Motif ID: Gata2_Gata1
Z-value: 0.965
Transcription factors associated with Gata2_Gata1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Gata1 | ENSMUSG00000031162.8 | Gata1 |
Gata2 | ENSMUSG00000015053.8 | Gata2 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Gata1 | mm10_v2_chrX_-_7967817_7967910 | 0.60 | 1.3e-03 | Click! |
Gata2 | mm10_v2_chr6_+_88198656_88198675 | 0.08 | 7.1e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
4.7 | 23.6 | GO:0015671 | oxygen transport(GO:0015671) |
2.0 | 5.9 | GO:0032650 | regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730) cardiac cell fate determination(GO:0060913) |
0.8 | 2.5 | GO:0030300 | regulation of intestinal cholesterol absorption(GO:0030300) |
0.7 | 4.3 | GO:0001980 | regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980) |
0.4 | 3.1 | GO:0021913 | regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913) |
0.4 | 2.5 | GO:0032346 | positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349) |
0.4 | 1.1 | GO:0044333 | Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041) |
0.3 | 2.6 | GO:2001214 | positive regulation of vasculogenesis(GO:2001214) |
0.3 | 1.5 | GO:0043654 | recognition of apoptotic cell(GO:0043654) |
0.2 | 1.5 | GO:0002317 | plasma cell differentiation(GO:0002317) negative regulation of amyloid precursor protein biosynthetic process(GO:0042985) |
0.2 | 3.1 | GO:0097067 | negative regulation of erythrocyte differentiation(GO:0045647) cellular response to thyroid hormone stimulus(GO:0097067) |
0.2 | 2.4 | GO:0070574 | cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574) |
0.2 | 1.2 | GO:0035331 | negative regulation of hippo signaling(GO:0035331) |
0.2 | 3.6 | GO:0034377 | plasma lipoprotein particle assembly(GO:0034377) |
0.2 | 1.9 | GO:0006071 | glycerol metabolic process(GO:0006071) |
0.2 | 1.1 | GO:0033632 | regulation of cell-cell adhesion mediated by integrin(GO:0033632) |
0.2 | 1.8 | GO:0034242 | negative regulation of syncytium formation by plasma membrane fusion(GO:0034242) |
0.2 | 1.8 | GO:0018065 | protein-cofactor linkage(GO:0018065) |
0.2 | 0.5 | GO:0048352 | neural plate mediolateral regionalization(GO:0021998) mesoderm structural organization(GO:0048338) paraxial mesoderm structural organization(GO:0048352) |
0.2 | 0.5 | GO:0007290 | spermatid nucleus elongation(GO:0007290) |
0.2 | 0.8 | GO:0072488 | ammonium transmembrane transport(GO:0072488) |
0.2 | 2.2 | GO:0046697 | decidualization(GO:0046697) |
0.2 | 1.7 | GO:0042541 | hemoglobin biosynthetic process(GO:0042541) |
0.2 | 0.5 | GO:0002430 | complement receptor mediated signaling pathway(GO:0002430) |
0.1 | 2.7 | GO:0046597 | negative regulation of viral entry into host cell(GO:0046597) |
0.1 | 0.4 | GO:0035811 | negative regulation of urine volume(GO:0035811) |
0.1 | 0.5 | GO:0009957 | epidermal cell fate specification(GO:0009957) |
0.1 | 0.2 | GO:0014738 | regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900) |
0.1 | 0.5 | GO:0097168 | condensed mesenchymal cell proliferation(GO:0072137) mesenchymal stem cell proliferation(GO:0097168) |
0.1 | 0.4 | GO:0010593 | negative regulation of lamellipodium assembly(GO:0010593) |
0.1 | 1.2 | GO:0060501 | positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) |
0.1 | 4.6 | GO:0021884 | forebrain neuron development(GO:0021884) |
0.1 | 1.0 | GO:0006309 | apoptotic DNA fragmentation(GO:0006309) |
0.1 | 0.4 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
0.1 | 1.6 | GO:0035855 | megakaryocyte development(GO:0035855) |
0.1 | 0.3 | GO:0001880 | Mullerian duct regression(GO:0001880) |
0.1 | 0.2 | GO:2000857 | positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860) |
0.1 | 0.6 | GO:0043249 | erythrocyte maturation(GO:0043249) |
0.1 | 0.4 | GO:0042866 | pyruvate biosynthetic process(GO:0042866) |
0.1 | 0.2 | GO:0061153 | trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) |
0.0 | 0.5 | GO:0044539 | long-chain fatty acid import(GO:0044539) |
0.0 | 0.5 | GO:0045899 | positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899) |
0.0 | 0.2 | GO:0030263 | apoptotic chromosome condensation(GO:0030263) |
0.0 | 2.2 | GO:1902653 | cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653) |
0.0 | 0.4 | GO:0046036 | GTP biosynthetic process(GO:0006183) CTP biosynthetic process(GO:0006241) CTP metabolic process(GO:0046036) |
