Motif ID: Gbx2

Z-value: 0.366


Transcription factors associated with Gbx2:

Gene SymbolEntrez IDGene Name
Gbx2 ENSMUSG00000034486.7 Gbx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gbx2mm10_v2_chr1_-_89933290_89933290-0.106.3e-01Click!


Activity profile for motif Gbx2.

activity profile for motif Gbx2


Sorted Z-values histogram for motif Gbx2

Sorted Z-values for motif Gbx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Gbx2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_-_48667508 1.368 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
 Otx2



orthodenticle homolog 2 (Drosophila)



chr3_+_94372794 1.352 ENSMUST00000029795.3
 Rorc
RAR-related orphan receptor gamma
chr11_+_59306920 1.268 ENSMUST00000000128.3
ENSMUST00000108783.3
 Wnt9a

wingless-type MMTV integration site 9A

chr12_+_79297345 1.084 ENSMUST00000079533.5
ENSMUST00000171210.1
 Rad51b

RAD51 homolog B

chrX_+_106920618 0.948 ENSMUST00000060576.7
 Lpar4
lysophosphatidic acid receptor 4
chr19_+_23723279 0.928 ENSMUST00000067077.1
 Gm9938
predicted gene 9938
chr17_-_48432723 0.869 ENSMUST00000046549.3
 Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr1_-_128102412 0.785 ENSMUST00000112538.1
ENSMUST00000086614.5
 Zranb3

zinc finger, RAN-binding domain containing 3

chr7_-_30664986 0.778 ENSMUST00000019697.8
 Haus5
HAUS augmin-like complex, subunit 5
chr19_-_59170978 0.723 ENSMUST00000172821.2
 Vax1
ventral anterior homeobox containing gene 1
chr7_+_75455534 0.720 ENSMUST00000147005.1
ENSMUST00000166315.1
 Akap13

A kinase (PRKA) anchor protein 13

chr18_+_56432116 0.627 ENSMUST00000070166.5
 Gramd3
GRAM domain containing 3
chr2_+_152754156 0.593 ENSMUST00000010020.5
 Cox4i2
cytochrome c oxidase subunit IV isoform 2
chr3_-_141982224 0.566 ENSMUST00000029948.8
 Bmpr1b
bone morphogenetic protein receptor, type 1B
chr13_-_97747373 0.408 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr13_+_23763660 0.385 ENSMUST00000055770.1
 Hist1h1a
histone cluster 1, H1a
chr11_-_5878207 0.374 ENSMUST00000102922.3
 Pold2
polymerase (DNA directed), delta 2, regulatory subunit
chr3_+_96645579 0.338 ENSMUST00000119365.1
ENSMUST00000029744.5
 Itga10

integrin, alpha 10

chr3_-_116129615 0.337 ENSMUST00000029574.8
 Vcam1
vascular cell adhesion molecule 1
chr10_-_95501921 0.319 ENSMUST00000075829.2
 Mrpl42
mitochondrial ribosomal protein L42
chr9_+_96258697 0.317 ENSMUST00000179416.1
 Tfdp2
transcription factor Dp 2
chr4_-_129261394 0.300 ENSMUST00000145261.1
 C77080
expressed sequence C77080
chr13_-_97747399 0.299 ENSMUST00000144993.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr7_-_78783026 0.290 ENSMUST00000032841.5
 Mrpl46
mitochondrial ribosomal protein L46
chr16_+_44394771 0.285 ENSMUST00000099742.2
 Wdr52
WD repeat domain 52
chr3_+_152714094 0.275 ENSMUST00000159899.1
ENSMUST00000045029.8
 Pigk

phosphatidylinositol glycan anchor biosynthesis, class K

chr1_-_175625580 0.258 ENSMUST00000027810.7
 Fh1
fumarate hydratase 1
chrX_-_56598069 0.250 ENSMUST00000059899.2
 Mmgt1
membrane magnesium transporter 1
chr13_+_49544443 0.212 ENSMUST00000177948.1
ENSMUST00000021820.6
 Aspn

asporin

chr4_-_26346882 0.203 ENSMUST00000041374.7
ENSMUST00000153813.1
 Manea

mannosidase, endo-alpha

chr11_-_21370452 0.189 ENSMUST00000102875.4
 Ugp2
UDP-glucose pyrophosphorylase 2
chr11_-_45955183 0.175 ENSMUST00000109254.1
 Thg1l
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr10_+_128083273 0.155 ENSMUST00000026459.5
 Atp5b
ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit
chr7_+_78783119 0.142 ENSMUST00000032840.4
 Mrps11
mitochondrial ribosomal protein S11
chrM_-_14060 0.127 ENSMUST00000082419.1
 mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr14_+_69347587 0.118 ENSMUST00000064831.5
 Entpd4
ectonucleoside triphosphate diphosphohydrolase 4
chr16_-_22439719 0.110 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr16_-_36784784 0.107 ENSMUST00000165531.1
 Slc15a2
solute carrier family 15 (H+/peptide transporter), member 2
chr11_+_97315716 0.104 ENSMUST00000019026.3
ENSMUST00000132168.1
 Mrpl45

