Motif ID: Foxo6

Z-value: 0.622


Transcription factors associated with Foxo6:

Gene SymbolEntrez IDGene Name
Foxo6 ENSMUSG00000052135.8 Foxo6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo6mm10_v2_chr4_-_120287349_120287349-0.877.8e-09Click!


Activity profile for motif Foxo6.

activity profile for motif Foxo6


Sorted Z-values histogram for motif Foxo6

Sorted Z-values for motif Foxo6



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxo6

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_23248264 3.234 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr11_-_12027958 1.842 ENSMUST00000109654.1
 Grb10
growth factor receptor bound protein 10
chr4_+_134510999 1.826 ENSMUST00000105866.2
 Aunip
aurora kinase A and ninein interacting protein
chr1_+_51987139 1.779 ENSMUST00000168302.1
 Stat4
signal transducer and activator of transcription 4
chr5_+_110330697 1.663 ENSMUST00000112481.1
 Pole
polymerase (DNA directed), epsilon
chr5_-_99037035 1.611 ENSMUST00000031277.6
 Prkg2
protein kinase, cGMP-dependent, type II
chr19_-_45742873 1.587 ENSMUST00000026241.5
ENSMUST00000026240.7
ENSMUST00000111928.1
 Fgf8


fibroblast growth factor 8


chr2_-_67194695 1.496 ENSMUST00000147939.1
 Gm13598
predicted gene 13598
chrX_+_106920618 1.321 ENSMUST00000060576.7
 Lpar4
lysophosphatidic acid receptor 4
chr17_-_31277327 1.289 ENSMUST00000024832.7
 Rsph1
radial spoke head 1 homolog (Chlamydomonas)
chr11_+_46235460 1.223 ENSMUST00000060185.2
 Fndc9
fibronectin type III domain containing 9
chr14_-_47418407 1.183 ENSMUST00000043296.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr12_-_91384403 1.173 ENSMUST00000141429.1
 Cep128
centrosomal protein 128
chr11_-_89639631 1.045 ENSMUST00000128717.1
 Ankfn1
ankyrin-repeat and fibronectin type III domain containing 1
chr9_+_6168638 0.822 ENSMUST00000058692.7
 Pdgfd
platelet-derived growth factor, D polypeptide
chr7_-_123369870 0.780 ENSMUST00000106442.2
ENSMUST00000098060.3
ENSMUST00000167309.1
 Arhgap17


Rho GTPase activating protein 17


chr1_-_184883218 0.771 ENSMUST00000048308.5
 C130074G19Rik
RIKEN cDNA C130074G19 gene
chr15_+_3270767 0.749 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chrY_-_6681243 0.733 ENSMUST00000115940.1
 Gm21719
predicted gene, 21719
chr5_-_117389029 0.725 ENSMUST00000111953.1
ENSMUST00000086461.6
 Rfc5

replication factor C (activator 1) 5

chrX_+_134585644 0.718 ENSMUST00000113211.1
 Rpl36a
ribosomal protein L36A
chr13_-_71963713 0.689 ENSMUST00000077337.8
 Irx1
Iroquois related homeobox 1 (Drosophila)
chr1_+_74391479 0.678 ENSMUST00000027367.7
 Ctdsp1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr7_+_28808795 0.619 ENSMUST00000172529.1
 Hnrnpl
heterogeneous nuclear ribonucleoprotein L
chr3_-_34351685 0.616 ENSMUST00000174114.1
 Gm20514
predicted gene 20514
chr1_+_110099295 0.596 ENSMUST00000134301.1
 Cdh7
cadherin 7, type 2
chrX_-_8193387 0.582 ENSMUST00000143223.1
ENSMUST00000033509.8
 Ebp

phenylalkylamine Ca2+ antagonist (emopamil) binding protein

chr2_-_11603192 0.581 ENSMUST00000040314.5
 Rbm17
RNA binding motif protein 17
chr5_-_65391408 0.562 ENSMUST00000057885.6
 Rpl9
ribosomal protein L9
chr18_+_5593566 0.558 ENSMUST00000160910.1
 Zeb1
zinc finger E-box binding homeobox 1
chr5_+_44100442 0.553 ENSMUST00000072800.4
 Gm16401
predicted gene 16401
chr12_+_108410625 0.547 ENSMUST00000109857.1
 Eml1
echinoderm microtubule associated protein like 1
chr12_+_108410542 0.532 ENSMUST00000054955.7
 Eml1
echinoderm microtubule associated protein like 1
chr9_-_78587968 0.484 ENSMUST00000117645.1
ENSMUST00000119213.1
ENSMUST00000052441.5
 Slc17a5


solute carrier family 17 (anion/sugar transporter), member 5


chr11_+_87853207 0.457 ENSMUST00000038196.6
 Mks1
Meckel syndrome, type 1
chr5_-_65391380 0.456 ENSMUST00000120094.1
ENSMUST00000118543.1
ENSMUST00000127874.1
 Rpl9


