
ENSMUST00000092532.6
 Nfia

nuclear factor I/A

chr9_-_119322421 0.545 ENSMUST00000040853.4
 Oxsr1
oxidative-stress responsive 1
chr8_+_26119611 0.541 ENSMUST00000140819.1
 Rnf170
ring finger protein 170
chr9_+_57076395 0.532 ENSMUST00000168177.1
 Sin3a
transcriptional regulator, SIN3A (yeast)
chr4_-_6454262 0.510 ENSMUST00000029910.5
 Nsmaf
neutral sphingomyelinase (N-SMase) activation associated factor
chr18_-_38918642 0.488 ENSMUST00000040647.4
 Fgf1
fibroblast growth factor 1
chr11_-_102365111 0.482 ENSMUST00000006749.9
 Slc4a1
solute carrier family 4 (anion exchanger), member 1
chr2_-_177840318 0.481 ENSMUST00000108939.2
ENSMUST00000150650.1
 Gm14325

predicted gene 14325

chr2_+_176226569 0.478 ENSMUST00000099009.2
ENSMUST00000136719.1
 2210418O10Rik

RIKEN cDNA 2210418O10 gene

chr15_-_97767798 0.443 ENSMUST00000129223.2
ENSMUST00000126854.2
ENSMUST00000135080.1
 Rapgef3


Rap guanine nucleotide exchange factor (GEF) 3


chr9_+_57076343 0.411 ENSMUST00000168678.1
 Sin3a
transcriptional regulator, SIN3A (yeast)
chr5_-_90366176 0.408 ENSMUST00000014421.8
ENSMUST00000081914.6
ENSMUST00000168058.2
 Ankrd17


ankyrin repeat domain 17


chr5_-_70842617 0.384 ENSMUST00000031119.1
 Gabrg1
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
chrX_+_7579666 0.368 ENSMUST00000115740.1
ENSMUST00000115739.1
 Foxp3

forkhead box P3

chr2_-_177206421 0.357 ENSMUST00000108964.1
 Gm14410
predicted gene 14410
chr2_-_176927809 0.288 ENSMUST00000099007.2
 Gm14296
predicted gene 14296
chr8_+_70234613 0.245 ENSMUST00000145078.1
 Sugp2
SURP and G patch domain containing 2
chr1_+_171437535 0.240 ENSMUST00000043839.4
 F11r
F11 receptor
chr4_-_32950813 0.213 ENSMUST00000084750.1
ENSMUST00000084748.2
 Ankrd6

ankyrin repeat domain 6

chr3_+_107895916 0.195 ENSMUST00000172247.1
ENSMUST00000167387.1
 Gstm5

glutathione S-transferase, mu 5

chr17_+_36869567 0.162 ENSMUST00000060524.9
 Trim10
tripartite motif-containing 10
chr4_-_131937165 0.130 ENSMUST00000155990.1
 Epb4.1
erythrocyte protein band 4.1
chr9_+_109096659 0.122 ENSMUST00000130366.1
 Plxnb1
plexin B1
chr17_+_87078255 0.105 ENSMUST00000090731.5
 Gm5499
predicted pseudogene 5499
chr8_-_105943382 0.096 ENSMUST00000038896.7
 Lcat
lecithin cholesterol acyltransferase
chr1_-_168431695 0.090 ENSMUST00000176790.1
 Pbx1
pre B cell leukemia homeobox 1
chr8_-_94012120 0.075 ENSMUST00000143265.1
 Amfr
autocrine motility factor receptor
chr13_-_117025505 0.070 ENSMUST00000022239.6
 Parp8
poly (ADP-ribose) polymerase family, member 8
chr1_-_133131782 0.067 ENSMUST00000180528.1
 Gm26616
predicted gene, 26616
chr10_-_40257648 0.061 ENSMUST00000019982.7
 Gtf3c6
general transcription factor IIIC, polypeptide 6, alpha
chr7_+_3629985 0.028 ENSMUST00000008517.6
ENSMUST00000179769.1
 Prpf31

PRP31 pre-mRNA processing factor 31 homolog (yeast)

chr11_-_85139939 0.020 ENSMUST00000108075.2
 Usp32
ubiquitin specific peptidase 32
chr1_+_171213969 0.013 ENSMUST00000005820.4
ENSMUST00000075469.5
ENSMUST00000155126.1
 Nr1i3


nuclear receptor subfamily 1, group I, member 3


chr5_-_149636164 0.013 ENSMUST00000076410.4
 Hsph1
heat shock 105kDa/110kDa protein 1
chr12_-_69892989 0.011 ENSMUST00000110567.1
ENSMUST00000171211.1
 Map4k5

mitogen-activated protein kinase kinase kinase kinase 5


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.6 1.8 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.3 0.9 GO:1901675 negative regulation of histone H3-K27 acetylation(GO:1901675)
0.2 0.7 GO:0045349 regulation of dendritic cell cytokine production(GO:0002730) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.2 1.2 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.2 2.6 GO:0060539 diaphragm development(GO:0060539)
0.2 0.8 GO:1904749 rRNA export from nucleus(GO:0006407) regulation of protein localization to nucleolus(GO:1904749) positive regulation of protein localization to nucleolus(GO:1904751)
0.2 0.5 GO:2000686 regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.2 0.5 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.2 0.6 GO:0035063 nuclear speck organization(GO:0035063)
0.2 1.6 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 0.4 GO:0039530 MDA-5 signaling pathway(GO:0039530)
0.1 1.0 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.1 0.4 GO:0032829 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913) regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) negative regulation of interleukin-2 biosynthetic process(GO:0045085) negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.1 0.4 GO:1904451 regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904451) positive regulation of hydrogen:potassium-exchanging ATPase activity(GO:1904453)
0.1 0.6 GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980)
0.1 0.7 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.1 0.8 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 1.4 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.8 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.1 GO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
0.0 0.2 GO:0070458 detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458)
0.0 0.5 GO:0015701 bicarbonate transport(GO:0015701) response to arsenic-containing substance(GO:0046685)
0.0 0.2 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 1.5 GO:0046888 negative regulation of hormone secretion(GO:0046888)
0.0 0.1 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372)
0.0 0.2 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 0.6 GO:0060074 synapse maturation(GO:0060074)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0001652 granular component(GO:0001652)
0.1 0.6 GO:0005861 troponin complex(GO:0005861)
0.1 0.4 GO:1990795 lateral part of cell(GO:0097574) basolateral part of cell(GO:1990794) rod bipolar cell terminal bouton(GO:1990795)
0.0 0.2 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.9 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.6 GO:0005614 interstitial matrix(GO:0005614)
0.0 1.2 GO:0034707 chloride channel complex(GO:0034707)
0.0 1.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.2 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.8 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 0.1 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.1 GO:0000836 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.2 0.6 GO:0030172 troponin C binding(GO:0030172)
0.1 0.5 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.1 0.7 GO:0016936 galactoside binding(GO:0016936)
0.1 1.8 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 1.6 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 0.8 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.1 0.4 GO:0051525 NFAT protein binding(GO:0051525)
0.1 0.4 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.5 GO:0044548 S100 protein binding(GO:0044548)
0.0 0.5 GO:0015106 bicarbonate transmembrane transporter activity(GO:0015106)
0.0 0.9 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.1 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.0 2.6 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 0.4 GO:0050811 GABA receptor binding(GO:0050811)
0.0 1.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.4 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.1 GO:1904288 BAT3 complex binding(GO:1904288)