mitochondrial ribosomal protein L45

chr12_+_111814170 0.096 ENSMUST00000021714.7
 Zfyve21
zinc finger, FYVE domain containing 21
chr12_-_98259416 0.093 ENSMUST00000021390.7
 Galc
galactosylceramidase
chr7_+_28810886 0.090 ENSMUST00000038572.8
 Hnrnpl
heterogeneous nuclear ribonucleoprotein L
chr5_+_115341225 0.090 ENSMUST00000031508.4
 Triap1
TP53 regulated inhibitor of apoptosis 1
chrM_+_14138 0.088 ENSMUST00000082421.1
 mt-Cytb
mitochondrially encoded cytochrome b
chr3_-_89998656 0.066 ENSMUST00000079724.4
 Hax1
HCLS1 associated X-1
chr7_-_140822124 0.060 ENSMUST00000106052.1
ENSMUST00000080651.6
 Zfp941

zinc finger protein 941

chr5_-_5266038 0.055 ENSMUST00000115451.1
ENSMUST00000115452.1
ENSMUST00000131392.1
 Cdk14


cyclin-dependent kinase 14


chr3_-_10331358 0.052 ENSMUST00000065938.8
ENSMUST00000118410.1
 Impa1

inositol (myo)-1(or 4)-monophosphatase 1

chr4_+_110397661 0.043 ENSMUST00000106589.2
ENSMUST00000106587.2
ENSMUST00000106591.1
ENSMUST00000106592.1
 Agbl4



ATP/GTP binding protein-like 4



chr15_-_103239812 0.032 ENSMUST00000118152.1
 Cbx5
chromobox 5
chr1_-_4785671 0.032 ENSMUST00000130201.1
ENSMUST00000156816.1
 Mrpl15

mitochondrial ribosomal protein L15

chr18_+_57354733 0.026 ENSMUST00000025490.8
 Prrc1
proline-rich coiled-coil 1
chr5_-_115341142 0.018 ENSMUST00000139167.1
 Gatc
glutamyl-tRNA(Gln) amidotransferase, subunit C homolog (bacterial)
chr18_-_67245818 0.010 ENSMUST00000073054.3
 Mppe1
metallophosphoesterase 1
chr3_+_88615367 0.009 ENSMUST00000176539.1
 Arhgef2
rho/rac guanine nucleotide exchange factor (GEF) 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.3 1.1 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.3 0.8 GO:0036292 DNA rewinding(GO:0036292)
0.2 1.4 GO:0072539 T-helper 17 cell differentiation(GO:0072539)
0.1 0.6 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.1 0.7 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.1 0.7 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
0.1 0.6 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 0.3 GO:0006106 fumarate metabolic process(GO:0006106)
0.1 0.2 GO:0006011 UDP-glucose metabolic process(GO:0006011) glucose 1-phosphate metabolic process(GO:0019255)
0.1 0.2 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.0 0.9 GO:0080111 DNA demethylation(GO:0080111)
0.0 0.3 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 1.3 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 0.2 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.0 0.1 GO:0009193 pyrimidine ribonucleoside diphosphate metabolic process(GO:0009193) UDP metabolic process(GO:0046048)
0.0 0.3 GO:0061032 visceral serous pericardium development(GO:0061032)
0.0 0.2 GO:0006824 cobalt ion transport(GO:0006824)
0.0 0.1 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.0 0.1 GO:0033762 response to glucagon(GO:0033762)
0.0 0.1 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.0 0.1 GO:1902416 positive regulation of mRNA binding(GO:1902416) positive regulation of RNA binding(GO:1905216)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.1 0.4 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 0.8 GO:0070652 HAUS complex(GO:0070652)
0.1 0.6 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.3 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.2 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.8 GO:0043596 nuclear replication fork(GO:0043596)
0.0 0.2 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0 0.3 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.0 0.3 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 0.5 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.3 GO:0002102 podosome(GO:0002102)
0.0 0.1 GO:0045275 respiratory chain complex III(GO:0045275)
0.0 0.1 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0008142 oxysterol binding(GO:0008142)
0.2 0.9 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.2 1.1 GO:0000150 recombinase activity(GO:0000150)
0.1 0.7 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.1 0.3 GO:0098634 protein binding involved in cell-matrix adhesion(GO:0098634) collagen binding involved in cell-matrix adhesion(GO:0098639)
0.1 0.3 GO:0008131 primary amine oxidase activity(GO:0008131)
0.1 0.8 GO:0036310 annealing helicase activity(GO:0036310)
0.1 0.6 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.7 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 1.3 GO:0005109 frizzled binding(GO:0005109)
0.0 0.2 GO:0015087 cobalt ion transmembrane transporter activity(GO:0015087)
0.0 0.6 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.9 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.0 0.1 GO:0019966 interleukin-1 binding(GO:0019966)
0.0 0.2 GO:0008193 tRNA guanylyltransferase activity(GO:0008193)
0.0 0.2 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 0.1 GO:0031403 lithium ion binding(GO:0031403)
0.0 0.1 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.0 0.1 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.0 0.4 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.2 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.1 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.1 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)