ribosomal protein L9


chr2_-_84425258 0.455 ENSMUST00000074262.2
 Calcrl
calcitonin receptor-like
chr7_-_24236632 0.430 ENSMUST00000037448.6
 Zfp109
zinc finger protein 109
chr17_-_24696147 0.429 ENSMUST00000046839.8
 Gfer
growth factor, erv1 (S. cerevisiae)-like (augmenter of liver regeneration)
chr1_-_162898665 0.422 ENSMUST00000111510.1
ENSMUST00000045902.6
 Fmo2

flavin containing monooxygenase 2

chr3_+_103968110 0.414 ENSMUST00000117150.1
ENSMUST00000063717.7
ENSMUST00000055425.8
ENSMUST00000123611.1
ENSMUST00000090685.4
 Phtf1




putative homeodomain transcription factor 1




chr19_+_44293676 0.408 ENSMUST00000026221.5
 Scd2
stearoyl-Coenzyme A desaturase 2
chr3_-_49757257 0.407 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr2_+_4718145 0.397 ENSMUST00000056914.6
 Bend7
BEN domain containing 7
chr5_+_7179299 0.361 ENSMUST00000179460.1
 Tubb4b-ps1
tubulin, beta 4B class IVB, pseudogene 1
chr10_+_29313164 0.336 ENSMUST00000160399.1
 Echdc1
enoyl Coenzyme A hydratase domain containing 1
chr16_+_10812915 0.331 ENSMUST00000115822.1
 Gm11172
predicted gene 11172
chr7_+_140881898 0.299 ENSMUST00000026560.7
 Psmd13
proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
chr7_+_19368498 0.293 ENSMUST00000132655.1
 Ppp1r13l
protein phosphatase 1, regulatory (inhibitor) subunit 13 like
chr2_+_129593195 0.292 ENSMUST00000099113.3
ENSMUST00000103202.3
 Sirpa

signal-regulatory protein alpha

chr5_-_52190484 0.288 ENSMUST00000031061.7
 Dhx15
DEAH (Asp-Glu-Ala-His) box polypeptide 15
chr8_+_46986913 0.284 ENSMUST00000039840.7
ENSMUST00000119686.1
 Enpp6

ectonucleotide pyrophosphatase/phosphodiesterase 6

chr2_+_129592914 0.265 ENSMUST00000103203.1
 Sirpa
signal-regulatory protein alpha
chr2_+_121955964 0.235 ENSMUST00000036647.6
 Ctdspl2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr4_+_108479081 0.231 ENSMUST00000155068.1
 Zcchc11
zinc finger, CCHC domain containing 11
chr6_+_59208870 0.227 ENSMUST00000062626.3
 Tigd2
tigger transposable element derived 2
chr14_+_34170640 0.207 ENSMUST00000104925.3
 Rpl23a-ps3
ribosomal protein L23A, pseudogene 3
chr2_-_93046053 0.202 ENSMUST00000111272.1
ENSMUST00000178666.1
ENSMUST00000147339.1
 Prdm11


PR domain containing 11


chr14_-_50924626 0.195 ENSMUST00000160375.1
ENSMUST00000162177.1
ENSMUST00000159292.1
 Osgep


O-sialoglycoprotein endopeptidase


chr18_-_84589491 0.170 ENSMUST00000125763.1
 Zfp407
zinc finger protein 407
chr7_+_64287665 0.167 ENSMUST00000032736.4
 Mtmr10
myotubularin related protein 10
chr12_-_98577940 0.164 ENSMUST00000110113.1
 Kcnk10
potassium channel, subfamily K, member 10
chr3_-_106167564 0.154 ENSMUST00000063062.8
 Chi3l3
chitinase 3-like 3
chr7_+_28440927 0.152 ENSMUST00000078845.6
 Gmfg
glia maturation factor, gamma
chr16_+_44943737 0.128 ENSMUST00000114622.3
ENSMUST00000166731.1
 Cd200r3

CD200 receptor 3

chr19_+_8892987 0.120 ENSMUST00000096249.5
 Ints5
integrator complex subunit 5
chr5_+_65391497 0.107 ENSMUST00000031101.3
ENSMUST00000122026.1
 Lias

lipoic acid synthetase

chr10_-_93310963 0.093 ENSMUST00000151153.1
 Elk3
ELK3, member of ETS oncogene family
chr4_+_48663502 0.093 ENSMUST00000030033.4
 Murc
muscle-related coiled-coil protein
chr15_-_75111684 0.088 ENSMUST00000100542.3
 Ly6c2
lymphocyte antigen 6 complex, locus C2
chr7_-_14562171 0.063 ENSMUST00000181796.1
 Vmn1r90
vomeronasal 1 receptor 90
chr9_+_25089422 0.042 ENSMUST00000086238.2
 Gm10181
predicted gene 10181
chr12_-_113260217 0.040 ENSMUST00000178282.1
 Igha
immunoglobulin heavy constant alpha
chr10_+_39732364 0.029 ENSMUST00000164763.1
 Rev3l
REV3-like, catalytic subunit of DNA polymerase zeta RAD54 like (S. cerevisiae)
chr2_-_155357392 0.023 ENSMUST00000165234.1
ENSMUST00000077626.6
 Pigu

