Motif ID: Gata2_Gata1

Z-value: 0.965

Transcription factors associated with Gata2_Gata1:

Gene SymbolEntrez IDGene Name
Gata1 ENSMUSG00000031162.8 Gata1
Gata2 ENSMUSG00000015053.8 Gata2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gata1mm10_v2_chrX_-_7967817_79679100.601.3e-03Click!
Gata2mm10_v2_chr6_+_88198656_881986750.087.1e-01Click!


Activity profile for motif Gata2_Gata1.

activity profile for motif Gata2_Gata1


Sorted Z-values histogram for motif Gata2_Gata1

Sorted Z-values for motif Gata2_Gata1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gata2_Gata1

PNG image of the network

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Top targets:


Showing 1 to 20 of 155 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_32276400 13.086 ENSMUST00000020531.2
 Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr11_+_32276893 10.525 ENSMUST00000145569.1
 Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr3_-_154330543 6.316 ENSMUST00000184966.1
ENSMUST00000177846.2
 Lhx8

LIM homeobox protein 8

chr13_-_116309639 5.914 ENSMUST00000036060.6
 Isl1
ISL1 transcription factor, LIM/homeodomain
chr2_-_153241402 3.222 ENSMUST00000056924.7
 Plagl2
pleiomorphic adenoma gene-like 2
chr2_+_103957976 3.102 ENSMUST00000156813.1
ENSMUST00000170926.1
 Lmo2

LIM domain only 2

chr7_-_139582790 3.095 ENSMUST00000106095.2
 Nkx6-2
NK6 homeobox 2
chr7_-_4522427 2.646 ENSMUST00000098859.3
 Tnni3
troponin I, cardiac 3
chr6_+_30541582 2.544 ENSMUST00000096066.4
 Cpa2
carboxypeptidase A2, pancreatic
chr17_-_84682932 2.519 ENSMUST00000066175.3
 Abcg5
ATP-binding cassette, sub-family G (WHITE), member 5
chr13_+_38345716 2.514 ENSMUST00000171970.1
 Bmp6
bone morphogenetic protein 6
chr17_+_36869567 2.425 ENSMUST00000060524.9
 Trim10
tripartite motif-containing 10
chrX_+_150547375 2.350 ENSMUST00000066337.6
ENSMUST00000112715.1
 Alas2

aminolevulinic acid synthase 2, erythroid

chr3_-_84479418 2.177 ENSMUST00000091002.1
 Fhdc1
FH2 domain containing 1
chr4_+_11579647 2.049 ENSMUST00000180239.1
 Fsbp
fibrinogen silencer binding protein
chr15_-_103251465 1.806 ENSMUST00000133600.1
ENSMUST00000134554.1
ENSMUST00000156927.1
ENSMUST00000149111.1
ENSMUST00000132836.1
 Nfe2