0.0 | 0.9 | GO:1902043 | positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043) |
0.0 | 0.9 | GO:0019432 | triglyceride biosynthetic process(GO:0019432) |
0.0 | 0.3 | GO:0032261 | purine nucleotide salvage(GO:0032261) IMP salvage(GO:0032264) |
0.0 | 0.1 | GO:1904995 | negative regulation of leukocyte tethering or rolling(GO:1903237) negative regulation of leukocyte adhesion to vascular endothelial cell(GO:1904995) |
0.0 | 0.6 | GO:0036342 | post-anal tail morphogenesis(GO:0036342) |
0.0 | 0.1 | GO:0006586 | tryptophan metabolic process(GO:0006568) indolalkylamine metabolic process(GO:0006586) |
0.0 | 0.1 | GO:1901164 | negative regulation of trophoblast cell migration(GO:1901164) |
0.0 | 0.2 | GO:0032836 | glomerular basement membrane development(GO:0032836) |
0.0 | 1.8 | GO:0006497 | protein lipidation(GO:0006497) |
0.0 | 0.0 | GO:0035928 | mitochondrial RNA 3'-end processing(GO:0000965) RNA 5'-end processing(GO:0000966) rRNA import into mitochondrion(GO:0035928) |
0.0 | 0.2 | GO:0032693 | negative regulation of interleukin-10 production(GO:0032693) |
0.0 | 1.4 | GO:0030168 | platelet activation(GO:0030168) |
0.0 | 0.6 | GO:0045746 | negative regulation of Notch signaling pathway(GO:0045746) |
0.0 | 0.3 | GO:0048642 | negative regulation of skeletal muscle tissue development(GO:0048642) |
0.0 | 0.4 | GO:1902236 | negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236) |
0.0 | 1.4 | GO:0048015 | phosphatidylinositol-mediated signaling(GO:0048015) |
0.0 | 0.1 | GO:0048563 | post-embryonic organ morphogenesis(GO:0048563) equilibrioception(GO:0050957) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
3.0 | 23.6 | GO:0005833 | hemoglobin complex(GO:0005833) |
1.1 | 6.3 | GO:0001674 | female germ cell nucleus(GO:0001674) |
0.9 | 4.3 | GO:0005861 | troponin complex(GO:0005861) |
0.3 | 2.5 | GO:0098533 | ATPase dependent transmembrane transport complex(GO:0098533) |
0.2 | 0.8 | GO:0033093 | Weibel-Palade body(GO:0033093) |
0.1 | 0.5 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
0.1 | 1.5 | GO:0031528 | microvillus membrane(GO:0031528) |
0.1 | 0.3 | GO:1990393 | 3M complex(GO:1990393) |
0.0 | 0.3 | GO:0030870 | Mre11 complex(GO:0030870) |
0.0 | 0.5 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
0.0 | 0.2 | GO:0005587 | collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651) |
0.0 | 0.4 | GO:0045298 | tubulin complex(GO:0045298) |
0.0 | 0.4 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
0.0 | 0.8 | GO:0001891 | phagocytic cup(GO:0001891) |
0.0 | 0.4 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
0.0 | 0.6 | GO:0008305 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
0.0 | 0.4 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
0.0 | 0.2 | GO:0061574 | ASAP complex(GO:0061574) |
0.0 | 0.2 | GO:0012506 | vesicle membrane(GO:0012506) |
0.0 | 1.6 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
0.0 | 1.2 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
0.0 | 0.2 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
0.0 | 1.8 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
0.0 | 1.8 | GO:0000793 | condensed chromosome(GO:0000793) |
0.0 | 0.1 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
0.0 | 1.4 | GO:0043204 | perikaryon(GO:0043204) |
0.0 | 4.5 | GO:0005667 | transcription factor complex(GO:0005667) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
4.7 | 23.6 | GO:0005344 | oxygen transporter activity(GO:0005344) |
1.4 | 4.3 | GO:0030172 | troponin C binding(GO:0030172) |
0.5 | 1.5 | GO:0003846 | 2-acylglycerol O-acyltransferase activity(GO:0003846) |
0.4 | 1.6 | GO:0004921 | interleukin-11 receptor activity(GO:0004921) interleukin-11 binding(GO:0019970) |
0.3 | 1.0 | GO:0004531 | deoxyribonuclease II activity(GO:0004531) |
0.3 | 1.8 | GO:0004852 | uroporphyrinogen-III synthase activity(GO:0004852) |
0.3 | 0.9 | GO:0008195 | phosphatidate phosphatase activity(GO:0008195) |
0.3 | 2.5 | GO:0070700 | BMP receptor binding(GO:0070700) |
0.2 | 0.7 | GO:0001875 | lipopolysaccharide receptor activity(GO:0001875) |
0.2 | 2.2 | GO:0004128 | cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128) |
0.2 | 8.6 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