phosphatidylinositol glycan anchor biosynthesis, class U

chrX_+_103493769 0.015 ENSMUST00000182447.1
ENSMUST00000182486.1
 Jpx

Jpx transcript, Xist activator (non-protein coding)

chrX_+_103493558 0.010 ENSMUST00000181020.2
ENSMUST00000183027.1
 Jpx

Jpx transcript, Xist activator (non-protein coding)

chr5_+_115279666 0.009 ENSMUST00000040421.4
 Coq5
coenzyme Q5 homolog, methyltransferase (yeast)
chr15_+_52712434 0.003 ENSMUST00000037115.7
 Med30
mediator complex subunit 30

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.2 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.5 1.6 GO:0060129 thyroid-stimulating hormone-secreting cell differentiation(GO:0060129)
0.3 1.7 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.3 0.8 GO:0035696 monocyte extravasation(GO:0035696) regulation of monocyte extravasation(GO:2000437)
0.2 1.8 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.1 1.6 GO:0036289 peptidyl-serine autophosphorylation(GO:0036289)
0.1 1.0 GO:0050957 equilibrioception(GO:0050957)
0.1 0.5 GO:0034285 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.1 0.7 GO:0001887 selenium compound metabolic process(GO:0001887)
0.1 0.4 GO:0072592 oxygen metabolic process(GO:0072592)
0.1 0.4 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.1 0.7 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.1 0.6 GO:1902416 positive regulation of mRNA binding(GO:1902416) positive regulation of RNA binding(GO:1905216)
0.1 0.5 GO:1903887 motile primary cilium assembly(GO:1903887)
0.1 0.6 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.1 0.4 GO:1903204 negative regulation of oxidative stress-induced neuron death(GO:1903204)
0.0 0.2 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.0 0.3 GO:0019695 choline metabolic process(GO:0019695)
0.0 0.1 GO:0009106 lipoate metabolic process(GO:0009106)
0.0 1.3 GO:0035082 axoneme assembly(GO:0035082)
0.0 0.2 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 0.2 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.0 0.4 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.6 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.3 GO:0003215 cardiac right ventricle morphogenesis(GO:0003215)
0.0 2.9 GO:0007051 spindle organization(GO:0007051)
0.0 0.3 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.2 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 1.0 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 0.7 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.7 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.2 1.3 GO:0001520 outer dense fiber(GO:0001520)
0.1 0.7 GO:0005663 DNA replication factor C complex(GO:0005663)
0.1 1.1 GO:1990023 mitotic spindle midzone(GO:1990023)
0.1 0.3 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.1 1.2 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 0.2 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.0 0.0 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.3 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 3.0 GO:0000922 spindle pole(GO:0000922)
0.0 0.6 GO:0045120 pronucleus(GO:0045120)
0.0 0.5 GO:0036038 MKS complex(GO:0036038)
0.0 0.3 GO:0045171 intercellular bridge(GO:0045171)
0.0 1.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.4 1.6 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.2 1.3 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.2 0.6 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.1 0.5 GO:0097642 calcitonin family receptor activity(GO:0097642)
0.1 0.3 GO:0004492 methylmalonyl-CoA decarboxylase activity(GO:0004492)
0.1 0.4 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.1 0.4 GO:0032896 palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.1 0.4 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 1.8 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 0.7 GO:0008420 CTD phosphatase activity(GO:0008420)
0.1 0.7 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 0.2 GO:0061711 N(6)-L-threonylcarbamoyladenine synthase(GO:0061711)
0.1 0.6 GO:1990715 mRNA CDS binding(GO:1990715)
0.0 0.7 GO:0008430 selenium binding(GO:0008430)
0.0 0.8 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.2 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 1.3 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.3 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 0.6 GO:0045309 protein phosphorylated amino acid binding(GO:0045309)
0.0 0.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 3.6 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.2 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.2 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 1.0 GO:0019843 rRNA binding(GO:0019843)
0.0 0.5 GO:1901505 carbohydrate derivative transporter activity(GO:1901505)
0.0 0.1 GO:0016783 sulfurtransferase activity(GO:0016783)
0.0 0.2 GO:0017161 phosphohistidine phosphatase activity(GO:0008969) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) NADP phosphatase activity(GO:0019178) 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity(GO:0043726) phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813) inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity(GO:0052825) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829) inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity(GO:0052830) inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity(GO:0052831) phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052867) IDP phosphatase activity(GO:1990003)