nuclear factor, erythroid derived 2




chr8_+_34115030 1.794 ENSMUST00000095345.3
 Mboat4
membrane bound O-acyltransferase domain containing 4
chr9_-_44342332 1.782 ENSMUST00000097558.3
 Hmbs
hydroxymethylbilane synthase
chr2_+_169632996 1.764 ENSMUST00000109159.2
 Tshz2
teashirt zinc finger family member 2
chr7_-_4522794 1.679 ENSMUST00000140424.1
 Tnni3
troponin I, cardiac 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.7 23.6 GO:0015671 oxygen transport(GO:0015671)
2.0 5.9 GO:0032650 regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730) cardiac cell fate determination(GO:0060913)
0.1 4.6 GO:0021884 forebrain neuron development(GO:0021884)
0.7 4.3 GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980)
0.2 3.6 GO:0034377 plasma lipoprotein particle assembly(GO:0034377)
0.4 3.1 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.2 3.1 GO:0097067 negative regulation of erythrocyte differentiation(GO:0045647) cellular response to thyroid hormone stimulus(GO:0097067)
0.1 2.7 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.3 2.6 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.8 2.5 GO:0030300 regulation of intestinal cholesterol absorption(GO:0030300)
0.4 2.5 GO:0032346 positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349)
0.2 2.4 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.2 2.2 GO:0046697 decidualization(GO:0046697)
0.0 2.2 GO:1902653 cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
0.2 1.9 GO:0006071 glycerol metabolic process(GO:0006071)
0.2 1.8 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.2 1.8 GO:0018065 protein-cofactor linkage(GO:0018065)
0.0 1.8 GO:0006497 protein lipidation(GO:0006497)
0.2 1.7 GO:0042541 hemoglobin biosynthetic process(GO:0042541)
0.1 1.6 GO:0035855 megakaryocyte development(GO:0035855)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 23.6 GO:0005833 hemoglobin complex(GO:0005833)
1.1 6.3 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 4.5 GO:0005667 transcription factor complex(GO:0005667)
0.9 4.3 GO:0005861 troponin complex(GO:0005861)
0.3 2.5 GO:0098533 ATPase dependent transmembrane transport complex(GO:0098533)
0.0 1.8 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 1.8 GO:0000793 condensed chromosome(GO:0000793)
0.0 1.6 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 1.5 GO:0031528 microvillus membrane(GO:0031528)
0.0 1.4 GO:0043204 perikaryon(GO:0043204)
0.0 1.2 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.2 0.8 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.8 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.6 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.1 0.5 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.5 GO:0031595 nuclear proteasome complex(GO:0031595)
0.0 0.4 GO:0045298 tubulin complex(GO:0045298)
0.0 0.4 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.4 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.4 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.7 23.6 GO:0005344 oxygen transporter activity(GO:0005344)
0.2 8.6 GO:0043425 bHLH transcription factor binding(GO:0043425)
1.4 4.3 GO:0030172 troponin C binding(GO:0030172)
0.0 3.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.3 2.5 GO:0070700 BMP receptor binding(GO:0070700)
0.1 2.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 2.4 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.2 2.3 GO:0017127 cholesterol transporter activity(GO:0017127)
0.1 2.3 GO:0016594 glycine binding(GO:0016594)
0.2 2.2 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.3 1.8 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.1 1.8 GO:0034945 dihydrolipoamide branched chain acyltransferase activity(GO:0004147) palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity(GO:0008951) serine O-acyltransferase activity(GO:0016412) O-succinyltransferase activity(GO:0016750) sinapoyltransferase activity(GO:0016752) O-sinapoyltransferase activity(GO:0016753) peptidyl-lysine N6-myristoyltransferase activity(GO:0018030) peptidyl-lysine N6-palmitoyltransferase activity(GO:0018031) benzoyl acetate-CoA thiolase activity(GO:0018711) 3-hydroxybutyryl-CoA thiolase activity(GO:0018712) 3-ketopimelyl-CoA thiolase activity(GO:0018713) N-palmitoyltransferase activity(GO:0019105) acyl-CoA N-acyltransferase activity(GO:0019186) protein-cysteine S-myristoyltransferase activity(GO:0019705) glucosaminyl-phosphotidylinositol O-acyltransferase activity(GO:0032216) ergosterol O-acyltransferase activity(GO:0034737) lanosterol O-acyltransferase activity(GO:0034738) naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity(GO:0034848) 2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity(GO:0034851) 2-methylhexanoyl-CoA C-acetyltransferase activity(GO:0034915) butyryl-CoA 2-C-propionyltransferase activity(GO:0034919) 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity(GO:0034945) L-2-aminoadipate N-acetyltransferase activity(GO:0043741) keto acid formate lyase activity(GO:0043806) azetidine-2-carboxylic acid acetyltransferase activity(GO:0046941) peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0052858) acetyl-CoA:L-lysine N6-acetyltransferase(GO:0090595)
0.0 1.8 GO:0050699 WW domain binding(GO:0050699)
0.4 1.6 GO:0004921 interleukin-11 receptor activity(GO:0004921) interleukin-11 binding(GO:0019970)
0.0 1.6 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.5 1.5 GO:0003846 2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0 1.5 GO:0001540 beta-amyloid binding(GO:0001540)
0.1 1.4 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 1.3 GO:0005272 sodium channel activity(GO:0005272)
0.1 1.2 GO:0045294 alpha-catenin binding(GO:0045294)