0.2 | 0.5 | GO:0005119 | smoothened binding(GO:0005119) hedgehog receptor activity(GO:0008158) hedgehog family protein binding(GO:0097108) |
0.2 | 2.3 | GO:0017127 | cholesterol transporter activity(GO:0017127) |
0.2 | 0.5 | GO:0043758 | acetate-CoA ligase (ADP-forming) activity(GO:0043758) |
0.2 | 0.5 | GO:0004942 | anaphylatoxin receptor activity(GO:0004942) |
0.1 | 2.3 | GO:0016594 | glycine binding(GO:0016594) |
0.1 | 2.4 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
0.1 | 0.4 | GO:0004743 | pyruvate kinase activity(GO:0004743) |
0.1 | 0.4 | GO:0004069 | L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069) |
0.1 | 0.6 | GO:0070051 | fibrinogen binding(GO:0070051) |
0.1 | 1.2 | GO:0045294 | alpha-catenin binding(GO:0045294) |
0.1 | 0.5 | GO:0098821 | BMP receptor activity(GO:0098821) |
0.1 | 0.8 | GO:0019865 | immunoglobulin binding(GO:0019865) |
0.1 | 2.4 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
0.1 | 0.2 | GO:0004517 | nitric-oxide synthase activity(GO:0004517) arginine binding(GO:0034618) |
0.1 | 1.4 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
0.1 | 0.5 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
0.1 | 0.4 | GO:0008294 | calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294) |
0.1 | 0.3 | GO:0051880 | G-quadruplex DNA binding(GO:0051880) |
0.1 | 0.7 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
0.1 | 1.8 | GO:0034945 | dihydrolipoamide branched chain acyltransferase activity(GO:0004147) palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity(GO:0008951) serine O-acyltransferase activity(GO:0016412) O-succinyltransferase activity(GO:0016750) sinapoyltransferase activity(GO:0016752) O-sinapoyltransferase activity(GO:0016753) peptidyl-lysine N6-myristoyltransferase activity(GO:0018030) peptidyl-lysine N6-palmitoyltransferase activity(GO:0018031) benzoyl acetate-CoA thiolase activity(GO:0018711) 3-hydroxybutyryl-CoA thiolase activity(GO:0018712) 3-ketopimelyl-CoA thiolase activity(GO:0018713) N-palmitoyltransferase activity(GO:0019105) acyl-CoA N-acyltransferase activity(GO:0019186) protein-cysteine S-myristoyltransferase activity(GO:0019705) glucosaminyl-phosphotidylinositol O-acyltransferase activity(GO:0032216) ergosterol O-acyltransferase activity(GO:0034737) lanosterol O-acyltransferase activity(GO:0034738) naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity(GO:0034848) 2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity(GO:0034851) 2-methylhexanoyl-CoA C-acetyltransferase activity(GO:0034915) butyryl-CoA 2-C-propionyltransferase activity(GO:0034919) 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity(GO:0034945) L-2-aminoadipate N-acetyltransferase activity(GO:0043741) keto acid formate lyase activity(GO:0043806) azetidine-2-carboxylic acid acetyltransferase activity(GO:0046941) peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0052858) acetyl-CoA:L-lysine N6-acetyltransferase(GO:0090595) |
0.0 | 1.8 | GO:0050699 | WW domain binding(GO:0050699) |
0.0 | 1.1 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
0.0 | 0.8 | GO:0008519 | ammonium transmembrane transporter activity(GO:0008519) |
0.0 | 0.4 | GO:0051022 | Rho GDP-dissociation inhibitor binding(GO:0051022) |
0.0 | 0.1 | GO:0004510 | tryptophan 5-monooxygenase activity(GO:0004510) |
0.0 | 0.2 | GO:0030156 | benzodiazepine receptor binding(GO:0030156) |
0.0 | 1.3 | GO:0005272 | sodium channel activity(GO:0005272) |
0.0 | 1.5 | GO:0001540 | beta-amyloid binding(GO:0001540) |
0.0 | 0.3 | GO:0003876 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
0.0 | 0.1 | GO:0031735 | CCR10 chemokine receptor binding(GO:0031735) |
0.0 | 3.9 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
0.0 | 0.1 | GO:0004427 | inorganic diphosphatase activity(GO:0004427) |
0.0 | 0.4 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
0.0 | 0.4 | GO:0034185 | apolipoprotein binding(GO:0034185) |
0.0 | 1.6 | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980) |
0.0 | 0.1 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
0.0 | 0.6 | GO:0005112 | Notch binding(GO:0005112) |
0.0 | 0.5 | GO:0050681 | androgen receptor binding(GO:0050681) |
0.0 | 0.7 | GO:0004896 | cytokine receptor activity(GO:0004896) |
0.0 | 0.9 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |