Motif ID: Gli1

Z-value: 0.399


Transcription factors associated with Gli1:

Gene SymbolEntrez IDGene Name
Gli1 ENSMUSG00000025407.6 Gli1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gli1mm10_v2_chr10_-_127341583_127341614-0.349.1e-02Click!


Activity profile for motif Gli1.

activity profile for motif Gli1


Sorted Z-values histogram for motif Gli1

Sorted Z-values for motif Gli1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gli1

PNG image of the network

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Top targets:


Showing 1 to 20 of 166 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_54954728 1.047 ENSMUST00000033915.7
 Gpm6a
glycoprotein m6a
chr11_-_42000284 0.918 ENSMUST00000109292.2
ENSMUST00000109290.1
 Gabrg2

gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2

chr1_-_133801031 0.822 ENSMUST00000143567.1
 Atp2b4
ATPase, Ca++ transporting, plasma membrane 4
chr11_-_42000532 0.788 ENSMUST00000070735.3
 Gabrg2
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2
chr11_-_119547744 0.680 ENSMUST00000026670.4
 Nptx1
neuronal pentraxin 1
chr1_-_56972437 0.668 ENSMUST00000042857.7
 Satb2
special AT-rich sequence binding protein 2
chr2_-_36104060 0.662 ENSMUST00000112961.3
ENSMUST00000112966.3
 Lhx6

LIM homeobox protein 6

chr12_-_81333129 0.654 ENSMUST00000085238.6
ENSMUST00000182208.1
 Slc8a3

solute carrier family 8 (sodium/calcium exchanger), member 3

chr15_-_95528228 0.627 ENSMUST00000075275.2
 Nell2
NEL-like 2
chr1_+_152954966 0.608 ENSMUST00000043313.8
 Nmnat2
nicotinamide nucleotide adenylyltransferase 2
chr10_-_64090265 0.597 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr17_+_37045963 0.588 ENSMUST00000025338.9
 Gabbr1
gamma-aminobutyric acid (GABA) B receptor, 1
chr9_+_50752758 0.588 ENSMUST00000034562.7
 Cryab
crystallin, alpha B
chr10_-_64090241 0.580 ENSMUST00000133588.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr17_-_24209377 0.571 ENSMUST00000024931.4
 Ntn3
netrin 3
chr11_+_80300866 0.570 ENSMUST00000017836.7
 Rhbdl3
rhomboid, veinlet-like 3 (Drosophila)
chr18_-_43373248 0.566 ENSMUST00000118043.1
 Dpysl3
dihydropyrimidinase-like 3
chr14_-_55560340 0.543 ENSMUST00000066106.3
 A730061H03Rik
RIKEN cDNA A730061H03 gene
chr10_+_69533761 0.543 ENSMUST00000182884.1
 Ank3
ankyrin 3, epithelial
chr8_+_70501116 0.539 ENSMUST00000127983.1
 Crlf1
cytokine receptor-like factor 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.9 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.2 1.8 GO:0071420 cellular response to histamine(GO:0071420)
0.1 1.2 GO:1902993 positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.4 1.1 GO:0010751 negative regulation of nitric oxide mediated signal transduction(GO:0010751)
0.1 1.0 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.0 1.0 GO:0003407 neural retina development(GO:0003407)
0.1 0.9 GO:0032811 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) negative regulation of epinephrine secretion(GO:0032811)
0.1 0.9 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.0 0.9 GO:0007520 myoblast fusion(GO:0007520)
0.1 0.8 GO:0042572 retinol metabolic process(GO:0042572)
0.2 0.7 GO:0035864 response to potassium ion(GO:0035864) cellular response to potassium ion(GO:0035865)
0.2 0.7 GO:1990034 calcium ion export from cell(GO:1990034)
0.1 0.7 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.1 0.7 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 0.7 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.2 0.6 GO:0019355 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process(GO:0034627) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.1 0.6 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.6 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.5 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.5 GO:0021516 dorsal spinal cord development(GO:0021516)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.9 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.1 1.8 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 1.3 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 1.0 GO:0060170 ciliary membrane(GO:0060170)
0.0 1.0 GO:0044295 axonal growth cone(GO:0044295)
0.2 0.9 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.0 0.8 GO:0097228 sperm principal piece(GO:0097228)
0.2 0.6 GO:0097512 cardiac myofibril(GO:0097512)
0.0 0.6 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.6 GO:0031941 filamentous actin(GO:0031941)
0.2 0.5 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 0.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.4 GO:0072546 ER membrane protein complex(GO:0072546)
0.1 0.3 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.3 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.3 GO:0042825 TAP complex(GO:0042825)
0.0 0.3 GO:0031931 TORC1 complex(GO:0031931)
0.1 0.2 GO:0031088 platelet dense granule membrane(GO:0031088) platelet dense tubular network(GO:0031094)
0.0 0.2 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.2 GO:0043194 axon initial segment(GO:0043194)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.9 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 1.8 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 1.5 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 1.3 GO:0015085 calcium ion transmembrane transporter activity(GO:0015085)
0.0 1.1 GO:0005080 protein kinase C binding(GO:0005080)
0.2 0.9 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 0.8 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 0.8 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 0.7 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.2 0.6 GO:0004515 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.1 0.6 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.1 0.6 GO:0005212 structural constituent of eye lens(GO:0005212)
0.2 0.5 GO:0004994 somatostatin receptor activity(GO:0004994)
0.1 0.5 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.1 0.4 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.0 0.4 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1 0.3 GO:0070052 collagen V binding(GO:0070052)
0.1 0.3 GO:0023029 peptide antigen-transporting ATPase activity(GO:0015433) MHC class Ib protein binding(GO:0023029) tapasin binding(GO:0046980)
0.1 0.3 GO:1902379 chemoattractant activity involved in axon guidance(GO:1902379)
0.0 0.3 GO:0004351 glutamate decarboxylase activity(GO:0004351)