Motif ID: Foxp2_Foxp3

Z-value: 0.718

Transcription factors associated with Foxp2_Foxp3:

Gene SymbolEntrez IDGene Name
Foxp2 ENSMUSG00000029563.10 Foxp2
Foxp3 ENSMUSG00000039521.6 Foxp3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxp2mm10_v2_chr6_+_14901344_149013640.376.5e-02Click!
Foxp3mm10_v2_chrX_+_7579666_7579693-0.145.0e-01Click!


Activity profile for motif Foxp2_Foxp3.

activity profile for motif Foxp2_Foxp3


Sorted Z-values histogram for motif Foxp2_Foxp3

Sorted Z-values for motif Foxp2_Foxp3



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxp2_Foxp3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_66386292 3.223 ENSMUST00000039540.5
ENSMUST00000110253.2
 March1

membrane-associated ring finger (C3HC4) 1

chr8_-_46294592 2.891 ENSMUST00000058636.7
 Helt
helt bHLH transcription factor
chr1_+_19212054 2.883 ENSMUST00000064976.4
 Tfap2b
transcription factor AP-2 beta
chr15_+_3270767 2.359 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr5_+_28165690 2.053 ENSMUST00000036177.7
 En2
engrailed 2
chr2_-_28916412 1.745 ENSMUST00000050776.2
ENSMUST00000113849.1
 Barhl1

BarH-like 1 (Drosophila)

chr10_+_60106452 1.731 ENSMUST00000165024.2
 Spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
chr12_-_57546121 1.660 ENSMUST00000044380.6
 Foxa1
forkhead box A1
chr6_+_30541582 1.539 ENSMUST00000096066.4
 Cpa2
carboxypeptidase A2, pancreatic
chr14_-_48662740 1.525 ENSMUST00000122009.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr2_-_28916668 1.522 ENSMUST00000113847.1
 Barhl1
BarH-like 1 (Drosophila)
chr3_+_5218546 1.411 ENSMUST00000026284.6
 Zfhx4
zinc finger homeodomain 4
chr8_+_23669653 1.373 ENSMUST00000042352.4
 Zmat4
zinc finger, matrin type 4
chr1_+_66386968 1.319 ENSMUST00000145419.1
 Map2
microtubule-associated protein 2
chr3_+_109573907 1.300 ENSMUST00000106576.2
 Vav3
vav 3 oncogene
chr3_+_5218516 1.291 ENSMUST00000175866.1
 Zfhx4
zinc finger homeodomain 4
chr2_+_9882622 1.279 ENSMUST00000114919.1
 4930412O13Rik
RIKEN cDNA 4930412O13 gene
chr3_+_5218589 1.274 ENSMUST00000177488.1
 Zfhx4
zinc finger homeodomain 4
chr19_-_34255325 1.206 ENSMUST00000039631.8
 Acta2
actin, alpha 2, smooth muscle, aorta
chr19_+_4855129 1.165 ENSMUST00000119694.1
 Ctsf
cathepsin F

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 160 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.7 GO:0097154 GABAergic neuron differentiation(GO:0097154)
0.2 3.2 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
1.0 2.9 GO:0097274 urea homeostasis(GO:0097274)
0.3 2.4 GO:0001887 selenium compound metabolic process(GO:0001887)
0.3 2.3 GO:0048625 myoblast fate commitment(GO:0048625)
0.1 2.2 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.2 2.1 GO:1990403 embryonic brain development(GO:1990403)
0.0 1.9 GO:0030901 midbrain development(GO:0030901)
0.6 1.7 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743) alveolar secondary septum development(GO:0061144)
0.2 1.7 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 1.6 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.5 1.5 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.4 1.5 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.0 1.5 GO:0001578 microtubule bundle formation(GO:0001578)
0.1 1.4 GO:0042572 retinol metabolic process(GO:0042572)
0.1 1.3 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.2 1.2 GO:0097421 liver regeneration(GO:0097421)
0.0 1.2 GO:0014829 vascular smooth muscle contraction(GO:0014829)
0.0 1.2 GO:0007616 long-term memory(GO:0007616)
0.0 1.1 GO:0046326 positive regulation of glucose import(GO:0046326)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 3.2 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.1 3.1 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 2.3 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.8 GO:0005902 microvillus(GO:0005902)
0.0 1.7 GO:0030018 Z disc(GO:0030018)
0.3 1.5 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.2 1.5 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 1.5 GO:0016605 PML body(GO:0016605)
0.3 1.3 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.1 1.0 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.9 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.8 GO:0031941 filamentous actin(GO:0031941)
0.1 0.6 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.0 0.6 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.6 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 0.5 GO:0031673 H zone(GO:0031673)
0.1 0.5 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.1 0.5 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 0.5 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.5 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 113 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.0 GO:0042287 MHC protein binding(GO:0042287)
0.2 2.9 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.2 2.4 GO:0008430 selenium binding(GO:0008430)
0.1 2.3 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 1.7 GO:0050840 extracellular matrix binding(GO:0050840)
0.5 1.5 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.2 1.5 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 1.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 1.5 GO:0002039 p53 binding(GO:0002039)
0.2 1.4 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 1.3 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 1.2 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 1.2 GO:0005178 integrin binding(GO:0005178)
0.3 1.1 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.1 1.1 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.1 1.0 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 1.0 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.2 0.9 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.1 0.9 GO:0045294 alpha-catenin binding(GO:0045294)
0.1 0.9 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)