Motif ID: Gbx1_Nobox_Alx3

Z-value: 0.740

Transcription factors associated with Gbx1_Nobox_Alx3:

Gene SymbolEntrez IDGene Name
Alx3 ENSMUSG00000014603.1 Alx3
Gbx1 ENSMUSG00000067724.4 Gbx1
Nobox ENSMUSG00000029736.9 Nobox

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gbx1mm10_v2_chr5_-_24527276_245272760.591.4e-03Click!
Alx3mm10_v2_chr3_+_107595031_1075951640.009.9e-01Click!


Activity profile for motif Gbx1_Nobox_Alx3.

activity profile for motif Gbx1_Nobox_Alx3


Sorted Z-values histogram for motif Gbx1_Nobox_Alx3

Sorted Z-values for motif Gbx1_Nobox_Alx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Gbx1_Nobox_Alx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_139543889 11.846 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr2_+_109917639 3.845 ENSMUST00000046548.7
ENSMUST00000111037.2
 Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr3_+_159839729 3.151 ENSMUST00000068952.5
 Wls
wntless homolog (Drosophila)
chr2_-_168767029 2.964 ENSMUST00000075044.3
 Sall4
sal-like 4 (Drosophila)
chr12_+_109545390 2.864 ENSMUST00000146701.1
 Meg3
maternally expressed 3
chr3_+_134236483 2.733 ENSMUST00000181904.1
ENSMUST00000053048.9
 Cxxc4

CXXC finger 4

chr12_-_57546121 2.653 ENSMUST00000044380.6
 Foxa1
forkhead box A1
chr3_+_55782500 2.589 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr2_+_9882622 2.394 ENSMUST00000114919.1
 4930412O13Rik
RIKEN cDNA 4930412O13 gene
chr14_-_48662740 2.290 ENSMUST00000122009.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr12_-_40037387 2.276 ENSMUST00000146905.1
 Arl4a
ADP-ribosylation factor-like 4A
chr6_-_23248264 2.208 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr1_-_190170671 2.174 ENSMUST00000175916.1
 Prox1
prospero-related homeobox 1
chr13_-_102906046 2.113 ENSMUST00000171791.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr8_+_23669653 2.021 ENSMUST00000042352.4
 Zmat4
zinc finger, matrin type 4
chr7_+_144838590 2.007 ENSMUST00000105898.1
 Fgf3
fibroblast growth factor 3
chr13_-_102905740 1.961 ENSMUST00000167462.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr6_-_124779686 1.948 ENSMUST00000147669.1
ENSMUST00000128697.1
ENSMUST00000032218.3
ENSMUST00000112475.2
 Lrrc23



leucine rich repeat containing 23



chr3_+_122419772 1.834 ENSMUST00000029766.4
 Bcar3
breast cancer anti-estrogen resistance 3
chr2_-_168767136 1.811 ENSMUST00000029061.5
ENSMUST00000103074.1
 Sall4

sal-like 4 (Drosophila)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 108 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 11.8 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.3 4.8 GO:0001833 inner cell mass cell proliferation(GO:0001833)
1.3 3.8 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.2 3.2 GO:0031017 exocrine pancreas development(GO:0031017)
1.0 2.9 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.1 2.9 GO:0008340 determination of adult lifespan(GO:0008340)
0.0 2.8 GO:0030178 negative regulation of Wnt signaling pathway(GO:0030178)
0.9 2.7 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743) alveolar secondary septum development(GO:0061144)
0.1 2.6 GO:0050873 brown fat cell differentiation(GO:0050873)
0.6 2.3 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.3 2.3 GO:0051798 positive regulation of hair follicle development(GO:0051798)
0.1 2.3 GO:0007638 mechanosensory behavior(GO:0007638)
0.1 2.3 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.0 2.3 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.3 2.0 GO:0030916 otic vesicle formation(GO:0030916)
0.0 2.0 GO:0001889 liver development(GO:0001889)
0.3 1.9 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261) positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.2 1.9 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 1.8 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.1 1.6 GO:0006907 pinocytosis(GO:0006907)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.9 GO:0000792 heterochromatin(GO:0000792)
0.1 3.2 GO:0032590 dendrite membrane(GO:0032590)
0.0 2.7 GO:0005902 microvillus(GO:0005902)
0.0 1.9 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 1.8 GO:0016607 nuclear speck(GO:0016607)
0.0 1.6 GO:0031201 SNARE complex(GO:0031201)
0.3 1.5 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 1.4 GO:0055038 recycling endosome membrane(GO:0055038)
0.2 1.2 GO:0005726 perichromatin fibrils(GO:0005726)
0.2 1.1 GO:0001674 female germ cell nucleus(GO:0001674)
0.1 1.1 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 1.0 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 1.0 GO:0043034 costamere(GO:0043034)
0.1 0.9 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.8 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.8 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.8 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.8 GO:0030315 T-tubule(GO:0030315)
0.1 0.7 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.7 GO:0002102 podosome(GO:0002102)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 16.8 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.0 8.4 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 4.0 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.3 3.8 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 3.7 GO:0000287 magnesium ion binding(GO:0000287)
0.0 3.3 GO:0030165 PDZ domain binding(GO:0030165)
0.4 2.9 GO:0050693 LBD domain binding(GO:0050693)
0.3 2.6 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.0 2.3 GO:0002039 p53 binding(GO:0002039)
0.3 1.9 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.2 1.9 GO:0019865 immunoglobulin binding(GO:0019865)
0.1 1.8 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.2 1.7 GO:0048185 activin binding(GO:0048185)
0.1 1.6 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 1.6 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 1.6 GO:0019905 syntaxin binding(GO:0019905)
0.2 1.4 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 1.4 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.2 1.2 GO:0034056 estrogen response element binding(GO:0034056)
0.1 1.2 GO:0008545 JUN kinase kinase activity(GO:0008545)